Don't miss this Friday's @uam-ibmib.bsky.social
seminar! Agata Stepień from @stoplab.bsky.social & AMU Centre of Advanced Technologies presents her latest research on pre-mRNA 3' end processing and #transcriptionTermination. #RNAbiology
seminar! Agata Stepień from @stoplab.bsky.social & AMU Centre of Advanced Technologies presents her latest research on pre-mRNA 3' end processing and #transcriptionTermination. #RNAbiology
October 30, 2025 at 2:44 PM
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Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons - ScienceDirect https://www.sciencedirect.com/science/article/pii/S0092867425010359?dgcid=rss_sd_all
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
Transposon-encoded TnpB nucleases gave rise to type V CRISPR-Cas12 effectors through multiple independent domestication events. These systems use diff…
www.sciencedirect.com
October 20, 2025 at 9:17 PM
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Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
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academic.oup.com/nar/article-...
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
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academic.oup.com/nar/article-...
A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium
Abstract. To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms
academic.oup.com
October 17, 2025 at 11:58 AM
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October 15, 2025 at 9:32 PM
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🧬 Curious how tiny molecules impact big discoveries?
Prof Sarah Newbury and Dr Leandro Castellano share why their work in RNA biology matters—from understanding health to inspiring future breakthroughs.
▶Watch: www.youtube.com/watch?v=BQIK...
#RNABiology #BSMSResearch #ScienceStories
Prof Sarah Newbury and Dr Leandro Castellano share why their work in RNA biology matters—from understanding health to inspiring future breakthroughs.
▶Watch: www.youtube.com/watch?v=BQIK...
#RNABiology #BSMSResearch #ScienceStories
Prof Sarah Newbury and Dr Leandro Castellano - RNA Biology Research Group
YouTube video by Brighton and Sussex Medical School
www.youtube.com
October 15, 2025 at 8:46 AM
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October 14, 2025 at 5:23 PM
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#RNAsky #RNAbiology check out the latest story from the Bartel lab!
Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...
mRNA poly(A)-tail length is a battleground for coronavirus–host competition
Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we re...
www.biorxiv.org
October 13, 2025 at 8:15 PM
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Let's talk about circular RNA!! 🧬🧬
Read the review:
“Molecular mechanisms of circular RNA translation” DOI: doi.org/10.1038/s122...
#MolecularBiology #Genomics #Science #Transcriptomics #RNAbiology #GeneExpression
Read the review:
“Molecular mechanisms of circular RNA translation” DOI: doi.org/10.1038/s122...
#MolecularBiology #Genomics #Science #Transcriptomics #RNAbiology #GeneExpression
October 7, 2025 at 6:01 PM
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But more importantly for #RNAsky #RNAbiology, I don't want your finger nucleases touching the ice touching my tubes holding my RNA. pubmed.ncbi.nlm.nih.gov/13715349/
Evidence for the liberation of a nuclease from human fingers - PubMed
Evidence for the liberation of a nuclease from human fingers
pubmed.ncbi.nlm.nih.gov
October 7, 2025 at 4:41 PM
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@science.org ⤵️challenges prevailing notion—repressor and activator act by distinct mechanisms: repressors block via steric hindrance/activators enable Pol II binding to promoter🧬
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism | Science bit.ly/adv2064
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism | Science bit.ly/adv2064
October 4, 2025 at 11:49 AM
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All roads lead to TDP43: Convergent mechanisms of TDP43 autoregulation. Morgan Miller & Sami Barmada highlight recent work from Hasegawa-Ogawa and colleagues (rupress.org/jcb/article/...):
rupress.org/jcb/article/...
#Neuroscience #RNAbiology #Neurodegeneration
rupress.org/jcb/article/...
#Neuroscience #RNAbiology #Neurodegeneration
September 30, 2025 at 1:12 PM
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📣 Don't miss this new Review!
Interplay between RNA-protein interactions and RNA structures in gene regulation
🔓 buff.ly/pu6TpVa
🖊️ @rnaminni.bsky.social
#RBPs #RNA #RNAbiology #RNAbindingproteins #RNAbinding #RNAstructure
Interplay between RNA-protein interactions and RNA structures in gene regulation
🔓 buff.ly/pu6TpVa
🖊️ @rnaminni.bsky.social
#RBPs #RNA #RNAbiology #RNAbindingproteins #RNAbinding #RNAstructure
September 29, 2025 at 9:01 AM
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Check this out all you RBP aficionados! #RNAsky #RNAbiology
www.biorxiv.org/content/10.1...
Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.
Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.
The DND1-NANOS3 complex shapes the primordial germ cell transcriptome via a heptanucleotide sequence in mRNA 3'UTRs
The RNA-binding proteins DND1 and NANOS3 are essential for primordial germ cell survival. Their co-immunoprecipitation and overlapping loss-of-function phenotypes suggest joint function, yet how they ...
www.biorxiv.org
September 27, 2025 at 3:53 PM
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How can parts of proteins that are thought to be structureless control organization and transport within a cell?
That’s exactly what #LaskerAward winners Steven McKnight and Dirk Görlich figured out. 🧪
@mpi-nat.bsky.social
#biophysics #RNAbiology #Lasker2025
📖 ow.ly/ZMRo50X0Cnz
📺 ow.ly/Ov9W50X0Cny
That’s exactly what #LaskerAward winners Steven McKnight and Dirk Görlich figured out. 🧪
@mpi-nat.bsky.social
#biophysics #RNAbiology #Lasker2025
📖 ow.ly/ZMRo50X0Cnz
📺 ow.ly/Ov9W50X0Cny
Structures and functions of low-complexity domains - Lasker Foundation
Explore All 2025 Winners & Awards > Dirk Görlich Max Planck Institute Steven L. McKnight UT Southwestern Medical Center For discoveries that exposed the structures and functions of…
ow.ly
September 25, 2025 at 1:45 PM
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Can’t wait to join the Riboclub 2025 Annual Meeting! See you there to talk RNA and share ideas! @rnacanada.bsky.social #BiologyConference #RNABiology
September 23, 2025 at 1:48 PM
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Can’t wait to join the Riboclub 2025 Annual Meeting! See you there to talk RNA and share ideas! @rnacanada.bsky.social #BiologyConference #RNABiology
September 22, 2025 at 1:41 PM
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Can’t wait to join the Riboclub 2025 Annual Meeting! See you there to talk RNA and share ideas! @rnacanada.bsky.social #BiologyConference #RNABiology
September 22, 2025 at 1:36 PM
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#ICYMI:
📖 In-depth coverage of the science and significance of the 2025 #LaskerAward(s): laskerfoundation.org/winners/2025...
#LaskerAward #LaskerLaureate #cysticfibrosis #devbio #phaseseparation #RNAbiology #structuralbiology #systemsbiology 🧪
📖 In-depth coverage of the science and significance of the 2025 #LaskerAward(s): laskerfoundation.org/winners/2025...
#LaskerAward #LaskerLaureate #cysticfibrosis #devbio #phaseseparation #RNAbiology #structuralbiology #systemsbiology 🧪
2025 Winners - Lasker Foundation
Dirk Görlich Steven L. McKnight Basic Research Structures and functions of low-complexity domains Learn More > Michael J. Welsh Jesús (Tito) González Paul A. Negulescu Clinical Research…
laskerfoundation.org
September 21, 2025 at 4:45 PM
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#ICYMI:
📺 Explainers of the #Lasker2025 Award winners and their work: laskerfoundation.org/the-2025-las...
#LaskerAward #LaskerLaureate #cysticfibrosis #devbio #phaseseparation #RNAbiology #biophysics #systemsbiology 🧪
📺 Explainers of the #Lasker2025 Award winners and their work: laskerfoundation.org/the-2025-las...
#LaskerAward #LaskerLaureate #cysticfibrosis #devbio #phaseseparation #RNAbiology #biophysics #systemsbiology 🧪
The 2025 Lasker Award Videos - Lasker Foundation
Watch a series of video shorts, made in collaboration with science journalist Ed Prosser and animator Andrew Khosravani, about the 2025 Lasker Laureates and their work.
laskerfoundation.org
September 20, 2025 at 4:45 PM
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Learn more about the 2025 #LaskerAward winners and their work:
📖 laskerfoundation.org/winners/2025...
📺 laskerfoundation.org/the-2025-las...
#devbio #phaseseparation #cysticfibrosis #Lasker2025 #LaskerLaureate #RNAbiology #systemsbiology 🧪
📖 laskerfoundation.org/winners/2025...
📺 laskerfoundation.org/the-2025-las...
#devbio #phaseseparation #cysticfibrosis #Lasker2025 #LaskerLaureate #RNAbiology #systemsbiology 🧪
2025 Winners - Lasker Foundation
Dirk Görlich Steven L. McKnight Basic Research Structures and functions of low-complexity domains Learn More > Michael J. Welsh Jesús (Tito) González Paul A. Negulescu Clinical Research…
laskerfoundation.org
September 19, 2025 at 6:45 PM
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Görlich & McKnight were recognized with the 2025 Basic #LaskerAward “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #phaseseparation #RNAbiology
@mpi-nat.bsky.social
#Lasker2025 #phaseseparation #RNAbiology
Structures and functions of low-complexity domains - Lasker Foundation
Explore All 2025 Winners & Awards > Dirk Görlich Max Planck Institute Steven L. McKnight UT Southwestern Medical Center For discoveries that exposed the structures and functions of…
laskerfoundation.org
September 19, 2025 at 5:02 PM
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#DYK? Mary Lasker conceived of the #LaskerAward(s) to showcase breakthroughs in medical research in order to galvanize public support for science. 🧪#Lasker2025 Awards:
📺 laskerfoundation.org/the-2025-las...
📖 laskerfoundation.org/winners/2025...
#cysticfibrosis #devbio #phaseseparation #RNAbiology
📺 laskerfoundation.org/the-2025-las...
📖 laskerfoundation.org/winners/2025...
#cysticfibrosis #devbio #phaseseparation #RNAbiology
The 2025 Lasker Award Videos - Lasker Foundation
Watch a series of video shorts, made in collaboration with science journalist Ed Prosser and animator Andrew Khosravani, about the 2025 Lasker Laureates and their work.
laskerfoundation.org
September 19, 2025 at 3:45 PM
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September 19, 2025 at 9:51 AM
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“The Enigma of Protein Domains of Low-Sequence Complexity”
#LaskerAward winner Steven McKnight writes about his interest in “these ugly duckling proteins” that turned out to be critical for cellular function.
#RNAbiology #phaseseparation #Lasker2025
@jama.com
jamanetwork.com/journals/jam...
#LaskerAward winner Steven McKnight writes about his interest in “these ugly duckling proteins” that turned out to be critical for cellular function.
#RNAbiology #phaseseparation #Lasker2025
@jama.com
jamanetwork.com/journals/jam...
September 18, 2025 at 3:28 PM
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