This suggests the brain regained its ability to clear toxic proteins. Tau phosphorylation, a damaging chemical change, also declined. The blood-brain barrier, which normally shields the brain from harmful substances, showed clear repair. Structural gaps closed. Leaky blood proteins stopped entering

normalized after treatment. Restoring the brain's energy balance successfully achieved pathological and functional recovery in both lines of mice with advanced Alzheimer's. The recovery went beyond behavior. Amyloid plaques were reduced, even though amyloid production itself did not change.

Brain structure improved. Memory and learning returned to near normal levels. In maze tests that measure spatial memory, untreated mice struggled. Treated mice performed like healthy controls. In object recognition tests, which measure recall, the same pattern appeared. Even mood-related behaviors

blood-brain barrier breakdown, nerve damage, and behavioral changes similar to those seen in people. When P7C3-A20 was given before symptoms began, it prevented disease features. More striking was what happened when treatment started later. Mice with advanced disease REGAINED normal NAD+ balance.

above safe levels, unlike some over-the-counter supplements. To model Alzheimer’s, researchers used two types of mice. One carried human mutations linked to amyloid buildup. The other carried a human mutation in tau, another hallmark of the disease. Both models developed memory loss, inflammation,

worsened as disease progressed. The team decided to focus on restoring NAD+ homeostasis (meaning healthy balance rather than excessive levels). They used a compound called P7C3-A20, developed in their lab, which helps cells maintain normal NAD+ under stress. Importantly, it does not push NAD+

In Alzheimer’s, the drop is sharper and more damaging. By examining human Alzheimer’s brains AND engineered mouse models, researchers observed that NAD+ balance was SEVERELY disrupted. Cells could no longer meet energy demands or defend themselves against stress. This failure appeared early and

important? Nicotinamide adenine dinucleotide, or NAD+, helps cells turn nutrients into energy and repair daily damage. It supports DNA repair, controls inflammation, protects the blood-brain barrier, and keeps nerve cells connected. As you age, NAD+ levels decline throughout the body.

Institute at University Hospitals. He also holds faculty appointments at Case Western Reserve University and serves as a clinician-scientist at the Cleveland VA. Together, the team set out to test an idea rarely explored in Alzheimer’s research: recovery.

So, what exactly is NAD+? And why is it so

HUMAN brain tissue, researchers found that restoring balance to a central cellular energy molecule, NAD+, not only prevented disease features but reversed them, even at late stages. The senior author, Andrew A. Pieper, MD, PhD, directs the Brain Health Medicines Center at the Harrington Discovery

Hospitals, Case Western Reserve University, and the Louis Stokes Cleveland VA Medical Center report evidence that challenges this assumption. The study, published in Cell Reports Medicine, tested whether brains with advanced Alzheimer’s-like damage could recover. Using multiple mouse models and

For more than a century, Alzheimer’s disease has been framed as irreversible. Once memory and thinking decline, recovery has not been considered possible. That belief shaped nearly all research, which focused on prevention or slowing damage, not repairing it. Now, researchers from University

In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well).
• case.edu/news/new-stu...

The study has been published in Cell. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

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Breakfast of champions, really.

People also do this about coffee. Truly, a sign of maturity is not needing everyone to have the same exact tastes as your own.