Faria Tryps Lab
@fariatrypslab.bsky.social
The Faria Lab is based at University of York and studies nuclear architecture, genome organisation and biomolecular condensates in the context of gene expression regulation in trypanosomatids
Pinned
We’re hiring a PDRA and a technician!
If you’re passionate about #parasites #genomes #condensates then this project is for you! Help us decode the role of nuclear architecture in gene expression regulation in #Leishmania alongside the @mottramlab.bsky.social @york.ac.uk @ybri-uoy.bsky.social
If you’re passionate about #parasites #genomes #condensates then this project is for you! Help us decode the role of nuclear architecture in gene expression regulation in #Leishmania alongside the @mottramlab.bsky.social @york.ac.uk @ybri-uoy.bsky.social
Reposted by Faria Tryps Lab
@fariatrypslab.bsky.social in a major collaborative effort with researchers from Imperial College, Oxford, Oxford Brookes, and Edinburgh, has identified a novel factor, ESBX, as the key coordinator between the activation and repression of surface antigen genes in trypanosomes.
February 4, 2026 at 4:05 PM
@fariatrypslab.bsky.social in a major collaborative effort with researchers from Imperial College, Oxford, Oxford Brookes, and Edinburgh, has identified a novel factor, ESBX, as the key coordinator between the activation and repression of surface antigen genes in trypanosomes.
Reposted by Faria Tryps Lab
New PNAS study identifies ESBX, a protein controlling which surface coat gene is active in sleeping sickness parasites - key to immune evasion.
@tiengwe-tryplab.bsky.social
@zephyris-science.bsky.social
@fariatrypslab.bsky.social
www.imperial.ac.uk/news/article...
@tiengwe-tryplab.bsky.social
@zephyris-science.bsky.social
@fariatrypslab.bsky.social
www.imperial.ac.uk/news/article...
Scientists reveal how sleeping sickness parasites control their surface coat
Researchers have revealed how parasites hide thousands of antigens behind a single-colour coat and how disrupting this control could make the parasit...
www.imperial.ac.uk
February 4, 2026 at 2:09 PM
New PNAS study identifies ESBX, a protein controlling which surface coat gene is active in sleeping sickness parasites - key to immune evasion.
@tiengwe-tryplab.bsky.social
@zephyris-science.bsky.social
@fariatrypslab.bsky.social
www.imperial.ac.uk/news/article...
@tiengwe-tryplab.bsky.social
@zephyris-science.bsky.social
@fariatrypslab.bsky.social
www.imperial.ac.uk/news/article...
Reposted by Faria Tryps Lab
Nice multiple-team effort shedding some light on the intriguing expression site body (ESB), the key to antigenic variation in trypanosomes
@fariatrypslab.bsky.social @zephyris-science.bsky.social @tiengwe-tryplab.bsky.social with Jack Sunter and Keith Gull among others
@fariatrypslab.bsky.social @zephyris-science.bsky.social @tiengwe-tryplab.bsky.social with Jack Sunter and Keith Gull among others
4/5 Science is better together. We hope these insights into ESBX open new doors for understanding immune evasion and fundamental principles of gene regulation.
Full paper here: doi.org/10.1073/pnas...
Full paper here: doi.org/10.1073/pnas...
A factor integrating transcription and repression of surface antigen genes in African trypanosomes | PNAS
Antigenic variation in Trypanosoma brucei (T. brucei) requires monoallelic expression
of one variant surface glycoprotein (VSG) from one of the sub...
doi.org
February 4, 2026 at 12:59 PM
Nice multiple-team effort shedding some light on the intriguing expression site body (ESB), the key to antigenic variation in trypanosomes
@fariatrypslab.bsky.social @zephyris-science.bsky.social @tiengwe-tryplab.bsky.social with Jack Sunter and Keith Gull among others
@fariatrypslab.bsky.social @zephyris-science.bsky.social @tiengwe-tryplab.bsky.social with Jack Sunter and Keith Gull among others
Reposted by Faria Tryps Lab
A factor integrating transcription and repression of surface antigen genes in African trypanosomes pubmed.ncbi.nlm.nih.gov/41632842/
February 4, 2026 at 11:33 AM
A factor integrating transcription and repression of surface antigen genes in African trypanosomes pubmed.ncbi.nlm.nih.gov/41632842/
1/5 How do parasites "shape-shift" to evade our immune system? It’s all about gene selection. Our latest work in @pnas.org identifies a new key player: ESBX.
@york.ac.uk @ybri-uoy.bsky.social
@york.ac.uk @ybri-uoy.bsky.social
February 4, 2026 at 11:25 AM
1/5 How do parasites "shape-shift" to evade our immune system? It’s all about gene selection. Our latest work in @pnas.org identifies a new key player: ESBX.
@york.ac.uk @ybri-uoy.bsky.social
@york.ac.uk @ybri-uoy.bsky.social
We’re hiring a PDRA and a technician!
If you’re passionate about #parasites #genomes #condensates then this project is for you! Help us decode the role of nuclear architecture in gene expression regulation in #Leishmania alongside the @mottramlab.bsky.social @york.ac.uk @ybri-uoy.bsky.social
If you’re passionate about #parasites #genomes #condensates then this project is for you! Help us decode the role of nuclear architecture in gene expression regulation in #Leishmania alongside the @mottramlab.bsky.social @york.ac.uk @ybri-uoy.bsky.social
January 28, 2026 at 12:32 PM
We’re hiring a PDRA and a technician!
If you’re passionate about #parasites #genomes #condensates then this project is for you! Help us decode the role of nuclear architecture in gene expression regulation in #Leishmania alongside the @mottramlab.bsky.social @york.ac.uk @ybri-uoy.bsky.social
If you’re passionate about #parasites #genomes #condensates then this project is for you! Help us decode the role of nuclear architecture in gene expression regulation in #Leishmania alongside the @mottramlab.bsky.social @york.ac.uk @ybri-uoy.bsky.social
Reposted by Faria Tryps Lab
ICYMI Out Now! A phage protein screen identifies triggers of the bacterial innate immune system #MicroSky
A phage protein screen identifies triggers of the bacterial innate immune system
Nature Microbiology, Published online: 16 January 2026; doi:10.1038/s41564-025-02239-6A library of 400 phage protein-coding genes is used to find a trove of antiphage systems, revealing systems that target tail fibre and major capsid proteins.
go.nature.com
January 19, 2026 at 4:55 PM
ICYMI Out Now! A phage protein screen identifies triggers of the bacterial innate immune system #MicroSky
Reposted by Faria Tryps Lab
Check out our latest study on the PfRIPR protein,
essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
January 18, 2026 at 6:21 PM
Check out our latest study on the PfRIPR protein,
essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
Reposted by Faria Tryps Lab
If you assume GPI insertion signals = surface destination, trypanosomes disagree.
Tom’s work shows GPI-anchored protein sorting occurs independently of GPI insertion signals, hinting at alternative sorting logic at the parasite surface.
tinyurl.com/gpi-anchor
#MembraneBiology #CellSurface
Tom’s work shows GPI-anchored protein sorting occurs independently of GPI insertion signals, hinting at alternative sorting logic at the parasite surface.
tinyurl.com/gpi-anchor
#MembraneBiology #CellSurface
Sorting of GPI-anchored proteins at the trypanosome surface is independent of GPI insertion signals
The segregation of glycosylphosphatidylinositol-anchored proteins (GPI-APs) to distinct domains on the plasma membrane of eukaryotic cells is importan…
tinyurl.com
January 18, 2026 at 8:54 PM
If you assume GPI insertion signals = surface destination, trypanosomes disagree.
Tom’s work shows GPI-anchored protein sorting occurs independently of GPI insertion signals, hinting at alternative sorting logic at the parasite surface.
tinyurl.com/gpi-anchor
#MembraneBiology #CellSurface
Tom’s work shows GPI-anchored protein sorting occurs independently of GPI insertion signals, hinting at alternative sorting logic at the parasite surface.
tinyurl.com/gpi-anchor
#MembraneBiology #CellSurface
Reposted by Faria Tryps Lab
CryoDDM: CryoEM denoising diffusion model for heterogeneous conformational reconstruction https://www.biorxiv.org/content/10.64898/2025.12.10.693455v1
December 13, 2025 at 6:47 AM
CryoDDM: CryoEM denoising diffusion model for heterogeneous conformational reconstruction https://www.biorxiv.org/content/10.64898/2025.12.10.693455v1
Reposted by Faria Tryps Lab
Why LLPS Scaffolds Cannot Exist – A Thermodynamic Thread
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
November 19, 2025 at 5:48 AM
Why LLPS Scaffolds Cannot Exist – A Thermodynamic Thread
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
Reposted by Faria Tryps Lab
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
November 11, 2025 at 9:26 AM
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
Reposted by Faria Tryps Lab
Very proud!
Alex Cook @alexandercook.bsky.social in the Matt Higgins @parasitematt.bsky.social lab here @ox.ac.uk has been awarded a Wellcome Career Development Award to start his own laboratory @york.ac.uk . Congratulations Alex! We are delighted for your success but will be sad to see you go. 🏆🎉👏👏👏
Alex Cook awarded Wellcome Career Development Award
Dr Alex Cook has been awarded a Career Development Award to start his own laboratory at the University of York
bit.ly
November 10, 2025 at 6:04 PM
Very proud!
Reposted by Faria Tryps Lab
OptoLoop: An optogenetic tool to probe the functional role of genome organization https://www.biorxiv.org/content/10.1101/2025.11.06.686574v1
November 8, 2025 at 1:17 PM
OptoLoop: An optogenetic tool to probe the functional role of genome organization https://www.biorxiv.org/content/10.1101/2025.11.06.686574v1
Reposted by Faria Tryps Lab
PI3Kdelta-driven expansion of regulatory B cells impairs protective immune responses to Trypanosoma congolense parasite infection pubmed.ncbi.nlm.nih.gov/41191641/
November 6, 2025 at 11:48 AM
PI3Kdelta-driven expansion of regulatory B cells impairs protective immune responses to Trypanosoma congolense parasite infection pubmed.ncbi.nlm.nih.gov/41191641/
Reposted by Faria Tryps Lab
Trypanosoma brucei cattle infections contain cryptic transmission-adapted bloodstream forms at low parasitaemia pubmed.ncbi.nlm.nih.gov/41193429/
November 6, 2025 at 10:02 AM
Trypanosoma brucei cattle infections contain cryptic transmission-adapted bloodstream forms at low parasitaemia pubmed.ncbi.nlm.nih.gov/41193429/
Reposted by Faria Tryps Lab
November 5, 2025 at 5:48 PM
Delighted to have been awarded a BBSRC grant to study the role of nuclear architecture in gene expression regulation in Leishmania alongside @mottramlab.bsky.social
@york.ac.uk
We will soon be recruiting, stay tuned!
@york.ac.uk
We will soon be recruiting, stay tuned!
November 5, 2025 at 11:13 AM
Delighted to have been awarded a BBSRC grant to study the role of nuclear architecture in gene expression regulation in Leishmania alongside @mottramlab.bsky.social
@york.ac.uk
We will soon be recruiting, stay tuned!
@york.ac.uk
We will soon be recruiting, stay tuned!
academic.oup.com/nar/article/...
Great to see this out! Big shout out to Douglas Escrivani, Seb Hutchinson & the Horn Lab!
@dundee.ac.uk
@ybri-uoy.bsky.social @york.ac.uk
Great to see this out! Big shout out to Douglas Escrivani, Seb Hutchinson & the Horn Lab!
@dundee.ac.uk
@ybri-uoy.bsky.social @york.ac.uk
A non-coding role for trypanosome VSG transcripts in allelic exclusion
Abstract. Bloodstream-form African trypanosomes display antigenic variation. This requires mono-telomeric but switchable expression of a Variant Surface Gl
academic.oup.com
October 22, 2025 at 9:35 AM
academic.oup.com/nar/article/...
Great to see this out! Big shout out to Douglas Escrivani, Seb Hutchinson & the Horn Lab!
@dundee.ac.uk
@ybri-uoy.bsky.social @york.ac.uk
Great to see this out! Big shout out to Douglas Escrivani, Seb Hutchinson & the Horn Lab!
@dundee.ac.uk
@ybri-uoy.bsky.social @york.ac.uk
Reposted by Faria Tryps Lab
An efficient eukaryotic cell-free expression and correlative cryo-electron tomography platform for structural biology of macromolecular complexes www.biorxiv.org/content/10.1101/2025.10.18.683253v1
October 21, 2025 at 7:16 AM
An efficient eukaryotic cell-free expression and correlative cryo-electron tomography platform for structural biology of macromolecular complexes www.biorxiv.org/content/10.1101/2025.10.18.683253v1
Reposted by Faria Tryps Lab
This article is a homecoming for me.
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
Principles of protein abundance regulation across single cells in a mammalian tissue
Protein synthesis and clearance are major regulatory steps of gene expression, but their in vivo regulatory roles across the cells comprising complex tissues remains unexplored. Here, we systematicall...
www.biorxiv.org
October 18, 2025 at 11:56 AM
This article is a homecoming for me.
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
Reposted by Faria Tryps Lab
New article on equitable reuse of public sequencing data, published in @natmicrobiol.nature.com!
Led by the Data reuse core team @lhug.bsky.social @environmicrobio.bsky.social Cristina Moraru, @geomicrosoares.bsky.social, @folker.bsky.social and with Anke Heyer and The Data Reuse Consotrium!
Led by the Data reuse core team @lhug.bsky.social @environmicrobio.bsky.social Cristina Moraru, @geomicrosoares.bsky.social, @folker.bsky.social and with Anke Heyer and The Data Reuse Consotrium!
September 26, 2025 at 7:34 PM
New article on equitable reuse of public sequencing data, published in @natmicrobiol.nature.com!
Led by the Data reuse core team @lhug.bsky.social @environmicrobio.bsky.social Cristina Moraru, @geomicrosoares.bsky.social, @folker.bsky.social and with Anke Heyer and The Data Reuse Consotrium!
Led by the Data reuse core team @lhug.bsky.social @environmicrobio.bsky.social Cristina Moraru, @geomicrosoares.bsky.social, @folker.bsky.social and with Anke Heyer and The Data Reuse Consotrium!
Reposted by Faria Tryps Lab
#Editorial
If you have ever been surprised by seeing an editor at a conference and wondered what they are doing there, this month's editorial has all the answers you need.
#MicroSky #AcademicChatter
www.nature.com/articles/s41...
If you have ever been surprised by seeing an editor at a conference and wondered what they are doing there, this month's editorial has all the answers you need.
#MicroSky #AcademicChatter
www.nature.com/articles/s41...
Why editors go to conferences - Nature Microbiology
You may have spotted us at different conferences and wondered what we’re doing amid active researchers. Here, we demystify the editorial aims of conference attendance.
www.nature.com
October 1, 2025 at 5:59 PM
#Editorial
If you have ever been surprised by seeing an editor at a conference and wondered what they are doing there, this month's editorial has all the answers you need.
#MicroSky #AcademicChatter
www.nature.com/articles/s41...
If you have ever been surprised by seeing an editor at a conference and wondered what they are doing there, this month's editorial has all the answers you need.
#MicroSky #AcademicChatter
www.nature.com/articles/s41...
Reposted by Faria Tryps Lab
In a Consensus Statement in Nature Microbiology, a consortium of #microbiome scientists discusses current sequencing data sharing policies and proposes the use of a Data Reuse Information tag to promote equitable and collaborative data sharing. go.nature.com/4o1Gl1f 🧪
September 30, 2025 at 1:15 PM
In a Consensus Statement in Nature Microbiology, a consortium of #microbiome scientists discusses current sequencing data sharing policies and proposes the use of a Data Reuse Information tag to promote equitable and collaborative data sharing. go.nature.com/4o1Gl1f 🧪
Reposted by Faria Tryps Lab
Targets of the human antibody response to the variant surface glycoprotein of Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41040341/
October 4, 2025 at 12:12 PM
Targets of the human antibody response to the variant surface glycoprotein of Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41040341/