This cross-sectional study examines trends in rates of nicotine vaping and unsuccessful quit attempts from 2020 to 2024 among US youths in 8th, 10th, and 12th grade.

An anti-smoking and anti-vaping youth group pushed for the change.

Anyone born on or after 1 January 2007 will be banned from using, buying or selling tobacco products in the archipelago.

Nicotine has been used in e-cigarettes for many years; however, recently, nicotine analogs have risen in popularity. E-cigarettes containing nicotine analogs such as nicotinamide and 6-methylnicotine are currently sold without regulatory oversight. They are marketed as safer alternatives to nicotine-containing products, although there is little or no scientific evidence to support this claim. This study investigated the nicotine analog, nicotinamide (NA), along with its major degradant, 3-cyanopyridine (3CP), which is produced when NA is vaped. Upon heating and aerosolization, both chemicals are present in the exposure dose. Dose–response curves are created for relative concentrations of NA and 3CP, and an isobologram is formed to investigate their mixture effects. NA is toxic at concentrations greater than 2637 ppm; however, 3CP is harmful in concentrations as low as 0.0001 ppm. The most significant finding is that the isobologram indicates that the mixture effects are synergistic, where a decrease in viability can be seen in minimal doses of 3CP (i.e., 0.000001 ppm) and 1350 ppm of NA. The interaction index was calculated for each point, and all values were less than 1, indicating a statistically synergistic biological response. The study highlights how such small levels of 3CP can play a large role in inducing toxic responses of a presumed safe chemical (i.e., nicotinamide or niacinamide, a form of vitamin B3 (niacin)). These results indicate that chemical and biochemical reactions, as well as interactions between e-cigarette aerosol components, including nicotine analogs, warrant further investigation.

The new Trump administration multiyear funding policy for NIH grants has dropped National Cancer Institute grant funding rates from one in 10 applicants to one in 25.

Despite a federal hiring freeze, the Trump administration just appointed a scientist who calls Vance one of his “closest friends” to head the nation’s key environmental health research arm.

FDA Awards First-Ever National Priority Vouchers to Nine Sponsors

Non-tobacco nicotine products (eg, e-cigarettes, nicotine pouches) are increasingly used by cigarette smokers and prior nonsmokers. While the detrimen…

Southeast Asia once had the highest rates of tobacco use, affecting three-quarters of men. But the region has cut smoking rates by more than a quarter. Europe is now the smokiest place on Earth.

Abstract figure legend Rodent pregnancy exposure to electronic cigarette (E-cig) aerosol occurred from gestational day (GD)2 until G21 (birth). We evaluate the cerebrovascular function [i.e. middle c...

Combining scientific studies with community engagement to reduce deaths and other harms from drug use.