@yuhminchook.bsky.social
Selinexor is an allosteric degrader. It stabilizes XPO1/CRM1 to expose a cryptic ASB8 E3 ligase site, triggering ubiquitination. Led by Casey Wing, Joyce Fung & Bert Kwanten. #TargetedDegradation #Allostery
SINE compounds activate exportin 1 degradation through an allosteric mechanism - Nature Chemical Biology
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). Wing, Fung and Kwanten et al. found that selinexor mediates XPO1 degradation through an allosteric molecule glue mec...
www.nature.com
December 14, 2025 at 4:57 AM
Selinexor is an allosteric degrader. It stabilizes XPO1/CRM1 to expose a cryptic ASB8 E3 ligase site, triggering ubiquitination. Led by Casey Wing, Joyce Fung & Bert Kwanten. #TargetedDegradation #Allostery
Reposted
📝 Available online - the Review "The nuclear export receptor CRM1/XPO1 and its diverse cargoes" from Ralph Kehlenbach and @yuhminchook.bsky.social.
#CRM1 #Exportin1 #NuclearTransport #NuclearPoreComplex #RNAExport
Read it here: authors.elsevier.com/sd/article/S...
#CRM1 #Exportin1 #NuclearTransport #NuclearPoreComplex #RNAExport
Read it here: authors.elsevier.com/sd/article/S...
October 7, 2025 at 3:51 PM
📝 Available online - the Review "The nuclear export receptor CRM1/XPO1 and its diverse cargoes" from Ralph Kehlenbach and @yuhminchook.bsky.social.
#CRM1 #Exportin1 #NuclearTransport #NuclearPoreComplex #RNAExport
Read it here: authors.elsevier.com/sd/article/S...
#CRM1 #Exportin1 #NuclearTransport #NuclearPoreComplex #RNAExport
Read it here: authors.elsevier.com/sd/article/S...
The review article on CRM1/XPO1 that Ralph Kehlenbach and I wrote (we made the figures too) is online at TIBS @cp-trendsbiochem.bsky.social. authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
September 29, 2025 at 2:50 PM
The review article on CRM1/XPO1 that Ralph Kehlenbach and I wrote (we made the figures too) is online at TIBS @cp-trendsbiochem.bsky.social. authors.elsevier.com/sd/article/S...