The Lancet Diabetes Endocrinology
The Lancet is a weekly peer-reviewed general medical journal, founded in England in 1823. It is one of the world's… more
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#Glucocorticoid treatment has become the most common drug-induced form of #osteoporosis because of its broad therapeutic use for various inflammatory & haematological diseases & its pivotal role in transplantation medicine www.thelancet.com/journals/lan...
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Glucocorticoid-induced osteoporosis: novel concepts and clinical implications
Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay
in the management of various immune-mediated diseases. High cumulative doses of exogenous
glucocorticoids lead...
www.thelancet.com
Has the WHO Model Essential Medicines List lost its way? www.thelancet.com/journals/lan...
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Recovery of β-cell function is the dominant determinant of the remission of prediabetes, akin to its role in remission of diabetes but at an earlier point in the natural history of dysglycaemia www.thelancet.com/journals/lan...
#prediabetes #remission
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#prediabetes #remission
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The central role of recovery of β-cell function in the remission of prediabetes: a prospective cohort study in Canada
Recovery of β-cell function is the dominant determinant of the remission of prediabetes,
akin to its role in remission of diabetes but at an earlier point in the natural history
of dysglycaemia.
www.thelancet.com
As screening and early treatment for type 1 #diabetes become more widespread, the European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) consortium highlights the need for clearer, more consistent terminology www.thelancet.com/journals/lan... #T1D
A syndromic framework grounded in molecular pathophysiology could ultimately reorient #diabetes care towards precise, stratified risk prediction, personalised prevention, and targeted therapy www.thelancet.com/journals/lan... #T2D
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Type 2 diabetes subtypes classification: a global reckoning with heterogeneity
For decades, type 2 diabetes has been managed as a monolithic condition, defined by
hyperglycaemia and treated via uniform, stepwise algorithms. Although operationally
convenient, this practice increa...
www.thelancet.com
by The Lancet — Reposted by: The Lancet Diabetes Endocrinology
Incretin-based therapies are becoming a core component of diabetes care.
By linking digestion, metabolism, & cardiovascular function, incretin-based therapies can help reduce morbidity & mortality.
Find out more in @thelancetendo.bsky.social: tinyurl.com/dvtv7j28
By linking digestion, metabolism, & cardiovascular function, incretin-based therapies can help reduce morbidity & mortality.
Find out more in @thelancetendo.bsky.social: tinyurl.com/dvtv7j28
Joint Linked Comment by Adrian F Daly:
Experience evolves into evidence in the new MEN1 guidelines thelancet.com/journals/lan...
#MEN1
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Experience evolves into evidence in the new MEN1 guidelines thelancet.com/journals/lan...
#MEN1
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Experience evolves into evidence in the new MEN1 guidelines
Nearly a quarter of a century has passed since the publication of the first clinical
practice guideline on multiple endocrine neoplasia type 1 (MEN1) in 2001, which followed
the identification of the ...
thelancet.com
Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis thelancet.com/journals/lan...
#MEN1
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#MEN1
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Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis
In patients with MEN1, subtotal parathyroidectomy achieved greater reductions in persistence
and recurrence of primary hyperparathyroidism than less than subtotal parathyroidectomy;
for non-functionin...
thelancet.com
Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice thelancet.com/journals/lan...
#MEN1
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#MEN1
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Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice
Multiple endocrine neoplasia type 1 (MEN1) is characterised by combined occurrence
of parathyroid tumours, duodenopancreatic neuroendocrine tumours, and anterior pituitary
adenomas. Some patients migh...
thelancet.com
Fragility fractures remain a common & serious
complication of long-term oral glucocorticoid therapy
that can affect all skeletal sites although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky
complication of long-term oral glucocorticoid therapy
that can affect all skeletal sites although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky
Glucocorticoid-induced osteoporosis: novel concepts and clinical implications
Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay
in the management of various immune-mediated diseases. High cumulative doses of exogenous
glucocorticoids lead...
www.thelancet.com
Kishore M Gadde & colleagues comment on:
Peripheral CB1 receptor blockade for treatment of obesity www.thelancet.com/journals/lan...
#monlunabant #obesity #metabolic #syndrome
#MedSky #EndoSky
Peripheral CB1 receptor blockade for treatment of obesity www.thelancet.com/journals/lan...
#monlunabant #obesity #metabolic #syndrome
#MedSky #EndoSky
Peripheral CB1 receptor blockade for treatment of obesity
The endocannabinoid system—comprising cannabinoid receptors (CB1 and CB2), lipid-derived
ligands, and metabolic enzymes—plays a major role in regulating energy homoeostasis.1
CB1 receptors are abundan...
www.thelancet.com
The implications of this trial, combined with existing evidence, suggest that #monlunabant has potential as a novel treatment option for people with #obesity and #metabolic #syndrome, if a safe and effective therapeutic window can be established www.thelancet.com/journals/lan...
#MedSky #EndoSky
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The evolutionary basis for type 2 #diabetes prevalence in the Arabian Peninsula www.thelancet.com/journals/lan... #T2D
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#Hyperprolactinaemia can result from physiological causes, pharmacological agents, or pathological conditions such as #prolactin-secreting #pituitary #adenomas and other pituitary stalk-compressing masses
www.thelancet.com/journals/lan...
#prolactinomas
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www.thelancet.com/journals/lan...
#prolactinomas
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Prolactin-secreting adenomas: pathogenesis, diagnosis, and management
Hyperprolactinaemia can result from physiological causes, pharmacological agents,
or pathological conditions such as prolactin-secreting pituitary adenomas and other
pituitary stalk-compressing masses...
www.thelancet.com
As the targets of tyrosine kinase inhibitors (#TKIs) also have roles in many physiological processes, TKIs can cause multiple treatment-related adverse events, among which an increase in serum #thyroid stimulating hormone (TSH) concentrations frequently occurs www.thelancet.com/journals/lan... .
The unique signature of tyrosine kinase inhibitor-induced hypothyroidism
Tyrosine kinase inhibitors (TKIs) are anti-cancer agents that inhibit the activity
of oncogenic protein kinases. Thyroid hormone abnormalities are common during treatment
with TKIs, typically manifest...
www.thelancet.com
by The Lancet — Reposted by: The Lancet Diabetes Endocrinology
Tune in on October 3rd for the official launch of the 2025 EAT-Lancet Commission. A major update to the science and what it means for our global food system.
🔗 Register for the livestream here: bit.ly/3Kg9SW8
🔗 Register for the livestream here: bit.ly/3Kg9SW8
by The Lancet — Reposted by: The Lancet Diabetes Endocrinology
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial tinyurl.com/bdenbtyb
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlle...
In young people with recent-onset, clinical type 1 diabetes, 2·5 mg/kg and 0·5 mg/kg
ATG reduced loss of β-cell function, showing the potential of an affordable, repurposed
agent, ATG, in a low and sa...
tinyurl.com
The gut–bone axis: implications of gut hormone-based therapies for bone health thelancet.com/journals/lan...
#GLP-1 #GIP #incretins #weightloss #obesity #overweight #Bonehealth #osteoporosis
#MedSky #EndoSky #RheumSky
#GLP-1 #GIP #incretins #weightloss #obesity #overweight #Bonehealth #osteoporosis
#MedSky #EndoSky #RheumSky
The gut–bone axis: implications of gut hormone-based therapies for bone health
Historical trends and future projections of the number of people with overweight and
obesity suggest alarming parallel increases in serious and potentially fatal comorbidities,
particularly type 2 dia...
thelancet.com
Also read the Linked Comment:
Peripheral CB1 receptor blockade for treatment of obesity thelancet.com/journals/lan...
#obesity #MetabolicSyndrome
#MedSky #EndoSky
Peripheral CB1 receptor blockade for treatment of obesity thelancet.com/journals/lan...
#obesity #MetabolicSyndrome
#MedSky #EndoSky
Peripheral CB1 receptor blockade for treatment of obesity
The endocannabinoid system—comprising cannabinoid receptors (CB1 and CB2), lipid-derived
ligands, and metabolic enzymes—plays a major role in regulating energy homoeostasis.1
CB1 receptors are abundan...
thelancet.com
New—Efficacy and safety of #monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial thelancet.com/journals/lan...
#obesity #MetabolicSyndrome
#MedSky #EndoSky
#obesity #MetabolicSyndrome
#MedSky #EndoSky
Efficacy and safety of monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial
Participants receiving monlunabant showed statistically significant and clinically
meaningful weight loss compared with those receiving placebo for all tested doses.
Only slightly greater weight loss ...
thelancet.com
High cumulative doses of exogenous #glucocorticoids lead to a spectrum of side-effects, in particular increased #fracture risk. Fragility fractures might result in immobility, frequent admission to hospitals, and loss of quality of life thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky
#OpenAccess
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New Editorial:
World Heart Day: diabetes and cardiovascular risk www.thelancet.com/journals/lan...
#diabetes #CVD
#WorldHeartDay
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#MedSky #EndoSky #CardioSky
World Heart Day: diabetes and cardiovascular risk www.thelancet.com/journals/lan...
#diabetes #CVD
#WorldHeartDay
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World Heart Day: diabetes and cardiovascular risk
Cardiovascular disease is one of the leading causes of death globally. Tragically,
as many as 80% of heart disease and stroke cases could be avoided through prevention.
For people with diabetes, the r...
www.thelancet.com
#Fractures affect a substantial proportion of people with #obesity and result from reduced #bone strength relative to increased mechanical loading, together with an increased risk of #falls www.thelancet.com/journals/lan...
#weightloss #BariatricSurgery #GLP-1 receptor agonists
#MedSky #EndoSky
#weightloss #BariatricSurgery #GLP-1 receptor agonists
#MedSky #EndoSky
Bone health in adults with obesity before and after interventions to promote weight loss
Obesity and its associated comorbidities constitute a serious and growing public health
burden. Fractures affect a substantial proportion of people with obesity and result
from reduced bone strength r...
www.thelancet.com
by The Lancet Diabetes Endocrinology — Reposted by: The Lancet Global Health
Published in @lancetgh.bsky.social
Classifying a distinct form of #diabetes in lean individuals with a history of undernutrition: an international consensus statement www.thelancet.com/journals/lan...
#OpenAccess
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Classifying a distinct form of #diabetes in lean individuals with a history of undernutrition: an international consensus statement www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky
Classifying a distinct form of diabetes in lean individuals with a history of undernutrition: an international consensus statement
Since 1955, a form of diabetes in lean, young (BMI <18·5 kg/m2, age <30 years) individuals
with a history suggestive of undernutrition from before birth and throughout childhood
has been described in ...
www.thelancet.com
Fragility #fractures remain a common and serious
complication of long-term oral #glucocorticoid therapy
that might affect all skeletal sites, although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess
#EndoSky
complication of long-term oral #glucocorticoid therapy
that might affect all skeletal sites, although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess
#EndoSky
Glucocorticoid-induced osteoporosis: novel concepts and clinical implications
Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay
in the management of various immune-mediated diseases. High cumulative doses of exogenous
glucocorticoids lead...
www.thelancet.com
Sporadic #prolactinomas are the most common functioning #pituitary #adenomas, with a female predominance during reproductive years. In men, these adenomas are usually larger and more aggressive www.thelancet.com/journals/lan...
#hyperprolactinaemia
#MedSky #EndoSky #OncSky
#hyperprolactinaemia
#MedSky #EndoSky #OncSky
by The Lancet — Reposted by: The Lancet Diabetes Endocrinology, The Lancet Oncology, The Lancet Public Health
Cancer deaths expected to rise to over 18 million in 2050—an increase of nearly 75% from 2024, study forecasts.
Explore the data ▶️ tinyurl.com/5n7dfnws @ihmeuw.bsky.social #NCDs
Explore the data ▶️ tinyurl.com/5n7dfnws @ihmeuw.bsky.social #NCDs
International Federation for the Surgery of Obesity statement on metabolic bariatric surgery after pharmacotherapy-induced weight loss in clinical obesity www.thelancet.com/journals/lan...
#obesity
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#obesity
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International Federation for the Surgery of Obesity statement on metabolic bariatric surgery after pharmacotherapy-induced weight loss in clinical obesity
Clinical obesity is a chronic systemic disease characterised by alterations in the
function of tissues, organs, physical ability, or a combination of these due to excess
adiposity, which can increase ...
www.thelancet.com
As weight loss solutions continue to proliferate, the enduring debate over whether obesity stems from personal responsibility or broader environmental influences is once again drawing attention thelancet.com/journals/lan...
#weightloss #obesity
#MedSky #EndoSky
#weightloss #obesity
#MedSky #EndoSky
Rethinking obesity through the lens of genetics, environment and differential life circumstances
As weight loss solutions continue to proliferate, the enduring debate over whether
obesity stems from personal responsibility or broader environmental influences is
once again drawing attention. Many ...
thelancet.com
Malnutrition-related #diabetes, rather than being an outlier, might simply represent one extreme of a wider biological spectrum—its persistence reflecting the ongoing clinical need that sustains its relevance www.thelancet.com/journals/lan...
#MedSky #EndoSky
#MedSky #EndoSky
Revisiting malnutrition-related diabetes
Malnutrition-related diabetes has drifted in and out of global diabetes classification
over the past 40 years.1,2 It was removed from WHO diabetes classification in 1999,2
but in 2025, it was again fo...
www.thelancet.com