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Thibault Mayor

@cellsandprots.bsky.social

790 followers 410 following 45 posts

Prof of Biochemistry & Molecular Biology at @ubc and @msl Our team focuses on proteostasis and yeast cell biofactories ❤️ ubiquitin, chaperones & proteomics 💙 outdoor, repast, electro-rock & traveling 🇨🇭🇨🇦 https://mayor51.wixsite.com/mayorlab

mayor51.wixsite.com

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Thibault Mayor @cellsandprots.bsky.social · Jan 10

Protein quality control is a tug-of-war between degradation machinery and chaperones that promote folding. Thrilled to see our latest manuscript is now published!
👇 Follow 🧵 for quick summary
journals.biologists.com/jcs/article-...

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Thibault Mayor @cellsandprots.bsky.social · May 24

I survived the 2025 EMBO protein quality control meeting - it was amazing despite a defective projector on day 1, and epileptic crisis on day 2, a black out in day 3, and we all got a shaky wake up call ~6am on day 5 by an earthquake… never a dull moment but most importantly great science

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Thibault Mayor @cellsandprots.bsky.social · May 11

We ran over 200 eggaggregation experiments for Science Rendezvous - a blast!

Thibault Mayor @cellsandprots.bsky.social · Apr 5

4 months after biorxiv submission sounds like a smooth ride - congrats

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Reposted by Thibault Mayor

Saccharomyces Genome Database @yeastgenome.bsky.social · Apr 2

Application deadline extended to Apr 15 for this summer's #Yeast #Genetics & #Genomics course at @cshlaboratory.bsky.social July22 - Aug12! Get a comprehensive education in all things yeast, from classical genetics through up-to-the-minute genomics. Don't miss out!
meetings.cshl.edu/courses.aspx...

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Thibault Mayor @cellsandprots.bsky.social · Mar 20

Here’s a quick throwback to celebrate the last day of winter: curling with the lab!

Thibault Mayor @cellsandprots.bsky.social · Mar 4

Some of you will recognize this - I am done with our CIHR application. Just in time to start teaching a big course section ✌️

Reposted by Thibault Mayor

Wyeth Wasserman @wywywa.bsky.social · Feb 27

Bioinformatics Job Opportunity
Research Associate / Staff Scientist
Vancouver Canada

Join the Silent Genomes Project to provide an outstanding genetic variation database for Indigenous peoples of Canada to improve rare disease diagnosis

tinyurl.com/bm4ptux3

Priority to Canadians

Please repost

Research Associate

Academic Job Category Faculty Non Bargaining Job Title Research Associate Department Wasserman Laboratory | Department of Medical Genetics | Faculty of Medicine (Wyeth Wasserman) Posting End Date Febr...

tinyurl.com

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Reposted by Thibault Mayor

Pablo Nepomnaschy @pablonep.bsky.social · Feb 22

Job available for Full Professor Tier 1 Canada Research Chair (CRC) - Indigenous Health and Well-Being at the Faculty of Health Science, Simon Fraser University (RT 🙏🏼 please):

www.sfu.ca/vpacademic/a...

Canada Research Chair - Indigenous Health and Well-Being

www.sfu.ca

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Thibault Mayor @cellsandprots.bsky.social · Feb 7

I enjoyed both @cherisirois.bsky.social presentation and conversation about the publishing world and Cell Press today

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Thibault Mayor @cellsandprots.bsky.social · Jan 28

With the help of e@UBC our BMB and MSL postdocs organized this great 1/2 day Academia to Industry workshop with a focus on entrepreneurship today

Thibault Mayor @cellsandprots.bsky.social · Jan 27

You almost look like Leonard on that picture ;-)

Happy birthday- enjoy the rest of the trip

Thibault Mayor @cellsandprots.bsky.social · Jan 15

Even though David Baker's presentation was online, it was rad and inspiring. I really enjoyed today's session on machine learning at the 2025 PepTalk & BioLogic Summit

Reposted by Thibault Mayor

Amanda Moehring @flybehaviour.bsky.social · Jan 14

Calling early-career colleagues with stories of racism / sexism / microaggressions to share (anonymously or not) for an article someone I know is doing! Please send me a DM asap. They'd need to interview you tomorrow (Tues). It's important these stories are shared, so please do reach out!

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Thibault Mayor @cellsandprots.bsky.social · Jan 10

Many people contributed to this project led by @hthrbaker.bsky.social with help from @shriyakamat.bsky.social and great collaborators in @miketilapia.bsky.social and Brian Raught's labs

The illustration was created by @taniodraws.bsky.social our go-to freelance artist for summarizing our studies.

Thibault Mayor @cellsandprots.bsky.social · Jan 10

One limitation of our study is the use of rapidly dividing cells, where the protein homeostasis network likely differs from that in differentiated cells with lower protein production. Despite our efforts, we have yet to identify the E3 ligase involved—but we’re not giving up, so stay tuned!

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Thibault Mayor @cellsandprots.bsky.social · Jan 10

In this case, the disease-associated mutation increases interaction with the DNAJA2 chaperone, which appear to be dispensable for the folding of the wild-type protein. This interaction delays the proteolysis of the mutant protein, potentially buffering its deleterious effects.

Thibault Mayor @cellsandprots.bsky.social · Jan 10

Using BioID, we identified chaperones, including the co-chaperone DNAJA2, that interact more with the unstable thiopurine S-methyltransferase (TPMT) variant than the wild type. DNAJA2 deletion accelerates degradation of the mutated TPMT but does not affect the wild-type protein

Thibault Mayor @cellsandprots.bsky.social · Jan 10

Many disease-associated mutations are missense mutations causing single amino acid changes that signal proteins for degradation. We surveyed 18 unstable variants from 13 cytosolic proteins and found that all but one are at least partially degraded via proteasome- and ubiquitin-dependent pathways.

Thibault Mayor @cellsandprots.bsky.social · Jan 10

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Thibault Mayor @cellsandprots.bsky.social · Dec 21

Congratulations to the whole team!

Reposted by Thibault Mayor

Marc Johnson (he/him) @evoecolab.bsky.social · Dec 10

CONGRATS to @supportourscience.bsky.social, Dr. Kaitlin Kharas, @sarahlaframboise.bsky.social & @cdrobich.bsky.social who were named "Nature's 10", a list of people who shaped science in 2024. #SupportOurScience achieved amazing things. The advocacy continues! www.nature.com/articles/d41...

This PhD student helped to win a major pay hike for Canadian researchers

Kaitlin Kharas is part of Nature’s 10, a list of people who shaped science in 2024.

www.nature.com

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Cheshire @thatsregrettab1.bsky.social · Dec 16

ICYMI: Finland downgrades a bunch of Frontiers and MDPI journals to level 0.

julkaisufoorumi.fi/en/news/chan...

Changes to the classification

julkaisufoorumi.fi

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Thibault Mayor @cellsandprots.bsky.social · Dec 12

🤔 a lot of us will have to leave. Yes I am co-author on a MPDI journal 😬 But yeah if a see a lot of these journals in a CV, it will dampen my enthusiasm for an application

We first need to better educate our trainees about the issue (e.g. does your grad program cover the topic in a course?)

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Thibault Mayor @cellsandprots.bsky.social · Dec 11

I would love to be added !

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Thibault Mayor @cellsandprots.bsky.social · Dec 11

Thanks – who doesn't love to ride good vibes?!

P.S. I'm fine, just wanted to share this hiccup since we often tend to overemphasize our successes on SM

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