Keri Martinowich
@martinowk.bsky.social
Director, Translational Neuroscience at Lieber Institute and Professor, Johns Hopkins School of Medicine studying molecular regulation across species in circuits impacted in complex brain disorders. Native plants/flowers/wetland habitats. Own opinions.
Pinned
Keri Martinowich
@martinowk.bsky.social
· Nov 10
For all the new followers (thank you!!), I love to post images about our science - team #FluorescenceFriday - as well as DC city stuff, #nativeplants, sunsets, sunrises, paddling and all things Chesapeake!
Reposted by Keri Martinowich
New lab paper drop, this one has been a long time coming! Driven by Rob Aukema (now a postdoc with Kerry Ressler) this paper in Science Advances answered the lingering question of what role the amygdala plays in stress-induced neuroendocrine responses.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A network of basolateral amygdala projection neurons contributes to stress-induced activation of the hypothalamic-pituitary-adrenal axis
A network of basolateral amygdala neurons, but not singular projections, contributes to the neuroendocrine response to stress.
www.science.org
November 25, 2025 at 10:13 PM
New lab paper drop, this one has been a long time coming! Driven by Rob Aukema (now a postdoc with Kerry Ressler) this paper in Science Advances answered the lingering question of what role the amygdala plays in stress-induced neuroendocrine responses.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Keri Martinowich
One cool thing about having a tidal river running through your backyard is that a couple of times a year you will have a slack tide line up with an incredible sunset and get the most amazing reflections.
November 24, 2025 at 6:36 PM
One cool thing about having a tidal river running through your backyard is that a couple of times a year you will have a slack tide line up with an incredible sunset and get the most amazing reflections.
Reposted by Keri Martinowich
Congratulations to Harriet De Wit, Ph.D., for being awarded the Barbara Fish Memorial Award! ☺️ #ACNP2026
Please click here ➡️tinyurl.com/2ndexz5k to watch the nominator video by Abraham Palmer, Ph.D.
Please click here ➡️tinyurl.com/2ndexz5k to watch the nominator video by Abraham Palmer, Ph.D.
November 21, 2025 at 7:10 PM
Congratulations to Harriet De Wit, Ph.D., for being awarded the Barbara Fish Memorial Award! ☺️ #ACNP2026
Please click here ➡️tinyurl.com/2ndexz5k to watch the nominator video by Abraham Palmer, Ph.D.
Please click here ➡️tinyurl.com/2ndexz5k to watch the nominator video by Abraham Palmer, Ph.D.
Reposted by Keri Martinowich
Congratulations to Sophia Vinogradov, M.D. on being awarded the 2025 Julius Axelrod Mentorship Award! #ACNP2026
Please click here ➡️ tinyurl.com/3b7jdtcy to watch the acceptance video by Sophia Vinogradov, M.D.
Please click here ➡️ tinyurl.com/3b7jdtcy to watch the acceptance video by Sophia Vinogradov, M.D.
November 24, 2025 at 7:00 PM
Congratulations to Sophia Vinogradov, M.D. on being awarded the 2025 Julius Axelrod Mentorship Award! #ACNP2026
Please click here ➡️ tinyurl.com/3b7jdtcy to watch the acceptance video by Sophia Vinogradov, M.D.
Please click here ➡️ tinyurl.com/3b7jdtcy to watch the acceptance video by Sophia Vinogradov, M.D.
Reposted by Keri Martinowich
Congratulations to Carlos Bolanos Guzman, Ph.D. and Jared Young, Ph. D. for being awarded the Dolores Shockley Advancement Award! 👏 #ACNP2026
November 24, 2025 at 7:05 PM
Congratulations to Carlos Bolanos Guzman, Ph.D. and Jared Young, Ph. D. for being awarded the Dolores Shockley Advancement Award! 👏 #ACNP2026
Reposted by Keri Martinowich
Congratulations to Gwenn Smith, Ph.D. for being awarded the Advocacy Award! 😀 #ACNP2026 @SmithGwenn
Please click here ➡️ tinyurl.com/2s3ut4v7 to view the acceptance video by Gwenn Smith Ph.D. for the Advocacy Award.
Please click here ➡️ tinyurl.com/2s3ut4v7 to view the acceptance video by Gwenn Smith Ph.D. for the Advocacy Award.
November 24, 2025 at 7:10 PM
Congratulations to Gwenn Smith, Ph.D. for being awarded the Advocacy Award! 😀 #ACNP2026 @SmithGwenn
Please click here ➡️ tinyurl.com/2s3ut4v7 to view the acceptance video by Gwenn Smith Ph.D. for the Advocacy Award.
Please click here ➡️ tinyurl.com/2s3ut4v7 to view the acceptance video by Gwenn Smith Ph.D. for the Advocacy Award.
Reposted by Keri Martinowich
Let's compare our world models. I find that different people seem to have rather distinct internal world models. E.g. I personally have neither visual imagination nor an inner voice, found it weird others do. Here is a quick google forms to check idea:
docs.google.com/forms/d/e/1F...
docs.google.com/forms/d/e/1F...
World-models in your head
Talking with a lot of people, they have rather shocking different kinds of world-models. I believe that people have somewhat specialized simulators. Let me list some and then give you the chance to ad...
docs.google.com
November 24, 2025 at 1:31 AM
Let's compare our world models. I find that different people seem to have rather distinct internal world models. E.g. I personally have neither visual imagination nor an inner voice, found it weird others do. Here is a quick google forms to check idea:
docs.google.com/forms/d/e/1F...
docs.google.com/forms/d/e/1F...
Reposted by Keri Martinowich
NIH extends the Oct-Nov deadlines to Dec 8, 2025 drugmonkey.wordpress.com/2025/11/24/n...
NIH extends the Oct-Nov deadlines to Dec 8, 2025
The NIH has issued a Notice (NOT-OD-26-012) which expands upon the prior warning (NOT-OD-26-005) about extending the current submission deadlines. It seems to be quite comprehensive. All grant appl…
drugmonkey.wordpress.com
November 24, 2025 at 8:19 PM
NIH extends the Oct-Nov deadlines to Dec 8, 2025 drugmonkey.wordpress.com/2025/11/24/n...
Reposted by Keri Martinowich
“Summary statements will be simplified. Narrative paragraphs summarizing committee discussion will not be used. Instead, summaries will have a sentence describing the degree of consensus in the committee vote, plus bullets listing the main score driving points.” FYI
Updated guidance on NIH grant application due dates (10/1/2025-12/5/2025), along with some other Info. grants.nih.gov/grants/guide...
NOT-OD-26-012: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations NOT-...
grants.nih.gov
November 24, 2025 at 6:25 PM
“Summary statements will be simplified. Narrative paragraphs summarizing committee discussion will not be used. Instead, summaries will have a sentence describing the degree of consensus in the committee vote, plus bullets listing the main score driving points.” FYI
Reposted by Keri Martinowich
Information about the roles of each author of a paper can help to build trust, integrity and responsible research assessment
go.nature.com/4a7THFd
go.nature.com/4a7THFd
A ten-year drive to credit authors for their work — and why there’s still more to do
Information about the roles of each author of a paper can help to build trust, integrity and responsible research assessment. Coordinated efforts are needed to consolidate progress.
go.nature.com
November 24, 2025 at 4:58 PM
Information about the roles of each author of a paper can help to build trust, integrity and responsible research assessment
go.nature.com/4a7THFd
go.nature.com/4a7THFd
Reposted by Keri Martinowich
So excited to see our latest paper out today in @natcomms.nature.com! Studies led by the amazing @margestelzner.bsky.social www.nature.com/articles/s41.... VTA GABA neurons have a unique role in economic decision making - they integrate reward seeking motivation and the current cost of seeking
Ventral tegmental area GABA neurons integrate positive and negative valence - Nature Communications
The role of ventral tegmental area GABA neurons in behavior is unclear. Here, authors show that VTA GABA but not dopamine neurons integrate positive and negative valence to encode motivational conflic...
www.nature.com
November 24, 2025 at 4:18 PM
So excited to see our latest paper out today in @natcomms.nature.com! Studies led by the amazing @margestelzner.bsky.social www.nature.com/articles/s41.... VTA GABA neurons have a unique role in economic decision making - they integrate reward seeking motivation and the current cost of seeking
Reposted by Keri Martinowich
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia - Nature Neuroscience
Lecanemab, a leading therapy for Alzheimer’s disease, induces an Fc-mediated transcriptional program in human microglia, linked to osteopontin and enhanced plaque phagocytosis, suggesting alternative ...
www.nature.com
November 24, 2025 at 2:35 PM
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Keri Martinowich
Had an amazing visit to the NIEHS to present the lab's research. The depth of expertise in #epigenetics and chromatin biology there is remarkable. Big thanks to @jxhoffman.bsky.social for hosting me. 🧪
November 22, 2025 at 2:17 PM
Had an amazing visit to the NIEHS to present the lab's research. The depth of expertise in #epigenetics and chromatin biology there is remarkable. Big thanks to @jxhoffman.bsky.social for hosting me. 🧪
Reposted by Keri Martinowich
popEVE is out in Nature Genetics! 🎉
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
Proteome-wide model for human disease genetics
Nature Genetics - popEVE is a proteome-wide deep generative model to identify and predict pathogenicity of missense mutations causing genetic disorders.
rdcu.be
November 24, 2025 at 1:35 PM
popEVE is out in Nature Genetics! 🎉
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
Reposted by Keri Martinowich
Check out the November 2025 issue of Trends in Neurosciences:
www.cell.com/issue/S0166-...
On the cover: Interacting cortico-basal ganglia-thalamocortical loops in behavioral control, by Fred Hamker, Javier Baladron & Lieneke Janssen
www.cell.com/trends/neuro...
www.cell.com/issue/S0166-...
On the cover: Interacting cortico-basal ganglia-thalamocortical loops in behavioral control, by Fred Hamker, Javier Baladron & Lieneke Janssen
www.cell.com/trends/neuro...
November 24, 2025 at 1:52 PM
Check out the November 2025 issue of Trends in Neurosciences:
www.cell.com/issue/S0166-...
On the cover: Interacting cortico-basal ganglia-thalamocortical loops in behavioral control, by Fred Hamker, Javier Baladron & Lieneke Janssen
www.cell.com/trends/neuro...
www.cell.com/issue/S0166-...
On the cover: Interacting cortico-basal ganglia-thalamocortical loops in behavioral control, by Fred Hamker, Javier Baladron & Lieneke Janssen
www.cell.com/trends/neuro...
My kid explaining over breakfast that I probably don't get 6-7 because Gen-X is not one, not two, but actually three generations removed. How's your Monday?
November 24, 2025 at 1:49 PM
My kid explaining over breakfast that I probably don't get 6-7 because Gen-X is not one, not two, but actually three generations removed. How's your Monday?
Reposted by Keri Martinowich
Re: recent studies about neural coding being high-dimensional, and I thought I'd contribute our recent preprint: www.researchsquare.com/article/rs-1...
@eliezyer.bsky.social and I will do a full thread on this when the paper comes out, but his work shows it's (as usual) a little more complicated 🧵
@eliezyer.bsky.social and I will do a full thread on this when the paper comes out, but his work shows it's (as usual) a little more complicated 🧵
November 24, 2025 at 1:12 PM
Re: recent studies about neural coding being high-dimensional, and I thought I'd contribute our recent preprint: www.researchsquare.com/article/rs-1...
@eliezyer.bsky.social and I will do a full thread on this when the paper comes out, but his work shows it's (as usual) a little more complicated 🧵
@eliezyer.bsky.social and I will do a full thread on this when the paper comes out, but his work shows it's (as usual) a little more complicated 🧵
Reposted by Keri Martinowich
We are looking for a new Chair of our Department of Imaging. Please RP! www.nejmcareercenter.org/job/940419/c... #imaging #radiology
Chair of the Department of Imaging - Los Angeles, California job with Cedars Sinai Medical Center | 940419
Cedars-Sinai Health System seeks a collaborative and strategic leader to serve as chair of the Department of Imaging
www.nejmcareercenter.org
November 23, 2025 at 9:14 PM
We are looking for a new Chair of our Department of Imaging. Please RP! www.nejmcareercenter.org/job/940419/c... #imaging #radiology
Reposted by Keri Martinowich
Calvert Cliffs - beautiful anyway - but the fossil and shark teeth hunting are also amazing fun 🤩
November 23, 2025 at 11:01 PM
Calvert Cliffs - beautiful anyway - but the fossil and shark teeth hunting are also amazing fun 🤩
Reposted by Keri Martinowich
Fluorescent microscopy is beautiful🔬✨
People who are pushing the envelope will not only uncover new biology, but captivate (and entice!) new generations of brilliant minds to love biology the same way we do
People who are pushing the envelope will not only uncover new biology, but captivate (and entice!) new generations of brilliant minds to love biology the same way we do
November 23, 2025 at 9:02 PM
Fluorescent microscopy is beautiful🔬✨
People who are pushing the envelope will not only uncover new biology, but captivate (and entice!) new generations of brilliant minds to love biology the same way we do
People who are pushing the envelope will not only uncover new biology, but captivate (and entice!) new generations of brilliant minds to love biology the same way we do
Reposted by Keri Martinowich
Astrazeneca US onshoring rare diseases
November 23, 2025 at 9:16 PM
Astrazeneca US onshoring rare diseases
Calvert Cliffs - beautiful anyway - but the fossil and shark teeth hunting are also amazing fun 🤩
November 23, 2025 at 11:01 PM
Calvert Cliffs - beautiful anyway - but the fossil and shark teeth hunting are also amazing fun 🤩
Turbo 3K mystery puzzle 🧩 - highly recommend, really fun!
November 23, 2025 at 1:13 PM
Turbo 3K mystery puzzle 🧩 - highly recommend, really fun!
Reposted by Keri Martinowich
Origins of language, one of humanity’s most distinctive traits, may be best explained as a unique convergence of multiple capacities each with its own evolutionary history, involving intertwined roles of biology & culture. This framing can expand research horizons. A 🧵 on our @science.org paper.🧪1/n
What enables human language? A biocultural framework
Explaining the origins of language is a key challenge in understanding ourselves as a species. We present an empirical framework that draws on synergies across fields to facilitate robust studies of l...
www.science.org
November 23, 2025 at 11:54 AM
Origins of language, one of humanity’s most distinctive traits, may be best explained as a unique convergence of multiple capacities each with its own evolutionary history, involving intertwined roles of biology & culture. This framing can expand research horizons. A 🧵 on our @science.org paper.🧪1/n
Reposted by Keri Martinowich
How often have you heard that schizophrenia is “80% genetic”?
That number is almost certainly too high because it comes from twin studies that overestimate heritabilty.
Great explainer of this phenomenon👇
#neuroskyence #neuroscience #psychiatry
That number is almost certainly too high because it comes from twin studies that overestimate heritabilty.
Great explainer of this phenomenon👇
#neuroskyence #neuroscience #psychiatry
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 23, 2025 at 11:49 AM
How often have you heard that schizophrenia is “80% genetic”?
That number is almost certainly too high because it comes from twin studies that overestimate heritabilty.
Great explainer of this phenomenon👇
#neuroskyence #neuroscience #psychiatry
That number is almost certainly too high because it comes from twin studies that overestimate heritabilty.
Great explainer of this phenomenon👇
#neuroskyence #neuroscience #psychiatry