A 165 Myr record of N and Corg isotopes show that the N-cycle responds to feedbacks associated with productivity and the location of upwelling centers changing due to continental meander.

This study reveals strong soil moisture–precipitation coupling over ~16% of global land, with eight hotspots identified. The coupling is regulated by soil moisture variability, and the sensible heat–mediated pathway emerges as a crucial mechanism, depending on local climate regime.

Experiments and modelling unravel mechanisms of nitrous oxide production from nitrate, the primary nitrous oxide production pathway in oxygen minimum zones. Results highlight the critical role of microbial interactions in regulating this pathway.

The Rosenstiel School of Marine, Atmospheric, and Earth Science is one of the world’s premier education and research institutions.

Current antimalarials often fail to target mature stage V gametocytes. To aid antimalarial drug discovery, the authors present a preclinical malaria transmission-blocking drug research platform, using engineered parasites, that facilitates the screening for gametocytocidal compounds in vitro and the evaluation of transmission-blocking drug activity in vivo.

Niclosamide has been shown to have activity against SARS-CoV-2 in vitro, but poor bioavailability has hindered clinical development. In this clinical trial, the authors show that the niclosamide nanohybrid CP-COV03 alleviates COVID-19 symptoms and reduces viral load, offering a promising therapeutic option.

In this study of ~7 million Brazilian births, the authors show that chikungunya, dengue, or Zika infection during pregnancy is associated with an increased risk of adverse perinatal outcomes, with the...

Here, the authors exploit the genetic information encoded in Klebsiella prophages to model the interplay between bacteria, prophages, and their depolymerases, using a directed acyclic graph-model and a sequence clustering-based model.

Dengue virus transmission by Ae. aegypti mosquitoes poses a significant public health threat, necessitating innovative control strategies. Here, the authors demonstrate that, while successive blood feeding increases earlier dengue virus dissemination, the inhibitory effects of Wolbachia remain strong, highlighting Wolbachia’s potential to disrupt dengue transmission under natural feeding conditions.

This study used multiplex serology to monitor multiple diseases simultaneously from a single serosurvey. Seroprevalence estimates were performed for five disease categories in Zambezia Province, Mozambique.

Adherent-invasive strains of E. coli are commonly isolated from patients with Crohn’s disease. Here, the authors show that an AIEC harbours a hybrid Type IV secretion system (T4SS) that mediates pilin polymerization and biofilm formation in vivo.

Current antimalarials often fail to target mature stage V gametocytes. To aid antimalarial drug discovery, the authors present a preclinical malaria transmission-blocking drug research platform, using engineered parasites, that facilitates the screening for gametocytocidal compounds in vitro and the evaluation of transmission-blocking drug activity in vivo.

In this study, the authors determine the structure of a Type I-A retron from E. coli FORC82 and reveal the functional interplay between Reverse Transcriptases (RTs) and Structural Maintenance of Chromosomes (SMC) ATPases.’

This study used multiplex serology to monitor multiple diseases simultaneously from a single serosurvey. Seroprevalence estimates were performed for five disease categories in Zambezia Province, Mozambique.

Machine learning (ML) is rapidly influencing the development of many research areas, including biocatalysis, the use of enzymes and living systems to mediate chemical reactions, often of pharmaceutical and industrial importance. To find out how can machine learning be applied to biocatalysis research, we talked to three scientists, Professor Rebecca Buller (Zurich University of Applied Sciences), Dr. Stanislav Mazurenko (Masaryk University) and Associate Professor Yang Yang (University of California, Santa Barbara). We discussed the potentials and challenges associated with ML, how collaborations between computational and biocatalysis experts can be promoted, and how will the field develop in the future.

The Biomolecular Screening Facility has contributed to a successful collaborative study led by Till Voss (Swiss Tropical and Public Health Institute, University of Basel), resulting in the development of a robust, all in one pipeline for the discovery and testing of transmission blocking drugs against Plasmodium falciparum. This multidisciplinary effort combines a high-throughput in vitro assay with a novel in vivo model, enabling systematic evaluation of compounds that target mature stage V gametocytes - the only forms of the parasite that infect mosquitoes.

Dengue virus transmission by Ae. aegypti mosquitoes poses a significant public health threat, necessitating innovative control strategies. Here, the authors demonstrate that, while successive blood fe...

Serological studies are needed to understand the ongoing clade Ib mpox outbreak in the Democratic Republic of the Congo and neighboring countries. Here, the authors conduct a cross-sectional serological study in South Kivu, highlighting the role of professional sex workers and household transmission in mpox epidemiology.

In this study, the authors determine the structure of a Type I-A retron from E. coli FORC82 and reveal the functional interplay between Reverse Transcriptases (RTs) and Structural Maintenance of Chromosomes (SMC) ATPases.’

Niclosamide has been shown to have activity against SARS-CoV-2 in vitro, but poor bioavailability has hindered clinical development. In this clinical trial, the authors show that the niclosamide nanohybrid CP-COV03 alleviates COVID-19 symptoms and reduces viral load, offering a promising therapeutic option.