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MTX exerts antitumor immune activity by inducing cGAMP generation in cancer cells and concurrently inhibiting its hydrolysis mediated by ENPP1.

In this blog post, we explore the decades old science behind mRNA and the exciting technology behind mRNA vaccines will help ensure preparedness against future health threats.

Since Eli Lilly announced a major price hike for the weight loss drug Mounjaro, the pharmacy sector has been in a tailspin

Purpose: Prompt treatment of sepsis and septic shock is critical as delays increase mortality risk. Various tools, such as electronic alerts, standardized order...

The supplement industry is booming—but so are serious health issues tied to taking these pills and powders. Here’s what experts say you need to watch out for.

Half a dozen drugs are in trials for conditions of the brain, but success is not guaranteed.

The American Journal of Managed Care provides insights into the latest news and research in managed care across multimedia platforms.

Sodium-glucose cotransporter-2 inhibitors and sodium zirconium cyclosilicate may be paired with these kidney disease medications to reduce high serum potassium.

Schemas are rich and complex knowledge structures about the typical unfolding of events in a context; for example, a schema of a dinner at a restaurant. In this Perspective, we suggest that reinforcement learning (RL), a computational theory of learning the structure of the world and relevant goal-oriented behaviour, underlies schema learning. We synthesize literature about schemas and RL to offer that three RL principles might govern the learning of schemas: learning via prediction errors, constructing hierarchical knowledge using hierarchical RL, and dimensionality reduction through learning a simplified and abstract representation of the world. We then suggest that the orbitomedial prefrontal cortex is involved in both schemas and RL due to its involvement in dimensionality reduction and in guiding memory reactivation through interactions with posterior brain regions. Last, we hypothesize that the amount of dimensionality reduction might underlie gradients of involvement along the v

Amneal Pharmaceutical LLC, is recalling three lots of Sulfamethoxazole/Trimethoprim Tablets, USP, 400 mg/80 mg to the consumer level as the tablets may exhibit black spots on the tablet surface due to...

Background Post-COVID Condition (PCC), emerging as a significant long-term consequence of SARS-CoV-2 infection, affects not only adults but also the pediatric population. Despite ongoing research, the...

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In patients with high-risk early breast cancer, cytotoxic chemotherapy is a crucial component of treatment for all disease subtypes.1 Regimens containing an anthracycline and a taxane are the most eff...

Targeted protein degradation has become a notable drug development strategy, but its application has been limited by the dependence on protein-based chimeras with restricted genetic manipulation capabilities. The use of long non-coding RNAs (lncRNAs) has emerged as a viable alternative, offering interactions with cellular proteins to modulate pathways and enhance degradation capabilities. Here we introduce a strategy employing artificial lncRNAs (alncRNAs) for precise targeted protein degradation. By integrating RNA aptamers and sequences from the lncRNA HOTAIR, our alncRNAs specifically target and facilitate the ubiquitination and degradation of oncogenic transcription factors and tumor-related proteins, such as c-MYC, NF-κB, ETS-1, KRAS and EGFR. These alncRNAs show potential in reducing malignant phenotypes in cells, both in vitro and in vivo, offering advantages in efficiency, adaptability and versatility. This research enhances knowledge of lncRNA-driven protein degradation and pr