#PAC1-PACAP
New early view article🫀:

Cardiac fibrosis induced by high-fat diet in ApoE-deficient male mice is exacerbated by genetic deletion of PACAP–PAC1 signaling.

Schubart JM, Schaefer MKH, Bonaterra GA, et al.

Read: onlinelibrary.wiley....
November 28, 2025 at 4:03 PM
Very happy to share that my spatial transcriptomic sequencing study on a DIPG-infiltrated patient brainstem has now been published. #DIPG #tumor-TME-interactions #PAC1-PACAP
All sequencing data available on GEO: GSE280990.
Sharing is much appreciated!

link.springer.com/article/10.1...
Spatial analysis of a complete DIPG-infiltrated brainstem reveals novel ligand-receptor mediators of tumour-to-TME crosstalk - Acta Neuropathologica Communications
Previous studies have highlighted the capacity of brain cancer cells to functionally interact with the tumour microenvironment (TME). This TME-cancer crosstalk crucially contributes to tumour cell inv...
link.springer.com
February 19, 2025 at 5:45 PM