Researchers Developed a Novel Tool for Proteome-Wide Identification of Small-Molecule Degrader Targets
www.marinbio.com/researchers-...

#PROTAC #TargetedProteinDegradation #LYTAC #MolecularGlues #GlueTAC #bioPROTAC #AUTAC. #AbTAC #Cancertherapy #Immunotherapy #drugdiscovery

Targeted Protein Degradation/PROTAC for Innovative Drug Development: Current Trends and Future Prospects.
www.marinbio.com/protacs-inno...

#PROTAC #TargetedProteinDegradation #LYTAC #MolecularGlues #GlueTAC #bioPROTAC #AUTAC. #AbTAC #Cancertherapy #Immunotherapy #drugdiscovery

This is a very interesting financing for those who follow #MolecularGlues #TPD #TargetedProteinDegradation round by #BioTheryX. @jaybradner @HartungIngo @MilkaKostic @elkingtonxy @ChemGenetics @CrisMayorRuiz @CraigMCrews

Proteolysis-Targeting Vaccines (PROTAVs): A Novel Approach in Cancer Immunotherapy
www.marinbio.com/proteolysis-...

#PROTAC #TargetedProteinDegradation #LYTAC #MolecularGlues #GlueTAC #bioPROTAC #AUTAC #AbTAC #Cancertherapy #Immunotherapy #drugdiscovery

🤝 #MeetOurScientists: Dr. Cristina Mayor-Ruiz, from #IRBBarcelona

🎯🔬 Learn how Dr. Mayor-Ruiz's pioneering work in #TargetedProteinDegradation is unlocking new ways to treat untouchable diseases.

📽️ youtu.be/d8ig0j7fQMM?feature=shared

#Chembio #ProteinDegradation #TPD #IRBScience

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🤝 #MeetOurScientists: Dr. @crismayorruiz.bsky.social.

🎯🔬 Learn how Dr. Mayor-Ruiz's pioneering work in #TargetedProteinDegradation is unlocking new ways to treat untouchable diseases.

📽️ https://s.mtrbio.com/higqmhbfzt

#IRBScience #ProteinDegradation #TPD

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A great day at the University of Pavia presenting on new directions in #targetedproteindegradation. Vibrant environment and discussions with colleagues and friends @kajastelab.bsky.social
Thanks @fmagnani.bsky.social for the warm welcome and the opportunity to connect with this scientific community

📝 Online now - the Review "E3 ubiquitin ligases in signaling, disease, and therapeutics" from Shaun Olsen et al.

#ubiquitin #E3UbiquitinLigase #UbiquitinProteasomeSystem #TargetedProteinDegradation

Read it here 👉 authors.elsevier.com/sd/article/S...

VHL ligands engage the VHL E3 ligase, a highly validated recruiter in PROTAC design, offering robust degradation profiles. Their structural diversity supports fine-tuning of ternary complex stability and pharmacological properties.

fluorochem.co.uk/product-cate...

🧪 #TargetedProteinDegradation

AI Breakthrough By UW Scientists Targets ‘Undruggable’ Proteins, Paving Path to Novel Therapies.

#UndruggableNoMore, #AIDrugDiscovery, #PROTAC, #TargetedProteinDegradation, #UWMedicine, #CancerTherapy, #AlzheimersResearch, #MedicalBreakthrough,

medium.com/@jckapadia00...

Potential therapeutic target in acute myeloid leukemia (AML): Geng et al. explore the development of molecular glue degraders (MGDs) targeting casein kinase 1 alpha (CK1α), a potential therapeutic target in AML.

Learn more: bit.ly/3OFLfBo

#TargetedProteinDegradation #proteomics #massspectrometry

Online now - the Review "Routes to #MolecularGlueDegrader discovery" from Yanfen Liu, Yong Cang, and colleagues.

#MGD #TargetedProteinDegradation #TPD #PROTAC #HighThroughputScreening

authors.elsevier.com/a/1kN5M3S6Gf...

Induced Proximity Strategies: Bridging Molecules for Advanced Immunotherapy
www.marinbio.com/antibody-rec...
#immunotherapy #protac #targetedproteindegradation #tpd #molecularglue #cancer #antibody #macrophages

🚨🚨 Preprint from @craigcrews could be transformative for #TargetedProteinDegradation. @sandymacrae23, @SangamoTx's #ZFN transcription modulation is PERFECT for this. $SGMO

👉🌞👉 "laborious small molecule ligand discovery campaigns are not required"

@jaybradner @ChemGenetics