Cai et al. revealed that transplanting gut microbiota from women with fibromyalgia—a chronic widespread pain condition of unknown etiology—into mice induces pain. It also induces phenotypes commonly o...

The colonic mucus barrier and sentinel goblet cells protect the distal gut from microbial challenges. This study demonstrates that microbial colonization d

Nature Reviews Gastroenterology & Hepatology, Published online: 14 May 2025; doi:10.1038/s41575-025-01072-wCurrent treatments for Crohn’s disease prioritize early intervention with biological therapies, with several landmark trials demonstrating that starting biologic agents within the first years of diagnosis leads to superior patient outcomes. Although challenges remain, early use of biological treatments is increasingly supported in managing moderate to severe Crohn’s disease.

Nature Reviews Gastroenterology & Hepatology, Published online: 13 May 2025; doi:10.1038/s41575-025-01080-wInflammatory bowel disease: classifying global regions by epidemiological stage

Author summary This study explores the interplay between biology and mechanics in tissue architecture, particularly the 3D organization of human colonic epithelial organoid. The experimental approach ...