Background The culmination of the Human Genome Project in the early 2000s came wreathed in promises of a revolution in medicine and healthcare. The ensuing quarter century has seen remarkable growth...

The Jackson Laboratory’s Cooperative Ph.D. Program provides training in mammalian genetics and genomic medicine through partnerships with degree-granting academic institutions.

Scientists have discovered a way to read natural DNA ‘barcodes’ that reveal how our blood stem cells age—and when a few dominant clones quietly take over. This breakthrough may transform how we detect and prevent age-related diseases.

A nationwide Australian pilot screened more than 10,000 adults aged 18–40 years for high-risk genetic variants linked to hereditary cancer and familial hypercholesterolaemia, identifying clinically ac...

Artificial Intelligence (AI) is transforming medicine, and its influence on clinical genetics cannot be ignored. From variant analysis and diagnostic interpretation to predictive and prognostic medici...

The Jackson Laboratory’s Cooperative Ph.D. Program provides training in mammalian genetics and genomic medicine through partnerships with degree-granting academic institutions.

The International Mammalian Synthetic Biology Workshop (mSBW) brings together leaders in synthetic biology with experts from other relevant fields to highlight and inspire cutting-edge synthetic biolo...

Polygenic genome editing in human embryos and germ cells is predicted to become feasible in the next three decades. Several recent books and academic papers have outlined the ethical concerns raised by germline genome editing and the opportunities that it may present1–3. To date, no attempts have been made to predict the consequences of altering specific variants associated with polygenic diseases. In this Analysis, we show that polygenic genome editing could theoretically yield extreme reductions in disease susceptibility. For example, editing a relatively small number of genomic variants could make a substantial difference to an individual’s risk of developing coronary artery disease, Alzheimer’s disease, major depressive disorder, diabetes and schizophrenia. Similarly, large changes in risk factors, such as low-density lipoprotein cholesterol and blood pressure, could, in theory, be achieved by polygenic editing. Although heritable polygenic editing (HPE) is still speculative, we co

The Jackson Laboratory’s Cooperative Ph.D. Program provides training in mammalian genetics and genomic medicine through partnerships with degree-granting academic institutions.

The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.

The Jackson Laboratory’s Cooperative Ph.D. Program provides training in mammalian genetics and genomic medicine through partnerships with degree-granting academic institutions.