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Nature Microbiology
@natmicrobiol.nature.com
Nature Microbiology publishes the latest research and commentary in all areas of microbiology.

https://www.nature.com/nmicrobiol/
Pinned
Dive into our November issue featuring:

🪆nested archaeal symbioses
🌱microbiota driven drought responses in plants
🏗️ BAM complex in Bacteroidota
💨microbial fermentative growth in the gut
🍸hospital-specific phage therapy cocktail

and much more..!

www.nature.com/nmicrobiol/v...
Reposted by Nature Microbiology
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia - @yizhoudonglab.bsky.social @icahngenomics.bsky.social go.nature.com/3LZS6HD
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia - Nature Biotechnology
Antimicrobial peptides delivered to mouse lung as mRNA peptibodies eradicate multidrug-resistant pneumonia.
go.nature.com
November 26, 2025 at 3:11 PM
#NewResearch

A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.

#MicroSky 🦠

www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 26, 2025 at 3:59 PM
#NewResearch

Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice through CCL11-driven recruitment and MBP-dependent modulation of macrophage polarization and bacterial clearance.

#MicroSky 🦠 #ImmunoSky

www.nature.com/articles/s41...
Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice - Nature Microbiology
Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice through CCL11-driven recruitment and MBP-dependent modulation of macrophage polarization and bacterial clearan...
www.nature.com
November 26, 2025 at 3:58 PM
#NewResearch

Mathematical representations of overflow metabolism, mixotrophy, exoenzymes and reactive oxygen species detoxification recapitulate dynamics in co-cultures of Prochlorococcus and eight heterotrophic bacteria.

#MicroSky 🦠

www.nature.com/articles/s41...
Models and co-culture experiments assess four mechanisms of phytoplankton–bacteria interactions - Nature Microbiology
Mathematical representations of overflow metabolism, mixotrophy, exoenzymes and reactive oxygen species detoxification recapitulate dynamics in co-cultures of Prochlorococcus and eight heterotrophic b...
www.nature.com
November 26, 2025 at 3:55 PM
#NewResearch

The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.

#MicroSky #AMR 🦠 @andresfloto.bsky.social

www.nature.com/articles/s41...
Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli - Nature Microbiology
The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.
www.nature.com
November 26, 2025 at 3:54 PM
#NewResearch

Iron‒sulfur nanozymes catalyse the production of an indole derivative in Lactobacillus, leading to a synergistic antibacterial activity that protects mice and weaned pigs against Salmonella infection.

#MicroSky 🦠 #NanoSky

www.nature.com/articles/s41...
Nanozymes modulate probiotic tryptophan metabolism to prevent Salmonella infection in mammalian models - Nature Microbiology
Iron‒sulfur nanozymes catalyse the production of an indole derivative, 2-indolecarboxylic acid, in Lactobacillus vaginalis, leading to a synergistic antibacterial activity that protects mice and weane...
www.nature.com
November 26, 2025 at 3:53 PM
#NewResearch

The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.

#MicroSky 🦠

www.nature.com/articles/s41...
Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection - Nature Microbiology
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
www.nature.com
November 26, 2025 at 3:51 PM
Reposted by Nature Microbiology
Our paper mapping the effects of hundreds of pesticides and industrial chemicals on gut bacteria is out in @natmicrobiol.nature.com today!
Turns out many such chemicals, although labelled as 'fungicides' or similar, can inadvertently inhibit friendly gut bacteria.
www.nature.com/articles/s41...
November 26, 2025 at 11:07 AM
Reposted by Nature Microbiology
Excited to share our latest research in @natmicrobiol.nature.com . We uncover hundreds of inhibitory interactions between common chemical pollutants and human gut bacteria. A thread🧵 (1/10) #microbiomesky #microsky @kiranrpatil.bsky.social lab @mrc-tu.bsky.social www.nature.com/articles/s41...
Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro - Nature Microbiology
Screening of 1,076 compounds reveals 168 chemical pollutants with inhibitory effects on gut bacteria and genetic screens indicate commonality between pollutant and antibiotic resistance.
www.nature.com
November 26, 2025 at 10:30 AM
Reposted by Nature Microbiology
🚨1 week left until Abstract submission closes for the upcoming Nature conference "Corals, Coasts and One Health" 🪸 natureconferences.streamgo.live/corals-coast...

Join editors from @natecoevo.nature.com , @natclimate.nature.com , @natrevearthenviron.nature.com & @commsbio.nature.com 14–16 Feb 2026
Corals, Coasts and One Health
Corals, Coasts and One Health is focused on addressing the urgent challenges facing coral reefs and connected coastal ecosystems. The conference program will bridge scales and disciplines, linking mic...
natureconferences.streamgo.live
November 24, 2025 at 11:03 AM
#NatMicroPicks

Cracking the code of Yellow Fever Virus entry! 🔑🧪

YFV uses multiple LDL receptor family members, including LRP4, LRP1, and VLDLR, as entry receptors, offering new targets for antiviral strategies

#MicroSky #VirusSky

www.nature.com/articles/s41...
Multiple LDLR family members act as entry receptors for yellow fever virus - Nature
The low-density lipoprotein receptor family members LRP1, LRP4 and VLDLR are entry receptors for yellow fever virus.
www.nature.com
November 20, 2025 at 5:46 PM
#NatMicroPicks

CRISPR Metagenome Engineering! 🦠🔧🧬

MetaEdit enables precise genetic editing of native gut bacteria in mice.

#MicroSky #SynBio

www.science.org/doi/10.1126/...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
www.science.org
November 20, 2025 at 5:16 PM
#NatMicroPicks

Drug-delivering bacteria for Parkinson's! 🦠🧠

A genetically engineered E. coli delivers L-DOPA improving motor and mood outcomes in Parkinson’s models

#MicroSky #SynBio

www.sciencedirect.com/science/arti...
Bioengineered gut bacterium synthesizing levodopa alleviates motor deficits in models of Parkinson’s disease
L-3,4-Dihydroxyphenylalanine (L-DOPA), synthesized from L-tyrosine, is a direct precursor to dopamine. L-DOPA is the gold-standard treatment for Parki…
www.sciencedirect.com
November 20, 2025 at 5:13 PM
News & Views out now - Entomopathogenic fungi bait and kill insects with longifolene

By Thiago Luiz Alves e Silva & Joel Vega-Rodriguez

#microsky #malaria

www.nature.com/articles/s41...
November 20, 2025 at 10:37 AM
Reposted by Nature Microbiology
Registration is now open for @keystonesymposia.bsky.social "Beyond #Antibiotics: Emerging Strategies Combating #BacterialInfection." Deadline for scholarships and abstract selected short talks is Jan 7! Join us this May for an amazing meeting! keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26
Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone Symposia
Join us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!
keysym.us
November 19, 2025 at 5:37 PM
Reposted by Nature Microbiology
A preclinical study in Nature Microbiology shows that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that protect against whooping cough. #medsky 🧪
Respiratory immunization using antibiotic-inactivated Bordetella pertussis confers T cell-mediated protection against nasal infection in mice - Nature Microbiology
In this preclinical study, the authors find that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that protect against lung and nasal infection with Bordetella pertussis.
go.nature.com
November 18, 2025 at 5:34 PM
Reposted by Nature Microbiology
This week is World #AntimicrobialResistance Awareness week

To mark the occasion, Dr Scott-Dearing reflects on her @natcomms.nature.com paper published in January, noting the setbacks and progress made in tackling #AMR since
World AMR Awareness Week call to action: Patient and public involvement and engagement to improve impact on antimicrobial resistance – the time to act is now
A step change is required in citizen awareness of the global AMR health crisis and, crucially, public involvement in tackling it. The global context presents new challenges but real-world examples show what is possible and an historic moment approaches, that we can leverage for positive action.
bit.ly
November 19, 2025 at 9:39 AM
Reposted by Nature Microbiology
Really fun collaboration with Roman Melnyk from The Hospital for Sick Children Research Institute and Peter Dosa from University of Minnesota, making synthetic bile acids to be gut-restricted prevents C. difficile infection in a preclinical mouse model
November 18, 2025 at 2:26 PM
Reposted by Nature Microbiology
Bacteria have to adapt rapidly to changes in environment. Can they ‘remember’ those conditions? Another one for my “to read” pile! cc @microberamon.bsky.social @victoriachu.bsky.social @nickyuen.bsky.social @fratorelli.bsky.social #UTISky #MicroSky
November 18, 2025 at 9:13 AM
#NewResearch

A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.

#MicroSky 🦠💊

www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 18, 2025 at 2:07 PM
#Review

Bacteria can “remember” past environments through genetic & biochemical imprints helping them adapt and thrive! 🦠🧠

#MicroSky

www.nature.com/articles/s41...
Exploring the concept of bacterial memory - Nature Microbiology
This Perspective discusses the concept, mechanisms and evidence for memory in bacteria at individual and community levels.
www.nature.com
November 18, 2025 at 8:51 AM
Reposted by Nature Microbiology
Assembly, architecture and functional roles of microbial surface layers

Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.

S-layers are everywhere!

www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 13, 2025 at 8:14 PM
Reposted by Nature Microbiology
Gluing a bulky host protein onto an immune surveillance complex is a wild mechanism of viral immune evasion!

@natmicrobiol.nature.com
#phagesky #phage #microsky

www.nature.com/articles/s41...
November 12, 2025 at 5:47 PM
#News&Views

Metarhizium fungi can be engineered to produce the volatile longifolene to attract and kill mosquitoes, offering a new approach to sustainable vector control.

#MicroSky 🦠🦟

www.nature.com/articles/s41...
Entomopathogenic fungi bait and kill insects with longifolene - Nature Microbiology
Metarhizium fungi can be engineered to produce the volatile longifolene to attract and kill mosquitoes, offering a new approach to sustainable vector control.
www.nature.com
November 12, 2025 at 1:45 PM