The Chain Reaction Leading to Systemic Inflammation - Prof David Putrino MD breaks down what's happening.
#longcovid #longcovidtheanswers #longhauler #mecfs #mastcell #spikeprotein #inflammation
www.youtube.com/shorts/whHw_...
#longcovid #longcovidtheanswers #longhauler #mecfs #mastcell #spikeprotein #inflammation
www.youtube.com/shorts/whHw_...
The Chain Reaction Leading to Systemic Inflammation - Prof David Putrino MD breaks down what's happe
YouTube video by Long Covid The Answers
www.youtube.com
October 15, 2025 at 7:43 PM
The Chain Reaction Leading to Systemic Inflammation - Prof David Putrino MD breaks down what's happening.
#longcovid #longcovidtheanswers #longhauler #mecfs #mastcell #spikeprotein #inflammation
www.youtube.com/shorts/whHw_...
#longcovid #longcovidtheanswers #longhauler #mecfs #mastcell #spikeprotein #inflammation
www.youtube.com/shorts/whHw_...
The Chain Reaction Leading to Systemic Inflammation - Prof David Putrino MD breaks down what's happening.
#longcovid #longcovidtheanswers #longhauler #mecfs #mastcell #spikeprotein #inflammation
#longcovid #longcovidtheanswers #longhauler #mecfs #mastcell #spikeprotein #inflammation
October 15, 2025 at 5:29 PM
The Chain Reaction Leading to Systemic Inflammation - Prof David Putrino MD breaks down what's happening.
#longcovid #longcovidtheanswers #longhauler #mecfs #mastcell #spikeprotein #inflammation
#longcovid #longcovidtheanswers #longhauler #mecfs #mastcell #spikeprotein #inflammation
and tryptase levels increased in human FMS skin samples compared to healthy controls. Taken together our results suggests that FMS IgG mediates hypersensitivity via activation of mast cells bearing the MRGPRX2 receptor and that these cells are a potential therapeutic target.
#Fibromyalgia #MastCell
#Fibromyalgia #MastCell
October 6, 2025 at 4:09 PM
and tryptase levels increased in human FMS skin samples compared to healthy controls. Taken together our results suggests that FMS IgG mediates hypersensitivity via activation of mast cells bearing the MRGPRX2 receptor and that these cells are a potential therapeutic target.
#Fibromyalgia #MastCell
#Fibromyalgia #MastCell
A pathway to next-generation mast cell stabilizers identified through the novel Phytomedical Analytics for Research Optimization at Scale data platform
#mcas #mastcell
pmc.ncbi.nlm.nih.gov/articles/PMC...
#mcas #mastcell
pmc.ncbi.nlm.nih.gov/articles/PMC...
A pathway to next-generation mast cell stabilizers identified through the novel Phytomedical Analytics for Research Optimization at Scale data platform
Mast cell stabilizers (MCS) have the potential to address unmet therapeutic need in allergy and inflammation management. MCS chronically suppress all arms of the pro-inflammatory mast cell response to...
pmc.ncbi.nlm.nih.gov
September 23, 2025 at 8:39 PM
A pathway to next-generation mast cell stabilizers identified through the novel Phytomedical Analytics for Research Optimization at Scale data platform
#mcas #mastcell
pmc.ncbi.nlm.nih.gov/articles/PMC...
#mcas #mastcell
pmc.ncbi.nlm.nih.gov/articles/PMC...
I am particularly thrilled to share our new paper published in @nature.com. We uncover a previously unknown mechanism linking maternal #stress during #pregnancy to the development of #pediatric #eczema
www.nature.com/articles/s41...
@inserm.fr @cnrs.fr @erc.europa.eu
#Neuroimmunology #Mastcell
www.nature.com/articles/s41...
@inserm.fr @cnrs.fr @erc.europa.eu
#Neuroimmunology #Mastcell
August 28, 2025 at 6:54 AM
I am particularly thrilled to share our new paper published in @nature.com. We uncover a previously unknown mechanism linking maternal #stress during #pregnancy to the development of #pediatric #eczema
www.nature.com/articles/s41...
@inserm.fr @cnrs.fr @erc.europa.eu
#Neuroimmunology #Mastcell
www.nature.com/articles/s41...
@inserm.fr @cnrs.fr @erc.europa.eu
#Neuroimmunology #Mastcell
Unraveling Mast Cell Activation Syndrome. Many of us are seeing increasing numbers of patients asking if they might have a mast cell disorder. Join Onyinye Iweala, MD, PhD, FAAAAI, as we discuss MCAS and how to better understand this confusing disorder. #MCAS #MastCell
www.aaaai.org/professional...
www.aaaai.org/professional...
August 19, 2025 at 4:46 PM
Unraveling Mast Cell Activation Syndrome. Many of us are seeing increasing numbers of patients asking if they might have a mast cell disorder. Join Onyinye Iweala, MD, PhD, FAAAAI, as we discuss MCAS and how to better understand this confusing disorder. #MCAS #MastCell
www.aaaai.org/professional...
www.aaaai.org/professional...
If you haven’t had an allergy screen yet, worth doing. Also track symptoms as relates to your period- highs and lows of estrogen affects more than mood- can increase histamine load prior to cycle. 🩷 So sorry for your experience.
#mastcell
#mastcell
August 18, 2025 at 3:46 PM
If you haven’t had an allergy screen yet, worth doing. Also track symptoms as relates to your period- highs and lows of estrogen affects more than mood- can increase histamine load prior to cycle. 🩷 So sorry for your experience.
#mastcell
#mastcell
Who was a clever pumpkin who remembered to stop having an imagined conversation with herself for long enough to take simethicone so she doesn't wake up crying? #lactose #mastcell #mybodyisajerk
July 29, 2025 at 3:54 AM
Who was a clever pumpkin who remembered to stop having an imagined conversation with herself for long enough to take simethicone so she doesn't wake up crying? #lactose #mastcell #mybodyisajerk
#Sponsored by: ARS Pharma
Tune in to #FAACTsRoundtable #Podcast: Navigate Discussing Personal Health Information Online
Listen to #FAACT's Ep. 240:
www.buzzsprout.com/848314/episo...
#FoodAllergy #FoodAllergies #Allergy #MCAS #MastCell #POTS #Anaphylaxis #AutoImmune #AutoImmuneDisorders
Tune in to #FAACTsRoundtable #Podcast: Navigate Discussing Personal Health Information Online
Listen to #FAACT's Ep. 240:
www.buzzsprout.com/848314/episo...
#FoodAllergy #FoodAllergies #Allergy #MCAS #MastCell #POTS #Anaphylaxis #AutoImmune #AutoImmuneDisorders
July 16, 2025 at 12:01 PM
#Sponsored by: ARS Pharma
Tune in to #FAACTsRoundtable #Podcast: Navigate Discussing Personal Health Information Online
Listen to #FAACT's Ep. 240:
www.buzzsprout.com/848314/episo...
#FoodAllergy #FoodAllergies #Allergy #MCAS #MastCell #POTS #Anaphylaxis #AutoImmune #AutoImmuneDisorders
Tune in to #FAACTsRoundtable #Podcast: Navigate Discussing Personal Health Information Online
Listen to #FAACT's Ep. 240:
www.buzzsprout.com/848314/episo...
#FoodAllergy #FoodAllergies #Allergy #MCAS #MastCell #POTS #Anaphylaxis #AutoImmune #AutoImmuneDisorders
Please see my latest #interview on “Bonds without Bounds” #podcast. The name of the episode is, ”#Floxed then Injected with #Gadolinium: Talia Smith's Story of Resilience.”
WATCH 👇🏼
youtu.be/Emsr6WY_X0A
#mystory #Cipro #Ciprofloxacin #fqtoxicity #FQAD #mcas #mastcell #MRI
WATCH 👇🏼
youtu.be/Emsr6WY_X0A
#mystory #Cipro #Ciprofloxacin #fqtoxicity #FQAD #mcas #mastcell #MRI
Floxed then Injected with Gadolinium: Talia Smith’s Story of Resilience
YouTube video by Bonds without Bounds
youtu.be
July 10, 2025 at 6:59 PM
Please see my latest #interview on “Bonds without Bounds” #podcast. The name of the episode is, ”#Floxed then Injected with #Gadolinium: Talia Smith's Story of Resilience.”
WATCH 👇🏼
youtu.be/Emsr6WY_X0A
#mystory #Cipro #Ciprofloxacin #fqtoxicity #FQAD #mcas #mastcell #MRI
WATCH 👇🏼
youtu.be/Emsr6WY_X0A
#mystory #Cipro #Ciprofloxacin #fqtoxicity #FQAD #mcas #mastcell #MRI
When all you want is to be healed…
#healme #cipro #praying for a #miracle #healingjourney #ciprofloxacin #floxed #fqtoxicity #fluoroquinolonetoxicity #mcas #mastcellactivationsyndrome #mastcell
#healme #cipro #praying for a #miracle #healingjourney #ciprofloxacin #floxed #fqtoxicity #fluoroquinolonetoxicity #mcas #mastcellactivationsyndrome #mastcell
July 7, 2025 at 11:25 PM
When all you want is to be healed…
#healme #cipro #praying for a #miracle #healingjourney #ciprofloxacin #floxed #fqtoxicity #fluoroquinolonetoxicity #mcas #mastcellactivationsyndrome #mastcell
#healme #cipro #praying for a #miracle #healingjourney #ciprofloxacin #floxed #fqtoxicity #fluoroquinolonetoxicity #mcas #mastcellactivationsyndrome #mastcell
“Why doesn’t anyone have to follow the FDA guidelines for Black Box Warnings? Who is protecting patients?”
To watch the entire #interview,👇🏼
youtu.be/Xqf6Rl3Y6aw?...
#podcast #hospice #Ciprofloxacin #Cipro #floxed #mcas #mastcell #floxie #fqtoxicity #awareness
To watch the entire #interview,👇🏼
youtu.be/Xqf6Rl3Y6aw?...
#podcast #hospice #Ciprofloxacin #Cipro #floxed #mcas #mastcell #floxie #fqtoxicity #awareness
July 1, 2025 at 1:10 PM
“Why doesn’t anyone have to follow the FDA guidelines for Black Box Warnings? Who is protecting patients?”
To watch the entire #interview,👇🏼
youtu.be/Xqf6Rl3Y6aw?...
#podcast #hospice #Ciprofloxacin #Cipro #floxed #mcas #mastcell #floxie #fqtoxicity #awareness
To watch the entire #interview,👇🏼
youtu.be/Xqf6Rl3Y6aw?...
#podcast #hospice #Ciprofloxacin #Cipro #floxed #mcas #mastcell #floxie #fqtoxicity #awareness
The Healthcare Henry #Podcast will be airing in 15 mins, HOW #HOSPICE SAVED MY LIFE.
Click to watch 👇🏼
youtu.be/Xqf6Rl3Y6aw?...
#interview #hospicecare #Ciprofloxacin #Cipro #floxed #mastcellactivationsyndrome #mcas #mastcell #fqtoxicity #fluoroquinolonetoxicity #Awareness #needtoknow
Click to watch 👇🏼
youtu.be/Xqf6Rl3Y6aw?...
#interview #hospicecare #Ciprofloxacin #Cipro #floxed #mastcellactivationsyndrome #mcas #mastcell #fqtoxicity #fluoroquinolonetoxicity #Awareness #needtoknow
She Was Floxed. Then She Fought the FDA | The Story of Talia Smith | Healthcare Henry
YouTube video by Henry Mason Jr.
youtu.be
June 30, 2025 at 10:46 PM
The Healthcare Henry #Podcast will be airing in 15 mins, HOW #HOSPICE SAVED MY LIFE.
Click to watch 👇🏼
youtu.be/Xqf6Rl3Y6aw?...
#interview #hospicecare #Ciprofloxacin #Cipro #floxed #mastcellactivationsyndrome #mcas #mastcell #fqtoxicity #fluoroquinolonetoxicity #Awareness #needtoknow
Click to watch 👇🏼
youtu.be/Xqf6Rl3Y6aw?...
#interview #hospicecare #Ciprofloxacin #Cipro #floxed #mastcellactivationsyndrome #mcas #mastcell #fqtoxicity #fluoroquinolonetoxicity #Awareness #needtoknow
Have realized that the summer nausea has less to do with my medicines, and what I eat and wayyyy more to do with the temperature in my apartment. Its probably some fibro+/mastcell shit going on
June 24, 2025 at 2:43 AM
Have realized that the summer nausea has less to do with my medicines, and what I eat and wayyyy more to do with the temperature in my apartment. Its probably some fibro+/mastcell shit going on
Is being floxed “the perfect storm or the last straw?”
To watch the full interview, click on the link👇🏼
www.youtube.com/live/4tVGaBD...
#thisisfloxed #mastcellactivationsyndrome #mcas #mastcell #floxed #FQtoxicity #fluoroquinoloneantibiotics #interview #awareness #mastcelldisease
To watch the full interview, click on the link👇🏼
www.youtube.com/live/4tVGaBD...
#thisisfloxed #mastcellactivationsyndrome #mcas #mastcell #floxed #FQtoxicity #fluoroquinoloneantibiotics #interview #awareness #mastcelldisease
June 21, 2025 at 2:40 PM
Is being floxed “the perfect storm or the last straw?”
To watch the full interview, click on the link👇🏼
www.youtube.com/live/4tVGaBD...
#thisisfloxed #mastcellactivationsyndrome #mcas #mastcell #floxed #FQtoxicity #fluoroquinoloneantibiotics #interview #awareness #mastcelldisease
To watch the full interview, click on the link👇🏼
www.youtube.com/live/4tVGaBD...
#thisisfloxed #mastcellactivationsyndrome #mcas #mastcell #floxed #FQtoxicity #fluoroquinoloneantibiotics #interview #awareness #mastcelldisease
This is a #preview from my #interview with Dr. Kelly McCann on #MastCellActivationSyndrome on the USA Global TV & Radio Network. This clip is Dr. Kelly McCann’s Message of HOPE.
Watch the full interview👇🏼 www.youtube.com/live/4tVGaBD...
#thisisfloxed #mcas #mastcell #floxed #FQtoxicity #awareness
Watch the full interview👇🏼 www.youtube.com/live/4tVGaBD...
#thisisfloxed #mcas #mastcell #floxed #FQtoxicity #awareness
June 20, 2025 at 1:09 PM
This is a #preview from my #interview with Dr. Kelly McCann on #MastCellActivationSyndrome on the USA Global TV & Radio Network. This clip is Dr. Kelly McCann’s Message of HOPE.
Watch the full interview👇🏼 www.youtube.com/live/4tVGaBD...
#thisisfloxed #mcas #mastcell #floxed #FQtoxicity #awareness
Watch the full interview👇🏼 www.youtube.com/live/4tVGaBD...
#thisisfloxed #mcas #mastcell #floxed #FQtoxicity #awareness
Oh I get these too, but from fibro/dermografism/mastcell/hashimotos stuff. Then you think you're gonna get off your chair and then you're like "oh..no im not"
June 18, 2025 at 7:14 PM
Oh I get these too, but from fibro/dermografism/mastcell/hashimotos stuff. Then you think you're gonna get off your chair and then you're like "oh..no im not"
#Sponsored by: Blueprint Medicines
Tune in to #FAACTsRoundtable #Podcast: Finding Support with #MastCell Diseases
Listen to #FAACT's Ep. 237:
www.buzzsprout.com/848314/episo...
#MastCellDisease #MCAS #Mastocytosis #SystemicMastocytosis #Anaphylaxis #Allergy #FoodAllergy #AllergyAwareness
Tune in to #FAACTsRoundtable #Podcast: Finding Support with #MastCell Diseases
Listen to #FAACT's Ep. 237:
www.buzzsprout.com/848314/episo...
#MastCellDisease #MCAS #Mastocytosis #SystemicMastocytosis #Anaphylaxis #Allergy #FoodAllergy #AllergyAwareness
June 18, 2025 at 1:30 PM
#Sponsored by: Blueprint Medicines
Tune in to #FAACTsRoundtable #Podcast: Finding Support with #MastCell Diseases
Listen to #FAACT's Ep. 237:
www.buzzsprout.com/848314/episo...
#MastCellDisease #MCAS #Mastocytosis #SystemicMastocytosis #Anaphylaxis #Allergy #FoodAllergy #AllergyAwareness
Tune in to #FAACTsRoundtable #Podcast: Finding Support with #MastCell Diseases
Listen to #FAACT's Ep. 237:
www.buzzsprout.com/848314/episo...
#MastCellDisease #MCAS #Mastocytosis #SystemicMastocytosis #Anaphylaxis #Allergy #FoodAllergy #AllergyAwareness
“From the highly-researched Swiss Interest Group, #histamine intolerance food compatibility list, this #book provides info on #MastCell disorders & also a #recipe collection of simple meal ideas that use #LowHistamine foods.": buff.ly/223unvJ
via @lowhistamine.bsky.social
via @lowhistamine.bsky.social
Helpful Books on Chronic Illness - Through The Fibro Fog
When I was first diagnosed with chronic migraine, I didn’t have much familiarity with the healthcare system or know of any resources to turn to for advice. I simply went along with my doctors. In…
buff.ly
June 17, 2025 at 8:30 PM
“From the highly-researched Swiss Interest Group, #histamine intolerance food compatibility list, this #book provides info on #MastCell disorders & also a #recipe collection of simple meal ideas that use #LowHistamine foods.": buff.ly/223unvJ
via @lowhistamine.bsky.social
via @lowhistamine.bsky.social
TOMORROW! Do u have #MCAS or think you have MCAS? Watch #ThisisFloxed Wed. June 18, 2025 at 11am ET with Dr. Kelly McCann.
www.youtube.com/live/4tVGaBD...
#mastcellactivationsyndrome #mastcell #floxed #fluoroquinolonetoxicity
#FQtoxicity #Fluoroquinolones
#interview #tunein #liveshow
www.youtube.com/live/4tVGaBD...
#mastcellactivationsyndrome #mastcell #floxed #fluoroquinolonetoxicity
#FQtoxicity #Fluoroquinolones
#interview #tunein #liveshow
June 17, 2025 at 12:55 PM
TOMORROW! Do u have #MCAS or think you have MCAS? Watch #ThisisFloxed Wed. June 18, 2025 at 11am ET with Dr. Kelly McCann.
www.youtube.com/live/4tVGaBD...
#mastcellactivationsyndrome #mastcell #floxed #fluoroquinolonetoxicity
#FQtoxicity #Fluoroquinolones
#interview #tunein #liveshow
www.youtube.com/live/4tVGaBD...
#mastcellactivationsyndrome #mastcell #floxed #fluoroquinolonetoxicity
#FQtoxicity #Fluoroquinolones
#interview #tunein #liveshow
2 days! Do u have #MCAS or think u have MCAS?
My fourth episode of #ThisisFloxed will air on Wed, June 18, 2025 at 11am ET.
www.youtube.com/live/4tVGaBD...
#savethedate #mastcellactivationsyndrome #mastcell #floxed #fluoroquinolonetoxicity
#FQtoxicity #liveshow #interview #awareness #needtoknow
My fourth episode of #ThisisFloxed will air on Wed, June 18, 2025 at 11am ET.
www.youtube.com/live/4tVGaBD...
#savethedate #mastcellactivationsyndrome #mastcell #floxed #fluoroquinolonetoxicity
#FQtoxicity #liveshow #interview #awareness #needtoknow
June 16, 2025 at 12:59 PM
2 days! Do u have #MCAS or think u have MCAS?
My fourth episode of #ThisisFloxed will air on Wed, June 18, 2025 at 11am ET.
www.youtube.com/live/4tVGaBD...
#savethedate #mastcellactivationsyndrome #mastcell #floxed #fluoroquinolonetoxicity
#FQtoxicity #liveshow #interview #awareness #needtoknow
My fourth episode of #ThisisFloxed will air on Wed, June 18, 2025 at 11am ET.
www.youtube.com/live/4tVGaBD...
#savethedate #mastcellactivationsyndrome #mastcell #floxed #fluoroquinolonetoxicity
#FQtoxicity #liveshow #interview #awareness #needtoknow
4 days away!
Do you have #MCAS or think you have MCAS? My fourth episode of #ThisisFloxed will air on Wed, June 18, 2025 at 11am ET.
www.youtube.com/live/4tVGaBD...
#mastcellactivationsyndrome #mastcell #floxed #fluoroquinolonetoxicity
#FQtoxicity #interview #livepodcast #awareness
#tunein
Do you have #MCAS or think you have MCAS? My fourth episode of #ThisisFloxed will air on Wed, June 18, 2025 at 11am ET.
www.youtube.com/live/4tVGaBD...
#mastcellactivationsyndrome #mastcell #floxed #fluoroquinolonetoxicity
#FQtoxicity #interview #livepodcast #awareness
#tunein
June 14, 2025 at 12:36 PM
4 days away!
Do you have #MCAS or think you have MCAS? My fourth episode of #ThisisFloxed will air on Wed, June 18, 2025 at 11am ET.
www.youtube.com/live/4tVGaBD...
#mastcellactivationsyndrome #mastcell #floxed #fluoroquinolonetoxicity
#FQtoxicity #interview #livepodcast #awareness
#tunein
Do you have #MCAS or think you have MCAS? My fourth episode of #ThisisFloxed will air on Wed, June 18, 2025 at 11am ET.
www.youtube.com/live/4tVGaBD...
#mastcellactivationsyndrome #mastcell #floxed #fluoroquinolonetoxicity
#FQtoxicity #interview #livepodcast #awareness
#tunein
Do u have #MCAS or think u have MCAS? If so, watch my next episode of This is Floxed air on Wed. June 18, 2025 at 11am ET.
Link to #interview, click, 'Notify me' to get a reminder before the episode airs.
www.youtube.com/live/4tVGaBD...
#thisisfloxed #mastcell #cipro #ciprofloxacin
#FQtoxicity
Link to #interview, click, 'Notify me' to get a reminder before the episode airs.
www.youtube.com/live/4tVGaBD...
#thisisfloxed #mastcell #cipro #ciprofloxacin
#FQtoxicity
WHAT YOU NEED TO KNOW ABOUT MAST CELL ACTIVATION SYNDROME (MCAS) WITH DR. KELLY MCCANN
WHAT YOU NEED TO KNOW ABOUT MAST CELL ACTIVATION SYNDROME (MCAS) WITH DR. KELLY MCCANN
USA GLOBAL TV® & RADIO
PRESENTS
THIS IS FLOXED TV SHOW
HOSTED BY RED O'LAUGHLIN
FEATURING TALIA SMITH
GUEST DR. ...
www.youtube.com
June 11, 2025 at 9:31 PM
Do u have #MCAS or think u have MCAS? If so, watch my next episode of This is Floxed air on Wed. June 18, 2025 at 11am ET.
Link to #interview, click, 'Notify me' to get a reminder before the episode airs.
www.youtube.com/live/4tVGaBD...
#thisisfloxed #mastcell #cipro #ciprofloxacin
#FQtoxicity
Link to #interview, click, 'Notify me' to get a reminder before the episode airs.
www.youtube.com/live/4tVGaBD...
#thisisfloxed #mastcell #cipro #ciprofloxacin
#FQtoxicity
#Sponsored by: Blueprint Medicines
Tune in to #FAACTsRoundtable #Podcast on Indolent #SystemicMastocytosis - the #Patient Perspective
Listen to #FAACT's Ep. 236:
www.buzzsprout.com/848314/episo...
#ISM #SystemicMastocytosis #Mastocytosis #MastCell #MCAS #FoodAllergyPodcast #Anaphylaxis #Allergy
Tune in to #FAACTsRoundtable #Podcast on Indolent #SystemicMastocytosis - the #Patient Perspective
Listen to #FAACT's Ep. 236:
www.buzzsprout.com/848314/episo...
#ISM #SystemicMastocytosis #Mastocytosis #MastCell #MCAS #FoodAllergyPodcast #Anaphylaxis #Allergy
June 11, 2025 at 12:02 PM
#Sponsored by: Blueprint Medicines
Tune in to #FAACTsRoundtable #Podcast on Indolent #SystemicMastocytosis - the #Patient Perspective
Listen to #FAACT's Ep. 236:
www.buzzsprout.com/848314/episo...
#ISM #SystemicMastocytosis #Mastocytosis #MastCell #MCAS #FoodAllergyPodcast #Anaphylaxis #Allergy
Tune in to #FAACTsRoundtable #Podcast on Indolent #SystemicMastocytosis - the #Patient Perspective
Listen to #FAACT's Ep. 236:
www.buzzsprout.com/848314/episo...
#ISM #SystemicMastocytosis #Mastocytosis #MastCell #MCAS #FoodAllergyPodcast #Anaphylaxis #Allergy
How's the weight and ergonomy in handheld mode, and how does the material feel? I got pressure marks that burns from holding the first one (dermografism/ mastcell issues)
June 9, 2025 at 7:48 AM
How's the weight and ergonomy in handheld mode, and how does the material feel? I got pressure marks that burns from holding the first one (dermografism/ mastcell issues)