The French Connection (1971) Directed by William Friedkin starring Gene Hackman, Roy Scheider, and Fernando Rey. Based on Robin Moore's 1969 book of the same name about narcotics detectives Eddie Egan and Sonny Grosso.
November 8, 2025 at 4:48 AM
The French Connection (1971) Directed by William Friedkin starring Gene Hackman, Roy Scheider, and Fernando Rey. Based on Robin Moore's 1969 book of the same name about narcotics detectives Eddie Egan and Sonny Grosso.
athletes that are completely transitioned should be WELCOME in sport
but in 2016, IOC reduced 4 year wait rule based on bad science
that was a COMPLETE SET-UP to eventually make a ban
full gene-expression doesn't happen in just 1 year or 2
go back to 4 year rule, problem solved, but won't happen
but in 2016, IOC reduced 4 year wait rule based on bad science
that was a COMPLETE SET-UP to eventually make a ban
full gene-expression doesn't happen in just 1 year or 2
go back to 4 year rule, problem solved, but won't happen
November 10, 2025 at 4:20 PM
athletes that are completely transitioned should be WELCOME in sport
but in 2016, IOC reduced 4 year wait rule based on bad science
that was a COMPLETE SET-UP to eventually make a ban
full gene-expression doesn't happen in just 1 year or 2
go back to 4 year rule, problem solved, but won't happen
but in 2016, IOC reduced 4 year wait rule based on bad science
that was a COMPLETE SET-UP to eventually make a ban
full gene-expression doesn't happen in just 1 year or 2
go back to 4 year rule, problem solved, but won't happen
From Germany:
Transcriptome analysis of classical blood cells reveals down-regulation of proinflammatory genes in the classical monocytes of Long-COVID patients
www.frontiersin.org/journals/imm...
Screenshot from latest Science for ME weekly update
#LongCovid #PASC
Transcriptome analysis of classical blood cells reveals down-regulation of proinflammatory genes in the classical monocytes of Long-COVID patients
www.frontiersin.org/journals/imm...
Screenshot from latest Science for ME weekly update
#LongCovid #PASC
November 11, 2025 at 1:41 AM
From Germany:
Transcriptome analysis of classical blood cells reveals down-regulation of proinflammatory genes in the classical monocytes of Long-COVID patients
www.frontiersin.org/journals/imm...
Screenshot from latest Science for ME weekly update
#LongCovid #PASC
Transcriptome analysis of classical blood cells reveals down-regulation of proinflammatory genes in the classical monocytes of Long-COVID patients
www.frontiersin.org/journals/imm...
Screenshot from latest Science for ME weekly update
#LongCovid #PASC
As bad as the antisemitism on the left is, the one on the right is worse.
By its nature, the left AS has a limit, it cannot go beyond hate based on an allegiance to Israel without betraying its principles. The right AS is without limits as it can become inescapable; tied to your gene or religion
By its nature, the left AS has a limit, it cannot go beyond hate based on an allegiance to Israel without betraying its principles. The right AS is without limits as it can become inescapable; tied to your gene or religion
November 10, 2025 at 8:35 PM
As bad as the antisemitism on the left is, the one on the right is worse.
By its nature, the left AS has a limit, it cannot go beyond hate based on an allegiance to Israel without betraying its principles. The right AS is without limits as it can become inescapable; tied to your gene or religion
By its nature, the left AS has a limit, it cannot go beyond hate based on an allegiance to Israel without betraying its principles. The right AS is without limits as it can become inescapable; tied to your gene or religion
Lastly this CMMI model seems to be based in part on a model now being implemented to negotiate supplemental rebates with 2 manufacturers of cell/gene therapies for sickle cell disease on behalf of participating states. But there are no results yet and that model is not based on MFN prices (9/x)
November 6, 2025 at 10:50 PM
Lastly this CMMI model seems to be based in part on a model now being implemented to negotiate supplemental rebates with 2 manufacturers of cell/gene therapies for sickle cell disease on behalf of participating states. But there are no results yet and that model is not based on MFN prices (9/x)
In an analysis of OpenAI's costs, revenues and funding from 2023 to 1H 2025, it raised $28.6bn in cash ($10bn rev included), and had $13.7bn in cash losses.
Reports say OpenAI ended 1H 2025 with $9.6bn. It should have $14.9bn in cash. There's a $4.1bn+ hole.
www.wheresyoured.at/where-is-ope...
Reports say OpenAI ended 1H 2025 with $9.6bn. It should have $14.9bn in cash. There's a $4.1bn+ hole.
www.wheresyoured.at/where-is-ope...
![A Brief History of OpenAI’s Revenues and Costs
If there are other articles reporting OpenAI's revenues or costs, please do get in touch. But I don't think anybody has ever done a full run-down. Behold!
On February 9, 2024, The Financial Times said that “OpenAI’s revenues have surpassed $2bn on an annualised basis,” with the company apparently hitting it “In December 2023,” according to “two people with knowledge of its finances.”
There was no mention of any comment related to OpenAI in this article.
On June 12, 2024, The Information reported that “OpenAI has more than doubled its annualized revenue to $3.4 billion in the past six months or so, OpenAI CEO Sam Altman has told staff.” This amounts to around $283m in revenue a month at the end of calendar year Q2 2024.
This appears to be sourced from something that Sam Altman told staff.
Curiously, this is the only time I’ve seen OpenAI comment on one of these stories, with “...an OpenAI spokeswoman [saying] the financial details were “inaccurate,” without elaborating.” I have read every single one of these and I cannot find another instance of this happening. This makes me believe, along with other information from sources, that these numbers are particularly accurate.
This article also confirms that OpenAI gets a “roughly” 20% revenue share cut from Microsoft selling its models.
On July 24, 2024, The Information published that OpenAI “could lose as much as $5 billion” in 2024, “according to an analysis by The Information, based on previously undisclosed internal financial data and people involved in the business.”
Spokespeople for Microsoft and OpenAI did not have a comment.
On September 27. 2024, the New York Times reported that “OpenAI’s monthly revenue hit $300 million in August…and the company expects about $3.7 billion in annual sales [in 2024],” according to a financial professional’s review of documents.
That’s $300m in revenue in the month of August 2024. Details are important. OpenAI declined to comment.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:qc6xzgctorfsm35w6i3vdebx/bafkreidkp2ogtpvnrhevelg4cudtu3u33wbmlsmfgnvqq76yzoxt3s6qbq@jpeg)
![On October 9, 2024, The Information reported that “OpenAI burned $340 million in the first half of 2024” and that its “cash burn was lower than previously thought,” based on “OpenAI financial documents viewed by The Information.”
These documents also “project [OpenAI’s] total losses between 2023 and 2028 to be $44 billion” not including stock compensation, and, laughably, that OpenAI would “make $14 billion in profit [based on the analysis] in 2029.”
OpenAI also, in this document, said that “model training costs could rise sharply in the next couple of years, to as high as $9.5 billion a year in 2026.”
This same piece included projections that OpenAI would make $12bn in 2025, $26bn in 2026, $44bn in 2027, $69bn in 2028, and $100bn in 2029.
There was no mention of any comment related to OpenAI in this article.
On February 21, 2025, The Information reported that OpenAI forecasted that “one-third of [its] revenue growth would come from spending by SoftBank to use OpenAI’s products across its companies,” with SoftBank spending $3bn per year. It took until November 5, 2025 for the joint venture involving this spend to actually form.
This is sourced to disclosures by OpenAI to its investors.
This piece also asserts that $3bn from SoftBank would get OpenAI to $12.7bn in revenue for 2025.
There was no mention of any comment related to OpenAI in this article.
In this piece, The Information reports that “...[OpenAI’s] spending on Microsoft-owned data centers should ramp up significantly in the next few years, more than doubling from $13 billion this year to $28 billion in 2028.”
On March 26, 2025, Bloomberg reported that OpenAI “expects to more than triple its revenue to $12.7 billion in 2025,” and that it generated “$3.7 billion in annual revenue last year,” according to a person familiar with the matter who “spoke on condition of anonymity to discuss internal communications.
In the piece, Bloomberg states that “OpenAI does not expect to be cash-flow positive until 2029, t…](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:qc6xzgctorfsm35w6i3vdebx/bafkreib5hbzqr6m6semfdbw4c53q3y2sfkajjiag5ymourhb3rf5uul3vi@jpeg)
November 7, 2025 at 5:35 PM
In an analysis of OpenAI's costs, revenues and funding from 2023 to 1H 2025, it raised $28.6bn in cash ($10bn rev included), and had $13.7bn in cash losses.
Reports say OpenAI ended 1H 2025 with $9.6bn. It should have $14.9bn in cash. There's a $4.1bn+ hole.
www.wheresyoured.at/where-is-ope...
Reports say OpenAI ended 1H 2025 with $9.6bn. It should have $14.9bn in cash. There's a $4.1bn+ hole.
www.wheresyoured.at/where-is-ope...
The concept of "fitness" is central to evolutionary biology but it's not entirely worked out. There are multiple definitions, doubts about predictive power, problems with internal consistency. Here's a paper from last year attempting to solve some of these problems. doi.org/10.1093/evol...
November 5, 2025 at 2:27 PM
The concept of "fitness" is central to evolutionary biology but it's not entirely worked out. There are multiple definitions, doubts about predictive power, problems with internal consistency. Here's a paper from last year attempting to solve some of these problems. doi.org/10.1093/evol...
gender is performance and I am
!["Night and the City is a 1950 British film noir directed by Jules Dassin and starring Richard Widmark, Gene Tierney and Googie Withers.[1] It is based on the novel of the same name by Gerald Kersh. Shot on location in London and at Shepperton Studios, the plot revolves around an ambitious hustler who meets continual failures." https://en.wikipedia.org/wiki/Night_and_the_City](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:mvtbhn2n722u2nojssfhpwvb/bafkreicd44axqladhmxvwnwgc2fdld6twi77fvzu3rdegruckf7fhwxr3y@jpeg)
November 8, 2025 at 9:00 PM
gender is performance and I am
TK Bellows’ look as a whole is anachronistic. It seems to be based on this picture of Gene Roddenberry at a convention in 1976 ↙️, though Gene wears much more stylish frames than Bellows. In 1967, toward the end of Star Trek’s first season, Gene was way more clean cut ↘️.
November 2, 2025 at 5:45 PM
TK Bellows’ look as a whole is anachronistic. It seems to be based on this picture of Gene Roddenberry at a convention in 1976 ↙️, though Gene wears much more stylish frames than Bellows. In 1967, toward the end of Star Trek’s first season, Gene was way more clean cut ↘️.
been thinking about this since I saw it a couple days ago. just might keep on thinking about it forever.
November 4, 2025 at 2:35 PM
been thinking about this since I saw it a couple days ago. just might keep on thinking about it forever.
Monumental effort led by Peter Simmonds and Jens Kuhn to reorganize the Family Flaviviridae based on analysis of RNA-directed RNA polymerase (RdRP) hallmark gene sequences is finally out. Enjoy reading. #ICTV @utmbhealth.bsky.social @astmh.bsky.social @sbvirologia.bsky.social
October 31, 2025 at 12:44 PM
Monumental effort led by Peter Simmonds and Jens Kuhn to reorganize the Family Flaviviridae based on analysis of RNA-directed RNA polymerase (RdRP) hallmark gene sequences is finally out. Enjoy reading. #ICTV @utmbhealth.bsky.social @astmh.bsky.social @sbvirologia.bsky.social
Based on my results, I have a gene mutation (likely inherited from my mother, who also had severe osteoporosis) that causes a deficiency in a key bone enzyme (alkaline phosphatase, ALP) that’s responsible for creating the bone matrix (hydroxyapatite) in the skeleton.
(2/10)
(2/10)
November 1, 2025 at 1:39 AM
Based on my results, I have a gene mutation (likely inherited from my mother, who also had severe osteoporosis) that causes a deficiency in a key bone enzyme (alkaline phosphatase, ALP) that’s responsible for creating the bone matrix (hydroxyapatite) in the skeleton.
(2/10)
(2/10)
Fantastic talk by Hervé Vaucheret as part of #IHSMLaMayoraSeminars series.
Hervé presented new unpublished results on how gene silencing is triggered in plants, and left us with a clear take-home message: be careful with what you conclude based on CRISPR and transgenic lines!
Hervé presented new unpublished results on how gene silencing is triggered in plants, and left us with a clear take-home message: be careful with what you conclude based on CRISPR and transgenic lines!
October 31, 2025 at 12:48 PM
Fantastic talk by Hervé Vaucheret as part of #IHSMLaMayoraSeminars series.
Hervé presented new unpublished results on how gene silencing is triggered in plants, and left us with a clear take-home message: be careful with what you conclude based on CRISPR and transgenic lines!
Hervé presented new unpublished results on how gene silencing is triggered in plants, and left us with a clear take-home message: be careful with what you conclude based on CRISPR and transgenic lines!
🚀 New preprint!
We introduce K-PROB, a k-mer–based Bayesian framework that mines pangenomic promoter and expression diversity to predict cis-regulatory elements driving gene expression variation in crops 🌽🌱
🔗 biorxiv.org/content/10.1101/2025.10.27.684862v1
#Genomics #GeneRegulation #Maize #Soybean
We introduce K-PROB, a k-mer–based Bayesian framework that mines pangenomic promoter and expression diversity to predict cis-regulatory elements driving gene expression variation in crops 🌽🌱
🔗 biorxiv.org/content/10.1101/2025.10.27.684862v1
#Genomics #GeneRegulation #Maize #Soybean
Natural variation in regulatory code revealed through Bayesian analysis of plant pan-genomes and pan-transcriptomes
Understanding the genetic code of cis-regulatory elements (CREs) is essential for engineering gene expression and modulating agronomic traits in crops. In plants, CREs underlying rapid evolution of ge...
biorxiv.org
October 29, 2025 at 4:47 PM
🚀 New preprint!
We introduce K-PROB, a k-mer–based Bayesian framework that mines pangenomic promoter and expression diversity to predict cis-regulatory elements driving gene expression variation in crops 🌽🌱
🔗 biorxiv.org/content/10.1101/2025.10.27.684862v1
#Genomics #GeneRegulation #Maize #Soybean
We introduce K-PROB, a k-mer–based Bayesian framework that mines pangenomic promoter and expression diversity to predict cis-regulatory elements driving gene expression variation in crops 🌽🌱
🔗 biorxiv.org/content/10.1101/2025.10.27.684862v1
#Genomics #GeneRegulation #Maize #Soybean
New method could improve manufacturing of gene-therapy drugs news.mit.edu/2025/new-met...
Selective crystallization can greatly improve the purity, selectivity, and active yield of viral vector-based gene therapy drugs, MIT study finds.
Selective crystallization can greatly improve the purity, selectivity, and active yield of viral vector-based gene therapy drugs, MIT study finds.
New method could improve manufacturing of gene-therapy drugs
Selective crystallization can greatly improve the purity, selectivity, and active yield of viral vector-based gene therapy drugs, according to a study by the Richard Braatz group at MIT.
news.mit.edu
October 28, 2025 at 9:29 PM
New method could improve manufacturing of gene-therapy drugs news.mit.edu/2025/new-met...
Selective crystallization can greatly improve the purity, selectivity, and active yield of viral vector-based gene therapy drugs, MIT study finds.
Selective crystallization can greatly improve the purity, selectivity, and active yield of viral vector-based gene therapy drugs, MIT study finds.
The original proposal asking the Massachusetts SJC to consider it mentioned "sex-based pronouns." I missed the part where pronouns were encoded into our genes. Most of the world outside the west must be missing this gene because they don't have gendered language.
October 29, 2025 at 2:28 AM
The original proposal asking the Massachusetts SJC to consider it mentioned "sex-based pronouns." I missed the part where pronouns were encoded into our genes. Most of the world outside the west must be missing this gene because they don't have gendered language.
Interdisciplinary paper with @paulhufe.net Astrid Sandsør and Nicolai Borgen now out in PNAS!
www.pnas.org/doi/epdf/10....
Causal evidence of gene-environment interaction for reading test scores based on:
🧬 Exogenous within-family genetic differences
🏫 Exogenous variation in school value added
www.pnas.org/doi/epdf/10....
Causal evidence of gene-environment interaction for reading test scores based on:
🧬 Exogenous within-family genetic differences
🏫 Exogenous variation in school value added
The genetic lottery goes to school: Better schools compensate for the effects of students’ genetic differences
www.pnas.org
October 28, 2025 at 11:25 AM
Interdisciplinary paper with @paulhufe.net Astrid Sandsør and Nicolai Borgen now out in PNAS!
www.pnas.org/doi/epdf/10....
Causal evidence of gene-environment interaction for reading test scores based on:
🧬 Exogenous within-family genetic differences
🏫 Exogenous variation in school value added
www.pnas.org/doi/epdf/10....
Causal evidence of gene-environment interaction for reading test scores based on:
🧬 Exogenous within-family genetic differences
🏫 Exogenous variation in school value added
More than two decades have passed since we discovered that rare disruptions of the FOXP2 gene disturb development of proficient speech/language skills. Today we know of multiple FOXP genes that are directly implicated in distinct brain-related conditions with differences in symptoms & severity.🧪 1/n
October 29, 2025 at 5:09 PM
More than two decades have passed since we discovered that rare disruptions of the FOXP2 gene disturb development of proficient speech/language skills. Today we know of multiple FOXP genes that are directly implicated in distinct brain-related conditions with differences in symptoms & severity.🧪 1/n
Willy Wonka & the Chocolate Factory (1971) Directed by Mel Stuart stars Gene Wilder. Screenplay by Roald Dahl, based on his 1964 novel Charlie and the Chocolate Factory.
October 27, 2025 at 10:30 PM
Willy Wonka & the Chocolate Factory (1971) Directed by Mel Stuart stars Gene Wilder. Screenplay by Roald Dahl, based on his 1964 novel Charlie and the Chocolate Factory.
There was a parsing error in the sGEA module of v2.2 that affected the gene list outputs (not the stats). It is corrected now in v2.3. Sorry for the inconvenience.
github.com/niethamp/Log...
github.com/niethamp/Log...
October 29, 2025 at 6:16 PM
There was a parsing error in the sGEA module of v2.2 that affected the gene list outputs (not the stats). It is corrected now in v2.3. Sorry for the inconvenience.
github.com/niethamp/Log...
github.com/niethamp/Log...
CMU biologist @jhenninger.bsky.social is uncovering how RNA shapes gene expression and drives disease. His lab is developing tools to visualize transcription and design RNA-based therapies, paving the way for precision treatments for cancers like leukemia.
www.cmu.edu/mcs/news-eve...
www.cmu.edu/mcs/news-eve...
Henninger Explores Targeting RNA in Cancer Prevention, Treatment
Jonathan Henninger, assistant professor of biological sciences at Carnegie Mellon, is finding ways to treat cancer with molecular precision.
www.cmu.edu
October 27, 2025 at 7:30 PM
CMU biologist @jhenninger.bsky.social is uncovering how RNA shapes gene expression and drives disease. His lab is developing tools to visualize transcription and design RNA-based therapies, paving the way for precision treatments for cancers like leukemia.
www.cmu.edu/mcs/news-eve...
www.cmu.edu/mcs/news-eve...
A heritable nanoplatform based on gene editing of haem oxygenase-1 effectively eliminates genetic tolerance to reactive oxygen species in tumours without causing adverse effects on main immune cells. www.nature.com/articles/s41...
A HO-1 gene knockout using a NanoCRISPR scaffold suppresses metastasis in mouse models - Nature Biomedical Engineering
A gene-editing-based nanoplatform for knockout of HO-1 in tumours is combined with photodynamic therapy, triggering immunogenic cell death.
www.nature.com
October 24, 2025 at 11:22 PM
A heritable nanoplatform based on gene editing of haem oxygenase-1 effectively eliminates genetic tolerance to reactive oxygen species in tumours without causing adverse effects on main immune cells. www.nature.com/articles/s41...
At its root conservatism is a fear based ideology. I honestly see a future where parents gene edit conservatism out of their own children who wants their kids to grow up to be small fearful shitty fucking humans.
Just ever so slightly reduced the size of the amygdala and conservatism disappears
Just ever so slightly reduced the size of the amygdala and conservatism disappears
October 25, 2025 at 11:31 PM
At its root conservatism is a fear based ideology. I honestly see a future where parents gene edit conservatism out of their own children who wants their kids to grow up to be small fearful shitty fucking humans.
Just ever so slightly reduced the size of the amygdala and conservatism disappears
Just ever so slightly reduced the size of the amygdala and conservatism disappears
#Candida albicans is a leading opportunistic fungal #pathogen of humans. Ci Fu, Leah Cowen &co expand the GRACE #Calbicans #FunctionalGenomics resource, identifying genes important for temperature-dependent fitness & highlighting its power to reveal vulnerabilities @plosbiology.org 🧪 plos.io/3Wft0Xg
October 20, 2025 at 5:11 PM
#Candida albicans is a leading opportunistic fungal #pathogen of humans. Ci Fu, Leah Cowen &co expand the GRACE #Calbicans #FunctionalGenomics resource, identifying genes important for temperature-dependent fitness & highlighting its power to reveal vulnerabilities @plosbiology.org 🧪 plos.io/3Wft0Xg