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Hussein N. Yassine @yassinelab1.bsky.social · 8d

www.theguardian.com/us-news/2025...
A good analysis by the Guardian explaining how associations are often not causations. Love the heat and Ice cream analogy..

How the White House used studies with ‘weak’ evidence to tie Tylenol to autism

Experts say White House presented ‘association as causation’ and based conclusions on ‘poor quality studies’

www.theguardian.com

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Hussein N. Yassine @yassinelab1.bsky.social · 16d

At human doses? Sorry did not look closely
A problem with many mice studies is doses used are quite exaggerated by design to see an effect.

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Hussein N. Yassine @yassinelab1.bsky.social · 16d

I don’t think anyone paid attention to this paper until now. A meta analysis can be useful if the papers they are citing are credible and the authors follow proper methodology. Without a mechanism, the association of Tylenol with autism is vague. This paper makes us look more deeply into this.

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Hussein N. Yassine @yassinelab1.bsky.social · Sep 7

Enjoyed your podcast! Appreciated the insights into education and cognition.

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Hussein N. Yassine @yassinelab1.bsky.social · Aug 27

Very beautiful Meredith!

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Hussein N. Yassine @yassinelab1.bsky.social · Aug 22

Well said! Science is for all of us and should be above politics.

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Hussein N. Yassine @yassinelab1.bsky.social · Aug 15

This study, led by the talented grad student Boyang Li, identifies microglia undergoing cellular senescence in AD, and targeting cholesterol metabolism in senescent microglia is a therapeutic approach to slow AD progression. onlinelibrary.wiley.com/doi/10.1111/...

Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

Senescent microglia in Alzheimer's disease exhibit dysregulated cholesterol metabolism and express Disease-Associated Microglia (DAM) signatures, including inflammatory and phagocytic markers. Single....

onlinelibrary.wiley.com

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Hussein N. Yassine @yassinelab1.bsky.social · Aug 13

news.uci.edu/2025/08/12/w...
Great work by a fantastic team!

Women with Down syndrome may develop Alzheimer's disease more rapidly than men

UC Irvine study finds sex differences may impact treatment approaches

news.uci.edu

Reposted by Hussein N. Yassine

Ian Kremer @leadcoalition.bsky.social · Aug 13

Women with Down syndrome may develop Alzheimer's disease more rapidly than men news.uci.edu/2025/08/12/w... by @ucirvine.bsky.social

#Alzheimers #dementia #DownSyndrome #WomensHealth @elizabethhead.bsky.social

Women with Down syndrome may develop Alzheimer's disease more rapidly than men

UC Irvine study finds sex differences may impact treatment approaches

news.uci.edu

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Hussein N. Yassine @yassinelab1.bsky.social · Aug 1

SNAP program in vulnerable groups more effective in lowering cognitive decline than the more expensive intensive lifestyle intervention in the general population

HealthBegins @healthbegins.bsky.social · Aug 1

More evidence that decreasing #foodinsecurity and improving access to #nutrition improves health outcomes. #foodismedicine

SNAP Food Program Linked to Slower Cognitive Decline in Older Adults www.nytimes.com/2025/07/30/w... by @smithdanag.bsky.social via @nytimes.com CC: @yassinelab1.bsky.social

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Reposted by Hussein N. Yassine

National Alzheimer's Coordinating Center @naccdata.org · Jul 27

Don't miss out on poster presentations by #NIAfundedADRC REC scholars today at #AAIC2025!

Learn more about the Research, Education, Component (REC) and REC scholars: naccdata.org/adrc-resourc...

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Hussein N. Yassine @yassinelab1.bsky.social · Jul 25

Congratulations to @sdukehan.bsky.social for leading a major gerontology journal

Alt The National Institute on Aging @altthenia.bsky.social · Jul 25

We are working our hardest to help the #ADRD and #geronsky community. @sdukehan.bsky.social , this dedication means so much to us. You are a fine editor. #NIHStrong #FEDstrong #RESIST

Dr. S. Duke Han @sdukehan.bsky.social · Jul 25

My second year editorial as Editor-In-Chief of The Journal of Gerontology: Psychological Sciences. This one is dedicated to the heroes among us and may be one of the most important pieces I've ever written...

@uscpsychology.bsky.social @oxfordunipress.bsky.social

academic.oup.com/psychsocgero...

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Hussein N. Yassine @yassinelab1.bsky.social · Jul 23

The system can be gamed
Reviews are highly cited and often self citing the authors work
Unfortunately we all do this
Both journals and authors can inflate their citation indices with paper mills or high IF reviews
The number of citations does not replace a critical appraisal

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Hussein N. Yassine @yassinelab1.bsky.social · Jul 23

Someone who kept citing himself..

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Hussein N. Yassine @yassinelab1.bsky.social · Jul 22

Letrozole and irinotecan are not typically used for aging-related diseases. These are chemotherapies with severe side effects. While the approach is novel, the results are unconventional to say the least!

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Hussein N. Yassine @yassinelab1.bsky.social · Jul 16

Congratulations! There is light at the end of the tunnel

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Hussein N. Yassine @yassinelab1.bsky.social · Jul 12

Fantastic work by a fantastic team!

Priyanka Narayan @prinarayan.bsky.social · Jul 11

‼️ New paper from the lab! ‼️
We uncovered links between triglyceride metabolism, microglial activation, and our favorite—APOE! 🧬🔥🧫🔬

Led by the amazing Dr. Roxan Stephenson, with a fantastic team of collaborators. Super proud of this one!

Check it out 👇🏽
www.cell.com/cell-reports...

Yay team! 🙌🏽

A graphical abstract showing how triglyceride metabolism is necessary for microglial activation and can be used to modulate inflammation and disease phenotypes in APOE4 microglia.

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Hussein N. Yassine @yassinelab1.bsky.social · Jul 10

Congratulations to Dobrin Nedelkov and Zoe Tsokolas! We demonstrate that apoE glycosylation in CSF predicts tau pathology in the ADNI cohort. We identify a new role for sugars attached to apoE in AD. Could less glycosylated apoE play a major role in tau spread? link.springer.com/article/10.1...

Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer’s disease biomarkers - Alzheimer's Research & Therapy

The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). ApoE is glycosylated with an O-linked Core-1 sialylated glycan at several sites; how...

link.springer.com

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Hussein N. Yassine @yassinelab1.bsky.social · Jun 1

Perhaps the problem as you note is an incomplete understanding of how science works. Selection bias is one, but there are many others. Interpretation of study designs, limitations, conflating causation with associations. This can be fixed if children were exposed to critical thinking early on.

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Hussein N. Yassine @yassinelab1.bsky.social · Mar 7

Terrible!

Hussein N. Yassine @yassinelab1.bsky.social · Feb 27

We are all in the same boat. We just have to keep going.

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Hussein N. Yassine @yassinelab1.bsky.social · Feb 15

Any tips? I deleted X…

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Hussein N. Yassine @yassinelab1.bsky.social · Feb 5

4/4: When we lowered oxysterols using cyclodextrin in vivo, ABCA1 recycled to the plasma membrane, and neuroinflammation was reduced. Accumulation of oxidized cholesterol in lysosomes in APOE4 AD is an important mechanism for senescence. Drugs targeting lysosomal lipids are promising strategies.

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Hussein N. Yassine @yassinelab1.bsky.social · Feb 5

3/4: Proteomic discovery experiments identified the cholesterol sensor, Caveolin-1 as the mechanism for ABCA1 sequestration into lysosomes. The accumulation of oxysterol species in APOE4 induced ABCA1 and trapped it in lysosomes.

Hussein N. Yassine @yassinelab1.bsky.social · Feb 5

2/4: We previously identified that APOE4 traps ABCA1 in lysosomes of cell and animal models. In agreement, we found more ABCA1 in lysosomal fractions isolated from post-mortem brain tissue samples compared with controls, indicating that more ABCA1 is sequestered into lysosomes with APOE4 AD.