𝗜𝗺𝗲𝗱𝗼𝘀 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝗿𝗲𝘃𝗲𝗮𝗹𝘀 𝗽𝗲𝗿𝘀𝗶𝘀𝘁𝗲𝗻𝘁 𝗺𝗶𝗰𝗿𝗼𝘃𝗮𝘀𝗰𝘂𝗹𝗮𝗿 𝗲𝗻𝗱𝗼𝘁𝗵𝗲𝗹𝗶𝗮𝗹 𝗱𝘆𝘀𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻 𝗶𝗻 𝗽𝗼𝘀𝘁-𝗖𝗢𝗩𝗜𝗗 𝘀𝘆𝗻𝗱𝗿𝗼𝗺𝗲 A highly regarded and still highly relevant study demonstrates that retinal vessel analysis provides ...

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Blood flow through capillary vessels in cancerous tissue plays a crucial role in disease progression and treatment. Unlike the microvasculature in healthy tissue, which is hierarchically well…

**Abstract:** This research proposes a novel approach to non-invasive assessment of microcirculation and cardiovascular risk stratification utilizing adaptive optical tomography (AOT) combined with graph neural networks (GNNs). We significantly improve upon existing optical coherence tomography (OCT) methods by incorporating real-time adaptive optics correction for enhanced resolution and developing a GNN architecture to analyze the complex vascular networks captured by AOT. Our system aims to identify subtle vascular pathologies indicative of early-stage cardiovascular disease, offering a previously unattainable level of diagnostic accuracy, potentially reducing the need for invasive procedures and enabling proactive therapeutic interventions.

This case series reports limb salvage with transverse tibial transport showing complete healing in recalcitrant diabetic foot ulcers with no pin site infections.

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1. 2- , , , , "" , , , , . , - ""-, , . 2. . 3. , , , , 2- . - 1. Microvascular tone disturbances, including tortuosity, spasms, aneurysm formation, capillary "empty" zones, and narrowing of arterioles and venules observed in patients with ...

For the first time, a team of Inserm researchers from the Physics for Medicine Institute (Inserm/ESPCI Paris-PSL/CNRS) has succeeded in mapping the blood flow of an entire organ in animals (heart, kidney and liver) with great precision, in four dimensions: 3D and time.

Background: Hypertension is a significant risk factor for cardiovascular diseases and is associated with an increased risk of mild cognitive impairment (MCI). The lack of effective treatment for these conditions underscores the urgent need for novel therapeutic approaches. Previous studies have indicated that microcirculation serves as the pathological basis for the comorbidity of hypertension and cognitive dysfunction. Our initial clinical studies have indicated that acupuncture could be a safe and effective treatment for managing hypertension and MCI. Whether acupuncture can enhance hypertension and cognitive impairment by modulating microcirculation, and the precise mechanisms involved, warrants further exploration. Objective: The objective of the trial is to evaluate the clinical efficacy of electroacupuncture on MCI of patients with hypertension and to explore whether it can improve hypertension and cognitive impairment by regulating microcirculation. Methods: In this multicenter, large-scale, single-blind, #RCT #ClinicalTrial, we will recruit 252 patients with hypertension and cognitive impairment from 3 hospitals and randomly assign them to 3 groups in a 1:1:1 ratio: the electroacupuncture group, the sham electroacupuncture (SEA) group, and the waiting list group. The electroacupuncture group and SEA group will receive either electroacupuncture or SEA for 12 weeks, while the waiting list group will not receive acupuncture treatment for the first 12 weeks. The primary outcome will be the changes in overall cognitive function, as measured by the Montreal Cognitive Assessment. The secondary outcomes include blood pressure status, subdomain cognitive function, mental status, sleep quality, hemodynamics, and microcirculation indicators. Results: The #Study #Protocol has been approved by the institutional review board of the First Affiliated Hospital of Tianjin University of traditional Chinese medicine. This #Study was registered on April 26, 2024, with the Chinese Clinical Trial Registry. Data collection began in May 2024 and ended in April 2025. Currently, data from this trial are in the collection phase, and no data analysis has been performed. As of January 1, 2025, we have collected data from 65 patients. The results of this trial are expected to be submitted for publication in July 2026. Conclusions: This clinical trial aims to compare the efficacy of electroacupuncture versus SEA or waiting list control in the treatment of hypertension with cognitive impairment and to explore its impact on microcirculation through hemodynamic and microcirculatory indices. The results of this trial will contribute to clarifying the microcirculatory mechanisms of electroacupuncture in the treatment of hypertension with cognitive impairment, providing a solid foundation for further #Research on electroacupuncture therapy. Clinical Trial: Chinese Clinical Trial Registry ChiCTR2400083501; https://www.chictr.org.cn/showproj.html?proj=220722