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York Biomedical Research Institute

@ybri-uoy.bsky.social

140 followers 130 following 21 posts

Our mission at the York Biomedical Research Institute (YBRI) is to advance discoveries in biomedical science, to inspire, train, and mentor the next generation of biomedical researchers.

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York Biomedical Research Institute @ybri-uoy.bsky.social · Dec 17

We will share good news, public events, research opportunities & the latest publications from our members, all related to our research themes:

💉Immunology, Haematology, & Infection
🧠Neuroscience
🔬Molecular & Cellular Medicine

Follow us to connect with our community of biomedical researchers!
👨‍🔬👩‍🔬

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York Biomedical Research Institute @ybri-uoy.bsky.social · 6d

Excited to have @alainkohlvirology.bsky.social as this weeks Biomedical Science seminar speaker, talking about his work on antiviral RNAi in mosquitoes. Hosted by Dr Natalie Prow.

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Reposted by York Biomedical Research Institute

Steve Quinn @steve-quinn-lab.bsky.social · 7d

We are delighted that our latest @york.ac.uk & @ybri-uoy.bsky.social work showcasing our photonic biosensor for Alzheimer's disease blood biomarkers has been published in @optica.org!
👇
opg.optica.org/optica/fullt...

Thanks to @alzheimerssoc.bsky.social & @alzheimersresearchuk.org for support!

Optica Publishing Group

opg.optica.org

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Reposted by York Biomedical Research Institute

Steve Quinn @steve-quinn-lab.bsky.social · 10d

New preprint! 🚨 I'm delighted to share our latest @york.ac.uk & @ybri-uoy.bsky.social pre-print: "Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching." Congratulations to Claudia from the team on her first manuscript!
👇👇
www.biorxiv.org/content/10.1...

Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching

Detergent-induced membrane solubilization is important for several biotechnological applications including membrane protein isolation, cell lysis and virus inactivation. The thermodynamic details of t...

www.biorxiv.org

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York Biomedical Research Institute @ybri-uoy.bsky.social · 13d

Pleased to have @elkslab.bsky.social kicking off the 2025-26 series of our Biomedical Seminars, hosted by @noemiehamilton.bsky.social

Phil presented his work on using zebrafish models to study the roles of HIF in host response to infection

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Reposted by York Biomedical Research Institute

Centre for Blood Research @cbr-uoy.bsky.social · 22d

Research conducted by our Director @ian-hitchcock.bsky.social's collaborators in Oxford has found that platelets could help make cancer-detecting blood tests much more effective

Read more about the study on ‪@cancerresearchuk.org‬ website

news.cancerresearchuk.org/2025/08/14/p...

The "humble" blood cells that could expose cancer's secrets - Cancer Research UK - Cancer News

Our scientists have discovered that platelets are swelling with information which could help us detect cancers earlier.

news.cancerresearchuk.org

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Reposted by York Biomedical Research Institute

Ines Hahn @exdrososcientia.bsky.social · 27d

We're kicking off the third #NeuroBioUK - an exciting day full of neuronal cell biology ahead!
Massive thank for @bscb-official.bsky.social support and a shout out to our industry sponsors!

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Reposted by York Biomedical Research Institute

Dimitris Lagos @dimitrislagos.bsky.social · Aug 28

What’s the difference between female and male Th cells? We have a new paper on this! The mighty Malat1 controls Th2 differentiation in female but not male cells.
Work by Mags Gwynne and Katie West
‪@jimmunol.bsky.social‬
doi.org/10.1093/jimm...

@york.ac.uk‬, @ybri-uoy.bsky.social‬, ‪@hyms.ac.uk‬

Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2

Abstract. Identifying cell intrinsic regulators of immune sexual dimorphism is critical for treatment of several immunopathologies. We show that Malat1 is

doi.org

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Reposted by York Biomedical Research Institute

Gavin Thomas (he/him) @gavinhthomas.bsky.social · Sep 2

Delighted with our new paper on a novel itaconate transporter in the human pathogen Pseudomonas aeruginosa, led by Javeria and Reyme. @ybri-uoy.bsky.social @javeriamehboob.bsky.social @bethkw.bsky.social A duplicated transporter on its way to itaconate selectivity
portlandpress.com/biochemj/art...

Itaconate utilisation by the human pathogen Pseudomonas aeruginosa requires uptake via the IctPQM TRAP transporter

Pseudomonas aeruginosa PA01 is one of the major causes of disease persistence and mortality in patients with lung pathologies, relying on various host metabolites as carbon and energy sources for grow...

portlandpress.com

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Reposted by York Biomedical Research Institute

Gavin Thomas (he/him) @gavinhthomas.bsky.social · Aug 12

First paper from Orlagh Anderson PhD project is out. She found a chromid is a distinct & unique feature of Clostridium butyricum. More to come on the virulence related genes.. @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social
www.microbiologyresearch.org/content/jour...

Comparative genomics of Clostridium butyricum reveals a conserved genome architecture and novel virulence-related gene clusters

Bacteria from the species Clostridium butyricum encompass a diverse range of phenotypes. While some strains are used as probiotics, others have been isolated from cases of botulism and necrotizing ent...

www.microbiologyresearch.org

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Reposted by York Biomedical Research Institute

Faria Tryps Lab @fariatrypslab.bsky.social · Aug 11

How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social !

@biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr

www.sciencedirect.com/science/arti...

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Reposted by York Biomedical Research Institute

Steve Quinn @steve-quinn-lab.bsky.social · Jul 30

🚨 New preprint!🚨We introduce a DNA-scaffold strategy for efficient dye labelling of structured RNAs, enabling #smFRET studies of freely-diffusing SARS-CoV-2 pseudoknots🧬
👉 biorxiv.org/content/10.1...

#smFRET #RNA #biophysics #SARSCoV2 #singlemolecule #Covid

A DNA scaffold approach facilitates 5′ labelling of the SARS-CoV-2 RNA pseudoknot for smFRET investigation

Single-molecule Förster resonance energy transfer (smFRET) studies of highly structured RNA molecules are often frustrated by issues with efficient dye conjugation. Here, we develop a DNA scaffold-bas...

biorxiv.org

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Reposted by York Biomedical Research Institute

Steve Quinn @steve-quinn-lab.bsky.social · Jul 21

🚨New Preprint! Latest research led by
@jemmabetts.bsky.social & @chillzaa.bsky.social
reveals the structure of a protein-dependent riboswitch, revealing new mechanistic principles that could inspire novel antivirals! Thanks @ukri.org, @ei-science.bsky.social, @ybri-uoy.bsky.social for support! 🔬

Chris H. Hill @chillzaa.bsky.social · Jul 19

New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨

www.biorxiv.org/content/10.1...

A new protein-dependent riboswitch activates ribosomal frameshifting

Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...

www.biorxiv.org

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Reposted by York Biomedical Research Institute

Centre for Blood Research @cbr-uoy.bsky.social · Jul 18

Yorkshire Cancer Research hosted the White Rose Cancer Report launch event in Sheffield on 3rd July

Yorkshire is one of the regions hardest hit by cancer

Karen, David and Geoff shared their positive experiences, and how patient-centric care has literally saved their lives

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Reposted by York Biomedical Research Institute

Dimitris Lagos @dimitrislagos.bsky.social · Jul 15

We have a new 3-year PDRA post in Cancer Immunology. Ideal if you have a background in T cells, ideally human, and are interested in cancer immunology and RNA medicine. It’ll be fun!
www.jobs.ac.uk/job/DNV085/r...
Funded by ‪@yorkagainstcancer.bsky.social‬
@hyms.ac.uk
@ybri-uoy.bsky.social

jobs.york.ac.uk

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Reposted by York Biomedical Research Institute

Department of Biology, University of York @biologyatyork.bsky.social · Jul 10

(1/4) Three new pieces of research have been published from the ProteoStem ( www.proteostem.co.uk ) research group @billgrey.bsky.social working in @biologyatyork.bsky.social @ybri-uoy.bsky.social @cbr-uoy.bsky.social

Homepage - Proteo Stem

www.proteostem.co.uk

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Reposted by York Biomedical Research Institute

Faria Tryps Lab @fariatrypslab.bsky.social · Jul 5

www.nature.com/articles/s41...

Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications

Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...

www.nature.com

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Reposted by York Biomedical Research Institute

Department of Biology, University of York @biologyatyork.bsky.social · Jul 1

New review on synthetic HEG drives in Ae. aegypti from Joshua Ang and Luke Alphey (@ybri-uoy.bsky.social‬) They examine challenges, propose the CHIROS framework to guide future development, and discuss paths forward for this vector control strategy. pmc.ncbi.nlm.nih.gov/articles/PMC...

Synthetic Homing Endonuclease Gene Drives to Revolutionise Aedes aegypti Biocontrol - Game Changer or Pipe Dream?

The increasing burden of Aedes aegypti-borne diseases, particularly dengue, is a growing global concern, further exacerbated by climate change. Current control strategies have proven insufficient, nec...

pmc.ncbi.nlm.nih.gov

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Reposted by York Biomedical Research Institute

Department of Biology, University of York @biologyatyork.bsky.social · Jun 30

Congratulations to @bridgekatherine.bsky.social who has been awarded an @The_MRC New Investigator Research Grant! This £0.83M award will enable her laboratory to research hijacked hypoxia signalling in blood cancer @ybri-uoy.bsky.social @biologyatyork.bsky.social

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Reposted by York Biomedical Research Institute

Centre for Blood Research @cbr-uoy.bsky.social · Jun 26

Blood Cancer Survivor and founder of the York Haematology Support Group Carol Miller told That's TV why she thinks being part of a community can help people manage the anxiety of receiving a diagnosis.

www.york.ac.uk/biomedical-r...

World Blood Cancer Day: Interview with Carol Miller

Blood Cancer Survivor Carol Miller was interviewed by That's TV on World Blood Cancer Day.

www.york.ac.uk

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Reposted by York Biomedical Research Institute

Chris H. Hill @chillzaa.bsky.social · Jun 20

I'm thrilled and honoured to receive the 2025 Lister Prize, along with seven other fantastic biomedical scientists 🔬🦠🧬

This award will enable us to determine high-resolution structures of viral protein synthesis inside infected cells

The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · Jun 19

We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...

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York Biomedical Research Institute @ybri-uoy.bsky.social · Jun 6

A pleasure to host Prof James B. Rowe as our final speaker for the 2024-25 BMS seminar series

James presented his work on the effect of dementia on causal circuits. Incredible to hear his expertise as an active consultant neurologist and Director of Cambridge Centre for Frontotemporal Dementia

Reposted by York Biomedical Research Institute

Aidan Horner @aidanhorner.bsky.social · Jun 4

Today the York Neuroimaging Centre (YNiC) is celebrating its 20th Birthday with a series of talks from amazing present and past researchers! @yorkpsychology.bsky.social @ybri-uoy.bsky.social

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Reposted by York Biomedical Research Institute

Lucy Stafford @lucysta02475610.bsky.social · May 29

Also happy to do this with Masters (and PhDs) outside of the Psychology department @ybri-uoy.bsky.social @uoy-sociology.bsky.social @familywellbeinguoy.bsky.social @uoylangling.bsky.social @uoyenvironment.bsky.social @uoyeducation.bsky.social ⬇️

Lucy Stafford @lucysta02475610.bsky.social · May 29

Do you have Masters students at the University of York who needs research participants? Please forward them my details for a study exchange! By doing my experiment, they get £12 and I will happily do their study in return. ⬇️

@yorkpsychology.bsky.social

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Reposted by York Biomedical Research Institute

Faria Tryps Lab @fariatrypslab.bsky.social · May 27

So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk

Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes

Antigenic variation is a sophisticated immune evasion strategy employed by many pathogens. Trypanosoma brucei expresses a single Variant-Surface-Glycoprotein (VSG) from a large genetic repertoire, whi...

www.biorxiv.org

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York Biomedical Research Institute @ybri-uoy.bsky.social · May 23

Pleased to host Prof Federico Brandalise as our Biomedical Science seminar speaker today, hosted by Prof Will Brackenbury, funded by @physoc.bsky.social

Federico presented his work on the voltage-gated sodium channel's impact on glioblastoma progression