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The drinkable water scarcity has been increased worldwide due to the mixing of numerous hazardous organic and inorganic pollutants in water bodies, ur…

In this study, the natural tubular clay mineral of halloysite nanotubes (HNTs) is utilized as a support material to fabricate a Fe3O4-based composite …

Battery systems are experiencing unprecedented growth due to the unprecedented application of new energy vehicles. However, most materials used in bat…

ABSTRACT Quinine, chloroquine, and hydroxychloroquine are effective antimalarial drugs that have shown antiviral activity against SARS-CoV-2 in initial in vitro studies. However, their excessive use can lead to adverse effects in humans. Therefore, rapid and accurate analysis of these inhibitors in whole blood samples is crucial for public health, although this presents significant challenges. In this study, perfluorooctyl-functionalized halloysite nanotubes were synthesized and used as sorbents for dispersive solid-phase extraction. The developed sorbents interacted with inhibitors through various mechanisms, including hydrophobic interactions, electrostatic interactions, F–π interactions, and hydrogen bonding. Notably, their adsorption capacity was twice that of unmodified halloysite nanotubes. By combining the perfluorooctyl-functionalized halloysite nanotubes-based dispersive solid-phase extraction method with liquid chromatography-tandem mass spectrometry, an analytical method was developed to determine concentrations of the three inhibitors in whole blood samples. Under optimized conditions, the limits of detection ranged from 1.2 to 2.1 ng/mL. The recoveries achieved 91.9%–101.5% for intra-day and 92.8%–101.2% for inter-day. The inter- and intra-day relative standard deviations were in the range of 0.6%–3.8% and 2.3%–8.1%, respectively. This study introduces a novel approach for developing sorbents to target drugs and presents an innovative analytical method for therapeutic monitoring. These advancements will facilitate the evaluation of the pharmacokinetics of these inhibitors in patients and support ongoing clinical trials.

In the contemporary era, the fields of science and technology are undergoing rapid advancement, concomitant with a concomitant increase in the demand …

Market Overview Polaris Market Research’s latest research report, titled Halloysite Market, offers a comprehensive and data-driven analysis of the market landscape. Designed for decision-makers, strategists, and industry participants, this in-depth study offers critical insights into current trends, market dynamics, competitive strategies, and growth projections. In a market defined by constant change and high-stakes decisions, the report serves as a trusted tool for navigating complexities and identifying actionable opportunities.