Using sequence alignment and AlphaFold modeling, the Carman lab at Rutgers identified four conserved motifs in yeast Pah1 essential for catalytic activity and lipid balance. go.njmicrobe.org/lmCbZg #Microbiology #YeastResearch #LipidMetabolism #Pah1 #AlphaFold #Lipin #MajeedSyndrome #Rhabdomyolysis
Deciphering the active site: Why motif conservation in Pah1 matters for yeast lipid homeostasis
The enzyme Pah1 is a central figure in the lipid metabolism of Saccharomyces cerevisiae, acting as a Mg2+-dependent phosphatidate (PA) phosphatase that converts PA into diacylglycerol. This catalytic ...
go.njmicrobe.org
December 20, 2025 at 3:34 PM
Using sequence alignment and AlphaFold modeling, the Carman lab at Rutgers identified four conserved motifs in yeast Pah1 essential for catalytic activity and lipid balance. go.njmicrobe.org/lmCbZg #Microbiology #YeastResearch #LipidMetabolism #Pah1 #AlphaFold #Lipin #MajeedSyndrome #Rhabdomyolysis