#SPINA_GT
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spinateam.bsky.social
Growing evidence supports a role of sensorimotor and autonomic #neuropathy in #syndrome_T or #SORSHOT, i.e. reduced quality of life in treated #hypothyroidism. #SPINA_GT and #SPINA_GD predict nerve function and depression.

pubmed.ncbi.nlm.nih.gov/38811750/

doi.org/10.1038/s415...
Scatterplots showing a significant correlation of functional parameters of thyroid homeostasis (SPINA-GT and SPINA-GD) with the mechanical pain sensitivity (MPS) of QST (A), respiratory arrhythmia in HRV analysis (B) and depression percentiles in HADS (C).
February 8, 2025 at 10:18 AM
spinateam.bsky.social
Again, a study showed a strong influence of endocrine disruptors on #thyroid homeostasis. Exposure to butylparaben significantly reduces #SPINA-GD, whereas ethylparaben slightly increases #SPINA_GT in pregnancy.

pubmed.ncbi.nlm.nih.gov/39889471/

doi.org/10.1016/j.ec...
Figure (Forest plot): Changes in the levels of thyroid hormone indicators in relation to a 1 ng/mL increase in paraben exposure across trimesters. Data are presented in terms of adjusted regression coefficient and 95% confidence interval values. Exposure to butylparaben significantly reduces #SPINA-GD, whereas ethylparaben slightly increases #SPINA_GT in pregnancy, depending on the trimenon. Forest plot: Results of generalized estimating equation–based analyses of the associations between thyroid hormones and urinary parabens in pregnant women (N = 207). The effect on SPINA-GD is different from and stronger than that on T3/T4 ratio.
February 2, 2025 at 4:53 PM
drjwdietrich.bsky.social
Should we, therefore, classify #syndrome_T as a psychosomatic disease? This would be premature and probably wrong. We found signs of sensorimotor and autonomic #neuropathy that depend on autoimmunity and #thyroid's secretory capacity (#SPINA_GT).
Bar plot showing a significant association of markers of respiratory arrhythmia with anti-TPO antibody titres. Shown are means ± SEM (bars and whiskers) as well as results of individual participants (dots) Significant correlation of functional parameters of thyroid homeostasis with the mechanical pain sensitivity (MPS) of QST (A), respiratory arrhythmia in HRV analysis (B) and depression percentiles in HADS (C)
May 29, 2024 at 9:34 PM
spinateam.bsky.social
#SPINA_GT, #SPINA_GD and Jostel's TSH index (#JTI or #TSHI) are predictors of survival in patients with #Takotsubo syndrome (#stress #cardiomyopathy), as recently demonstrated in the international GEIST registry. 🩺

pubmed.ncbi.nlm.nih.gov/38502972/
doi.org/10.1016/j.eb...
Table: Markers of thyroid function in the study population: FT3 and SPINA-GD are significantly decreased in non-survivors, whereas SPINA-GT is increased in fatal cases of Takotsubo syndrome. Kaplan–Meier survival curves based on cutoff values derived from phi statistics. Low TSH, FT3, SPINA-GD and JTI as well as high FT4 and SPINA-GT predict shorter survival in Takotsubo syndrome.
March 24, 2024 at 5:48 PM
spinateam.bsky.social
#SPINA_GD is reduced in major #depression, #bipolar disorder and #schizophrenia, whereas #SPINA_GT is elevated in schizophrenia and bipolar disorder, marking a unique profile of #thyroid_allostasis. pubmed.ncbi.nlm.nih.gov/38277991/ doi.org/10.1016/j.ps...
Table: Comparison of demographic factors, thyroid function and structure parameters of thyroid homeostasis among psychiatric patients and controls
March 3, 2024 at 11:28 PM
spinateam.bsky.social
#Metformin is known to reduce #TSH concentration, but it was unknown if this effect reflects central action or improved thyroid function. A recent study shows that #SPINA_GT rises in women with autoimmune thyroiditis under treatment with metformin. 🧪 pubmed.ncbi.nlm.nih.gov/38051473/
Table: SPINA-GT rises in women with autoimmune thyroiditis under therapy with metformin, but remains constant in women without thyroid autoimmunity. Figure: The change of SPINA-GT after initiation of therapy with metformin correlates with the change of highly sensitive CRP. Does the result reflect reduced inflammation of the thyroid gland due to metformin?
December 24, 2023 at 5:18 PM
spinateam.bsky.social
🧪 #Thyroid's secretory (#SPINA_GT) is higher in borderline personality disorder (#BPD) compared to controls. Is this a result of dynamical compensation or from sympathetic innervation of the thyroid gland? doi.org/10.3390/jcm1... @UriAlonWeizmann
Table: Metabolic and echocardiographic parameters in borderline personality disorder (BPD) and age-matched control subjects. Thyroid output is increased in BPD. This results from elevated thyroid's secretory capacity (SPINA-GT).
October 28, 2023 at 2:35 PM
drjwdietrich.bsky.social
#Nickel is a toxic metal and an important endocrine disruptor. Recent research shows that exposure to nickel impairs #thyroid's secretory capacity (#SPINA_GT). pubmed.ncbi.nlm.nih.gov/37800147/ doi.org/10.3389/fend...
Spearman correlation analysis shows a significant association between exposure to nickel (NI) and thyroid's secretory capacity (SPINA-GT).
October 14, 2023 at 1:49 PM