PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
November 5, 2025 at 5:30 PM
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
November 5, 2025 at 2:04 PM
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
November 5, 2025 at 8:59 AM
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
🚨 New paper alert! 🚨
Our paper entitled: "Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3" is out now on Journal of Biological Chemistry!
www.jbc.org/article/S002...
#AlternativeSplicing #RNAediting
🧵 👇
Our paper entitled: "Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3" is out now on Journal of Biological Chemistry!
www.jbc.org/article/S002...
#AlternativeSplicing #RNAediting
🧵 👇
Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3
Alternative splicing and adenosine-to-inosine (A-to-I) RNA editing are post-transcriptional
mechanisms that promote proteomic diversity in the brain. The impact of RNA editing
on brain physiology is u...
www.jbc.org
October 14, 2025 at 2:34 PM
🚨 New paper alert! 🚨
Our paper entitled: "Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3" is out now on Journal of Biological Chemistry!
www.jbc.org/article/S002...
#AlternativeSplicing #RNAediting
🧵 👇
Our paper entitled: "Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3" is out now on Journal of Biological Chemistry!
www.jbc.org/article/S002...
#AlternativeSplicing #RNAediting
🧵 👇
Predicting the structural impact of human alternative splicing. #AlternativeSplicing #GenomeBiology
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
September 24, 2025 at 9:15 AM
Predicting the structural impact of human alternative splicing. #AlternativeSplicing #GenomeBiology
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
Multiomics analyses of #SCLC #tumors reveals widespread #AlternativeSplicing and frequent #FocalAdhesionKinase splicing variants that drive aggressive disease, predict poor prognosis, & show marked sensitivity to FAK inhibitors. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
September 19, 2025 at 2:53 PM
Multiomics analyses of #SCLC #tumors reveals widespread #AlternativeSplicing and frequent #FocalAdhesionKinase splicing variants that drive aggressive disease, predict poor prognosis, & show marked sensitivity to FAK inhibitors. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Good morning Sky-Friends!
Our own @biochemtrix.bsky.social (and occasional poster!) is in Germany at the #Unleash consortium meeting. They are joining us here in the sky @unleash-as.bsky.social so follow along to find out about #AlternativeSplicing!
Our own @biochemtrix.bsky.social (and occasional poster!) is in Germany at the #Unleash consortium meeting. They are joining us here in the sky @unleash-as.bsky.social so follow along to find out about #AlternativeSplicing!
September 16, 2025 at 7:54 AM
Good morning Sky-Friends!
Our own @biochemtrix.bsky.social (and occasional poster!) is in Germany at the #Unleash consortium meeting. They are joining us here in the sky @unleash-as.bsky.social so follow along to find out about #AlternativeSplicing!
Our own @biochemtrix.bsky.social (and occasional poster!) is in Germany at the #Unleash consortium meeting. They are joining us here in the sky @unleash-as.bsky.social so follow along to find out about #AlternativeSplicing!
It's day 2 of the UNLEASH meeting! We are in beautiful Bernried and looking forward to hearing more about the progress our members have made unpicking the details of #AlternativeSplicing!
September 16, 2025 at 7:21 AM
It's day 2 of the UNLEASH meeting! We are in beautiful Bernried and looking forward to hearing more about the progress our members have made unpicking the details of #AlternativeSplicing!
We are all here in sunny Munich to talk about the progress we have all made UNLEASHing the secrets of #AlternativeSplicing
Members of four different scientific groups across three different countries collaborating and sharing data.
Follow us to see our progress too!
Members of four different scientific groups across three different countries collaborating and sharing data.
Follow us to see our progress too!
September 15, 2025 at 4:03 PM
We are all here in sunny Munich to talk about the progress we have all made UNLEASHing the secrets of #AlternativeSplicing
Members of four different scientific groups across three different countries collaborating and sharing data.
Follow us to see our progress too!
Members of four different scientific groups across three different countries collaborating and sharing data.
Follow us to see our progress too!
This exciting issue includes articles on #AI and #Huanglongbing resistance, vertical farming, #reviews on genetic variation in adaptive #evolution, and on #AlternativeSplicing, along with much more research!
Read more great #PlantScience from this issue here: onlinelibrary.wiley.com/toc/17447909...
Read more great #PlantScience from this issue here: onlinelibrary.wiley.com/toc/17447909...
September 4, 2025 at 2:48 PM
This exciting issue includes articles on #AI and #Huanglongbing resistance, vertical farming, #reviews on genetic variation in adaptive #evolution, and on #AlternativeSplicing, along with much more research!
Read more great #PlantScience from this issue here: onlinelibrary.wiley.com/toc/17447909...
Read more great #PlantScience from this issue here: onlinelibrary.wiley.com/toc/17447909...
Computational workflow to analyze #AlternativeSplicing
vast-tools
Matt
ExOrthist
VastDB (vertebrate database) vastdb.crg.eu/wiki/Main_Page
PastDB (A. thaliana database) pastdb.crg.eu/wiki/About
Manuel Irimia lab #MethodMolBiol 2022
link.springer.com/protocol/10....
vast-tools
Matt
ExOrthist
VastDB (vertebrate database) vastdb.crg.eu/wiki/Main_Page
PastDB (A. thaliana database) pastdb.crg.eu/wiki/About
Manuel Irimia lab #MethodMolBiol 2022
link.springer.com/protocol/10....
September 2, 2025 at 5:58 PM
Computational workflow to analyze #AlternativeSplicing
vast-tools
Matt
ExOrthist
VastDB (vertebrate database) vastdb.crg.eu/wiki/Main_Page
PastDB (A. thaliana database) pastdb.crg.eu/wiki/About
Manuel Irimia lab #MethodMolBiol 2022
link.springer.com/protocol/10....
vast-tools
Matt
ExOrthist
VastDB (vertebrate database) vastdb.crg.eu/wiki/Main_Page
PastDB (A. thaliana database) pastdb.crg.eu/wiki/About
Manuel Irimia lab #MethodMolBiol 2022
link.springer.com/protocol/10....
Our new review about RNA processing and mechanotransduction is out in Cell Reports! Link: lnkd.in/edApA4ZT. Proud of our very talented graduate student Gabrielle Bais and thankful to our institution and funding sources: UNC-Chapel Hill, NIH, NSF.
#mechanotransduction #RNA #alternativesplicing
#mechanotransduction #RNA #alternativesplicing
August 29, 2025 at 4:47 PM
Our new review about RNA processing and mechanotransduction is out in Cell Reports! Link: lnkd.in/edApA4ZT. Proud of our very talented graduate student Gabrielle Bais and thankful to our institution and funding sources: UNC-Chapel Hill, NIH, NSF.
#mechanotransduction #RNA #alternativesplicing
#mechanotransduction #RNA #alternativesplicing
This study reveals that TPM3P9 promotes #tumor growth in #ClearCellRenalCellCarcinoma (ccRCC) by enhancing the #alternativesplicing of oncogenic RNAs and highlights it as a potential therapeutic target in ccRCC management. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
August 23, 2025 at 8:30 AM
This study reveals that TPM3P9 promotes #tumor growth in #ClearCellRenalCellCarcinoma (ccRCC) by enhancing the #alternativesplicing of oncogenic RNAs and highlights it as a potential therapeutic target in ccRCC management. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Presenting DIGGER 2.0: we extended our #AlternativeSplicing software DIGGER with new functionalities, including support of the mouse interactome and NEASE for #EnrichmentAnalysis! Check it out here: exbio.wzw.tum.de/digger/
August 21, 2025 at 11:32 AM
Presenting DIGGER 2.0: we extended our #AlternativeSplicing software DIGGER with new functionalities, including support of the mouse interactome and NEASE for #EnrichmentAnalysis! Check it out here: exbio.wzw.tum.de/digger/
Discover a new tool: DIGGER 2.0 enables splice-aware functional annotation of interaction network changes using RNA seq analysis via NEASE.
#VirusBioinformatics #AlternativeSplicing #InteractomeTools
📄 doi.org/10.1093/nar/...
👤EVBC: Olga Kalinina
#VirusBioinformatics #AlternativeSplicing #InteractomeTools
📄 doi.org/10.1093/nar/...
👤EVBC: Olga Kalinina
DIGGER 2.0: digging into the functional impact of differential splicing on human and mouse disorders
Abstract. Changes in alternative splicing between groups or conditions contribute to protein–protein interaction rewiring, a consequence often neglected in
doi.org
August 11, 2025 at 7:16 AM
Discover a new tool: DIGGER 2.0 enables splice-aware functional annotation of interaction network changes using RNA seq analysis via NEASE.
#VirusBioinformatics #AlternativeSplicing #InteractomeTools
📄 doi.org/10.1093/nar/...
👤EVBC: Olga Kalinina
#VirusBioinformatics #AlternativeSplicing #InteractomeTools
📄 doi.org/10.1093/nar/...
👤EVBC: Olga Kalinina
🛠️ Resources
All code, datasets, and reproducible pipelines are openly available: github.com/alihamraoui/...
#bioinformatics #RNAseq #singlecell #alternativesplicing #benchmark #opensource #scRNAseq #MinION
cc @fr-genomics.bsky.social @mthomaschollier.bsky.social
All code, datasets, and reproducible pipelines are openly available: github.com/alihamraoui/...
#bioinformatics #RNAseq #singlecell #alternativesplicing #benchmark #opensource #scRNAseq #MinION
cc @fr-genomics.bsky.social @mthomaschollier.bsky.social
GitHub - alihamraoui/scKenver
Contribute to alihamraoui/scKenver development by creating an account on GitHub.
github.com
July 30, 2025 at 12:00 PM
🛠️ Resources
All code, datasets, and reproducible pipelines are openly available: github.com/alihamraoui/...
#bioinformatics #RNAseq #singlecell #alternativesplicing #benchmark #opensource #scRNAseq #MinION
cc @fr-genomics.bsky.social @mthomaschollier.bsky.social
All code, datasets, and reproducible pipelines are openly available: github.com/alihamraoui/...
#bioinformatics #RNAseq #singlecell #alternativesplicing #benchmark #opensource #scRNAseq #MinION
cc @fr-genomics.bsky.social @mthomaschollier.bsky.social
Single cell and spatial alternative splicing analysis with Nanopore long read sequencing. #SingleCell #scRNAseq #AlternativeSplicing #LongReads #Sequencing @nanoporetech.com @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 29, 2025 at 5:51 PM
Single cell and spatial alternative splicing analysis with Nanopore long read sequencing. #SingleCell #scRNAseq #AlternativeSplicing #LongReads #Sequencing @nanoporetech.com @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Next Up in the #LongTREC Series 📽️ : Yalan Bi!
Yalan is a LongTREC Doctoral Candidate working with Ralf Herwig at @molgen.mpg.de Yalan shares insights into her research project and her experience as part of the LongTREC network. #LongReadsTranscriptomics #AlternativeSplicing #ProteinInteraction
Yalan is a LongTREC Doctoral Candidate working with Ralf Herwig at @molgen.mpg.de Yalan shares insights into her research project and her experience as part of the LongTREC network. #LongReadsTranscriptomics #AlternativeSplicing #ProteinInteraction
July 12, 2025 at 2:21 PM
Next Up in the #LongTREC Series 📽️ : Yalan Bi!
Yalan is a LongTREC Doctoral Candidate working with Ralf Herwig at @molgen.mpg.de Yalan shares insights into her research project and her experience as part of the LongTREC network. #LongReadsTranscriptomics #AlternativeSplicing #ProteinInteraction
Yalan is a LongTREC Doctoral Candidate working with Ralf Herwig at @molgen.mpg.de Yalan shares insights into her research project and her experience as part of the LongTREC network. #LongReadsTranscriptomics #AlternativeSplicing #ProteinInteraction
📢 #PaperAlert
Review article in @WIREs_Reviews on #AlternativeSplicing, voltage-gated #calcium #channels, and #channelopathies. #IonChannels
Alternative Splicing and CaV‐Associated Channelopathies - Munyao - 2025 - WIREs RNA - Wiley Online Library wires.onlinelibrary.wiley.com/doi/10.1002/...
Review article in @WIREs_Reviews on #AlternativeSplicing, voltage-gated #calcium #channels, and #channelopathies. #IonChannels
Alternative Splicing and CaV‐Associated Channelopathies - Munyao - 2025 - WIREs RNA - Wiley Online Library wires.onlinelibrary.wiley.com/doi/10.1002/...
Alternative Splicing and CaV‐Associated Channelopathies
Voltage-gated calcium channels control vital cellular processes through complex alternative splicing mechanisms, and their dysfunction contributes to neurological, cardiac, endocrine, oncogenic, and ...
wires.onlinelibrary.wiley.com
June 11, 2025 at 8:16 PM
📢 #PaperAlert
Review article in @WIREs_Reviews on #AlternativeSplicing, voltage-gated #calcium #channels, and #channelopathies. #IonChannels
Alternative Splicing and CaV‐Associated Channelopathies - Munyao - 2025 - WIREs RNA - Wiley Online Library wires.onlinelibrary.wiley.com/doi/10.1002/...
Review article in @WIREs_Reviews on #AlternativeSplicing, voltage-gated #calcium #channels, and #channelopathies. #IonChannels
Alternative Splicing and CaV‐Associated Channelopathies - Munyao - 2025 - WIREs RNA - Wiley Online Library wires.onlinelibrary.wiley.com/doi/10.1002/...
Online now - the Review "#RNAprocessing in innate immunity: regulation by RNA binding proteins" from Asmita Panthi and Kristen Lynch.
#AlternativeSplicing #3EndProcessing #AlternativePolyadenylation #RBP
Read it here 👉 authors.elsevier.com/a/1l5yN_M0e4...
#AlternativeSplicing #3EndProcessing #AlternativePolyadenylation #RBP
Read it here 👉 authors.elsevier.com/a/1l5yN_M0e4...
May 22, 2025 at 3:41 PM
Online now - the Review "#RNAprocessing in innate immunity: regulation by RNA binding proteins" from Asmita Panthi and Kristen Lynch.
#AlternativeSplicing #3EndProcessing #AlternativePolyadenylation #RBP
Read it here 👉 authors.elsevier.com/a/1l5yN_M0e4...
#AlternativeSplicing #3EndProcessing #AlternativePolyadenylation #RBP
Read it here 👉 authors.elsevier.com/a/1l5yN_M0e4...
Our most recent paper is out! #alternativeSplicing #RNA #SNAP23 #heart #muscle
Full article: Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is mis-spliced in striated muscle diseases www.tandfonline.com/doi/full/10....
Full article: Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is mis-spliced in striated muscle diseases www.tandfonline.com/doi/full/10....
Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is mis-spliced in striated muscle diseases
The reprogramming of alternative splicing networks during development is a hallmark of tissue maturation and identity. Alternative splicing of microexons (small, genomic regions ≤ 51 nucleotides) f...
www.tandfonline.com
April 24, 2025 at 4:40 PM
Our most recent paper is out! #alternativeSplicing #RNA #SNAP23 #heart #muscle
Full article: Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is mis-spliced in striated muscle diseases www.tandfonline.com/doi/full/10....
Full article: Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is mis-spliced in striated muscle diseases www.tandfonline.com/doi/full/10....
📌The TMEM18 gene exhibits distinct alternative splicing patterns in LBD: potentially disrupting protein stability
📌The MICB gene, crucial for immune signaling, also showed LBD-specific splicing
#LewyBodyDementia #Neurodegeneration #Transcriptomics #AlternativeSplicing #Biomarkers #Neuroscience
📌The MICB gene, crucial for immune signaling, also showed LBD-specific splicing
#LewyBodyDementia #Neurodegeneration #Transcriptomics #AlternativeSplicing #Biomarkers #Neuroscience
March 3, 2025 at 11:37 AM
📌The TMEM18 gene exhibits distinct alternative splicing patterns in LBD: potentially disrupting protein stability
📌The MICB gene, crucial for immune signaling, also showed LBD-specific splicing
#LewyBodyDementia #Neurodegeneration #Transcriptomics #AlternativeSplicing #Biomarkers #Neuroscience
📌The MICB gene, crucial for immune signaling, also showed LBD-specific splicing
#LewyBodyDementia #Neurodegeneration #Transcriptomics #AlternativeSplicing #Biomarkers #Neuroscience
An interactive PSI visualization (developed using #RShiny) for the exon inclusion of #OBSCN in our studied pre- and post-natal skeletal and cardiac muscle samples is available at psivis.it.helsinki.fi:3838/OBSCN_PSIVIS/ , #NMD #AlternativeSplicing #RNA #PSIVIS
March 1, 2025 at 8:40 PM
An interactive PSI visualization (developed using #RShiny) for the exon inclusion of #OBSCN in our studied pre- and post-natal skeletal and cardiac muscle samples is available at psivis.it.helsinki.fi:3838/OBSCN_PSIVIS/ , #NMD #AlternativeSplicing #RNA #PSIVIS
Discover efficient targeted RNA-seq with LSV-seq! Enriches splicing-informative reads, using multiplexed reverse transcription. #AlternativeSplicing PMID:39727154, Nucleic Acids Res 2025, @NAR_Open @Cornell https://doi.org/10.1093/nar/gkae1260 🧪
February 28, 2025 at 12:10 PM
Discover efficient targeted RNA-seq with LSV-seq! Enriches splicing-informative reads, using multiplexed reverse transcription. #AlternativeSplicing PMID:39727154, Nucleic Acids Res 2025, @NAR_Open @Cornell https://doi.org/10.1093/nar/gkae1260 🧪
Thanks to @alperakay.bsky.social from @uniofeastanglia.bsky.social who joined us this morning for our weekly seminar, sharing his research in #alternativesplicing regulation by snRNA modifications.
@norwichrnaclub.bsky.social @whaerty.bsky.social
@norwichrnaclub.bsky.social @whaerty.bsky.social
February 11, 2025 at 2:04 PM
Thanks to @alperakay.bsky.social from @uniofeastanglia.bsky.social who joined us this morning for our weekly seminar, sharing his research in #alternativesplicing regulation by snRNA modifications.
@norwichrnaclub.bsky.social @whaerty.bsky.social
@norwichrnaclub.bsky.social @whaerty.bsky.social