Recent smFRET and DEER studies from the Kobilka lab (Zhang et al. 2024 Nature; Deutsch et al. 2025 bioRxiv, etc.) revealed clear links between MOR conformations and ligand efficacy. These findings inspired our next step. (3/n)
November 5, 2025 at 4:23 PM
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Love the optics here - see the reflection!
We are welcoming a lot of people to @ei-science.bsky.social getting great data on their own biological systems for prelim data for grants.
It’s nice to have a greta space to welcome them to!
Is there an #smFRET experiment you’d like to try? Ping me here!
We are welcoming a lot of people to @ei-science.bsky.social getting great data on their own biological systems for prelim data for grants.
It’s nice to have a greta space to welcome them to!
Is there an #smFRET experiment you’d like to try? Ping me here!
November 3, 2025 at 6:33 PM
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Our work on DNA G4 interactions with Zuo1 in collaboration with @paeschkelab.bsky.social and the Penedo lab is out in @narjournal.bsky.social 😍
Full text: academic.oup.com/nar/article/...
#G4 #G-Quadruplex #NMR #smFRET #ChIP-qPCR
Full text: academic.oup.com/nar/article/...
#G4 #G-Quadruplex #NMR #smFRET #ChIP-qPCR
The Zuo1 C-terminal domain stabilizes DNA guanosine quadruplex (G4) structures located on Chromosome IX in Saccharomyces cerevisiae
Abstract. Deoxyguanosine quadruplexes (G4s) form stable non-B-DNA structures that can affect transcription, replication, and genome stability. Depending on
academic.oup.com
November 3, 2025 at 5:18 PM
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Ya, indeed Exciting times ahead (!) - smFRET & FCS of IDPs seem to be the future!
October 30, 2025 at 1:22 PM
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🚀 Exciting news! Submit a short proposal on how you'd use the EI-FLEX in your lab for a chance at a 2-month, no-obligation trial! Plus: see smFRET in action, upcoming seminars and more 👉 www.linkedin.com/pulse/octobe...
#biophysics #lifescience #moleculardynamics #singlemolecule
#biophysics #lifescience #moleculardynamics #singlemolecule
October roundup
Hi there, I hope you're doing well. I'm excited to say our Exciting Seminars will be back with a bang in November! Join me and Kuang Shen from UMass Chan Medical School as we explore his latest smFRET...
www.linkedin.com
October 30, 2025 at 11:59 AM
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📢 Launch of FBI Connect, our new webinar series!
🧬 Robert Quast (CBS, Montpellier) presents a unique multicolor smFRET technique to visualize membrane protein dynamics, with a focus on brain receptors involved in synaptic transmission.
📅 Nov 27, 11:00 am
🔗 Register: bit.ly/43vqcZS
🧬 Robert Quast (CBS, Montpellier) presents a unique multicolor smFRET technique to visualize membrane protein dynamics, with a focus on brain receptors involved in synaptic transmission.
📅 Nov 27, 11:00 am
🔗 Register: bit.ly/43vqcZS
October 28, 2025 at 10:46 AM
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In the final lecture of the morning session at #ChemBioPhys2025, @romanrenger.bsky.social from Exciting Instruments talked about, how they add dynamics to structural biology using smFRET and FCCS.
academic.oup.com/nar/article/...
#ChemSky #ChemBio #DrugDiscovery
academic.oup.com/nar/article/...
#ChemSky #ChemBio #DrugDiscovery
October 24, 2025 at 11:50 AM
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Average doesn't really exist... so why measure it?
Our compact and easy-to-use instrument has been designed to help researchers access dynamic single-molecule insights from their own lab benchtops.
Find out more about the EI-FLEX and book a demo bit.ly/3KZK3Ku
#singlemolecule #smfret #fcs
Our compact and easy-to-use instrument has been designed to help researchers access dynamic single-molecule insights from their own lab benchtops.
Find out more about the EI-FLEX and book a demo bit.ly/3KZK3Ku
#singlemolecule #smfret #fcs
October 22, 2025 at 7:44 AM
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I am very much looking forward to an inspiring week at #Mifobio2025 - thanks for the invite! I am counting on learning new exciting (pun intended) insights on fluorescence and happy to share our experience and vision on large throughput #smFRET .
Let's explore the #Mifobio2025 programme !
👉 "Focus On” : “Single Molecule Fluorescence Microscopies for Drug Discovery”
✨ We are delighted to welcome @schlierflab.bsky.social
🎤 Lecture : Large Throughput Single-Molecule FRET to Study Protein Structure and Dynamics
👉 imabio-cnrs.fr
#GDRimabio
👉 "Focus On” : “Single Molecule Fluorescence Microscopies for Drug Discovery”
✨ We are delighted to welcome @schlierflab.bsky.social
🎤 Lecture : Large Throughput Single-Molecule FRET to Study Protein Structure and Dynamics
👉 imabio-cnrs.fr
#GDRimabio
October 8, 2025 at 3:12 PM
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Are you interested in Biomolecular Condensates and looking for a PhD training? Check out the 12 (!) open PhD positions (also 1 on smFRET & condensates 🙃) in Dresden @rtg3120.bsky.social @tudresden.bsky.social starting April 2026. Apply latest by 24 Oct 2025 here: dresdencondensates.org/join-us/
Join Us – RTG 3120 Biomolecular Condensates
dresdencondensates.org
October 7, 2025 at 12:46 PM
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Can smFRET deliver reproducible, absolute distance measurements?
Yes! Check out Hellenkamp et al.'s (2018) paper to learn more > www.nature.com/articles/s41...
#singlemolecule #smfret #biophyics #biochemistry
Yes! Check out Hellenkamp et al.'s (2018) paper to learn more > www.nature.com/articles/s41...
#singlemolecule #smfret #biophyics #biochemistry
Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study - Nature Methods
A multi-laboratory study finds that single-molecule FRET is a reproducible and reliable approach for determining accurate distances in dye-labeled DNA duplexes.
www.nature.com
October 7, 2025 at 7:58 AM
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🚀 Our 'professor in a box', a quick-watch smFRET explainer video, a very exciting Chair appointment and more... see what we've been up to in September in the latest edition of our newsletter - buff.ly/EDA6U5s
#structuralbiology #moleculardynamics #singlemolecule #smfret #fcs #deeptech #startups
#structuralbiology #moleculardynamics #singlemolecule #smfret #fcs #deeptech #startups
October 1, 2025 at 7:02 AM
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Rush! The application deadline for this #PhD or #Postdoc opportunity in my group is TODAY!
#smFRET #DyeCycling #nano-photonics & Co
#smFRET #DyeCycling #nano-photonics & Co
#2: #PhD Position in Single-Molecule Biophysics using Fluorescence & DyeCycling/FRET
➤ Also for #Postdocs!
➤ Biomolecular dynamics, dynamic disorder & more
➤ with nano-photonic & fluorogenic DyeCycling/ #FRET.
⏰: submit by 30/9, 2025.
More info & online application system: tinyurl.com/y9dnb38e
➤ Also for #Postdocs!
➤ Biomolecular dynamics, dynamic disorder & more
➤ with nano-photonic & fluorogenic DyeCycling/ #FRET.
⏰: submit by 30/9, 2025.
More info & online application system: tinyurl.com/y9dnb38e
September 30, 2025 at 12:04 PM
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🤔 How did Groves et al. use the FLEX to reveal insights about SARS-CoV-2’s RNA polymerase? Find out here > doi.org/10.1093/nar/...
Want to know more about the FLEX? Learn more, request a tech spec or book a demo on our website: excitinginstruments.com/ei-flex/?utm... #smfret #RNA #nucleicacids
Want to know more about the FLEX? Learn more, request a tech spec or book a demo on our website: excitinginstruments.com/ei-flex/?utm... #smfret #RNA #nucleicacids
Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Abstract. The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has resulted in significant global mortality, with over 7 million cases reported. Despite
doi.org
September 22, 2025 at 7:00 AM
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👋 At the Midlands Biophysics Network meeting today? So are we!
Visit our stand to chat about how we're bringing solution-based single-molecule techniques right to your benchtop - no extensive training required.
#midlandsbiophysicsnetworkmeeting #biophysics #singlemolecule #smfret #fcs
Visit our stand to chat about how we're bringing solution-based single-molecule techniques right to your benchtop - no extensive training required.
#midlandsbiophysicsnetworkmeeting #biophysics #singlemolecule #smfret #fcs
September 18, 2025 at 10:35 AM
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Thrilled to see long-time #FRET experts moving into single-molecule work with our technology at McMaster University! Plus, our instrument now also supports University at Albany's core facility with #smFRET & #FCS! A very Exciting week! 🙌 #biophysics #singlemolecule #structuralbiology
September 18, 2025 at 8:13 AM
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What controls how/when growing RNA unblocks the "door" to exit RNA polymerase? Brilliant duo Anna Wang and Abhishek Majumder led a study in my lab - now out in NAR - on this. *Sequence* matters a lot! Read on... Super smFRET/dynamics work as well. Excited! academic.oup.com/nar/article/...
The displacement of the σ70 finger in initial transcription is highly heterogeneous and promoter-dependent
Abstract. Most bacterial sigma factors (σ) contain a highly conserved structural module, the ‘σ-finger’, which forms a loop that protrudes towards the RNA
academic.oup.com
September 16, 2025 at 9:40 PM
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Missing biomolecular dynamics at picomolar levels? The EI-FLEX makes single-molecule research quick and easy with precision and stability. Watch Dr. Quinn below and book a demo: excitinginstruments.com/contact-us/?...
#singlemolecule #structuralbiology #moleculardynamics #smFRET #FCS
#singlemolecule #structuralbiology #moleculardynamics #smFRET #FCS
September 16, 2025 at 8:38 AM
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Heading to the Austrian Cryo-EM Symposium in November? Let's catch up! We'll be on hand to share how freely diffusing smFRET can complement this already exquisitely detailed technique #cryoEM #smfret #singlemolecule
Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
September 15, 2025 at 12:44 PM
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The role of intrinsically disordered domains in regulating G protein coupled receptor signaling https://www.biorxiv.org/content/10.1101/2025.09.10.675278v1
September 11, 2025 at 9:07 PM
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Discover how single-molecule fluorescence reveals transient DNA–protein interactions, kinetics and conformational changes, and more. Meet @timcraggs.bsky.social & Paul Wheeler at next week’s events - email [email protected]
to schedule! #biophysics #smfret #fcs
to schedule! #biophysics #smfret #fcs
September 11, 2025 at 8:57 AM
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What is single-molecule FRET? Watch
@timcraggs.bsky.social
explain how this technique measures nanometer-scale distances and captures single-molecule conformations - youtu.be/BpCsTVJkQyE #structuralbiology #moleculardynamics #discovery #smFRET
@timcraggs.bsky.social
explain how this technique measures nanometer-scale distances and captures single-molecule conformations - youtu.be/BpCsTVJkQyE #structuralbiology #moleculardynamics #discovery #smFRET
What is single-molecule FRET?
YouTube video by Exciting Instruments
youtu.be
September 10, 2025 at 2:26 PM
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X-ray crystallography gives static molecular snapshots with atomic precision. Freely diffusing smFRET adds dynamics, revealing alternative states, transition rates, and validating models. See how Craggs et al. (2019) used it to reveal hidden structures: bit.ly/45Vznoh
#smfret #structuralbiology
#smfret #structuralbiology
Substrate conformational dynamics facilitate structure-specific recognition of gapped DNA by DNA polymerase
Abstract. DNA-binding proteins utilise different recognition mechanisms to locate their DNA targets; some proteins recognise specific DNA sequences, while
doi.org
September 8, 2025 at 9:32 AM
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💡 Measure fleeting protein encounters with ease - no dark rooms, bulky equipment, or extensive training. Our compact instrument delivers fast, publication-ready results from the bench in ambient light. 👉 bit.ly/4683zLQ #smFRET #FCS #biophysics #science
September 4, 2025 at 7:08 AM
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🚀 Hear ALEX and smFRET pioneer Shimon Weiss talk on origins, breakthroughs, and the future 👀 Watch the Exciting Seminar in full > youtu.be/MBI82_QKAnk
#smFRET #ALEX #biophysics #structuralbiology #moleculardynamics
#smFRET #ALEX #biophysics #structuralbiology #moleculardynamics
September 2, 2025 at 8:43 AM
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