Using #Multiomics pathway analysis, researchers uncovered how #MAPK pathway activation drives OIS and SASP in a KIAA1549::BRAF fusion #pLGG model, revealing new therapeutic avenues for these #Tumors. #medsky
Read this #STTT #OpenAccess: doi.org/10.1038/s413...
Read this #STTT #OpenAccess: doi.org/10.1038/s413...
November 12, 2025 at 3:00 PM
Using #Multiomics pathway analysis, researchers uncovered how #MAPK pathway activation drives OIS and SASP in a KIAA1549::BRAF fusion #pLGG model, revealing new therapeutic avenues for these #Tumors. #medsky
Read this #STTT #OpenAccess: doi.org/10.1038/s413...
Read this #STTT #OpenAccess: doi.org/10.1038/s413...
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy
link.springer.com/article/10.1...
link.springer.com/article/10.1...
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy - Molecular Cancer
Cellular senescence, characterized by partially irreversible cell cycle arrest, has a dual role in cancer progression via the senescence-associated secretory phenotype (SASP). SASP encompasses a wide ...
link.springer.com
November 11, 2025 at 12:33 AM
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Switch2用USB Type-C L型変換コネクタ SASP-0734
November 7, 2025 at 11:09 PM
Switch2用USB Type-C L型変換コネクタ SASP-0734
I had so much fun chatting with SASP about Fit For Work, and not to mention, I got to talk about the exercises and activities I did there! I really enjoyed Fit For Work! #FitForWork #Exercises
November 3, 2025 at 10:58 PM
I had so much fun chatting with SASP about Fit For Work, and not to mention, I got to talk about the exercises and activities I did there! I really enjoyed Fit For Work! #FitForWork #Exercises
Entzündungsreaktionen ausgelöst werden, sondern auch in anderen Organen. So greift SARS-CoV-2 über die entstehende Entzündungsreaktion indirekt auch das Herz und die Gefäße an; noch Monate nach einer schweren Covid-Infektion ist deshalb das Risiko für einen Herzinfarkt erhöht.
November 3, 2025 at 4:49 PM
Entzündungsreaktionen ausgelöst werden, sondern auch in anderen Organen. So greift SARS-CoV-2 über die entstehende Entzündungsreaktion indirekt auch das Herz und die Gefäße an; noch Monate nach einer schweren Covid-Infektion ist deshalb das Risiko für einen Herzinfarkt erhöht.
This phenomenon is collectively known as the senescence-associated secretory phenotype (SASP).
The chronic inflammation & astrocytic dysfunction caused by the persistent S1 protein may contribute to neurodegenerative processes,
The chronic inflammation & astrocytic dysfunction caused by the persistent S1 protein may contribute to neurodegenerative processes,
Endolysosomal Mechanisms of SARS-CoV-2 Spike-Induced Inflammatory Response And Senescence In Human Astrocytes
The COVID-19 pandemic has led to widespread reports of prolonged neurological symptoms in individuals who have recovered from the acute phase of the infection. These persistent symptoms, collectively ...
commons.und.edu
October 31, 2025 at 7:44 PM
This phenomenon is collectively known as the senescence-associated secretory phenotype (SASP).
The chronic inflammation & astrocytic dysfunction caused by the persistent S1 protein may contribute to neurodegenerative processes,
The chronic inflammation & astrocytic dysfunction caused by the persistent S1 protein may contribute to neurodegenerative processes,
Our findings suggest that, in contrast to senescent transformed epithelial cells that are growth arrested and tumor suppressive, p21+ senescent stromal cells secrete a SASP that fuels immune suppression and tumor growth that can be targeted for therapeutic intervention and to enhance immunotherapy.
October 29, 2025 at 2:45 PM
Our findings suggest that, in contrast to senescent transformed epithelial cells that are growth arrested and tumor suppressive, p21+ senescent stromal cells secrete a SASP that fuels immune suppression and tumor growth that can be targeted for therapeutic intervention and to enhance immunotherapy.
Through a series of experiments to deplete p16+ or p21+ senescent cells in different cellular compartments in mice, we found that while p16 removal had no effect on tumor progression, p21+ stromal cell depletion could block SASP to reverse myeloid immune suppression and delay tumor growth.
October 29, 2025 at 2:41 PM
Through a series of experiments to deplete p16+ or p21+ senescent cells in different cellular compartments in mice, we found that while p16 removal had no effect on tumor progression, p21+ stromal cell depletion could block SASP to reverse myeloid immune suppression and delay tumor growth.
Whereas p16+ senescent epithelial cells had very low expression of inflammatory factors through the senescence-associated secretory phenotype (SASP), p21+ senescent stromal cells had high production of SASP cytokines that recruit suppressive myeloid cells.
October 29, 2025 at 2:41 PM
Whereas p16+ senescent epithelial cells had very low expression of inflammatory factors through the senescence-associated secretory phenotype (SASP), p21+ senescent stromal cells had high production of SASP cytokines that recruit suppressive myeloid cells.
The Senescence-associated secretome indicates Medical risk
#GradientBoostingMachine
7 SASP factors
GDF15 FAS OPN TNFR1 ActivinA CCL3 IL-15▶️
1⃣Risk of post-op adverse events severe #AorticStenosis
2⃣Risk of ICU in 30 d post-op #OvarianCancer
@insight.jci.org 2020
insight.jci.org/articles/vie...
#GradientBoostingMachine
7 SASP factors
GDF15 FAS OPN TNFR1 ActivinA CCL3 IL-15▶️
1⃣Risk of post-op adverse events severe #AorticStenosis
2⃣Risk of ICU in 30 d post-op #OvarianCancer
@insight.jci.org 2020
insight.jci.org/articles/vie...
October 27, 2025 at 7:11 PM
The Senescence-associated secretome indicates Medical risk
#GradientBoostingMachine
7 SASP factors
GDF15 FAS OPN TNFR1 ActivinA CCL3 IL-15▶️
1⃣Risk of post-op adverse events severe #AorticStenosis
2⃣Risk of ICU in 30 d post-op #OvarianCancer
@insight.jci.org 2020
insight.jci.org/articles/vie...
#GradientBoostingMachine
7 SASP factors
GDF15 FAS OPN TNFR1 ActivinA CCL3 IL-15▶️
1⃣Risk of post-op adverse events severe #AorticStenosis
2⃣Risk of ICU in 30 d post-op #OvarianCancer
@insight.jci.org 2020
insight.jci.org/articles/vie...
"THE RED BARON" - Patty Gurdy (Sabaton Cover, Folky Version with Hurdy-Gurdy and Bass-Nyckelharpa)
Patty Gurdy
www.youtube.com/watch?v=SasP...
Patty Gurdy
www.youtube.com/watch?v=SasP...
"THE RED BARON" - Patty Gurdy (Sabaton Cover, Folky Version with Hurdy-Gurdy and Bass-Nyckelharpa)
YouTube video by Patty Gurdy
www.youtube.com
October 27, 2025 at 5:04 AM
"THE RED BARON" - Patty Gurdy (Sabaton Cover, Folky Version with Hurdy-Gurdy and Bass-Nyckelharpa)
Patty Gurdy
www.youtube.com/watch?v=SasP...
Patty Gurdy
www.youtube.com/watch?v=SasP...
But wait, there’s more.
There is funding to continue SASP available, but they are refusing to use it - they are the ones starving people.
There is funding to continue SASP available, but they are refusing to use it - they are the ones starving people.
October 27, 2025 at 4:20 AM
But wait, there’s more.
There is funding to continue SASP available, but they are refusing to use it - they are the ones starving people.
There is funding to continue SASP available, but they are refusing to use it - they are the ones starving people.
Watched this woman over the years do some awesome stuff. But Power Metal on a Hurdy Gurdy is a whole new level of awesome. www.youtube.com/watch?v=SasP...
"THE RED BARON" - Patty Gurdy (Sabaton Cover, Folky Version with Hurdy-Gurdy and Bass-Nyckelharpa)
YouTube video by Patty Gurdy
www.youtube.com
October 25, 2025 at 4:26 PM
Watched this woman over the years do some awesome stuff. But Power Metal on a Hurdy Gurdy is a whole new level of awesome. www.youtube.com/watch?v=SasP...
🎶 🎶 💚 💚 💚 🎶 🎶
www.youtube.com/watch?v=SasP...
www.youtube.com/watch?v=SasP...
"THE RED BARON" - Patty Gurdy (Sabaton Cover, Folky Version with Hurdy-Gurdy and Bass-Nyckelharpa)
YouTube video by Patty Gurdy
www.youtube.com
October 25, 2025 at 4:40 AM
🎶 🎶 💚 💚 💚 🎶 🎶
www.youtube.com/watch?v=SasP...
www.youtube.com/watch?v=SasP...
Patty foi anunciada na turnê Europeia do Sabaton na "Legendary Orchestra" e eu espero muito que eles venham e tragam pro Brasil.
www.youtube.com/watch?v=SasP...
www.youtube.com/watch?v=SasP...
"THE RED BARON" - Patty Gurdy (Sabaton Cover, Folky Version with Hurdy-Gurdy and Bass-Nyckelharpa)
YouTube video by Patty Gurdy
www.youtube.com
October 24, 2025 at 12:42 PM
Patty foi anunciada na turnê Europeia do Sabaton na "Legendary Orchestra" e eu espero muito que eles venham e tragam pro Brasil.
www.youtube.com/watch?v=SasP...
www.youtube.com/watch?v=SasP...
Hi Ella! I don't currently have plans to head to Adelaide but I would definitely entertain the possibility if your department wanted to invite me to come give a talk. But I'll see you at SASP either way...looking forward to it. :)
October 20, 2025 at 6:00 AM
Hi Ella! I don't currently have plans to head to Adelaide but I would definitely entertain the possibility if your department wanted to invite me to come give a talk. But I'll see you at SASP either way...looking forward to it. :)
Key aspects of cellular senescence are measured: cell cycle arrest (CSP), macromolecular damage (SIP), and senescence-associated secretory phenotype - SASP (SRP). Overall measures include the average of the three pathways above and the expression level of SenMayo genes.
October 11, 2025 at 6:33 PM
Key aspects of cellular senescence are measured: cell cycle arrest (CSP), macromolecular damage (SIP), and senescence-associated secretory phenotype - SASP (SRP). Overall measures include the average of the three pathways above and the expression level of SenMayo genes.
Exciting moments from the 2nd SenAP Symposium at Hasselt University on October 7th!
Our senior scientist, Dr. Boshi Wang, delivered a keynote talk exploring the role of CDK4/6 inhibitors in senescence induction, SASP regulation, and combinatorial cancer therapy.
Our senior scientist, Dr. Boshi Wang, delivered a keynote talk exploring the role of CDK4/6 inhibitors in senescence induction, SASP regulation, and combinatorial cancer therapy.
October 9, 2025 at 11:05 AM
Exciting moments from the 2nd SenAP Symposium at Hasselt University on October 7th!
Our senior scientist, Dr. Boshi Wang, delivered a keynote talk exploring the role of CDK4/6 inhibitors in senescence induction, SASP regulation, and combinatorial cancer therapy.
Our senior scientist, Dr. Boshi Wang, delivered a keynote talk exploring the role of CDK4/6 inhibitors in senescence induction, SASP regulation, and combinatorial cancer therapy.
Chronic #SASP production→ ↑ #inflammation. Accumulation of #senescent cells→ ↑ cancer and other age-associated pathologies. Targeting and clearance of senescent cells ↆ pathologies. bit.ly/46Sbu1r
Targeting immunosenesence promotes clearance of senescent cells - Immunity & Ageing
Known as immunosenescence, the major dysregulation of the immune system with age is associated with poor vaccination efficacy, and increased susceptibility to infections, age-related pathologies, and neoplasms, with incidences exacerbated with age. Cellular senescence is a crucial process that puts cells in an irreversible cell-cycle arrest which prevents damaged or stressed cells from uncontrolled propagation and eventually potential malignancy. Paradoxically, senescence also contributes to the occurrence of cancer and increases the risk of metastasis through different secretory mediators. Altogether, the recent use of senotherapy to eliminate senescent cells has been shown to delay tumorigenesis, attenuate age-related deterioration of organs, and promote healthy aging. Interestingly, immune cells have been shown to specifically interact with, and kill senescent cells, thus opening new opportunities for the development of specific therapeutic strategies similar to immunotherapy in cancer. Through its detrimental impact on the immune system, immunosenescence is also leading to the accumulation of senescent cells with age thus further contributing to the occurrence and worsening of multiple age-related pathologies such as cancer. Understanding the molecular and cellular events occurring during the aging process, and triggering immunosenescence as well as the mechanisms by which senescent cells escape immune surveillance would help to improve immune responses to senescent cells and their clearance. In this review, we highlight how senescent cells interact with immune cells, and how immunosenescence-associated phenotypical and functional deregulation hinder the ability of immune cells to clear senescent cells. We further characterize strategies aimed at promoting the clearance of senescent cells by the immune system.
bit.ly
October 8, 2025 at 7:20 PM
Chronic #SASP production→ ↑ #inflammation. Accumulation of #senescent cells→ ↑ cancer and other age-associated pathologies. Targeting and clearance of senescent cells ↆ pathologies. bit.ly/46Sbu1r
Mitigating Pro-Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Mitigating Pro‐Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy
Senescent cells accumulate extranuclear DNA fragments that are recognized by the cyclic GMP-AMP synthase (cGAS) and its effector protein stimulator of interferon genes (STING), which promotes express....
onlinelibrary.wiley.com
October 1, 2025 at 5:56 PM
Mitigating Pro-Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Cat Turner releases latest single ‘Coming’ with Limerick’s SASP Records 👏💚🫶
#limerick #lovelimerick #ilovelimerick #limerickandproud #limerickcity #limerickcounty #newmusic
www.ilovelimerick.ie/cat-turner-c...
#limerick #lovelimerick #ilovelimerick #limerickandproud #limerickcity #limerickcounty #newmusic
www.ilovelimerick.ie/cat-turner-c...
Cat Turner releases latest single ‘Coming’ with Limerick’s SASP Records
Cat Turner releases latest single ‘Coming’ with Limerick’s SASP Records ‘Coming’ is the latest single from alt-pop artist, producer, and songwriter Cat Turner with Limerick’s SASP Records Irish alt-po...
www.ilovelimerick.ie
September 26, 2025 at 11:20 AM
Cat Turner releases latest single ‘Coming’ with Limerick’s SASP Records 👏💚🫶
#limerick #lovelimerick #ilovelimerick #limerickandproud #limerickcity #limerickcounty #newmusic
www.ilovelimerick.ie/cat-turner-c...
#limerick #lovelimerick #ilovelimerick #limerickandproud #limerickcity #limerickcounty #newmusic
www.ilovelimerick.ie/cat-turner-c...
Die bekanntesten Parteien Deutschlands unserer Zeit:
RPP - Rechts Populistische Partei
MBP - Mehrheits Beschaffer Partei
PSÖ - Partei auf der Suche nach der ökologischen Mitte
SASP - Soziale aber Außenpolitisch Schwierige Partei
NKP - Neoliberale Klientel Partei
NFP - Neoliberale Faschisten Partei
RPP - Rechts Populistische Partei
MBP - Mehrheits Beschaffer Partei
PSÖ - Partei auf der Suche nach der ökologischen Mitte
SASP - Soziale aber Außenpolitisch Schwierige Partei
NKP - Neoliberale Klientel Partei
NFP - Neoliberale Faschisten Partei
September 25, 2025 at 6:10 AM
Die bekanntesten Parteien Deutschlands unserer Zeit:
RPP - Rechts Populistische Partei
MBP - Mehrheits Beschaffer Partei
PSÖ - Partei auf der Suche nach der ökologischen Mitte
SASP - Soziale aber Außenpolitisch Schwierige Partei
NKP - Neoliberale Klientel Partei
NFP - Neoliberale Faschisten Partei
RPP - Rechts Populistische Partei
MBP - Mehrheits Beschaffer Partei
PSÖ - Partei auf der Suche nach der ökologischen Mitte
SASP - Soziale aber Außenpolitisch Schwierige Partei
NKP - Neoliberale Klientel Partei
NFP - Neoliberale Faschisten Partei
