Chinese company New Senyang’s Q11 wireless earbuds promise live translation of a whopping 156 languages “in seconds” via artificial intelligence, for around the same price as two cups of coffee. Purchased from Temu for only $11.60, the headphones are uncomfortable to wear and don’t have great sound quality. But surprisingly enough, the translation provided by their accompanying software actually works — some of the time, at least.

Chinese company New Senyang’s Q11 wireless earbuds promise live translation of a whopping 156 languages “in seconds” via artificial intelligence, for around the same price as two cups of coffee. Purchased from Temu for only $11.60, the headphones are uncomfortable to wear and don’t have great sound quality. But surprisingly enough, the translation provided by their accompanying software actually works — some of the time, at least.

40％のコンパクトな設計のキーボードです。実装済み基板にファームウェアも書き込み済みのため、ドライバー1本で簡単に作成できます。RemapによるWebブラウザからの簡単なキーマップのカスタム、ホットスワップ可能、フルキーバックライト対応など豊富な機能を備えています。

YouTube video by Will Sleeps Not

Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment. Pharmacological CYP2E1 inhibition with 4-methyl-5-acetylthiazole (Q11) reduces weight gain, alleviates adipose inflammation, and restores mitochondrial function via AMPK/PGC-1α signaling, presenting a promising therapeutic strategy for obesity. ABSTRACT Obesity is a major global health challenge characterized by chronic low-grade inflammation and impaired mitochondrial homeostasis. Although cytochrome P450 2E1 (CYP2E1) is implicated in oxidative stress and inflammatory signaling, its contribution to adipocyte dysfunction during obesity remains insufficiently defined. Here, we evaluate the functional role of CYP2E1 in obesity and the therapeutic potential of a highly selective CYP2E1 inhibitor, 4-methyl-5-acetylthiazole (Q11). High-fat diet-induced obese mice exhibited markedly elevated CYP2E1 expression and activity, which positively correlated with increased adiposity, hepatic steatosis, and mitochondrial dysfunction. Pharmacological inhibition of CYP2E1 by Q11 significantly attenuated body weight gain, improved hepatic lipid accumulation, and reduced inflammatory responses without affecting food intake, suggesting that its metabolic benefits are mediated through enhanced energy expenditure. Mechanistically, Q11 restored mitochondrial integrity by increasing oxygen consumption, normalizing membrane potential, promoting mitochondrial biogenesis, and improving fusion dynamics, accompanied by activation of the AMP-activated protein kinase/peroxisome proliferator-activated receptor-gamma coactivator 1-alpha pathway. Collectively, these findings identify CYP2E1 as a previously unrecognized regulator of obesity-associated metabolic dysfunction and establish Q11 as a promising therapeutic candidate that concurrently suppresses inflammation and reinstates mitochondrial homeostasis. This work provides a mechanistic and translational foundation for targeting CYP2E1 in obesity and related metabolic disorders.

12·3 비상계엄 이후 그 충격만큼 수많은 의혹이 양산됐다.