Karolinska Institutet
@ki.se
Science news from the medical university Karolinska Institutet (KI) in Sweden. Our vision is to advance knowledge about life and strive towards better health for all. https://ki.se/
A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...
Oligodendrocytes show early changes in multiple sclerosis
A new study from Karolinska Institutet, published in Nature Neuroscience, explores how oligodendrocytes, the cells that produce myelin in the brain and spinal cord, respond during the development of m...
news.ki.se
November 17, 2025 at 1:22 PM
A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...
Maternal #diabetes may predispose sons, but not daughters, to early #cardiovascular dysfunction, even without metabolic disease. Study in @cp-cellrepmed.bsky.social by @qiaolindeng.bsky.social and @zhaoallan.bsky.social highlights oxidative stress as a key driver🧪 news.ki.se/sons-of-moth...
November 12, 2025 at 11:34 AM
Maternal #diabetes may predispose sons, but not daughters, to early #cardiovascular dysfunction, even without metabolic disease. Study in @cp-cellrepmed.bsky.social by @qiaolindeng.bsky.social and @zhaoallan.bsky.social highlights oxidative stress as a key driver🧪 news.ki.se/sons-of-moth...
A new study by @tetsuichi.bsky.social et al published in @natgenet.nature.com shows that human blood #stemcells have stable, intrinsic lineage biases. Some replenish all blood cell types, others only a subset. These patterns persist over decades and after transplantation 🧪 #bloodcancer rdcu.be/ePlJW
Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis
Nature Genetics - This study uses somatic mutations as a natural barcoding system to retrospectively and prospectively trace the fate of hematopoietic stem cells across all major blood cell...
rdcu.be
November 12, 2025 at 8:05 AM
A new study by @tetsuichi.bsky.social et al published in @natgenet.nature.com shows that human blood #stemcells have stable, intrinsic lineage biases. Some replenish all blood cell types, others only a subset. These patterns persist over decades and after transplantation 🧪 #bloodcancer rdcu.be/ePlJW
A study by @borgkvistlab.bsky.social published in Science Advances shows that dopamine modulates basal ganglia output not via DA receptors, but through serotonin and 5-HT1B activation. Findings in mice suggest a new mechanism relevant to #Parkinsons therapy. #Neuroscience 🧪 doi.org/10.1126/scia...
Dopamine and serotonin cotransmission filters striatonigral synaptic activity via 5-HT1B receptor activation
A monoaminergic high-pass filter regulates basal ganglia output activity.
doi.org
November 6, 2025 at 5:27 PM
A study by @borgkvistlab.bsky.social published in Science Advances shows that dopamine modulates basal ganglia output not via DA receptors, but through serotonin and 5-HT1B activation. Findings in mice suggest a new mechanism relevant to #Parkinsons therapy. #Neuroscience 🧪 doi.org/10.1126/scia...
Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...
November 6, 2025 at 10:45 AM
Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...
New cryo-EM structures of HSV-1 origin-binding protein reveal how herpesvirus initiates DNA replication, offering new antiviral targets beyond DNA polymerase. Study published in
@narjournal.bsky.social 🧪
academic.oup.com/nar/article/...
@narjournal.bsky.social 🧪
academic.oup.com/nar/article/...
The herpes simplex origin-binding protein: mechanisms for sequence-specific DNA binding and dimerization revealed by Cryo-EM
Abstract. Herpes simplex viruses 1 and 2 (HSV-1,2) present growing treatment challenges due to increasing resistance to antivirals targeting viral DNA poly
academic.oup.com
October 24, 2025 at 1:55 PM
New cryo-EM structures of HSV-1 origin-binding protein reveal how herpesvirus initiates DNA replication, offering new antiviral targets beyond DNA polymerase. Study published in
@narjournal.bsky.social 🧪
academic.oup.com/nar/article/...
@narjournal.bsky.social 🧪
academic.oup.com/nar/article/...
Adrenal glia-support cells act as hidden #stemcells that regenerate tissue, but can also initiate adrenal #cancer. A new study in npj Precision Oncology by @schlisio-lab.bsky.social reveals a DLK1-NOTCH switch, deciding whether the cells build healthy tissue or fuel disease 🧪 doi.org/10.1038/s416...
Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas - npj Precision Oncology
npj Precision Oncology - Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas
doi.org
October 17, 2025 at 1:04 PM
Adrenal glia-support cells act as hidden #stemcells that regenerate tissue, but can also initiate adrenal #cancer. A new study in npj Precision Oncology by @schlisio-lab.bsky.social reveals a DLK1-NOTCH switch, deciding whether the cells build healthy tissue or fuel disease 🧪 doi.org/10.1038/s416...
The specific weight loss properties of GLP-1R agonists are key to improving neurological recovery after #stroke in diabetic mice, according to a new study from Karolinska Institutet and Södersjukhuset published in @diabetologiajnl.bsky.social 🧪 #diabetes doi.org/10.1007/s001...
Pre-stroke weight loss by glucagon-like peptide 1 receptor and neuropeptide Y receptor Y2 activation improves post-stroke functional recovery in male diabetic mouse models - Diabetologia
Aims/hypothesis Type 2 diabetes is associated with worsened stroke outcome and lasting disability. The underlying mechanisms are undetermined, and no therapy is available. We experimentally investigat...
doi.org
October 16, 2025 at 9:28 AM
The specific weight loss properties of GLP-1R agonists are key to improving neurological recovery after #stroke in diabetic mice, according to a new study from Karolinska Institutet and Södersjukhuset published in @diabetologiajnl.bsky.social 🧪 #diabetes doi.org/10.1007/s001...
A new type of #MRI technique that detects subtle changes in the brain’s microstructure can identify early signs of hereditary frontotemporal #dementia, according to an international study led by KI researchers. The study is published in Molecular Psychiatry 🧪 news.ki.se/new-brain-im...
October 16, 2025 at 7:57 AM
A new type of #MRI technique that detects subtle changes in the brain’s microstructure can identify early signs of hereditary frontotemporal #dementia, according to an international study led by KI researchers. The study is published in Molecular Psychiatry 🧪 news.ki.se/new-brain-im...
A new KI study published in Nature Immunology shows that CD56bright #NKcells temporarily reside in our organs and then leave them via the lymphatic system. The results change our understanding of how the immune system works in human organs. #Immunology 🧪 news.ki.se/the-immune-s...
October 14, 2025 at 2:38 PM
A new KI study published in Nature Immunology shows that CD56bright #NKcells temporarily reside in our organs and then leave them via the lymphatic system. The results change our understanding of how the immune system works in human organs. #Immunology 🧪 news.ki.se/the-immune-s...
AI can increase access to #CervicalCancer screening in low-resource settings, but the technology requires investments throughout the entire healthcare chain to be effective. New study from KI, Uppsala University and @helsinki.fi published in @bmj.com today 🧪 #GlobalHealth news.ki.se/ai-can-impro...
October 10, 2025 at 9:55 AM
AI can increase access to #CervicalCancer screening in low-resource settings, but the technology requires investments throughout the entire healthcare chain to be effective. New study from KI, Uppsala University and @helsinki.fi published in @bmj.com today 🧪 #GlobalHealth news.ki.se/ai-can-impro...
Eating a healthy plant-based diet may lower the risk of #dementia in older people with cardiovascular diseases, type 2 diabetes, or stroke, and the quality of the plant-based diet could be crucial. This is according to a new KI study published in JACC: Advances 🧪 news.ki.se/plant-based-...
October 9, 2025 at 7:31 AM
Eating a healthy plant-based diet may lower the risk of #dementia in older people with cardiovascular diseases, type 2 diabetes, or stroke, and the quality of the plant-based diet could be crucial. This is according to a new KI study published in JACC: Advances 🧪 news.ki.se/plant-based-...
KI researchers comment on this year’s #NobelPrize in Physiology or Medicine. The prize rewards discoveries that reveal how our immune system is kept in check, paving the way for possible new therapies for cancer and autoimmune diseases like type 1 diabetes and MS 🧪 news.ki.se/nobel-prize-...
Nobel Prize rewards key to future MS and cancer treatment
The year’s Nobel Prize in Physiology or Medicine rewards discoveries that reveal how our immune system is kept in check – in other words, how the body protects itself from attack by its own immune cel...
news.ki.se
October 8, 2025 at 12:03 PM
KI researchers comment on this year’s #NobelPrize in Physiology or Medicine. The prize rewards discoveries that reveal how our immune system is kept in check, paving the way for possible new therapies for cancer and autoimmune diseases like type 1 diabetes and MS 🧪 news.ki.se/nobel-prize-...
A study published in @pnas.org by Marie Wahren-Herlenius and colleagues at KI and @liu.se reveals that a gene associated with several rheumatic diseases affects how cells move, providing new insights into disease mechanisms and potential future therapies 🧪 #rheumatology news.ki.se/gene-linked-...
October 6, 2025 at 3:05 PM
A study published in @pnas.org by Marie Wahren-Herlenius and colleagues at KI and @liu.se reveals that a gene associated with several rheumatic diseases affects how cells move, providing new insights into disease mechanisms and potential future therapies 🧪 #rheumatology news.ki.se/gene-linked-...
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
October 6, 2025 at 9:42 AM
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
In a new study published in @natcomms.nature.com, researchers have investigated how the physical structure of fat tissue helps ovarian cancer cells invade the body, offering potential new treatment strategies 🧪
rdcu.be/eIJna
rdcu.be/eIJna
September 30, 2025 at 8:58 AM
In a new study published in @natcomms.nature.com, researchers have investigated how the physical structure of fat tissue helps ovarian cancer cells invade the body, offering potential new treatment strategies 🧪
rdcu.be/eIJna
rdcu.be/eIJna
A study in @ofidjournal.bsky.social demonstrates the feasibility of detecting Mycobacterium tuberculosis DNA in respiratory aerosols using the TB Hotspot detectOR (THOR) in primary care. This method could help identify infectious TB cases. #Tuberculosis 🧪
academic.oup.com/ofid/advance...
academic.oup.com/ofid/advance...
September 26, 2025 at 1:55 PM
A study in @ofidjournal.bsky.social demonstrates the feasibility of detecting Mycobacterium tuberculosis DNA in respiratory aerosols using the TB Hotspot detectOR (THOR) in primary care. This method could help identify infectious TB cases. #Tuberculosis 🧪
academic.oup.com/ofid/advance...
academic.oup.com/ofid/advance...
Tumour cells grow not only in the connective tissue-rich environment typical of #PancreaticCancer, but also in damaged parts of the pancreas. This may play a role in how tumours in the pancreas develop and respond to treatment. New study published in @natcomms.nature.com 🧪 news.ki.se/tumour-cells...
Tumour cells exploit damaged tissue in the pancreas
Pancreatic cancer is one of the most aggressive cancer types. A new study from Karolinska Institutet, in collaboration with the Department of Pathology at Karolinska University Hospital, shows that tu...
news.ki.se
September 26, 2025 at 9:38 AM
Tumour cells grow not only in the connective tissue-rich environment typical of #PancreaticCancer, but also in damaged parts of the pancreas. This may play a role in how tumours in the pancreas develop and respond to treatment. New study published in @natcomms.nature.com 🧪 news.ki.se/tumour-cells...
A new study published in @thelancet.bsky.social discusses the efficacy and controversies of anti-β amyloid monoclonal antibodies in treating #AlzheimersDisease. The findings highlight the potential and challenges of these treatments
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September 24, 2025 at 9:18 AM
A new study published in @thelancet.bsky.social discusses the efficacy and controversies of anti-β amyloid monoclonal antibodies in treating #AlzheimersDisease. The findings highlight the potential and challenges of these treatments
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www.thelancet.com/journals/lan...
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www.thelancet.com/journals/lan...
A study in @jamanetworkopen.com shows that women with premenstrual disorders (PMDs), particularly PMDD, have significantly lower quality of life compared to those without PMDs. This highlights the need for better healthcare and social support for affected women. 🧪
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
September 23, 2025 at 3:19 PM
A study in @jamanetworkopen.com shows that women with premenstrual disorders (PMDs), particularly PMDD, have significantly lower quality of life compared to those without PMDs. This highlights the need for better healthcare and social support for affected women. 🧪
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Researchers at KI, @uu.se and Northwestern University have identified a new way to protect the kidney’s blood vessels and reduce tissue damage in chronic #kidneydisease. The findings are published in @jclinical-invest.bsky.social. #Nephrology 🧪 news.ki.se/new-antibody...
New antibody may slow kidney damage
Researchers at Karolinska Institutet, Uppsala University and Northwestern University have identified a new way to protect the kidney’s blood vessels and reduce tissue damage in chronic kidney disease....
news.ki.se
September 16, 2025 at 12:57 PM
Researchers at KI, @uu.se and Northwestern University have identified a new way to protect the kidney’s blood vessels and reduce tissue damage in chronic #kidneydisease. The findings are published in @jclinical-invest.bsky.social. #Nephrology 🧪 news.ki.se/new-antibody...
Reposted by Karolinska Institutet
Wallenberg Scholar Rickard Sandberg @ki.se aims to deepen our understanding of how the brain’s synapses develop by mapping gene activity in neurons. To achieve this, he is developing new methods of exploring the uncharted field of splicing #research @rickardsandberg.bsky.social
tinyurl.com/mtpde34z
tinyurl.com/mtpde34z
Understanding the brain | Knut and Alice Wallenberg Foundation
Wallenberg Scholar Rickard Sandberg aims to deepen our understanding of how the brain’s synapses develop by mapping gene activity in neurons. To achieve this, he is developing new methods of exploring...
tinyurl.com
September 9, 2025 at 7:15 AM
Wallenberg Scholar Rickard Sandberg @ki.se aims to deepen our understanding of how the brain’s synapses develop by mapping gene activity in neurons. To achieve this, he is developing new methods of exploring the uncharted field of splicing #research @rickardsandberg.bsky.social
tinyurl.com/mtpde34z
tinyurl.com/mtpde34z
By 2021, 15% of young women in Stockholm identified as bisexual – a group facing greater mental health and social challenges than their heterosexual and homosexual peers. New KI study published in @amjpublichealth.bsky.social. #Sexuality #LGBTQ 🧪 ajph.aphapublications.org/doi/epdf/10....
Temporal Trends in Sexual Identity and Sociodemographic Disparities in Stockholm, Sweden, 2010–2021
ajph.aphapublications.org
September 8, 2025 at 10:39 AM
By 2021, 15% of young women in Stockholm identified as bisexual – a group facing greater mental health and social challenges than their heterosexual and homosexual peers. New KI study published in @amjpublichealth.bsky.social. #Sexuality #LGBTQ 🧪 ajph.aphapublications.org/doi/epdf/10....
Reposted by Karolinska Institutet
The Iberian ribbed newt has the ability to heal its own heart after an injury. The secret might lie in a specific protein also found in humans. Elif Eroglu @ki.se studies salamanders to discover new ways of regenerating our heart cells after a #heartattack.
#research #medicine tinyurl.com/mssmcmc2
#research #medicine tinyurl.com/mssmcmc2
September 1, 2025 at 8:53 AM
The Iberian ribbed newt has the ability to heal its own heart after an injury. The secret might lie in a specific protein also found in humans. Elif Eroglu @ki.se studies salamanders to discover new ways of regenerating our heart cells after a #heartattack.
#research #medicine tinyurl.com/mssmcmc2
#research #medicine tinyurl.com/mssmcmc2
A study from KI & @helsinki.fi published in @cp-cellrepmed.bsky.social shows that low interferon type I activity in ovarian cancer cells predicts poor response to platinum-based chemotherapy. Stimulating this pathway may improve outcomes for chemo-refractory #OvarianCancer 🧪 doi.org/10.1016/j.xc...
Redirecting
doi.org
September 1, 2025 at 9:48 AM
A study from KI & @helsinki.fi published in @cp-cellrepmed.bsky.social shows that low interferon type I activity in ovarian cancer cells predicts poor response to platinum-based chemotherapy. Stimulating this pathway may improve outcomes for chemo-refractory #OvarianCancer 🧪 doi.org/10.1016/j.xc...