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Nature Microbiology
@natmicrobiol.nature.com
Nature Microbiology publishes the latest research and commentary in all areas of microbiology.

https://www.nature.com/nmicrobiol/
Pinned
Dive into our November issue featuring:

🪆nested archaeal symbioses
🌱microbiota driven drought responses in plants
🏗️ BAM complex in Bacteroidota
💨microbial fermentative growth in the gut
🍸hospital-specific phage therapy cocktail

and much more..!

www.nature.com/nmicrobiol/v...
Reposted by Nature Microbiology
🚨1 week left until Abstract submission closes for the upcoming Nature conference "Corals, Coasts and One Health" 🪸 natureconferences.streamgo.live/corals-coast...

Join editors from @natecoevo.nature.com , @natclimate.nature.com , @natrevearthenviron.nature.com & @commsbio.nature.com 14–16 Feb 2026
Corals, Coasts and One Health
Corals, Coasts and One Health is focused on addressing the urgent challenges facing coral reefs and connected coastal ecosystems. The conference program will bridge scales and disciplines, linking mic...
natureconferences.streamgo.live
November 24, 2025 at 11:03 AM
#NatMicroPicks

Cracking the code of Yellow Fever Virus entry! 🔑🧪

YFV uses multiple LDL receptor family members, including LRP4, LRP1, and VLDLR, as entry receptors, offering new targets for antiviral strategies

#MicroSky #VirusSky

www.nature.com/articles/s41...
Multiple LDLR family members act as entry receptors for yellow fever virus - Nature
The low-density lipoprotein receptor family members LRP1, LRP4 and VLDLR are entry receptors for yellow fever virus.
www.nature.com
November 20, 2025 at 5:46 PM
#NatMicroPicks

CRISPR Metagenome Engineering! 🦠🔧🧬

MetaEdit enables precise genetic editing of native gut bacteria in mice.

#MicroSky #SynBio

www.science.org/doi/10.1126/...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
www.science.org
November 20, 2025 at 5:16 PM
#NatMicroPicks

Drug-delivering bacteria for Parkinson's! 🦠🧠

A genetically engineered E. coli delivers L-DOPA improving motor and mood outcomes in Parkinson’s models

#MicroSky #SynBio

www.sciencedirect.com/science/arti...
Bioengineered gut bacterium synthesizing levodopa alleviates motor deficits in models of Parkinson’s disease
L-3,4-Dihydroxyphenylalanine (L-DOPA), synthesized from L-tyrosine, is a direct precursor to dopamine. L-DOPA is the gold-standard treatment for Parki…
www.sciencedirect.com
November 20, 2025 at 5:13 PM
News & Views out now - Entomopathogenic fungi bait and kill insects with longifolene

By Thiago Luiz Alves e Silva & Joel Vega-Rodriguez

#microsky #malaria

www.nature.com/articles/s41...
November 20, 2025 at 10:37 AM
Reposted by Nature Microbiology
Registration is now open for @keystonesymposia.bsky.social "Beyond #Antibiotics: Emerging Strategies Combating #BacterialInfection." Deadline for scholarships and abstract selected short talks is Jan 7! Join us this May for an amazing meeting! keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26
Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone Symposia
Join us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!
keysym.us
November 19, 2025 at 5:37 PM
Reposted by Nature Microbiology
A preclinical study in Nature Microbiology shows that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that protect against whooping cough. #medsky 🧪
Respiratory immunization using antibiotic-inactivated Bordetella pertussis confers T cell-mediated protection against nasal infection in mice - Nature Microbiology
In this preclinical study, the authors find that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that protect against lung and nasal infection with Bordetella pertussis.
go.nature.com
November 18, 2025 at 5:34 PM
Reposted by Nature Microbiology
This week is World #AntimicrobialResistance Awareness week

To mark the occasion, Dr Scott-Dearing reflects on her @natcomms.nature.com paper published in January, noting the setbacks and progress made in tackling #AMR since
World AMR Awareness Week call to action: Patient and public involvement and engagement to improve impact on antimicrobial resistance – the time to act is now
A step change is required in citizen awareness of the global AMR health crisis and, crucially, public involvement in tackling it. The global context presents new challenges but real-world examples show what is possible and an historic moment approaches, that we can leverage for positive action.
bit.ly
November 19, 2025 at 9:39 AM
Reposted by Nature Microbiology
Really fun collaboration with Roman Melnyk from The Hospital for Sick Children Research Institute and Peter Dosa from University of Minnesota, making synthetic bile acids to be gut-restricted prevents C. difficile infection in a preclinical mouse model
November 18, 2025 at 2:26 PM
Reposted by Nature Microbiology
Bacteria have to adapt rapidly to changes in environment. Can they ‘remember’ those conditions? Another one for my “to read” pile! cc @microberamon.bsky.social @victoriachu.bsky.social @nickyuen.bsky.social @fratorelli.bsky.social #UTISky #MicroSky
November 18, 2025 at 9:13 AM
#NewResearch

A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.

#MicroSky 🦠💊

www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 18, 2025 at 2:07 PM
#Review

Bacteria can “remember” past environments through genetic & biochemical imprints helping them adapt and thrive! 🦠🧠

#MicroSky

www.nature.com/articles/s41...
Exploring the concept of bacterial memory - Nature Microbiology
This Perspective discusses the concept, mechanisms and evidence for memory in bacteria at individual and community levels.
www.nature.com
November 18, 2025 at 8:51 AM
Reposted by Nature Microbiology
Assembly, architecture and functional roles of microbial surface layers

Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.

S-layers are everywhere!

www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 13, 2025 at 8:14 PM
Reposted by Nature Microbiology
Gluing a bulky host protein onto an immune surveillance complex is a wild mechanism of viral immune evasion!

@natmicrobiol.nature.com
#phagesky #phage #microsky

www.nature.com/articles/s41...
November 12, 2025 at 5:47 PM
#News&Views

Metarhizium fungi can be engineered to produce the volatile longifolene to attract and kill mosquitoes, offering a new approach to sustainable vector control.

#MicroSky 🦠🦟

www.nature.com/articles/s41...
Entomopathogenic fungi bait and kill insects with longifolene - Nature Microbiology
Metarhizium fungi can be engineered to produce the volatile longifolene to attract and kill mosquitoes, offering a new approach to sustainable vector control.
www.nature.com
November 12, 2025 at 1:45 PM
Reposted by Nature Microbiology
New Review

British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update

www.thelancet.com/journals/lan...
British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update
The fungal diagnostic landscape is evolving; whereas previously, traditional culture-based methods dominated, most invasive fungal disease is now diagnosed with non-culture-based tests, including dire...
www.thelancet.com
November 11, 2025 at 8:12 AM
Reposted by Nature Microbiology
Respiratory immunization using antibiotic-inactivated Bordetella pertussis confers T cell-mediated protection against nasal infection in mice
www.nature.com/articles/s41...
@natmicrobiol.nature.com @tcddublin.bsky.social
www.nature.com/articles/s41...
November 10, 2025 at 5:47 PM
#News&Views

A respiratory vaccine platform shows promise against pertussis by providing sterilizing immunity and generating local mucosal immunity. This approach could potentially solve the inability of current vaccines to prevent transmission.

#MicroSky 🦠

www.nature.com/articles/s41...
New life into pertussis prevention - Nature Microbiology
A respiratory vaccine platform shows promise against pertussis (whooping cough) by providing sterilizing immunity and generating local mucosal immunity. This approach could potentially solve the inabi...
www.nature.com
November 11, 2025 at 3:52 PM
#NewResearch

Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding

#MicroSky #CRISPR 🦠

www.nature.com/articles/s41...
A phage-encoded anti-CRISPR protein co-opts host enolase to prevent type III CRISPR immunity - Nature Microbiology
Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding.
www.nature.com
November 11, 2025 at 3:49 PM
#NewResearch

A preclinical study finds that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that protect against lung and nasal infection with Bordetella pertussis

www.nature.com/articles/s41...
Respiratory immunization using antibiotic-inactivated Bordetella pertussis confers T cell-mediated protection against nasal infection in mice - Nature Microbiology
In this preclinical study, the authors find that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that p...
www.nature.com
November 11, 2025 at 3:48 PM
#NewResearch

Mathematical modelling and subsequent experimental validation reveal principles that govern displacement of a resident strain in a microbial community by an invader @erikbakkeren.bsky.social @dunnschool.bsky.social

www.nature.com/articles/s41...
Strain displacement in microbiomes via ecological competition - Nature Microbiology
Mathematical modelling and experimental tests reveal principles that govern displacement of a resident strain by an invader in microbial communities.
www.nature.com
November 11, 2025 at 3:46 PM
Reposted by Nature Microbiology
I'm thrilled to share our newest publication in @natmicrobiol.nature.com, led by Drs. @botanichole.bsky.social, Valéria Custódio, and David Gopaulchan: Precipitation legacy effects on #SoilMicrobiota facilitate adaptive drought responses in plants. 🌾 🧪 (thread)

www.nature.com/articles/s41...
Precipitation legacy effects on soil microbiota facilitate adaptive drought responses in plants - Nature Microbiology
Metagenomes from prairie soils in Kansas, USA, show how historical exposure to water stress impacts soil microorganisms and subsequently drought responses in plants.
www.nature.com
November 10, 2025 at 4:45 PM
Reposted by Nature Microbiology
Can we leverage bacterial competition for targeted replacement of harmful strains? Maybe! Our recent piece in @natmicrobiol.nature.com provides a theoretical framework and a set of experiments to show what it might take: www.nature.com/articles/s41...
Strain displacement in microbiomes via ecological competition - Nature Microbiology
Mathematical modelling and experimental tests reveal principles that govern displacement of a resident strain by an invader in microbial communities.
www.nature.com
November 7, 2025 at 10:34 PM