🔬RAP1GDS1 isoform specific importance in lung cancer
🧫 how kRas oncogenic enhanced proliferation can occur without hyperactive ERK or Akt
🧬 RhoGAP family interactions in endometrial cancer
@biochemsoc.bsky.social #BiochemEvent
🔬RAP1GDS1 isoform specific importance in lung cancer
🧫 how kRas oncogenic enhanced proliferation can occur without hyperactive ERK or Akt
🧬 RhoGAP family interactions in endometrial cancer
@biochemsoc.bsky.social #BiochemEvent
www.eventsforce.net/biochemsoc/2...
www.eventsforce.net/biochemsoc/2...
🔬 hunting for Ras allies
🧫 polarised trafficking regulation adaptability during change
🧬 RhoA and Cdc42 pathway crosstalk
Now onto the party!
@biochemsoc.bsky.social #BiochemEvent
🔬 hunting for Ras allies
🧫 polarised trafficking regulation adaptability during change
🧬 RhoA and Cdc42 pathway crosstalk
Now onto the party!
@biochemsoc.bsky.social #BiochemEvent
🧬 Lipid sensing, β-catenin, and phosphorylation reshape GTPase signalling
⚙️ Mechanical forces & trafficking: nuclear F-actin, actin-Rab27a, plexins, and COL1
⚡️Cancer cell adaptation through RhoA/NFAT, Rac1 SUMOylation, and KRAS rewiring
@biochemsoc.bsky.social #BiochemEvent
🧬 Lipid sensing, β-catenin, and phosphorylation reshape GTPase signalling
⚙️ Mechanical forces & trafficking: nuclear F-actin, actin-Rab27a, plexins, and COL1
⚡️Cancer cell adaptation through RhoA/NFAT, Rac1 SUMOylation, and KRAS rewiring
@biochemsoc.bsky.social #BiochemEvent
⛓️ Tri-complex inhibitor as molecular glue for oncogenic RAS
💊 Combining inhibitors to combat KRAS-driven cancer
🎯 p120RasGAP molecular glue targeting RAS
🔢 Mathematical modelling to study RAS activity
🧐 RAS/RAL, Cdc42, RhoG, RAC1, EPAC2, RalGAP…
@biochemsoc.bsky.social #BiochemEvent
⛓️ Tri-complex inhibitor as molecular glue for oncogenic RAS
💊 Combining inhibitors to combat KRAS-driven cancer
🎯 p120RasGAP molecular glue targeting RAS
🔢 Mathematical modelling to study RAS activity
🧐 RAS/RAL, Cdc42, RhoG, RAC1, EPAC2, RalGAP…
@biochemsoc.bsky.social #BiochemEvent
⛓️ Mapping KRAS interactomes in organoid models
🧬 Isoform-specific KRAS vulnerabilities: one mutation, big difference
🔬 Novel tool tracks Ras mutation dynamics in vivo
✨ And a reminder that clear science communication empowers patients!
@biochemsoc.bsky.social #BiochemEvent
⛓️ Mapping KRAS interactomes in organoid models
🧬 Isoform-specific KRAS vulnerabilities: one mutation, big difference
🔬 Novel tool tracks Ras mutation dynamics in vivo
✨ And a reminder that clear science communication empowers patients!
@biochemsoc.bsky.social #BiochemEvent
⚙️ “Branchgetic” Ras mutations indicate effector selection
🔬 RAF biosensors to monitor acivity in live cells
💥 C2 domain boosts RasGAP activity
💊 RhoB-Ral complex a target for EGFR TK inhibition?
@biochemsoc.bsky.social #BiochemEvent
⚙️ “Branchgetic” Ras mutations indicate effector selection
🔬 RAF biosensors to monitor acivity in live cells
💥 C2 domain boosts RasGAP activity
💊 RhoB-Ral complex a target for EGFR TK inhibition?
@biochemsoc.bsky.social #BiochemEvent
✨ unpicking Ras effector binding in different tissues
✨ developing RAF based biosensors
✨ C2 domains and GAP functionality
✨ how RhoB and Ral affect EGFT therapy in lung cancer
@Biochemsoc #BiochemEvent
✨ unpicking Ras effector binding in different tissues
✨ developing RAF based biosensors
✨ C2 domains and GAP functionality
✨ how RhoB and Ral affect EGFT therapy in lung cancer
@Biochemsoc #BiochemEvent
“Uniform Sampling of Surfaces by Casting Rays” w/ @abhishekmadan.bsky.social @nmwsharp.bsky.social and Alec Jacobson
“Uniform Sampling of Surfaces by Casting Rays” w/ @abhishekmadan.bsky.social @nmwsharp.bsky.social and Alec Jacobson
🧬 RAP1GDS1 isoform regulates KRAS signalling & lysosomal function in lung adenocarcinoma
❓Oncogenic KRAS may not alter Akt/ERK pathways
☠️ p190RhoGAP paralogs show synthetic lethality in endometrial cancer
@biochemsoc.bsky.social #BiochemEvent
🧬 RAP1GDS1 isoform regulates KRAS signalling & lysosomal function in lung adenocarcinoma
❓Oncogenic KRAS may not alter Akt/ERK pathways
☠️ p190RhoGAP paralogs show synthetic lethality in endometrial cancer
@biochemsoc.bsky.social #BiochemEvent
🔬Ras lipid sensing to control localisation
🧫 Rnd3/RhoE importance in hepatocellular carcinoma
🔥 the role of Cdc42 in inflammation in response to wildfire smoke
🧪 the RhoA mutational landscape
@biochemsoc.bsky.social #BiochemEvent
🔬Ras lipid sensing to control localisation
🧫 Rnd3/RhoE importance in hepatocellular carcinoma
🔥 the role of Cdc42 in inflammation in response to wildfire smoke
🧪 the RhoA mutational landscape
@biochemsoc.bsky.social #BiochemEvent
#SGP25 #Gproteins25
#SGP25 #Gproteins25
🔬mechanosensing in cancer development
🧫 Rac1 driven plasticity in small cell lung cancer
🧬 actin in organelle transport
🧪 tool development to study spatial organisation of receptors
@biochemsoc.bsky.social #BiochemEvent
🔬mechanosensing in cancer development
🧫 Rac1 driven plasticity in small cell lung cancer
🧬 actin in organelle transport
🧪 tool development to study spatial organisation of receptors
@biochemsoc.bsky.social #BiochemEvent
🧫 Overcoming RAS resistance: biobanking & precision medicine
💊 Adaptive immunity could enhance KRAS inhibitor activity
🔬 Organoids reveal allele-specific tumour growth
💥 Plus ARL15, RhoGDI1, RalGEF, SOS1/2 & proteomics pipelines
@biochemsoc.bsky.social #BiochemEvent
🧫 Overcoming RAS resistance: biobanking & precision medicine
💊 Adaptive immunity could enhance KRAS inhibitor activity
🔬 Organoids reveal allele-specific tumour growth
💥 Plus ARL15, RhoGDI1, RalGEF, SOS1/2 & proteomics pipelines
@biochemsoc.bsky.social #BiochemEvent