Amar Sahay
@amarsahay.bsky.social
Professor @ MGH & Harvard Medical School. Hippocampus + Cognition. www.sahaylab.com
Engineering strategies to restore, maintain and enhance cognition since 2011.
(U)Marathoner. Shark diver. Husband. Dad of human and wirehaired doxies
Engineering strategies to restore, maintain and enhance cognition since 2011.
(U)Marathoner. Shark diver. Husband. Dad of human and wirehaired doxies
Evolution is parsimonious in circuit usage.CA2 contributes to spatial and social cognition. TLTW IMO: Oxtr + V1br may bias CA2 recruitment to social cues to support social memory. See this study w/ Amigo2 Cre mice.https://link.springer.com/article/10.1007/s12264-025-01535-9
November 25, 2025 at 9:57 PM
Evolution is parsimonious in circuit usage.CA2 contributes to spatial and social cognition. TLTW IMO: Oxtr + V1br may bias CA2 recruitment to social cues to support social memory. See this study w/ Amigo2 Cre mice.https://link.springer.com/article/10.1007/s12264-025-01535-9
Barren, grey and yet rewarding to the senses on a morning run!
November 25, 2025 at 8:59 PM
Barren, grey and yet rewarding to the senses on a morning run!
Patients who took a daily semaglutide pill for 2yrs did not demonstrate a significant difference from those given placebo on a commonly used Alzheimer’s disease (CDR-SB) rating scale despite improving AD- biomarkers. Betting on MOA is > than chance.
endpoints.news/novo-nordisk...
endpoints.news/novo-nordisk...
Novo Nordisk's semaglutide misses in closely-watched Alzheimer’s trials
Novo Nordisk's semaglutide fails in two late-stage Alzheimer's trials, causing 9% stock drop. Drug didn't delay disease progression despite improving biomarkers.
endpoints.news
November 24, 2025 at 12:46 PM
Patients who took a daily semaglutide pill for 2yrs did not demonstrate a significant difference from those given placebo on a commonly used Alzheimer’s disease (CDR-SB) rating scale despite improving AD- biomarkers. Betting on MOA is > than chance.
endpoints.news/novo-nordisk...
endpoints.news/novo-nordisk...
Cant beat this weather for a run!
November 17, 2025 at 8:48 PM
Cant beat this weather for a run!
The irresistible allure of running thru florid imagery with Van Halen, White Lion, Joan Jett, Joy Division, REM, Glass Tiger, and “It’s my life” triggered memory recall. Natural Synesthesia!
November 8, 2025 at 3:38 PM
The irresistible allure of running thru florid imagery with Van Halen, White Lion, Joan Jett, Joy Division, REM, Glass Tiger, and “It’s my life” triggered memory recall. Natural Synesthesia!
Hey German to English Google translate, there is enough persecution in this world. Please dont persecute my delivery.
November 5, 2025 at 1:45 PM
Hey German to English Google translate, there is enough persecution in this world. Please dont persecute my delivery.
Must read! www.science.org/doi/10.1126/...
Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability
Flexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show that l...
www.science.org
October 31, 2025 at 2:35 PM
Must read! www.science.org/doi/10.1126/...
Reposted by Amar Sahay
First Neuralink patient at University College London Hospital. Great news for these patients.
The initial technology was largely developed in universities, with public funds.
I hope there will be competition in this space (but I worry that the market is small).
www.uclh.nhs.uk/news/first-u...
The initial technology was largely developed in universities, with public funds.
I hope there will be competition in this space (but I worry that the market is small).
www.uclh.nhs.uk/news/first-u...
First UK patient uses thought to control computer hours after Neuralink implant : University College London Hospitals NHS Foundation Trust
A patient with motor neurone disease was able to control a computer just by using his thoughts following the UK’s first Neuralink implant surgery at UCLH’s National Hospital for Neurology and Neurosur...
www.uclh.nhs.uk
October 28, 2025 at 8:56 AM
First Neuralink patient at University College London Hospital. Great news for these patients.
The initial technology was largely developed in universities, with public funds.
I hope there will be competition in this space (but I worry that the market is small).
www.uclh.nhs.uk/news/first-u...
The initial technology was largely developed in universities, with public funds.
I hope there will be competition in this space (but I worry that the market is small).
www.uclh.nhs.uk/news/first-u...
Rare afternoon trail run. Too beautiful to resist.
October 25, 2025 at 9:46 PM
Rare afternoon trail run. Too beautiful to resist.
Good morning from a recent memory.
October 21, 2025 at 10:54 AM
Good morning from a recent memory.
Happy Diwali to all those who observe it. Diwali signifies the victory of light over darkness, good over evil, and knowledge over ignorance. We will all benefit.
October 19, 2025 at 10:11 PM
Happy Diwali to all those who observe it. Diwali signifies the victory of light over darkness, good over evil, and knowledge over ignorance. We will all benefit.
Damn! Cant beat these fall morning runs! With @singhcredible.bsky.social
Thx for chatting about trials and tribulations of ultras, fueling, and running for life.
Thx for chatting about trials and tribulations of ultras, fueling, and running for life.
October 19, 2025 at 2:16 PM
Damn! Cant beat these fall morning runs! With @singhcredible.bsky.social
Thx for chatting about trials and tribulations of ultras, fueling, and running for life.
Thx for chatting about trials and tribulations of ultras, fueling, and running for life.
Reposted by Amar Sahay
Cognitive Resilience in Aging Degus is Linked to CA3 Hippocampal GABAergic Integrity https://www.biorxiv.org/content/10.1101/2025.10.18.682786v1
October 19, 2025 at 10:15 AM
Cognitive Resilience in Aging Degus is Linked to CA3 Hippocampal GABAergic Integrity https://www.biorxiv.org/content/10.1101/2025.10.18.682786v1
“The threat of AGI cannot be overstated”
~Dachshund Community notes, Regional Chapter.
~Dachshund Community notes, Regional Chapter.
October 16, 2025 at 12:33 PM
“The threat of AGI cannot be overstated”
~Dachshund Community notes, Regional Chapter.
~Dachshund Community notes, Regional Chapter.
Reposted by Amar Sahay
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Variability in numbers of new neurons in the adult hippocampus: Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors: Cell Stem Cell
Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors
Márquez-Valadez and colleagues show that neuropsychiatric disorders alter the generation
of new neurons in the adult human brain. Major depression, schizophrenia, and bipolar
disorder disrupt early st...
www.cell.com
October 14, 2025 at 4:07 PM
Variability in numbers of new neurons in the adult hippocampus: Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors: Cell Stem Cell
The concomitant warmth of fire and human-gaze triggered oxytocin is thought to have transformed the beastly wolf into domesticated hound.
October 11, 2025 at 10:17 PM
The concomitant warmth of fire and human-gaze triggered oxytocin is thought to have transformed the beastly wolf into domesticated hound.
Transitions. Imminence. Fleeting hues.
October 11, 2025 at 9:03 PM
Transitions. Imminence. Fleeting hues.
Reposted by Amar Sahay
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
October 6, 2025 at 9:42 AM
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
Cider donut (mini) while taking in foliage in southern VT after college reunion-Check. #Fallnevergetsold
October 5, 2025 at 4:11 PM
Cider donut (mini) while taking in foliage in southern VT after college reunion-Check. #Fallnevergetsold
Happy Birthday Mahatma Gandhi. May we all take a moment to learn from you today.
October 2, 2025 at 11:52 AM
Happy Birthday Mahatma Gandhi. May we all take a moment to learn from you today.
Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects www.cell.com/neuron/fullt...
Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects
Walsh et al. establish a human forebrain assembloid protocol that supports the derivation
of bona fide PVALB+ cortical interneurons and employ it to model schizophrenia in
disease-associated structura...
www.cell.com
October 1, 2025 at 8:17 PM
Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects www.cell.com/neuron/fullt...
According to Maine state law, workers are not entitled to overtime pay for the following activities: “The canning, processing, preserving, freezing, drying, marketing, storing, packing for shipment or distribution of: (1) Agricultural produce; (2) Meat and fish products; and (3) Perishable foods.”
On the case of the Maine milk-truck drivers who, for want of a comma, won an appeal against their employer, Oakhurst Dairy.
A Few Words About That Ten-Million-Dollar Serial Comma
On the case of the Maine milk-truck drivers who, for want of a comma, won an appeal against their employer, Oakhurst Dairy.
www.newyorker.com
September 30, 2025 at 10:41 PM
According to Maine state law, workers are not entitled to overtime pay for the following activities: “The canning, processing, preserving, freezing, drying, marketing, storing, packing for shipment or distribution of: (1) Agricultural produce; (2) Meat and fish products; and (3) Perishable foods.”