#clinicalquestions
1/ #NaturalExperiments are increasingly being used to answer #clinicalquestions, like how does treatment X affect disease outcome Y.

Recent review by Lizzie Bair and me in NEJM Evidence covers examples and best practices for these types of studies:

evidence.nejm.org/doi/full/10....
Natural Experiments to Inform Clinical Practice
Natural experiments refer to events or practices that result in similar individuals receiving different services or interventions for arbitrary reasons. In the clinical context, researchers may wis...
evidence.nejm.org
September 5, 2025 at 4:42 PM