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Thomas Reiberger @reibergerthomas.bsky.social · 9d

Pathomechanistic #Phenotypes of #Cirrhosis

Dalila Costa🇵🇹 Jonel Trebicka🇩🇪 Cristina Ripoll🇪🇸 Richard Moreau🇫🇷 @rajivjalan.bsky.social🇬🇧 Reiberger🇦🇹

📈 Portal Hypertension #PH & 🔥 Inflammation #SI coexist in pts w/ cirrhosis

💡review on PH-SI interplay in distinct cirrhosis stages
@easlnews.bsky.social

Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 9d

New online! Interaction of inflammation and portal hypertension in cirrhosis progression

Interaction of inflammation and portal hypertension in cirrhosis progression

Nature Reviews Gastroenterology & Hepatology, Published online: 29 September 2025; doi:10.1038/s41575-025-01107-2Portal hypertension and systemic inflammation are key factors driving decompensation and organ failure in cirrhosis. This Review examines those two factors and, based on their mechanistic interaction, proposes a new concept of the clinical phenotypes in decompensated cirrhosis.

www.nature.com

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Thomas Reiberger @reibergerthomas.bsky.social · 9d

Today these two fellows rocked their VENIA DOCENDI

🎓David CHROMY : STIs & #HepatitisC
🎓Mathias JACHS : NITs in #PortalHypertension

my personal highlights:

@mathiasjachs.bsky.social in @lancetgastrohep.bsky.social
Spleen Stiffness
🔗 t.ly/DysXB

Chromy in #UEGJ
DAAs in acute #HCV
🔗 t.ly/nIZ2a

Thomas Reiberger @reibergerthomas.bsky.social · 10d

Our @GeorgKRAMER myself & @CristinaRIPOLL perspective on staging of #Decompensated #Cirrhosis
- this was a Letter ✉️ to @jhepatology.bsky.social in response to an article by Dr. Verma @rajivjalan.bsky.social et al
#NonAcuteDecompensation (NAD) 🔗 t.ly/mc4VG
- who responded w/ an interesting proposal

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Thomas Reiberger @reibergerthomas.bsky.social · Sep 3

❓Does #Smoking matter in #Cirrhosis❓
@benedikthofer.bsky.social
of @meduniwien.ac.at
demonstrates that indeed smoking

📈 triggers 🔥 inflammation & 🩸angiogenesis
🦀 leads to extrahepatic cancer
🦀 and tends to increase risk of #livercancer #HCC

📕 @LiverInt
🔗 t.ly/8Vr-0

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Thomas Reiberger @reibergerthomas.bsky.social · Aug 30

Transcriptome analysis shows that 67% (n=13563) of all human proteins (n=20162) are expressed in the liver and 978 of these genes show an elevated expression in the liver compared to other tissue types.

Source: www.proteinatlas.org/humanproteom...

The human proteome in liver - The Human Protein Atlas

www.proteinatlas.org

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Reposted by Thomas Reiberger

Thomas Sorz-Nechay @tsorznechay.bsky.social · Jul 28

🚨 How do ⚡injury mechanisms and 🕑 disease states from health ➡️ fibrosis ➡️ regression shape the NO–sGC–cGMP pathway in chronic #liver #cirrhosis?

Check out our comprehensive assessment of regulation patterns of this pivotal pathway here:
rdcu.be/exM9Z

@reibergerthomas.bsky.social

Molecular patterns of the NO-sGC-cGMP pathway in progressive and regressive liver fibrosis models

Scientific Reports - Molecular patterns of the NO-sGC-cGMP pathway in progressive and regressive liver fibrosis models

rdcu.be

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Thomas Reiberger @reibergerthomas.bsky.social · Jul 28

🌍 #WorldHepatitisDay #2025
🇦🇹 contributions to understanding & Elimination of #Hepatitis

1⃣ #HBV-ART in #HIV 🔗 t.ly/6TXxR
2⃣ Curing #HCV in #HIV 🔗 t.ly/FiLPq
3⃣ Eliminate #HCV in 🇦🇹AT 🔗 t.ly/CBw3o
4⃣ Followup after #HCV cure 🔗 t.ly/KvSrs

Reposted by Thomas Reiberger

MedUni Wien @meduniwien.ac.at · Jul 17

Chronische #Lebererkrankungen im Fokus: @mathiasjachs.bsky.social, #ResearcherOfTheMonth der #MedUniWien, hat gezeigt, dass Pfortaderhochdruck schmerzfrei durch Messung der Organsteifigkeit diagnostiziert werden kann.

Mehr im Video in gesamter Länge! 🎥➡️ https://bit.ly/3G6VoGC

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Thomas Reiberger @reibergerthomas.bsky.social · Jul 17

REMEMBERING PROFESSOR JAUME BOSCH
President of Bavneo @bavenocoop.bsky.social
Friend and Mentor to many

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Reposted by Thomas Reiberger

The Baveno Cooperation: an EASL Consortium @bavenocoop.bsky.social · Jul 16

🖤 With deep sorrow, we announce the passing of Prof. Dr. Jaime Bosch, President of the Baveno Cooperation.

A brilliant scientist, inspiring leader, and dear friend. His immense legacy in hepatology will endure.

Rest in peace, Jaime

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Thomas Reiberger @reibergerthomas.bsky.social · Jul 14

🎂 30Y of .mp3 🎵
created @ Frauenhofer Institute 🔗 t.ly/f6A1t
by 🧑‍🎓 Karlheinz Brandenburg 🔗 t.ly/8vojd
🙏 for good vibes when i grew up
♻️ Napster 🔗 t.ly/lqPRP
⏯️ Winamp 🔗 t.ly/_sR05

Thomas Reiberger @reibergerthomas.bsky.social · Jul 8

Drs. @LorenzBALCAR of @meduniwien.ac.at & @MartaTONON identify a #cirrhosis population with #ascites at particular risk for shortterm #PortalHypertension complications

@jhepatology.bsky.social Reports: t.ly/iCvXY

Ascites #Grade3 + 🚨 MELD ≥12 or 🚨 Na ≤135
➡️ good candidates for #TIPS

Risk of portal hypertensive complications preventable by TIPS in patients with ascites

Transjugular intrahepatic portosystemic shunt (TIPS) is an effective treatment of recurrent/refractory ascites in patients with cirrhosis. The aim of this study was to identify patients with ascites a...

t.ly

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Thomas Reiberger @reibergerthomas.bsky.social · Jul 6

Drs. @LukasHARTL and @MarleneHINTERSTEININGER of @meduniwien.ac.at showed in @CGH @AGA that
adding the #Vasopressin #ADH Biomarker #Copeptin to the MELD score improves prognostication of patients with #cirrhosis #ACLD

📖 the full study 🔗 t.ly/11GOg
@easlnews.bsky.social @bavenocoop.bsky.social

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Reposted by Thomas Reiberger

MedUni Wien @meduniwien.ac.at · Jun 18

🌍⏩ #MedUniVienna ranks 66th in #ClinicalMedicine and is among the top 200 in the US News Global #UniversityRanking.

🔝📌 In the @timeshighered.bsky.social Impact Ranking 2025, MedUni Vienna is 10th worldwide in "Good Health and Well-Being".

Details ⬇️

US News Ranking: MedUni Vienna among the best medical universities in the world

Read more!

www.meduniwien.ac.at

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Thomas Reiberger @reibergerthomas.bsky.social · Jun 19

The #HEPEX Hepatic Experimental Lab at @meduniwien.ac.at and @cemm.oeaw.ac.at works on Disease-driving #Pathomechanisms in #Liver #Fibrosis & #PortalHypertension

🕸️ #Macrophages in #Fibrosis Resolution
🤖 #MachineLearning & #Pathomics in #LiverHistology
🦠 #Gut-Liver-Axis
🩸 #Anticoagulation

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Thomas Reiberger @reibergerthomas.bsky.social · Jun 17

@who.int has set Elimination of
🦠 #ViralHepatitis #B #C as a global goal for 2030

#Prisons remain a Hot ♨️ Spot for #HepC #HCV

In Vienna 🇦🇹 we focus on the incarcerated risk population
and offer onsite screening and treatment

@worldhepalliance.bsky.social
@easlnews.bsky.social

Reposted by Thomas Reiberger

CeMM @cemm.oeaw.ac.at · Jun 16

We kicked off the week with Roger Kamm (@mitdeptofbe.bsky.social) for a #CeMMinar on brain neurovascular models & its applications to modeling drug & toxin transport. Thanks to Roger for the great insights & hosts @lderooij.bsky.social & @ar-abdelfattah.bsky.social

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Thomas Reiberger @reibergerthomas.bsky.social · Jun 15

🇦🇹 Austrian GI/Liver Meeting 2025
3 rising 🌟 stars of our research group #MOTION
@crgmotion.bsky.social @meduniwien.ac.at presented
posters on hot 🔥 topics in #Hepatology
- Clinical Course of #NAD non-acute decompensation
- #SpleenStiffness in #PortalHypertension
- #Ultrasound Elastography in MASLD

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Thomas Reiberger @reibergerthomas.bsky.social · Jun 12

Improved clinical outcomes of patients with cirrhosis and acute variceal bleeding over the last 2 decades - Gastrointestinal Endoscopy www.giejournal.org/article/S001...

Improved clinical outcomes of patients with cirrhosis and acute variceal bleeding over the last 2 decades

Acute variceal bleeding (AVB), a severe adverse event of portal hypertension, may cause death in patients with cirrhosis. We investigated whether outcomes after AVB have improved over time.

www.giejournal.org

Thomas Reiberger @reibergerthomas.bsky.social · Jun 6

📈 Activation of🩸#Vasopressin System in #Cirrhosis tries to compensate for 🫀 #hemodynamic & 💧#sodium #fluid abnormalities

Drs. HARTL & HINTERSTEININGER of @meduniwien.ac.at
in 🤝with efclif.com show in📕 #CGH
🔗 t.ly/joCs5

▶️ #Vasopressin biomarker #COPEPTIN predicts #ACLF in cirrhosis

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Thomas Reiberger @reibergerthomas.bsky.social · Jun 4

#LiverResearch team #HEPEX-Lab @meduniwien.ac.at is affiliated w Center for Molecular Medicine @cemm.oeaw.ac.at

@KatjaSommer #Gut-Liver-Axis
@VladTaru #LiverFailure #ACLF
@BenHofer #Cirrhosis #Recompensation
@KathiBonitz restaurative #Macrophages
@ThomasSorz #AI Patho Spatial Transcritomics

CeMM @cemm.oeaw.ac.at · Jun 4

🔬 New #EquationsForLife! @reibergerthomas.bsky.social's Group studies #PortalHypertension & uses #OhmsLaw to model blood flow. Their 2024 studies reveal gene expression patterns linked to PH & show it is a key risk factor for complicatoins in #MASLD.
🔎 tinyurl.com/CeMMRR2024-R...

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Thomas Reiberger @reibergerthomas.bsky.social · Jun 4

Study by our #Liver #Team @meduniwien.ac.at
and @MedHochschuleHannover

Minimal residual ascites 3 months after #TIPS implantation implicates worse clinical outcome in patients with #liver #cirrhosis

published in @jhepatology.bsky.social #Reports

🔗 sciencedirect.com/science/arti...

Minimal residual ascites 3 months after TIPS implantation implicates worse clinical outcomes in patients with cirrhosis

Transjugular intrahepatic portosystemic shunt (TIPS) implantation is indicated for recurrent/refractory ascites in patients with cirrhosis. The progno…

sciencedirect.com

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Thomas Reiberger @reibergerthomas.bsky.social · Jun 3

#LiverSky

📘 JOURNAL OF HEPATOLOGY #JHEPATOL
@jhepatology.bsky.social

is the flagshipjournal of 🇪🇺 #EASL @easlnews.bsky.social
📈 Impact Factor of 26.8 ➡️ 2.1% 🔝Percentile

Consider to submit your #Liver #Research
🔗 www.journal-of-hepatology.eu

@heinerwedemeyer.bsky.social
@docberza.bsky.social

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Thomas Reiberger @reibergerthomas.bsky.social · Jun 1

#LiverSky
What is shown here?

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Thomas Reiberger @reibergerthomas.bsky.social · Jun 1

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