#CellFate
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narjournal.bsky.social
⭐ NAR Breakthrough! ⭐
New research highlights CHD1L in the chromosome 1q21.1 region—linked to #autism, head size & growth.
🧠 It controls #DNApackaging & genes for #braindevelopment, #cellfate & #connectivity.
Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Neuroscience @igbmc.bsky.social
Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant
Abstract. Distal 1q21.1 deletions and duplications are associated with variable phenotypes including autism, head circumference and height defects. To eluc
doi.org
September 24, 2025 at 5:34 PM
surfinnurd.bsky.social
Postdoc post in my lab from Autumn this year @lsiexeter.bsky.social @exeter.ac.uk
#Chromatin #StemCells #Enhancer #NeuralCrest #Transcription #CellFate
#NuRDIsTheWord
Apply and/or get in touch!
lsiexeter.bsky.social LSI-Exeter @lsiexeter.bsky.social · Jun 9
Looking for a Postdoc? A PDRA position is available in the LSI Exeter with Prof Brian Hendrich from September 2025. Do you have experience in mammalian stem cell culture and a solid understanding of molecular & biochemical lab techniques? Apply! Job Ref: Q05546 jobs.exeter.ac.uk/hrpr_webrecr...
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jobs.exeter.ac.uk
June 11, 2025 at 10:10 AM
tgoliver.bsky.social
Don’t miss a companion manuscript describing one way in which hillock-like cells may regulate the immune microenvironment, coming soon from our co-authors, the O’Donnell lab! You can read about our new work here: www.biorxiv.org/content/10.1... #CancerBiology #LUSC #SingleCell #CellFate
KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer
Lung squamous cell carcinoma (LUSC) is basal-like subtype of lung cancer with limited treatment options. While prior studies have identified tumor-propagating cell states in squamous tumors, the broad...
www.biorxiv.org
March 20, 2025 at 3:53 PM
luigalpal.bsky.social
H3K4 methylation instructs blood specification in vivo

Bivalent chromatin instructs lineage specification during hematopoiesis | Cell

#Hematopoiesis #CellFate #Chromatin

www.cell.com/cell/abstrac...
Bivalent chromatin instructs lineage specification during hematopoiesis
Yagi et al. show that, unexpectedly, H3K4 methylation is dispensable for hematopoietic stem cell maintenance but essential for progenitor cell maturation into all blood cell types by opposing H3K27 me...
www.cell.com
June 17, 2025 at 4:38 PM
socdevbio.bsky.social
Behold a mouse blastocyst: The earliest glimpse of a mammal’s first cell fate decision!
Green marks future placenta cells.
Red highlights cells fated to become the embryo. Image taken by @VirginiaSavy.bsky.social
#FluorescenceFriday #DevBio #MouseEmbryo #CellFate #ImagingScience 🧪
May 16, 2025 at 4:15 PM
tranejoan.bsky.social
#ECMatrix guides #CellFate and patterning

www.nature.com/articles/s41...
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness - Nature Cell Biology
Moghe et al. show that mouse embryonic primitive endoderm cells migrate towards the inner cell mass-cavity interface, depositing an extracellular matrix gradient that may guide migration. Primitive en...
www.nature.com
February 18, 2025 at 7:36 PM
sdelcilab.bsky.social
Uncovering how mechanical forces can influence nuclear ATP levels, with downstream effects on DNA damage response and cell cycle progression.

#Mechanobiology #NuclearMetabolism #CellFate #DNArepair #CellCycle
July 30, 2025 at 10:03 AM
keystonesymposia.bsky.social
Showcase your research! Submit your poster abstract by April 16 (11:59pm MST) to join speakers @lydiafinley.bsky.social, Ralph J. DeBeradinis, & Keynote Navdeep Chandel. Apply now: keysym.us/KSMetabDev25. Can't attend? Access insights On Demand for 6 months post-conference!

#KSMetabDev25 #cellfate
April 10, 2025 at 9:27 PM
luigalpal.bsky.social
Outstanding paper describing how SVAs are regulated,what's their function in gene regulation and its impact in cell fate

Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation | Cell

#TEs #CellFate #HSCs #Aging

www.cell.com/cell/fulltex...
Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation
This study reveals that composite transposons with bivalent histone marks can serve as RNA-dependent enhancers, controlling key developmental and aging-related gene programs.
www.cell.com
August 7, 2025 at 9:38 PM
stemcellpodcast.com
"I'm melting!" 🫠

The @bugajlab.bsky.social at @upenn.bsky.social used a temperature-sensitive protein switch called Melt to control mammalian #CellFate.

📑 @naturemethods.bsky.social - go.nature.com/3WRdku1
🎤 - bit.ly/4gydVYn
February 11, 2025 at 9:23 PM
helmholtzmunich.bsky.social
#EpigeneticsPodcast with #HelmholtzMunich expert Dr. Eva Hörmanseder, @epihmgu.bsky.social!

🎧 Listen and learn about epigenetic memories & more:
👉 t1p.de/30q54

👉Check out her latest findings on this topic:
t1p.de/43yrw

@epigeneticspod.bsky.social
#Epigenetics #Podcast #Reprogramming #CellFate
epigeneticspod.bsky.social Epigenetics Podcast @epigeneticspod.bsky.social · Mar 28
In this episode of the Epigenetics Podcast, we talked with @evahoermanseder.bsky.social from @www.helmholtz-munich.de‬ about her work on epigenetic mechanisms in cellular memory and gene regulation. #podcast #epigenetics

Listen here: activemotif.com/podcasts-eva...
March 28, 2025 at 11:02 AM
cluster3dmm2o.bsky.social
Alfonso Martinez Arias @AMartinezArias, Professor at the Department of Genetics at @Cambridge_Uni, is one of our invited speakers at #Future3DAM. His research @AMA_lab focuses on the structure and function of #LivingMatter, on #CellFate decisions and embryonic #stemcells.
March 12, 2025 at 4:52 AM
stemcellpodcast.com
This week: Dr. Tongyu Sun and a team in Dr. Yarui Diao's lab at @dukehealth.bsky.social showed that #TransposableElements act as ‘mechano-response enhancer elements’ that control human #CellFate and #GeneExpression. 🧬

🗒️ @natcellbio.nature.com - https://go.nature.com/3I88AMp
🗣️ https://bit.ly/48I9olK
October 2, 2025 at 3:54 PM
jlsardinalab.bsky.social
Really enjoyed visiting CABD (@cabd-upo-csic.bsky.social) in Sevilla last Friday — great discussions and inspiring science. I shared our group’s latest work on #epigenetics, #cellfate, #CRISPR and #leukemia.

Thanks to Ozren (@obog.bsky.social) for being a great host!
November 10, 2025 at 11:08 AM
scholarai.bsky.social
#DevelopmentalBiology #CellFate
June 3, 2025 at 5:43 AM
epigenometech.bsky.social
Epigenetics Update - Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate bit.ly/46B7YYP

#Epigenetics #SingleCell #CellFate
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Gain deeper insights into gene regulation; epigenometech.com
Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate
Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.
bit.ly
September 18, 2025 at 1:01 PM
luigalpal.bsky.social
Thrilled to share with you the latest work from my PhD in Bigas lab at @researchmar.bsky.social @carrerasijc.bsky.social published in @bloodjournal.bsky.social

We’ve programmed blood stem cells from PSCs using CRISPRa screen and found a new “bloody” cocktail

#CRISPR #HSCs #StemCells #CellFate
kwnsfk27.r.eu-west-1.awstrack.me
July 18, 2025 at 6:28 PM
genesndiseases.bsky.social
The Wnt pathway regulates stem cell division, differentiation, and even links to diseases like cancer. This review tracks its evolving roles—and its potential for future therapeutic targeting. doi.org/10.1016/j.ge...
#WntSignaling #CellFate #RegenerativeBiology
June 10, 2025 at 11:28 AM
mpinb.mpg.de
Cells use more than signal strength to decide their fate—they "listen" to the tempo of signaling. Check out this work by our Cellular Computations and Learning Lab introducing signaling homeorhesis, a concept where dynamic signal patterns guide cell decisions. #CellSignaling #cellfate
koseskalab.bsky.social koseskalab.bsky.social @koseskalab.bsky.social · Jun 6
👇🏻👇🏻👇🏻 Pre-print alert 👇🏻👇🏻👇🏻
We developed the concept of signaling homeorhesis to describe regulation of cell phenotype under dynamic signals, demonstrating that cells actively interpret signals from their environment to determine cell fate! @mpinb.mpg.de

www.biorxiv.org/content/10.1...
Homeorhetic regulation of cellular phenotype
How cells translate growth factor (GF) signals into context-specific phenotypes remains a fundamental question in cell biology. The classical view holds that cells translate a constant concentration o...
www.biorxiv.org
June 11, 2025 at 6:59 AM
luigalpal.bsky.social
Hello BlueSky world!! I’ll be BlueSkying stuff related to #Science #Chromatin #CellFate #StemCell #CRISPR
November 13, 2024 at 10:40 PM
moloncology.bsky.social
Survivin and Aurora Kinase A control cell fate decisions during mitosis

👉 buff.ly/PLDmH38

#AURKA #Mitosis #CellFate
November 3, 2025 at 10:01 AM
stemcellpodcast.com
Researchers at @uniheidelberg.bsky.social discovered that #PROX1 can block #CellFate plasticity in #hepatocytes, preventing #LiverCancer in mice.

@aryankamal.bsky.social
@moritzmall.bsky.social

📃 @naturegenet.bsky.social - go.nature.com/3D9AYuR
🎤 - bit.ly/4k42YAG
February 19, 2025 at 10:08 PM
ijdb.bsky.social
Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems

by K. S. Walczyńska, L. Zhu and Y. Liang

ijdb.ehu.eus/article/2201...

🔑 Wnt signaling pathway #WntSignaling, #RegenerationBiology, #AnimalModels, cell fate determination #CellFate, #TissueRepair
March 7, 2025 at 2:18 PM
luigalpal.bsky.social
Chromatin-based memory as a self-stabilizing influence on cell identity | Genome Biology

#Chromatin #CellFate #Review

genomebiology.biomedcentral.com/articles/10....
Chromatin-based memory as a self-stabilizing influence on cell identity - Genome Biology
Cell types are traditionally thought to be specified and stabilized by gene regulatory networks. Here, we explore how chromatin memory contributes to the specification and stabilization of cell states...
genomebiology.biomedcentral.com
December 31, 2024 at 7:08 AM
chymkowitchlab.bsky.social
We are extending the application deadline for this post-doc position! Do not miss the opportunity to join an exciting project in a dynamic and collaborative research environment. @igbmc.bsky.social @pasteur.fr @univbordeaux.bsky.social @uio.no #epigenetics #cellfate #SUMOylation @ncmbm.bsky.social
Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366) | University of Oslo
Job title: Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366), Employer: University of Oslo, Deadline: Thursday, May 15, 2025
www.jobbnorge.no
May 12, 2025 at 4:49 PM