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Reposted by Giorgia Tosoni

Johan Jakobsson @jakobssonlab.bsky.social · Sep 7

New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.

www.biorxiv.org/content/10.1...

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease

Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...

www.biorxiv.org

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Reposted by Giorgia Tosoni

Johan Jakobsson @jakobssonlab.bsky.social · Aug 23

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.

Funded by @asapresearch.parkinsonsroadmap.org

www.cell.com/cell-genomic...

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development

Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of L1s...

www.cell.com

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Reposted by Giorgia Tosoni

Keri Martinowich @martinowk.bsky.social · Jul 30

Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠

www.nature.com/articles/s41...

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience

The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...

www.nature.com

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Reposted by Giorgia Tosoni

Netherlands Institute for Neuroscience (NIN) @nin-knaw.bsky.social · Jul 18

Why do some people with Alzheimer’s do not show symptoms of Alzheimer's?

During her PhD, @giorgitos.bsky.social explored this question. Part of the answer led her to an unexpected group of brain cells: underdeveloped neurons.

Read the full article on our website: nin.nl/news/the-eld...

The elderly brain is less mature than you think and that could protect you from Alzheimer’s Disease - Netherlands Institute for Neuroscience - Master the Mind

nin.nl

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Giorgia Tosoni @giorgitos.bsky.social · Jul 3

Important perspective on a fascinating study from the Frisén group, which used machine learning to identify neural progenitors in the adult human brain, a fresh lens on a long-standing debate 💥
Always exciting to see this field evolve, and grateful to be part of it @labsalta.bsky.social

The Transmitter @thetransmitter.bsky.social · Jul 3

Single-nuclei RNA sequencing combined with machine learning provides a way to identify neural progenitor cells in the adult hippocampus, a new study suggests.

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/neurogenesis...

Machine learning spots neural progenitors in adult human brains

But the finding has not settled the long-standing debate over the existence and extent of neurogenesis during adulthood, says Yale University neuroscientist Juan Arellano.

www.thetransmitter.org

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Giorgia Tosoni @giorgitos.bsky.social · Jun 24

Hora est 🎓
Last Thursday, I defended my PhD at the University of Amsterdam, @nin-knaw.bsky.social—graduated cum laude ✨ Huge thanks to my amazing supervisor @labsalta.bsky.social, co-promoters Paul Lucassen, Inge Huitinga & @fitzsimonslab.bsky.social. Thanks to all who made the day unforgettable!

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Reposted by Giorgia Tosoni

Giacomo Sitzia @giachiblue.bsky.social · May 28

I'm proud of contributing to @nkrauth.bsky.social @clemmensenc.bsky.social @olekiehn.bsky.social discovery of the role of an hypothalamic-brainstem circuit for prioritization of safety. Really impressive amount of work led by @nkrauth.bsky.social

Nathalie Krauth @nkrauth.bsky.social · May 28

Honored to share that our paper is out today in Nature Neuroscience:

www.nature.com/articles/s41...

We identify a hypothalamic-brainstem circuit linking internal states to locomotion: These projections drive safety-focused movement over competing behavior.

#Neuroscience #Hypothalamus #Locomotion

A hypothalamus–brainstem circuit governs the prioritization of safety over essential needs - Nature Neuroscience

Animals need to adapt behavior to balance survival with fulfillment of essential needs. Krauth et al. identify neurons in the lateral hypothalamus that, when activated, prioritize survival over other ...

www.nature.com

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Reposted by Giorgia Tosoni

Keri Martinowich @martinowk.bsky.social · Apr 2

@labsalta.bsky.social identified persistent populations of immature neurons that were associated with ‘juvenile’ cellular functions, suggesting that these immature populations may actively contribute to maintaining homeostasis within the aged human hippocampus.
www.biorxiv.org/content/10.1...

Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilience

The existence and functional significance of immature neurons in the adult human brain, particularly in the context of neurodegenerative disorders, remain controversial. While rodent studies have high...

www.biorxiv.org

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Reposted by Giorgia Tosoni

Keri Martinowich @martinowk.bsky.social · Apr 2

Our paper has sparked a lot of people asking me – so Keri, what’s the tldr – is there, or isn’t there, new neurons in the human hippocampus?

It's a little more complicated than a yes or no IMO.

Keri Martinowich @martinowk.bsky.social · Feb 22

Updated from the preprint, our paper, "Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation" is now published.

www.cell.com/cell-reports...

Graphical abstract from the paper depicting the overall study design

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Reposted by Giorgia Tosoni

Amar Sahay @amarsahay.bsky.social · Mar 19

Excited to share our preprint led by Ain Chung
& @jasonalipio.bsky.social showing how immature adult-born DGCs preferentially recruit inhibition of CA2 and CA3 to disproportionately affect hippocampal network properties and social memory. We began by asking 1/n
www.biorxiv.org/content/10.1...

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Reposted by Giorgia Tosoni

Keri Martinowich @martinowk.bsky.social · Feb 22

Updated from the preprint, our paper, "Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation" is now published.

www.cell.com/cell-reports...

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Giorgia Tosoni @giorgitos.bsky.social · Mar 7

very interesting!!

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Reposted by Giorgia Tosoni

Yi "Joey" Zhou @zhoujoeyyi.bsky.social · Feb 19

Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨🐵🐷🐭, revealing specialized features in humans. www.biorxiv.org/content/10.1...

Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans

Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized features...

www.biorxiv.org

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Reposted by Giorgia Tosoni

Dawid Zyla @dzyla.bsky.social · Feb 16

I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz

Streamlit

mssearch.xyz

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Reposted by Giorgia Tosoni

Netherlands Institute for Neuroscience (NIN) @nin-knaw.bsky.social · Jan 28

The NINclusion team launched the NIN Gym to support mental and physical health within the institute. Over the next 10 weeks, employees can join alternating Yoga and Bootcamp sessions led by personal trainer Ties
(@tiesverbeekpt.bsky.social) on Thursdays. The first session took place last week! 💪

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Reposted by Giorgia Tosoni

Jane Liebschutz, MD MPH (she/her) @liebschutz.bsky.social · Jan 22

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

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