Regulatory T cells, which prevent the immune system from attacking the body, were the subject of this year’s Physiology or Medicine Nobel Prize. How do they work?

Nobel laureate Shimon Sakaguchi reflects on the role of regulatory T cells in peripheral immune tolerance and how the cells could transform treatment for cancer, autoimmune disease and organ transplant...

The scientific community has been galvanized by the announcement of the medicine nobel prize 2025, honoring three scientists whose work fundamentally redefined our understanding of the human immune system. Mary E. Brunkow, Fred Ramsdell (both USA), and Shimon Sakaguchi (Japan) were jointly awarded the prestigious prize for their “discoveries concerning peripheral immune tolerance.” ​This groundbreaking research unveiled the crucial mechanisms that prevent our powerful immune defenses from mistakenly attacking the body’s own tissues—a condition known as autoimmunity. Their collective work identified the immune system’s ultimate “security guards”: Regulatory T-cells (Tregs), establishing a new pillar in the field of modern immunology. […]

US, Japanese Scientists Win 2025 Nobel Prize For Medicine.

Research explained how body protects itself from the immune system, offering new ways to treat autoimmune disease

John Gordon: Researchers identified a substantial presence of peripherally induced Treg cells in TME / cancer, Chen Dong, Jing Ge, Jing Hao, John Gordon,