Amazing #glycotime immune research on display at GIA2025. Come join us at this free hybrid event and watch talk by some of the best in the field. Register here
We’re thrilled to introduce GIA2025 Trainee Invited Speaker Dr. Jim Paulson, Professor Emeritus in the Department of Immunology and Microbiology at The Scripps Research Institute in La Jolla, CA who’ll talk on the roles of inhibitory Siglecs in regulation of immune responses! #GIA2025 #glycotime
October 29, 2025 at 1:21 AM
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🧪 Want to learn more about #glycotime in cancer. Come watch @salomepinho.bsky.social talk at #GIA2025 . Register here for the free, hybrid symposia: glyco-alberta.ca/gia2025/
Our next Keynote Speaker for Day 2 of GIA2025 is Dr. @salomepinho.bsky.social . She is coming from the University of Porto, Portugal to talk about glycans as master regulators of immune response in inflammation, autoimmunity and cancer: from disease prediction to therapeutic opportunities.
October 24, 2025 at 6:15 PM
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Exciting Opportunity for #Master 's Students to build an innovative application and design #carbohydrate structures as part of the @erc.europa.eu -funded GlycoRoads project led by @delbiancom.bsky.social
#glycotime #MolecularDesign #Bioinformatics
#glycotime #MolecularDesign #Bioinformatics
🚀 Exciting Opportunity for Master's Students! 🌟
Join us at @mpici.bsky.social to build an innovative application to design carbohydrate structures as part of the ERC-funded GlycoRoads project!
Join us at @mpici.bsky.social to build an innovative application to design carbohydrate structures as part of the ERC-funded GlycoRoads project!
October 29, 2025 at 8:05 AM
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Come join us for some amazing #glycotime science. See free talks online (or if you are in Edmonton, in person). Register here: glyco-alberta.ca/gia2025/ 🧪
Our final Keynote Speaker this year will be Dr. Alisdair Boraston from the University of Victoria, BC. Dr. Boraston will be speaking on advances in understanding O-glycopeptidases from host-adapted bacteria. Catch his talk and all our Keynote Speakers at GIA2025, November 6 and 7! #GIA2025
October 28, 2025 at 4:55 PM
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He started by talking about, how his group has developed a method to detect living Gram-negative bacteria using metabolic oligosaccharide engineering with a KDO analog. (2/4) #glycotime
onlinelibrary.wiley.com/doi/abs/10.1...
onlinelibrary.wiley.com/doi/abs/10.1...
Click‐Mediated Labeling of Bacterial Membranes through Metabolic Modification of the Lipopolysaccharide Inner Core
Clicking bugs: Metabolically active Gram-negative bacteria can specifically incorporate an azide-modified analogue of 3-deoxy-D-manno-octulosonic acid (1; see scheme) into the lipopolysaccharides on ....
onlinelibrary.wiley.com
October 24, 2025 at 11:46 AM
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🧪#glycotime #RNAsky
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation: Molecular Cell www.cell.com/molecular-ce... @raflynn5.bsky.social @vinnieviruses.bsky.social
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
A new function of glycosylated RNAs has been discovered by Graziano et al. in which
the glycosylation of RNA molecules shields acp³U RNA modification from triggering
innate immune responses.
www.cell.com
October 18, 2025 at 4:28 PM
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Breaking down fucoidan takes some innovative thinking, but evolution already got it! #glycotime 🧪🔺
"Remarkably, two-thirds of the interacting residues are dedicated to the recognition of sulfate groups along the glycoside chains." 🤯😍
www.nature.com/articles/s41...
"Remarkably, two-thirds of the interacting residues are dedicated to the recognition of sulfate groups along the glycoside chains." 🤯😍
www.nature.com/articles/s41...
Structure-function relationship of the GH168 fucanase reveals an unusual enzyme recognition mechanism for sulfated polysaccharide - Nature Communications
Authors identify and characterize 16 endo−1,3-fucanases within the GH168 family sequence space, unveiling a recognition mechanism for sulfate polysaccharides. These findings can promote the applicatio...
www.nature.com
October 19, 2025 at 8:01 AM
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This is huge news!
UBC has developed an enzyme that can convert donor organs to type O, making them universal.
Normally a using organs of the wrong blood type causes the recipient's immune system to attack the organ, leading to failure.
❤️🇨🇦⚕️
news.ubc.ca/2025/10/univ...
UBC has developed an enzyme that can convert donor organs to type O, making them universal.
Normally a using organs of the wrong blood type causes the recipient's immune system to attack the organ, leading to failure.
❤️🇨🇦⚕️
news.ubc.ca/2025/10/univ...
UBC enzyme technology clears first human test toward universal donor organs for transplantation - UBC News
UBC-developed enzymes successfully converted a kidney to universal type O for transplant, marking a major step toward faster, more compatible organ donations.
news.ubc.ca
October 15, 2025 at 3:54 AM
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Interesting review from Richard Cummings lab about N- and O-glycosylation of brain cell surface glycoproteins. Role in brain development and neuronal functions, spatial distribution, CDG. Must-read!
tinyurl.com/ybbnb4x6
#glycotime
tinyurl.com/ybbnb4x6
#glycotime
October 16, 2025 at 9:39 AM
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Just on time for my intro lecture on #glycotime in 3D ⤵️🎉
The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed by the team led by Prof Stephen Withers and Prof Jayachandran Kizhakkedathu at UBC
news.ubc.ca/2025/10/univ...
The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed by the team led by Prof Stephen Withers and Prof Jayachandran Kizhakkedathu at UBC
news.ubc.ca/2025/10/univ...
UBC enzyme technology clears first human test toward universal donor organs for transplantation - UBC News
UBC-developed enzymes successfully converted a kidney to universal type O for transplant, marking a major step toward faster, more compatible organ donations.
news.ubc.ca
October 15, 2025 at 5:50 AM
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I usually leave my garden flowers to the bees, as I don't have heaps (yet), but the gorgeous purple dahlia from Schiphol Airport is starting to fade so I thought I should continue to celebrate its beauty for a wee bit longer 💐😍 #gardening
And for #glycotime friends, fans of sialic acid, rejoice 💜
And for #glycotime friends, fans of sialic acid, rejoice 💜
October 11, 2025 at 1:38 PM
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The 2025 Nobel Prize in Physiology or Medicine recognizes Brunkow, Ramsdell, and Sakaguchi for their discovery of Tregs and the regulatory role of FOXP3, an O-GlcNAcylated protein.
Explore FOXP3 on the GlyGen portal: glygen.org and learn more here: www.nature.com/articles/s41...
#glycotime
Explore FOXP3 on the GlyGen portal: glygen.org and learn more here: www.nature.com/articles/s41...
#glycotime
October 9, 2025 at 1:45 PM
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Imagine if the blood type of a donor organ no longer mattered.
Researchers from Canada and China used glycoenzymes FpGalNAc deacetylase and FpGalactosaminidase to "convert" a Type-A donor kidney into a Universal organ by removing unwanted A-antigens. Great glyco-work!! #glycotime
rdcu.be/eJ4Bc
Researchers from Canada and China used glycoenzymes FpGalNAc deacetylase and FpGalactosaminidase to "convert" a Type-A donor kidney into a Universal organ by removing unwanted A-antigens. Great glyco-work!! #glycotime
rdcu.be/eJ4Bc
Enzyme-converted O kidneys allow ABO-incompatible transplantation without hyperacute rejection in a human decedent model
Nature Biomedical Engineering - An ex vivo model and pre-clinical study in a brain-dead recipient provide enzyme-converted O organs to avoid hyperacute rejection in ABO-incompatible kidney...
rdcu.be
October 8, 2025 at 5:46 PM
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Using deuterium and neutron crystallography, the Imberty lab just cracked the atomic-level structure of the P. aeruginosa lectin, LecA, binding human sugars! 🧪
This structural insight is vital for designing new drugs. Great work, @anneimb.bsky.social team!
#DrugDesign #glycotime
This structural insight is vital for designing new drugs. Great work, @anneimb.bsky.social team!
#DrugDesign #glycotime
Neutrons are the best ... look at this histidine-galactose contact !! Our new neutron structure of lectin/gal is available as preprint in ChemRXiv chemrxiv.org/engage/chemr.... Thanks to @drmpblakeley.bsky.social @sebvidalchem.bsky.social and all colleagues for very fine collaboration
October 7, 2025 at 6:15 PM
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A pleasure to host Bruce Turnbull from @universityofleeds.bsky.social today at @chemistryncl.bsky.social as part of his @rsc.org 2024 Bader Prize lecture series and hear all about his group's work in synthetic glycobiology #chemicalbiology #glycotime
October 7, 2025 at 3:47 PM
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A Simplified NMR-based Method to Assign the Absolute Configuration of Aldose Monosaccharides.
#glycotime #CarbohydrateResearch
#glycotime #CarbohydrateResearch
A Simplified NMR-based Method to Assign the Absolute Configuration of Aldose Monosaccharides.
A Simplified NMR-based Method to Assign the Absolute Configuration of Aldose Monosaccharides.
www.sciencedirect.com
October 6, 2025 at 1:50 PM
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A real triumph for #glycotime and basic research, thanks to the work of Steve Withers and others.🧪
This first of its kind procedure could improve access to donor organs because the donor blood type would no longer matter
go.nature.com/3IToaM3
go.nature.com/3IToaM3
First human transplant of kidney modified to have ‘universal’ blood type
Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types.
go.nature.com
October 3, 2025 at 1:43 PM
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NEW PREPRINT: Spatial mapping of cell-surface protein glycosylation at molecular resolution 🍭🍬🔬
For the first time, we can analyze the spatial architecture of the cell-surface glycoproteome at single-protein and single-sugar resolution. #glycotime
www.biorxiv.org/content/10.1...
For the first time, we can analyze the spatial architecture of the cell-surface glycoproteome at single-protein and single-sugar resolution. #glycotime
www.biorxiv.org/content/10.1...
Spatial mapping of cell-surface protein glycosylation at molecular resolution
Cell-surface protein glycosylation is a fundamental post-translational modification that plays a crucial role in membrane protein function and cellular behavior. However, elucidating the molecular spa...
www.biorxiv.org
October 2, 2025 at 11:05 AM
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Eukaryotic expression and characterization of two α1,2-fucosyltransferase genes in the histo-blood group antigens synthesis pathway of the Pacific oyster (Crassostrea gigas)#glycotimee#GlycoconjugateJournall
Eukaryotic expression and characterization of two α1,2-fucosyltransferase genes in the histo-blood group antigens synthesis pathway of the Pacific oyster (Crassostrea gigas)
Norovirus (NoV), an important cause of human viral gastroenteritis worldwide, recognizes human histo-blood group antigens (HBGAs) as receptors. Oysters are
link.springer.com
October 1, 2025 at 4:45 PM
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Spending some time collecting memories of Harry today 🥺 - this is when he was elected a Fellow of the Royal Society. If anyone in the #glycotime universe has pictures or memories of Harry Gilbert they want to share please send them my way 💚
September 29, 2025 at 11:00 AM
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Did you know the extracellular matrix has a sweet side? New research from the Robert Haltiwanger at @universityofga.bsky.social is shaking up what we know about Marfan syndrome! #glycotime #biochemistry #humanhealth
- Journal of Biological Chemistry www.jbc.org/article/S002...
- Journal of Biological Chemistry www.jbc.org/article/S002...
Marfan syndrome variation of the POGLUT2 and POGLUT3 consensus sequence can produce aberrant fibrillin-1 O-glucosylation
Fibrillin-1 (FBN1) is an essential component of the extracellular matrix, forming
microfibril bundles that are important for the proper development of elastic tissues
found in the aorta and lung, as w...
www.jbc.org
September 29, 2025 at 3:10 PM
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Have you wondered how nanoparticle protein coronas (e.g., Seer’s Proteograph XT) can help with glycoprotein enrichment in biofluids?
We were curious, too, and this new @riley-research.bsky.social pre-print led by outstanding postdoc @emmajays.bsky.social details our #glycotime investigations.
We were curious, too, and this new @riley-research.bsky.social pre-print led by outstanding postdoc @emmajays.bsky.social details our #glycotime investigations.
Can nanoparticles help us probe the glycoproteome?
The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc.
Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...
The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc.
Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...
September 24, 2025 at 1:35 PM
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Happy to have this collaborative work out on Biorxiv on how Akkermansia muciniphila deploys it’s carbohydrate sulfatases to metabolise colonic mucin, and that processed glycopeptides/proteins of colonic mucin are a favoured carbon source #glycotime.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The role of Akkermansia muciniphila sulfatases in colonic mucin utilisation
Akkermansia muciniphila , an obligate mucin degrader, is a major member of the human colonic microbiota and has been associated positive health outcomes. Mucins are complex glycoproteins that contain ...
www.biorxiv.org
September 21, 2025 at 3:41 PM
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Meet the BioF:GREAT Team at The Society for Glycobiology's Annual Meeting in San Diego this November and be part of the future of glycoscience! Register for SfGlycobiology here:
www.glycobiology.org/annual-meeting
See you there!
#SfGlycobiology #glycotime #biotech #glycotime #glycosylation
www.glycobiology.org/annual-meeting
See you there!
#SfGlycobiology #glycotime #biotech #glycotime #glycosylation
September 19, 2025 at 4:19 PM
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🍭 Glycans are biology’s sugar code—super complex, super important. Thanks to AlphaFold3, we can now model their interactions with proteins! 🧪 Our new workflow unlocks fresh ways to explore immunity, infection & disease.
doi.org/10.1093/glyc...
#BioFGREAT #NSF #glycotime
doi.org/10.1093/glyc...
#BioFGREAT #NSF #glycotime
September 18, 2025 at 5:10 PM
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