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Étienne Becht

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Reposted by Étienne Becht

iannaconelab.bsky.social
🧵 (1/2) Interested in tertiary lymphoid structures (TLSs)? Check out our latest review, where we chart how TLSs form across organs and contexts — from lung to liver, CNS, skin, gut & more — and their dual roles in protection vs. pathology.
Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers
Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and be....
onlinelibrary.wiley.com
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Reposted by Étienne Becht

nature.com
Nature research paper: One mother for two species via obligate cross-species cloning in ants

go.nature.com/45PYV6d
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same mother having distinct genomes and morphologies.
go.nature.com
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Reposted by Étienne Becht

ritastrack.bsky.social
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
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by Étienne Becht

ebecht.bsky.social
🧪💻 We're hiring ! Post-doctoral position open for a data scientist

👉 Come work with us on high-throughput single cell protein expression data : drive.google.com/file/d/1w8Zv...
1

Reposted by Étienne Becht, Kevin F. McCarthy, Robbie Gilligan , and 2 more

dkthomp.bsky.social
Unbelievable news.

Pancreatic is one of the deadliest cancers.

New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.

www.nature.com/articles/s41...
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by Étienne Becht

ebecht.bsky.social
6. found just enough strength to relay dread while being funny

That is no tiny victory.

I hope you find support until you are strong enough to support those who need it !

Reposted by Étienne Becht

niclag.bsky.social
Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.
www.science.org
4 10 35

by Étienne Becht

ebecht.bsky.social
Flow cytometry batch effect correction without requiring normalization controls 🤩
onlinelibrary.wiley.com/doi/full/10....
CytoNorm 2.0: A flexible normalization framework for cytometry data without requiring dedicated controls
Cytometry is a single cell, high-dimensional, high-throughput technique that is being applied across a range of disciplines. However, many elements alongside the data acquisition process might give r...
onlinelibrary.wiley.com
2 9

Reposted by Étienne Becht

carolynbertozzi.bskyverified.social
Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.

www.biorxiv.org/content/10.1...
Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters
The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven b...
www.biorxiv.org
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Reposted by Étienne Becht, Thomas R. Cox

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Reposted by Étienne Becht

hipcproject.bsky.social
Our collaborators @rgottardo.bsky.social and Ken Stuart (+ others) describe tagtango, an application to compare #single-cell annotations.
#bioinformatics
academic.oup.com/bioinformati...
tagtango: an application to compare single-cell annotations
AbstractSummary. In this article, we present tagtango, an innovative R package and web application designed for robust and intuitive comparison of single-c
academic.oup.com
3 4

Reposted by Étienne Becht

follicular.bsky.social
So THAT'S what Granzyme K does-- cleave complement and promote inflammation in the airway. Fascinating!
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases - Nature
Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing ...
www.nature.com
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Reposted by Étienne Becht

cancerparisnord.bsky.social
La FHU* MOSAIC² relabellisée pour 5 ans !

Félicitations à la Pr Valérie Paradis et ses équipes qui portent ce FHU, illustrant l’engagement de l'Institut du Cancer en faveur de la recherche !

Plus d'informations sur le projet prochainement.

@hopitalbeaujon.bsky.social @ap-hp.bsky.social
1 4 7

Reposted by Étienne Becht

acir-org.bsky.social
Luo et al. developed ATLAS-seq (Aptamer-based T-Lymphocyte Activity Screening and Sequencing), a microfluidic-based high-throughput platform for isolating and profiling antigen-reactive T cells. bit.ly/4fThnwo
1 1

Reposted by Étienne Becht

labwaggoner.bsky.social
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
@jem.org‪
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....
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by Étienne Becht

ebecht.bsky.social
Permanent position (research and teaching) for a bioinformatician immunologist available in a great lab and institute, in a beautiful campus in the center of Paris

www.linkedin.com/posts/isabel...
Isabelle Cremer on LinkedIn: Poste MCU immunologie-bioinformatique
Un poste de maître de conférences en immunologie-bioinformatique est ouvert au concours à Sorbonne Université, au sein de la Faculté des Sciences et…
www.linkedin.com
2

Reposted by Étienne Becht

jsantoyo.bsky.social
Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references. #GenomeAssembly #HaplotypeResolved #Pangenomes #Genomics #GenomeBiology 🧬 🖥️
genomebiology.biomedcentral.com/articles/10....
Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references - Genome Biology
Background Long-read technologies from Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT) have transformed genomics research by providing diverse data types like HiFi, Duplex, and ult...
genomebiology.biomedcentral.com
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Reposted by Étienne Becht, Andreas J. Bäumler

mfgrp.bsky.social
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
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by Étienne Becht — Reposted by Rémy Nicolle

ebecht.bsky.social
🌟 Calling all computational biology enthusiasts! 🌟 The awesome @remynicolle.bsky.social & friends created this Discord community to connect, collaborate, and share insights in this rapidly evolving field.

👉 Click here to join : discord.gg/2PzSE4dC

#Bioinformatics #ComputationalBiology
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Reposted by Étienne Becht

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Reposted by Étienne Becht

tmontsay.bsky.social

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
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High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com
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Reposted by Étienne Becht

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Reposted by Étienne Becht

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Reposted by Étienne Becht

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References

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