Nature Reviews Gastroenterology & Hepatology, Published online: 19 November 2025; doi:10.1038/s41575-025-01155-8Despite more women entering medicine, women in gastroenterology continue to experience disparities in training, research and career opportunities. United European Gastroenterology calls to ensure that everyone has equal access to opportunities, mentoring and supportive workplaces that will benefit both professionals and patients.

Nature Reviews Gastroenterology & Hepatology, Published online: 24 November 2025; doi:10.1038/s41575-025-01149-6Individuals living with human immunodeficiency virus infection are experiencing an increase in liver disease burden. This Review summarizes current knowledge on the burden of liver diseases in this population and provides insights into clinical management and future directions.

Nature Reviews Gastroenterology & Hepatology, Published online: 24 November 2025; doi:10.1038/s41575-025-01147-8In this Review, Luedde and colleagues describe the complex role of regulated necrosis pathways, including necroptosis, pyroptosis and ferroptosis, in liver disease and cancer development. Potential therapeutic approaches modulating regulated cell death pathways in liver disease are explored.

Nature Reviews Gastroenterology & Hepatology, Published online: 24 November 2025; doi:10.1038/s41575-025-01149-6Individuals living with human immunodeficiency virus infection are experiencing an increase in liver disease burden. This Review summarizes current knowledge on the burden of liver diseases in this population and provides insights into clinical management and future directions.

Nature Reviews Gastroenterology & Hepatology, Published online: 24 November 2025; doi:10.1038/s41575-025-01147-8In this Review, Luedde and colleagues describe the complex role of regulated necrosis pathways, including necroptosis, pyroptosis and ferroptosis, in liver disease and cancer development. Potential therapeutic approaches modulating regulated cell death pathways in liver disease are explored.

Nature Reviews Gastroenterology & Hepatology, Published online: 18 November 2025; doi:10.1038/s41575-025-01156-7SOLSTICE: tobevibart plus elebsiran for hepatitis D

Nature Reviews Gastroenterology & Hepatology, Published online: 18 November 2025; doi:10.1038/s41575-025-01158-5Optimizing sacral nerve stimulation to relieve chronic constipation

Nature Reviews Gastroenterology & Hepatology, Published online: 17 November 2025; doi:10.1038/s41575-025-01138-9Despite the high incidence and mortality rates of hepatopancreatobiliary cancers in the African continent, epidemiological and clinical data are scarce. This Roadmap article describes the efforts of the Africa HepatoPancreatoBiliary Cancer Consortium to establish cancer registries in the region.

Nature Reviews Gastroenterology & Hepatology, Published online: 17 November 2025; doi:10.1038/s41575-025-01143-yThis Review examines how advances in tumour biology, immunogenomics and graft preservation are redefining surgical management of hepatocellular carcinoma. Malik et al. describe the shift from anatomical to biology-informed paradigms to individualize surgical decision-making.

Nature Reviews Gastroenterology & Hepatology, Published online: 14 November 2025; doi:10.1038/s41575-025-01154-9A new case report of successful treatment of refractory ulcerative colitis with CD19-directed chimeric antigen receptor T cell therapy sheds light on the role of B lineage cells in disease pathogenesis and the possibility of an ‘immune reset’. This approach could reshape therapeutic strategies, although its long-term efficacy, safety and positioning remain open questions.

Nature Reviews Gastroenterology & Hepatology, Published online: 19 November 2025; doi:10.1038/s41575-025-01155-8Despite more women entering medicine, women in gastroenterology continue to experience disparities in training, research and career opportunities. United European Gastroenterology calls to ensure that everyone has equal access to opportunities, mentoring and supportive workplaces that will benefit both professionals and patients.

Nature Reviews Gastroenterology & Hepatology, Published online: 19 November 2025; doi:10.1038/s41575-025-01155-8Despite more women entering medicine, women in gastroenterology continue to experience disparities in training, research and career opportunities. United European Gastroenterology calls to ensure that everyone has equal access to opportunities, mentoring and supportive workplaces that will benefit both professionals and patients.

Nature Reviews Gastroenterology & Hepatology, Published online: 18 November 2025; doi:10.1038/s41575-025-01156-7SOLSTICE: tobevibart plus elebsiran for hepatitis D

Nature Reviews Gastroenterology & Hepatology, Published online: 12 November 2025; doi:10.1038/s41575-025-01150-zPatients with pancreatic exocrine insufficiency are treated with pancreatic enzyme replacement therapy. However, there are several challenges facing the future of this treatment, including infectious agents and the presence of microplastics and nanoplastics.

Nature Reviews Gastroenterology & Hepatology, Published online: 17 November 2025; doi:10.1038/s41575-025-01138-9Despite the high incidence and mortality rates of hepatopancreatobiliary cancers in the African continent, epidemiological and clinical data are scarce. This Roadmap article describes the efforts of the Africa HepatoPancreatoBiliary Cancer Consortium to establish cancer registries in the region.

Nature Reviews Gastroenterology & Hepatology, Published online: 17 November 2025; doi:10.1038/s41575-025-01143-yThis Review examines how advances in tumour biology, immunogenomics and graft preservation are redefining surgical management of hepatocellular carcinoma. Malik et al. describe the shift from anatomical to biology-informed paradigms to individualize surgical decision-making.

Nature Reviews Gastroenterology & Hepatology, Published online: 18 November 2025; doi:10.1038/s41575-025-01156-7SOLSTICE: tobevibart plus elebsiran for hepatitis D

Nature Reviews Gastroenterology & Hepatology, Published online: 18 November 2025; doi:10.1038/s41575-025-01158-5Optimizing sacral nerve stimulation to relieve chronic constipation

Nature Reviews Gastroenterology & Hepatology, Published online: 17 November 2025; doi:10.1038/s41575-025-01138-9Despite the high incidence and mortality rates of hepatopancreatobiliary cancers in the African continent, epidemiological and clinical data are scarce. This Roadmap article describes the efforts of the Africa HepatoPancreatoBiliary Cancer Consortium to establish cancer registries in the region.

Nature Reviews Gastroenterology & Hepatology, Published online: 17 November 2025; doi:10.1038/s41575-025-01143-yThis Review examines how advances in tumour biology, immunogenomics and graft preservation are redefining surgical management of hepatocellular carcinoma. Malik et al. describe the shift from anatomical to biology-informed paradigms to individualize surgical decision-making.

Nature Reviews Gastroenterology & Hepatology, Published online: 10 November 2025; doi:10.1038/s41575-025-01142-zThe liver is a key metabolic organ that influences metabolic homeostasis by communicating with the central nervous system. This Review discusses the role of gut–liver–brain communication in chronic liver disease, highlighting underlying mechanisms and signalling pathways.

Nature Reviews Gastroenterology & Hepatology, Published online: 10 November 2025; doi:10.1038/s41575-025-01141-0In this Review, the authors discuss the role of the main IL-1 family members in gastrointestinal and liver diseases, focusing on preclinical and clinical research. Opportunities for therapeutic interventions are also outlined.

Nature Reviews Gastroenterology & Hepatology, Published online: 14 November 2025; doi:10.1038/s41575-025-01154-9A new case report of successful treatment of refractory ulcerative colitis with CD19-directed chimeric antigen receptor T cell therapy sheds light on the role of B lineage cells in disease pathogenesis and the possibility of an ‘immune reset’. This approach could reshape therapeutic strategies, although its long-term efficacy, safety and positioning remain open questions.