📝 Online now - the Review "Decoding protein structures with residue interaction networks" from Silvio Tosatto et al.
#RIN #ProteinStructure #ResidueCentrality #Allosterism #ArtificialIntelligence
Read it here: authors.elsevier.com/sd/article/S...
#RIN #ProteinStructure #ResidueCentrality #Allosterism #ArtificialIntelligence
Read it here: authors.elsevier.com/sd/article/S...
September 15, 2025 at 3:51 PM
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#Cytochrome #NitrogenCycle #Spectroscopy #Catalysis #Heme #Haem #NitrousOxide #Hydroxylamine #Greenhouse #ProteinResearch #ScientificReview #Biochemistry #MolecularBiology #ProteinStructure #LifeSciences #ResearchInnovation #ScienceCommunity #AcademicPublishing #ProteinFunction
March 27, 2025 at 4:21 PM
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NALCN/Cch1 channelosome subunits originated in early eukaryotes. New study from Adriano Senatore @utoronto.ca and colleagues: rupress.org/jgp/article/...
#Lipids #membranes #MolecularPhysiology #ProteinStructure #ProteinDynamics #CellBiology #Evolution #IonChannels
#Lipids #membranes #MolecularPhysiology #ProteinStructure #ProteinDynamics #CellBiology #Evolution #IonChannels
September 12, 2025 at 2:15 PM
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Ready to start exploring your molecular structures?🔎 Just click on “Load files” and upload your proteins or small molecules. Watch the video to see it in action!🎬 #ProteinStructure #DataVisualization
November 26, 2024 at 3:21 PM
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4️⃣ Ligand Binding Alters Caspase-11 Structure
CD analysis revealed a shift toward a more α-helical conformation upon binding non-aggregating ligands LPS-RS and PGPC. This suggests distinct ligand-induced structural changes. #Immunology #Caspase11 #ProteinStructure
CD analysis revealed a shift toward a more α-helical conformation upon binding non-aggregating ligands LPS-RS and PGPC. This suggests distinct ligand-induced structural changes. #Immunology #Caspase11 #ProteinStructure
March 8, 2025 at 2:19 PM
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Why is leadership in structural biology so important? Mark Hargrove shows us how impactful it can be.
www.asbmb.org/asbmb-...
#SciComm #StructuralBiology #ASBMBmemberNews #XRayCrystallography #ProteinStructure
www.asbmb.org/asbmb-...
#SciComm #StructuralBiology #ASBMBmemberNews #XRayCrystallography #ProteinStructure
Hargrove recognized for leadership
By tracking protein changes in stem cell–derived heart cells, researchers from Cedars-Sinai uncovered surprising diversity that could reshape how we study and treat heart disease. Read more about this recent Molecular & Cellular Proteomics article.
www.asbmb.org
June 16, 2025 at 8:16 PM
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Amino acid exchangeability and surface accessibility underpin the effects of single substitutions
Alpay, B. A., Desai, M. M. et al.
Paper
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#AminoAcidSubstitutions #ProteinStructure #BiochemistryResearch
Alpay, B. A., Desai, M. M. et al.
Paper
Details
#AminoAcidSubstitutions #ProteinStructure #BiochemistryResearch
June 20, 2025 at 9:02 AM
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🧬 New paper out from our Computational Molecular Systems Biology team at @UGSF-lille !
Proud to have contributed to the CAPRI 8 challenge
🔗 Read it here: onlinelibrary.wiley.com/doi/10.1002/...
#CAPRI8 #AlphaFold #ProteinStructure #StructuralBiology #AIinBiology #Bioinformatics #UGSF
Proud to have contributed to the CAPRI 8 challenge
🔗 Read it here: onlinelibrary.wiley.com/doi/10.1002/...
#CAPRI8 #AlphaFold #ProteinStructure #StructuralBiology #AIinBiology #Bioinformatics #UGSF
Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation
We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID-related Rounds), which have witnessed the transition to AI-driven predict...
onlinelibrary.wiley.com
October 6, 2025 at 11:47 AM
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One of the things that I am looking in at the moment is AlphaFold and protein structure and function prediction. So let me know your good, bad and everyting in between experiences.
#PlantScience #AlphaFold #ProteinStructure #Science
#PlantScience #AlphaFold #ProteinStructure #Science
November 14, 2024 at 8:34 AM
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New review: Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease. From Maya Noureddine, Fiyaz Mohammed and colleagues: https://buff.ly/4jKxZtj
#ComputationalBiology #ProteinStructure #CardiacMuscle #Myofilaments
#ComputationalBiology #ProteinStructure #CardiacMuscle #Myofilaments
February 7, 2025 at 5:17 PM
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"Exciting news! A new hybrid quantum and deep learning framework enhances protein structure prediction accuracy, potentially transforming drug discovery and disease understanding. Curious about its impact? #QuantumComputing #DeepLearning #ProteinStructure" LINK
October 10, 2025 at 2:11 PM
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6/12 Critical difference: The same mutations (N236K/Q238L) in wild-type H5N1 don't switch receptor specificity.
Only in B3.13 strain do these mutations enable human receptor binding. The conformational context matters enormously.
#ProteinStructure
Only in B3.13 strain do these mutations enable human receptor binding. The conformational context matters enormously.
#ProteinStructure
August 26, 2025 at 2:56 PM
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DEADLINE EXTENDED: The new deadline for submission of manuscripts for this special issue is 31 January 2025.
📝 Call for Papers: Special Issue on "AlphaFold in Protein Structure and Function Prediction".
🔗https://www.csbj.org/call_AlphaFold
#AlphaFold #ProteinStructure #ProteinFunction
📝 Call for Papers: Special Issue on "AlphaFold in Protein Structure and Function Prediction".
🔗https://www.csbj.org/call_AlphaFold
#AlphaFold #ProteinStructure #ProteinFunction
December 7, 2024 at 8:51 AM
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🧠 Can post-processing and deep learning push protein prediction to near perfection?
🔗 Post-processing enhances protein secondary structure prediction with second order deep learning and embeddings. DOI: doi.org/10.1016/j.cs...
📚 CSBJ: www.csbj.org
#PSSP #ProteinStructure #ProtBERT #AlphaFold #AI
🔗 Post-processing enhances protein secondary structure prediction with second order deep learning and embeddings. DOI: doi.org/10.1016/j.cs...
📚 CSBJ: www.csbj.org
#PSSP #ProteinStructure #ProtBERT #AlphaFold #AI
April 16, 2025 at 1:03 AM
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Allosteric and Energetic Remodeling by Protein Domain Extensions
Faure, A., Hidalgo-Carcedo, C. et al.
Paper
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#ProteinStructure #AllostericRegulation #BiochemistryResearch
Faure, A., Hidalgo-Carcedo, C. et al.
Paper
Details
#ProteinStructure #AllostericRegulation #BiochemistryResearch
July 30, 2025 at 4:01 PM
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This breakthrough could transform drug discovery, personalized medicine, and our understanding of biology, making complex protein functions accessible for everyday applications. #Bioinformatics #ProteinStructure
June 4, 2025 at 3:47 PM
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The protein structure problem: solving life’s origami #Science #Biology #MolecularBiology #ProteinStructure #LifeScience
The protein structure problem: solving life’s origami
The artificial intelligence program AlphaFold is proving to be a gamechanger for biological research, Imma Perfetto reports. This article was originally published in the Cosmos Print Magazine, September...
purescience.news
October 11, 2025 at 8:00 AM
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Human PAD6 structure and its inactivity @IUCrJhttps://doi.org/10.1107/S2052252524002549@Evotec@gatesfoundation##mammalian##fertilization##cytoplasmic##lattice##peptidylarginine##deiminase##proteinstructure##PAD6@IUCr##openaccess
Crystal structure of human peptidylarginine deiminase type VI (PAD6) provides insights into its inactivity
The human peptidylarginine deiminase type VI (PAD6) is essential in oocyte and embryonic development as a component of the supramolecular assemblies called cytoplasmic lattices. The crystal structure presented here suggests PAD6 assembles as a dimer resembling other PADs, albeit with compromised abilities to bind Ca2+ and substrates. This aligns with existing in vitro data which indicate an enzymatically inactive isoform of PAD.
doi.org
May 20, 2024 at 6:59 AM
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#MolecularDynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 & SPG44. New study from David Gong, Charles Abrams (University of Illinois Chicago) et al: rupress.org/jgp/article/...
@jennoligomyelin.bsky.social
#ProteinStructure #Pathophysiology #ComputationalBiology #Connexins
@jennoligomyelin.bsky.social
#ProteinStructure #Pathophysiology #ComputationalBiology #Connexins
June 17, 2025 at 3:16 PM
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I am excited to introduce our new @EvolLetters paper that has just come out:
https://academic.oup.com/evlett/advance-article/doi/10.1093/evlett/qraf026/8223096
🧵1/7
https://academic.oup.com/evlett/advance-article/doi/10.1093/evlett/qraf026/8223096
🧵1/7
August 6, 2025 at 5:09 PM
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Wow 🤯 - my former post doc advisor David Baker won the Nobel Prize for Protein Design. Huge congrats - well deserved! David and his lab have been a force of nature in protein design. Incredible watching the progress over the last 20 years. #NobelPrize2024 #proteindesign #ProteinStructure
October 10, 2024 at 7:13 PM
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The new DSSP version 4 uses mmCIF as its primary format and extends secondary structure detection to include left-handed polyproline II (κ) helices, common motifs that contribute to protein folding and stability.
Full announcement: www.ebi.ac.uk/pdbe/news/pd...
#PDBe #DSSP #ProteinStructure
Full announcement: www.ebi.ac.uk/pdbe/news/pd...
#PDBe #DSSP #ProteinStructure
PDBe adopts the new DSSP for protein secondary structure annotation | Protein Data Bank in Europe
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www.ebi.ac.uk
October 30, 2025 at 4:22 PM
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#AlphaFold #ProteinStructure vs metal sponge scrubber for dishes, find the difference :)
April 4, 2025 at 7:45 AM
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Exciting opportunity to see the main authors of Boltz-1 (Jeremy Wohlwend and Gabriele Corso @gcorso.bsky.social) present at #MIT on Thurs, Dec 5. Boltz-1 was shown to achieve SOTA performance at the level of AlphaFold3
#AlphaFold #drugdiscovery #proteinstructure
jclinic.mit.edu/events/boltz...
#AlphaFold #drugdiscovery #proteinstructure
jclinic.mit.edu/events/boltz...
Boltz-1 Seminar – MIT Jameel Clinic
jclinic.mit.edu
December 2, 2024 at 6:00 PM
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