#thrombin
Chimera, a hybrid molecule combining salivary peptides from a leech, tsetse fly and rat flea binds to the blood clotting enzyme thrombin with extraordinary strength.
Ultrapotent thrombin inhibitor combines peptide fragments from a trio of blood-sucking organisms
Hybrid molecule featuring leech, tsetse fly and flea peptide fragments binds thrombin at three sites
www.chemistryworld.com
October 16, 2025 at 11:00 AM Everybody can reply
2 likes
The researchers found that a single oxo-εA modification at specific positions can increase the aptamer's affinity for thrombin by tenfold. Furthermore, a double oxo-εA modification resulted in Ag+-dependent aptamer activity, mimicking the crucial T:T base pair.
October 15, 2025 at 12:39 PM Everybody can reply
This study explores the use of a fluorescent nucleotide analog, 7,8-dihydro-8-oxo-1,N6-ethenoadenine (oxo-εA), to investigate the conformational changes and folding kinetics of the thrombin-binding aptamer.
October 15, 2025 at 12:39 PM Everybody can reply
Unlock the secrets of G-quadruplex assembly with a fluorescent nucleotide! This breakthrough introduces cation-regulated activity into the thrombin-binding aptamer, paving the way for adv...

🧵 Thread below

Full analysis: https://helixbrief.com/article/bc0e2ed6-0391-494e-8555-b7dcca574e1e
October 15, 2025 at 12:39 PM Everybody can reply
worsening the clinical picture through shared mechanisms that damage 🫀 tissue & impair function.
www.frontiersin.org/journals/pha...

pmc.ncbi.nlm.nih.gov/articles/PMC....

www.researchgate.net/figure/Schem...

www.sciencedirect.com/science/arti....
October 13, 2025 at 11:51 AM Everybody can reply
Ultrapotent thrombin inhibitor combines peptide fragments from a trio of blood-sucking organisms | Research

https://www.newsbeep.com/il/65864/

Salivary peptide fragments from a leech, a tsetse fly and a rat flea have been combined to create…
Ultrapotent thrombin inhibitor combines peptide fragments from a trio of blood-sucking organisms | Research - Israel News Beep
Salivary peptide fragments from a leech, a tsetse fly and a rat flea have been combined to create a synthetic protein that clamps onto thrombin, the key
www.newsbeep.com
October 10, 2025 at 1:40 PM Everybody can reply
Crystalline Energy Funneling in Mixed-Ligand Zr-MOFs Drives Radical-Triggered ECL Amplification for Ultrasensitive Thrombin Sensing http://dx.doi.org/10.1021/acssensors.5c02948
October 9, 2025 at 3:31 PM Everybody can reply
Dabigatran prevents lipopolysaccharide mediated apoptosis in zebrafish through a thrombin independent mechanism https://www.biorxiv.org/content/10.1101/2025.10.03.680206v1
October 5, 2025 at 12:01 PM Everybody can reply
Dabigatran prevents lipopolysaccharide mediated apoptosis in zebrafish through a thrombin independent mechanism https://www.biorxiv.org/content/10.1101/2025.10.03.680206v1
October 5, 2025 at 12:01 PM Everybody can reply
Facet-Controlled Synthesis of Nanoporous Metal–Organic Frameworks for Enhanced Activity of Surface-Immobilized Thrombin http://dx.doi.org/10.1021/acsanm.5c04107
September 29, 2025 at 1:18 PM Everybody can reply
1 likes
🧬This team reports a new #prothrombin mutation (Ile441Met) linked to #venousthromboembolism in a Han Chinese family. Thrombin generation assays show clear hypercoagulability in carriers.

Details here: www.rpthjournal.org/article/S247...
September 12, 2025 at 6:04 PM Everybody can reply
Combined oral contraception (COC) alters hemostasis in ways standard labs may underestimate.

Thrombin generation assays with anti-PS and anti-TFPI antibodies revealed a marked reduction in anticoagulant activity after just 3 months of COC use.

www.rpthjournal.org/article/S247...
September 11, 2025 at 6:02 PM Everybody can reply
1 likes 1 saves
From South Africa:

The Effects of Pseudoserum on Thrombin-Induced Fibrin Networks: Potential for Clinical Insight into Coagulation Independent of Clotting Factors

www.preprints.org/manuscript/2...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC @resiapretorius.bsky.social
September 11, 2025 at 1:15 AM Everybody can reply
1 reposts 4 likes
Alt text retrieved
September 10, 2025 at 2:55 PM Everybody can reply
They found that tumor cells induce thrombin formation and fibrin polymerization, which stabilizes the tumor-platelet aggregates, even without full platelet activation.
August 27, 2025 at 8:31 PM Everybody can reply
Easy bruisability (pancake makeup on a bruise-from smashing his fist, or needing an IV?): he's got A-fib and is on a direct thrombin inhibitor as a guess. I guess that Adderall and tachycardia finally combined to matter. #medsky
August 23, 2025 at 1:39 AM Everybody can reply
2 reposts 12 likes
The paper summarizes the biology, synthesis, and activation of FVIII, emphasizing its role in thrombin generation and endothelial dysfunction. FVIII is implicated in various inflammatory and thrombotic disorders, including COVID-19, sepsis, and cancer-associated thrombosis.
August 22, 2025 at 7:08 AM Everybody can reply
A naturally occurring factor VIII variant with elevated clotting activity and reduced response to activated protein C may explain severe thrombosis and offers a possible new therapeutic approach for hemophilia A. Learn more: nej.md/45eDMSR

#MedSky #Hematology #CardioSky
August 17, 2025 at 1:01 PM Everybody can reply
2 reposts 6 likes