Faria Tryps Lab
@fariatrypslab.bsky.social
The Faria Lab is based at University of York and studies nuclear architecture, genome organisation and biomolecular condensates in the context of gene expression regulation in trypanosomatids
Pinned
Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes
Antigenic variation is a sophisticated immune evasion strategy employed by many pathogens. Trypanosoma brucei expresses a single Variant-Surface-Glycoprotein (VSG) from a large genetic repertoire, whi...
www.biorxiv.org
So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk
Reposted by Faria Tryps Lab
Why LLPS Scaffolds Cannot Exist – A Thermodynamic Thread
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
November 19, 2025 at 5:48 AM
Why LLPS Scaffolds Cannot Exist – A Thermodynamic Thread
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
Reposted by Faria Tryps Lab
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
November 11, 2025 at 9:26 AM
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
Reposted by Faria Tryps Lab
Very proud!
Alex Cook @alexandercook.bsky.social in the Matt Higgins @parasitematt.bsky.social lab here @ox.ac.uk has been awarded a Wellcome Career Development Award to start his own laboratory @york.ac.uk . Congratulations Alex! We are delighted for your success but will be sad to see you go. 🏆🎉👏👏👏
Alex Cook awarded Wellcome Career Development Award
Dr Alex Cook has been awarded a Career Development Award to start his own laboratory at the University of York
bit.ly
November 10, 2025 at 6:04 PM
Very proud!
Reposted by Faria Tryps Lab
OptoLoop: An optogenetic tool to probe the functional role of genome organization https://www.biorxiv.org/content/10.1101/2025.11.06.686574v1
November 8, 2025 at 1:17 PM
OptoLoop: An optogenetic tool to probe the functional role of genome organization https://www.biorxiv.org/content/10.1101/2025.11.06.686574v1
Reposted by Faria Tryps Lab
PI3Kdelta-driven expansion of regulatory B cells impairs protective immune responses to Trypanosoma congolense parasite infection pubmed.ncbi.nlm.nih.gov/41191641/
November 6, 2025 at 11:48 AM
PI3Kdelta-driven expansion of regulatory B cells impairs protective immune responses to Trypanosoma congolense parasite infection pubmed.ncbi.nlm.nih.gov/41191641/
Reposted by Faria Tryps Lab
Trypanosoma brucei cattle infections contain cryptic transmission-adapted bloodstream forms at low parasitaemia pubmed.ncbi.nlm.nih.gov/41193429/
November 6, 2025 at 10:02 AM
Trypanosoma brucei cattle infections contain cryptic transmission-adapted bloodstream forms at low parasitaemia pubmed.ncbi.nlm.nih.gov/41193429/
Reposted by Faria Tryps Lab
November 5, 2025 at 5:48 PM
Delighted to have been awarded a BBSRC grant to study the role of nuclear architecture in gene expression regulation in Leishmania alongside @mottramlab.bsky.social
@york.ac.uk
We will soon be recruiting, stay tuned!
@york.ac.uk
We will soon be recruiting, stay tuned!
November 5, 2025 at 11:13 AM
Delighted to have been awarded a BBSRC grant to study the role of nuclear architecture in gene expression regulation in Leishmania alongside @mottramlab.bsky.social
@york.ac.uk
We will soon be recruiting, stay tuned!
@york.ac.uk
We will soon be recruiting, stay tuned!
academic.oup.com/nar/article/...
Great to see this out! Big shout out to Douglas Escrivani, Seb Hutchinson & the Horn Lab!
@dundee.ac.uk
@ybri-uoy.bsky.social @york.ac.uk
Great to see this out! Big shout out to Douglas Escrivani, Seb Hutchinson & the Horn Lab!
@dundee.ac.uk
@ybri-uoy.bsky.social @york.ac.uk
A non-coding role for trypanosome VSG transcripts in allelic exclusion
Abstract. Bloodstream-form African trypanosomes display antigenic variation. This requires mono-telomeric but switchable expression of a Variant Surface Gl
academic.oup.com
October 22, 2025 at 9:35 AM
academic.oup.com/nar/article/...
Great to see this out! Big shout out to Douglas Escrivani, Seb Hutchinson & the Horn Lab!
@dundee.ac.uk
@ybri-uoy.bsky.social @york.ac.uk
Great to see this out! Big shout out to Douglas Escrivani, Seb Hutchinson & the Horn Lab!
@dundee.ac.uk
@ybri-uoy.bsky.social @york.ac.uk
Reposted by Faria Tryps Lab
An efficient eukaryotic cell-free expression and correlative cryo-electron tomography platform for structural biology of macromolecular complexes www.biorxiv.org/content/10.1101/2025.10.18.683253v1
October 21, 2025 at 7:16 AM
An efficient eukaryotic cell-free expression and correlative cryo-electron tomography platform for structural biology of macromolecular complexes www.biorxiv.org/content/10.1101/2025.10.18.683253v1
Reposted by Faria Tryps Lab
This article is a homecoming for me.
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
Principles of protein abundance regulation across single cells in a mammalian tissue
Protein synthesis and clearance are major regulatory steps of gene expression, but their in vivo regulatory roles across the cells comprising complex tissues remains unexplored. Here, we systematicall...
www.biorxiv.org
October 18, 2025 at 11:56 AM
This article is a homecoming for me.
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
Reposted by Faria Tryps Lab
New article on equitable reuse of public sequencing data, published in @natmicrobiol.nature.com!
Led by the Data reuse core team @lhug.bsky.social @environmicrobio.bsky.social Cristina Moraru, @geomicrosoares.bsky.social, @folker.bsky.social and with Anke Heyer and The Data Reuse Consotrium!
Led by the Data reuse core team @lhug.bsky.social @environmicrobio.bsky.social Cristina Moraru, @geomicrosoares.bsky.social, @folker.bsky.social and with Anke Heyer and The Data Reuse Consotrium!
September 26, 2025 at 7:34 PM
New article on equitable reuse of public sequencing data, published in @natmicrobiol.nature.com!
Led by the Data reuse core team @lhug.bsky.social @environmicrobio.bsky.social Cristina Moraru, @geomicrosoares.bsky.social, @folker.bsky.social and with Anke Heyer and The Data Reuse Consotrium!
Led by the Data reuse core team @lhug.bsky.social @environmicrobio.bsky.social Cristina Moraru, @geomicrosoares.bsky.social, @folker.bsky.social and with Anke Heyer and The Data Reuse Consotrium!
Reposted by Faria Tryps Lab
#Editorial
If you have ever been surprised by seeing an editor at a conference and wondered what they are doing there, this month's editorial has all the answers you need.
#MicroSky #AcademicChatter
www.nature.com/articles/s41...
If you have ever been surprised by seeing an editor at a conference and wondered what they are doing there, this month's editorial has all the answers you need.
#MicroSky #AcademicChatter
www.nature.com/articles/s41...
Why editors go to conferences - Nature Microbiology
You may have spotted us at different conferences and wondered what we’re doing amid active researchers. Here, we demystify the editorial aims of conference attendance.
www.nature.com
October 1, 2025 at 5:59 PM
#Editorial
If you have ever been surprised by seeing an editor at a conference and wondered what they are doing there, this month's editorial has all the answers you need.
#MicroSky #AcademicChatter
www.nature.com/articles/s41...
If you have ever been surprised by seeing an editor at a conference and wondered what they are doing there, this month's editorial has all the answers you need.
#MicroSky #AcademicChatter
www.nature.com/articles/s41...
Reposted by Faria Tryps Lab
In a Consensus Statement in Nature Microbiology, a consortium of #microbiome scientists discusses current sequencing data sharing policies and proposes the use of a Data Reuse Information tag to promote equitable and collaborative data sharing. go.nature.com/4o1Gl1f 🧪
September 30, 2025 at 1:15 PM
In a Consensus Statement in Nature Microbiology, a consortium of #microbiome scientists discusses current sequencing data sharing policies and proposes the use of a Data Reuse Information tag to promote equitable and collaborative data sharing. go.nature.com/4o1Gl1f 🧪
Reposted by Faria Tryps Lab
Targets of the human antibody response to the variant surface glycoprotein of Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41040341/
October 4, 2025 at 12:12 PM
Targets of the human antibody response to the variant surface glycoprotein of Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41040341/
Reposted by Faria Tryps Lab
🔬Fascinated by the unique mitochondrial biology that keeps deadly parasites alive?
🥼We have a fully funded NorthWestBio PhD just for you‼️
🌎 @blslancasteruni.bsky.social
📍Co-supervisor Kostas Tokatlidis @uofglasgow.bsky.social
⏰Deadline 21st Nov
📮Info and to apply👇
www.gla.ac.uk/postgraduate...
🥼We have a fully funded NorthWestBio PhD just for you‼️
🌎 @blslancasteruni.bsky.social
📍Co-supervisor Kostas Tokatlidis @uofglasgow.bsky.social
⏰Deadline 21st Nov
📮Info and to apply👇
www.gla.ac.uk/postgraduate...
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Caroline Dewar
www.gla.ac.uk
October 1, 2025 at 2:57 PM
🔬Fascinated by the unique mitochondrial biology that keeps deadly parasites alive?
🥼We have a fully funded NorthWestBio PhD just for you‼️
🌎 @blslancasteruni.bsky.social
📍Co-supervisor Kostas Tokatlidis @uofglasgow.bsky.social
⏰Deadline 21st Nov
📮Info and to apply👇
www.gla.ac.uk/postgraduate...
🥼We have a fully funded NorthWestBio PhD just for you‼️
🌎 @blslancasteruni.bsky.social
📍Co-supervisor Kostas Tokatlidis @uofglasgow.bsky.social
⏰Deadline 21st Nov
📮Info and to apply👇
www.gla.ac.uk/postgraduate...
Reposted by Faria Tryps Lab
vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression www.biorxiv.org/content/10.1101/2025.09.12.675796v1
September 18, 2025 at 7:16 AM
vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression www.biorxiv.org/content/10.1101/2025.09.12.675796v1
Reposted by Faria Tryps Lab
Calling all mitochondria enthusiasts, we are recruiting for a new project (and the post will be split between Glasgow and Helsinki)
www.jobs.gla.ac.uk/job/research...
www.jobs.gla.ac.uk/job/research...
Research Associate
Job PurposeThe purpose of this role is to carry out cutting-edge research to understand the structure and function of complexes essential for organelle biology and function in the apicomplexan para...
www.jobs.gla.ac.uk
September 18, 2025 at 1:20 AM
Calling all mitochondria enthusiasts, we are recruiting for a new project (and the post will be split between Glasgow and Helsinki)
www.jobs.gla.ac.uk/job/research...
www.jobs.gla.ac.uk/job/research...
Reposted by Faria Tryps Lab
Our 2025 Sep issue bit.ly/2N9R8Es reviews species sanitation & structural resilience in malaria control, animal trypanosomosis control, parasite genome organization, Leishmania attachment in sandflies, nonchemotherapeutic nematode control, tick & host microbiotas, parasitic neural manipulation &more
September 4, 2025 at 3:24 PM
Our 2025 Sep issue bit.ly/2N9R8Es reviews species sanitation & structural resilience in malaria control, animal trypanosomosis control, parasite genome organization, Leishmania attachment in sandflies, nonchemotherapeutic nematode control, tick & host microbiotas, parasitic neural manipulation &more
Reposted by Faria Tryps Lab
A study in Nature Medicine uses a supervised deep neural network to explain the network of concurrent molecular and macroscopic patterns related to insurgence and course of myalgic encephalomyelitis/chronic fatigue syndrome. go.nature.com/4mhoLpp #medsky 🧪
August 17, 2025 at 4:26 PM
A study in Nature Medicine uses a supervised deep neural network to explain the network of concurrent molecular and macroscopic patterns related to insurgence and course of myalgic encephalomyelitis/chronic fatigue syndrome. go.nature.com/4mhoLpp #medsky 🧪
Reposted by Faria Tryps Lab
Drs @singh-parul.bsky.social @trypsleon.bsky.social Maureen Cabahug @fariatrypslab.bsky.social & @jessmbryant.bsky.social review #Plasmodium & #Trypanosoma #genome organization.
#Trypanosome #Transcription #Chromatin #Epigenetics #Nuclear #Compartment
www.cell.com/trends/paras...
#Trypanosome #Transcription #Chromatin #Epigenetics #Nuclear #Compartment
www.cell.com/trends/paras...
August 14, 2025 at 6:42 PM
Drs @singh-parul.bsky.social @trypsleon.bsky.social Maureen Cabahug @fariatrypslab.bsky.social & @jessmbryant.bsky.social review #Plasmodium & #Trypanosoma #genome organization.
#Trypanosome #Transcription #Chromatin #Epigenetics #Nuclear #Compartment
www.cell.com/trends/paras...
#Trypanosome #Transcription #Chromatin #Epigenetics #Nuclear #Compartment
www.cell.com/trends/paras...
Reposted by Faria Tryps Lab
Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent.
We show widespread stochastic origin firing and insights into genome variability.
www.cell.com/cell-reports...
We show widespread stochastic origin firing and insights into genome variability.
www.cell.com/cell-reports...
August 6, 2025 at 8:20 AM
Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent.
We show widespread stochastic origin firing and insights into genome variability.
www.cell.com/cell-reports...
We show widespread stochastic origin firing and insights into genome variability.
www.cell.com/cell-reports...
Reposted by Faria Tryps Lab
#NewResearch
A human cytomegalovirus long non-coding RNA, RNA4.9, that interacts with cGAS and prevents its activation in the nucleus, thereby suppressing virus-induced IFN expression and antiviral activity
#MicroSky 🦠
www.nature.com/articles/s41...
A human cytomegalovirus long non-coding RNA, RNA4.9, that interacts with cGAS and prevents its activation in the nucleus, thereby suppressing virus-induced IFN expression and antiviral activity
#MicroSky 🦠
www.nature.com/articles/s41...
Human cytomegalovirus long non-coding RNA counteracts nuclear cGAS to facilitate immune evasion - Nature Microbiology
The authors identify a human cytomegalovirus long non-coding RNA, RNA4.9, that interacts with cGAS and prevents its activation in the nucleus, thereby suppressing virus-induced IFN expression and anti...
www.nature.com
August 11, 2025 at 2:37 PM
#NewResearch
A human cytomegalovirus long non-coding RNA, RNA4.9, that interacts with cGAS and prevents its activation in the nucleus, thereby suppressing virus-induced IFN expression and antiviral activity
#MicroSky 🦠
www.nature.com/articles/s41...
A human cytomegalovirus long non-coding RNA, RNA4.9, that interacts with cGAS and prevents its activation in the nucleus, thereby suppressing virus-induced IFN expression and antiviral activity
#MicroSky 🦠
www.nature.com/articles/s41...
Reposted by Faria Tryps Lab
#NewResearch
Streptomyces use both polar and dispersed cell wall synthesis during rapid, exploratory growth @mcmasteriidr.bsky.social
#BacteriaCellWall #MicroSky 🦠
www.nature.com/articles/s41...
Streptomyces use both polar and dispersed cell wall synthesis during rapid, exploratory growth @mcmasteriidr.bsky.social
#BacteriaCellWall #MicroSky 🦠
www.nature.com/articles/s41...
Streptomyces uses both polar and dispersed cell wall synthesis during exploratory growth - Nature Microbiology
Streptomyces venezuelae requires MreB1-dependent dispersed peptidoglycan cell wall synthesis and DivIVA-mediated polar cell wall synthesis during its rapid exploratory growth phase.
www.nature.com
August 11, 2025 at 2:39 PM
#NewResearch
Streptomyces use both polar and dispersed cell wall synthesis during rapid, exploratory growth @mcmasteriidr.bsky.social
#BacteriaCellWall #MicroSky 🦠
www.nature.com/articles/s41...
Streptomyces use both polar and dispersed cell wall synthesis during rapid, exploratory growth @mcmasteriidr.bsky.social
#BacteriaCellWall #MicroSky 🦠
www.nature.com/articles/s41...
Reposted by Faria Tryps Lab
#NewResearch
Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation - analyses reveal features that regulate glycoprotein pH-dependent membrane fusion activity.
#MicroSky 🦠
www.nature.com/articles/s41...
Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation - analyses reveal features that regulate glycoprotein pH-dependent membrane fusion activity.
#MicroSky 🦠
www.nature.com/articles/s41...
Molecular organization of the New World arenavirus spike glycoprotein complex - Nature Microbiology
Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that regulate glycoprotein pH-depend...
www.nature.com
August 11, 2025 at 2:40 PM
#NewResearch
Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation - analyses reveal features that regulate glycoprotein pH-dependent membrane fusion activity.
#MicroSky 🦠
www.nature.com/articles/s41...
Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation - analyses reveal features that regulate glycoprotein pH-dependent membrane fusion activity.
#MicroSky 🦠
www.nature.com/articles/s41...