Nature Reviews Gastroenterology & Hepatology, Published online: 02 October 2025; doi:10.1038/s41575-025-01126-zIn a new study by Liu and colleagues, researchers demonstrated a novel neuroepithelial circuit in colonic neuropod cells through which a molecular pattern from resident microorganisms was relayed to the brain — a ‘neurobiotic sense’ by which the host adjusted its feeding behaviour by monitoring a gut microbial pattern.

Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2025; doi:10.1038/s41575-025-01137-wAspirin and recurrence of PI3K-mutated CRC

Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2025; doi:10.1038/s41575-025-01136-xNivolumab and ipilimumab as neoadjuvant therapy for potentially resectable HCC

Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2025; doi:10.1038/s41575-025-01130-3Submucosal endoscopy creates a new space to implant bioelectronics in a ‘scarless’ way, establishing a reliable interface between device and tissue that remains stable for months in the gastrointestinal tract. Submucosal bioelectronics, combining diagnostic and therapeutic functions, hold great promise as powerful tools to advance both fundamental understanding and clinical management of gastrointestinal disease.

Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2025; doi:10.1038/s41575-025-01137-wAspirin and recurrence of PI3K-mutated CRC

Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2025; doi:10.1038/s41575-025-01130-3Submucosal endoscopy creates a new space to implant bioelectronics in a ‘scarless’ way, establishing a reliable interface between device and tissue that remains stable for months in the gastrointestinal tract. Submucosal bioelectronics, combining diagnostic and therapeutic functions, hold great promise as powerful tools to advance both fundamental understanding and clinical management of gastrointestinal disease.

Nature Reviews Gastroenterology & Hepatology, Published online: 29 September 2025; doi:10.1038/s41575-025-01131-2Maternal gut microbiome in early pregnancy: predictor of preterm birth?

Nature Reviews Gastroenterology & Hepatology, Published online: 29 September 2025; doi:10.1038/s41575-025-01107-2Portal hypertension and systemic inflammation are key factors driving decompensation and organ failure in cirrhosis. This Review examines those two factors and, based on their mechanistic interaction, proposes a new concept of the clinical phenotypes in decompensated cirrhosis.

Nature Reviews Gastroenterology & Hepatology, Published online: 02 October 2025; doi:10.1038/s41575-025-01126-zIn a new study by Liu and colleagues, researchers demonstrated a novel neuroepithelial circuit in colonic neuropod cells through which a molecular pattern from resident microorganisms was relayed to the brain — a ‘neurobiotic sense’ by which the host adjusted its feeding behaviour by monitoring a gut microbial pattern.

Nature Reviews Gastroenterology & Hepatology, Published online: 02 October 2025; doi:10.1038/s41575-025-01126-zIn a new study by Liu and colleagues, researchers demonstrated a novel neuroepithelial circuit in colonic neuropod cells through which a molecular pattern from resident microorganisms was relayed to the brain — a ‘neurobiotic sense’ by which the host adjusted its feeding behaviour by monitoring a gut microbial pattern.

Nature Reviews Gastroenterology & Hepatology, Published online: 26 September 2025; doi:10.1038/s41575-025-01120-5Metabolic and alcohol-related liver disease presents challenges in clinical trials due to complex pathophysiology. This Review discusses noninvasive imaging, serum biomarkers and adaptive designs as modalities to enhance patient-centric end points, aiming to refine diagnostics and improve drug development.

Nature Reviews Gastroenterology & Hepatology, Published online: 29 September 2025; doi:10.1038/s41575-025-01131-2Maternal gut microbiome in early pregnancy: predictor of preterm birth?

Nature Reviews Gastroenterology & Hepatology, Published online: 29 September 2025; doi:10.1038/s41575-025-01107-2Portal hypertension and systemic inflammation are key factors driving decompensation and organ failure in cirrhosis. This Review examines those two factors and, based on their mechanistic interaction, proposes a new concept of the clinical phenotypes in decompensated cirrhosis.

Nature Reviews Gastroenterology & Hepatology, Published online: 29 September 2025; doi:10.1038/s41575-025-01131-2Maternal gut microbiome in early pregnancy: predictor of preterm birth?

Nature Reviews Gastroenterology & Hepatology, Published online: 29 September 2025; doi:10.1038/s41575-025-01107-2Portal hypertension and systemic inflammation are key factors driving decompensation and organ failure in cirrhosis. This Review examines those two factors and, based on their mechanistic interaction, proposes a new concept of the clinical phenotypes in decompensated cirrhosis.

Nature Reviews Gastroenterology & Hepatology, Published online: 22 September 2025; doi:10.1038/s41575-025-01119-yThe gut microbiome has been associated with pancreatic cancer. This Review summarizes the latest findings of microbiota association studies of tumours of the pancreas and outlines the mechanisms as to how the microbiome influences pancreatic cancer and the clinical potential of harnessing the microbiome in pancreatic cancer.

Nature Reviews Gastroenterology & Hepatology, Published online: 22 September 2025; doi:10.1038/s41575-025-01118-zThis Review provides a comprehensive overview of the role of tissue-resident memory CD8+ T cells in hepatic immune responses, explores their dual function in liver immunoprotection and immunopathology, and discusses their therapeutic potential.

Nature Reviews Gastroenterology & Hepatology, Published online: 22 September 2025; doi:10.1038/s41575-025-01125-0Diagnosing paediatric coeliac disease

Nature Reviews Gastroenterology & Hepatology, Published online: 22 September 2025; doi:10.1038/s41575-025-01128-xNeuroGASTRO 2025

Nature Reviews Gastroenterology & Hepatology, Published online: 26 September 2025; doi:10.1038/s41575-025-01120-5Metabolic and alcohol-related liver disease presents challenges in clinical trials due to complex pathophysiology. This Review discusses noninvasive imaging, serum biomarkers and adaptive designs as modalities to enhance patient-centric end points, aiming to refine diagnostics and improve drug development.

Nature Reviews Gastroenterology & Hepatology, Published online: 26 September 2025; doi:10.1038/s41575-025-01120-5Metabolic and alcohol-related liver disease presents challenges in clinical trials due to complex pathophysiology. This Review discusses noninvasive imaging, serum biomarkers and adaptive designs as modalities to enhance patient-centric end points, aiming to refine diagnostics and improve drug development.