Konrad Kording
@kordinglab.bsky.social
@Penn Prof, deep learning, brains, #causality, rigor, http://neuromatch.io, Transdisciplinary optimist, Dad, Loves outdoors, 🦖 , c4r.io
I love this so much. After pushback on his recent "Medicine is the only field that reaches 6 sigma" with "my field, psychophysics is so awesome" he posted this. Hurray all Psychophysicists. LETS CELEBRATE PSYCHOPHYSICS. An island of large effects is us!
Psychophysics is a human-facing science with interventions arguably more robust than medicine.
1000 Hurts
Psychophysics is a human-facing science with interventions arguably more robust than medicine.
www.argmin.net
January 15, 2026 at 4:14 PM
I love this so much. After pushback on his recent "Medicine is the only field that reaches 6 sigma" with "my field, psychophysics is so awesome" he posted this. Hurray all Psychophysicists. LETS CELEBRATE PSYCHOPHYSICS. An island of large effects is us!
Reposted by Konrad Kording
@kordinglab.bsky.social and I ran a summer school last year to help young profs (<5 yrs) in systems/comp neuro thrive.
compneurosci.com/Neuro4Pros/i...
It was great! Now we want to know if you'd be interested in participating if we did this again this year?
Let us know!
compneurosci.com/Neuro4Pros/i...
It was great! Now we want to know if you'd be interested in participating if we did this again this year?
Let us know!
Neuro4Pros summer school
Neuroscience Leadership Training
compneurosci.com
January 15, 2026 at 3:51 PM
@kordinglab.bsky.social and I ran a summer school last year to help young profs (<5 yrs) in systems/comp neuro thrive.
compneurosci.com/Neuro4Pros/i...
It was great! Now we want to know if you'd be interested in participating if we did this again this year?
Let us know!
compneurosci.com/Neuro4Pros/i...
It was great! Now we want to know if you'd be interested in participating if we did this again this year?
Let us know!
Another cool paper from Iran: nature.com/articles/s41... Prenatal stress makes mouse offspring more anxious, hyperactive, forgetful, and more drawn to morphine while laterodorsal tegmentum cholinergic neurons become hyperexcitable. From Kerman, a city with reported violent crackdowns on protests.
The hyperexcitability of laterodorsal tegmentum cholinergic neurons accompanies adverse behavioral and cognitive outcomes of prenatal stress - Scientific Reports
Scientific Reports - The hyperexcitability of laterodorsal tegmentum cholinergic neurons accompanies adverse behavioral and cognitive outcomes of prenatal stress
nature.com
January 15, 2026 at 2:18 PM
Another cool paper from Iran: nature.com/articles/s41... Prenatal stress makes mouse offspring more anxious, hyperactive, forgetful, and more drawn to morphine while laterodorsal tegmentum cholinergic neurons become hyperexcitable. From Kerman, a city with reported violent crackdowns on protests.
An open source rodent forelimb paradigm cell.com/heliyon/full... Cool work from Tehran!
An open-source automated rodent paradigm for forelimb movement in motor control, executive functions, and learning studies
Reaching tasks are frequently employed in studies investigating cognitive functions,
motor control, and brain-computer interfaces. The center-out task, a subtype of reaching
movement, is widely utiliz...
cell.com
January 14, 2026 at 2:30 PM
An open source rodent forelimb paradigm cell.com/heliyon/full... Cool work from Tehran!
Nice writeup. I mostly agree. However in psychophysics effect sizes (at least main effects) tend to be crazy large. Like too big to even put it into numbers large. Eg look at this nature.com/articles/nat... the main effects is slope greater zero.
Client Challenge
nature.com
January 12, 2026 at 5:05 PM
Nice writeup. I mostly agree. However in psychophysics effect sizes (at least main effects) tend to be crazy large. Like too big to even put it into numbers large. Eg look at this nature.com/articles/nat... the main effects is slope greater zero.
Into neuromorphic? Consider the excellent nengo summer school www.nengo.ai/summer-school/
Nengo Summer School
Nengo is a graphical and scripting based Python package for simulating large-scale neural networks.
www.nengo.ai
January 12, 2026 at 4:06 PM
Into neuromorphic? Consider the excellent nengo summer school www.nengo.ai/summer-school/
Our paper that argues that the physical domain with its slow scaling should eventually dominate the fast scaling intelligence domain is now live on ssrn papers.ssrn.com/sol3/papers....
papers.ssrn.com
January 12, 2026 at 2:07 PM
Our paper that argues that the physical domain with its slow scaling should eventually dominate the fast scaling intelligence domain is now live on ssrn papers.ssrn.com/sol3/papers....
Why is it real fun in a mosh pit? It is hard to see normative nor mechanistic reasons.
January 11, 2026 at 3:41 AM
Why is it real fun in a mosh pit? It is hard to see normative nor mechanistic reasons.
This is very cool. Much faster DSA. Although we still don't know what DSA findings actually mean about brains.
Wanna compare dynamics across neural data, RNNs, or dynamical systems? We got a fast and furious method🏎️
The 1st preprint of my PhD 🥳 fast dynamical similarity analysis (fastDSA):
📜: arxiv.org/abs/2511.22828
💻: github.com/CMC-lab/fast...
I’ll be @cosynemeeting.bsky.social - happy to chat 😉
The 1st preprint of my PhD 🥳 fast dynamical similarity analysis (fastDSA):
📜: arxiv.org/abs/2511.22828
💻: github.com/CMC-lab/fast...
I’ll be @cosynemeeting.bsky.social - happy to chat 😉
January 8, 2026 at 5:17 PM
This is very cool. Much faster DSA. Although we still don't know what DSA findings actually mean about brains.
Reposted by Konrad Kording
Pleased to have finally ported our lab website to a github powered Jekyll site! With great thanks to @kordinglab.bsky.social whose template was quite easy to convert. www.the-ecg.org (some texts still WIP)
Embodied Computation Group
The Embodied Computation Group is a multidisciplinary research lab located at Aarhus University and Cambridge Psychiatr...
www.the-ecg.org
January 6, 2026 at 11:14 AM
Pleased to have finally ported our lab website to a github powered Jekyll site! With great thanks to @kordinglab.bsky.social whose template was quite easy to convert. www.the-ecg.org (some texts still WIP)
Reposted by Konrad Kording
Published @cp-trendscognsci.bsky.social with @drewlinsley.bsky.social & @tonyfeng.bsky.social: As vision models scale to human/superhuman accuracy, they’re becoming worse models of primate vision—benchmark engineering isn’t neuroscience. @carneyinstitute.bsky.social @browncopsy.bsky.social
Better artificial intelligence does not mean better models of biology
Deep neural networks (DNNs) once showed increasing alignment with primate perception
as they improved on vision benchmarks, raising hopes that advances in artificial intelligence
(AI) would naturally ...
cell.com
January 5, 2026 at 3:33 PM
Published @cp-trendscognsci.bsky.social with @drewlinsley.bsky.social & @tonyfeng.bsky.social: As vision models scale to human/superhuman accuracy, they’re becoming worse models of primate vision—benchmark engineering isn’t neuroscience. @carneyinstitute.bsky.social @browncopsy.bsky.social
Reposted by Konrad Kording
Are we ready to tackle perceptual segmentation of natural scenes?
Finally the review on perceptual segmentation you’ve been waiting for!
www.sciencedirect.com/science/arti...
Finally the review on perceptual segmentation you’ve been waiting for!
www.sciencedirect.com/science/arti...
January 5, 2026 at 12:10 PM
Are we ready to tackle perceptual segmentation of natural scenes?
Finally the review on perceptual segmentation you’ve been waiting for!
www.sciencedirect.com/science/arti...
Finally the review on perceptual segmentation you’ve been waiting for!
www.sciencedirect.com/science/arti...
Substack makes it super easy to test different titles against one another. I experimented for a while. I did learn something through testing with a range of titles over a few months. Whoever reads my substack posts does not care one bit what my posts are titled as.
January 3, 2026 at 8:12 PM
Substack makes it super easy to test different titles against one another. I experimented for a while. I did learn something through testing with a range of titles over a few months. Whoever reads my substack posts does not care one bit what my posts are titled as.
2025: What I built, what shifted my priors, and why I'm optimistic open.substack.com/pub/kording/...
2025: A Good Year for Reliability
What I built, what shifted my priors, and why I'm optimistic. (Pic from E11Bio)
open.substack.com
January 3, 2026 at 5:50 PM
2025: What I built, what shifted my priors, and why I'm optimistic open.substack.com/pub/kording/...
Reports of widespread protests at universities and beyond across Iran. Thinking of students and scholars there, and wishing them safety and a brighter future.
January 2, 2026 at 5:31 PM
Reports of widespread protests at universities and beyond across Iran. Thinking of students and scholars there, and wishing them safety and a brighter future.
Reposted by Konrad Kording
Amid a tumultuous year, researchers opined on policy changes, funding uncertainty, scientific trends and AI’s impact. Read essays by @tuthill.bsky.social, @bingbrunton.bsky.social, @kordinglab.bsky.social, @eboyden3.bsky.social, @docbecca.bsky.social, and Tim Requarth.
#neuroskyence
bit.ly/44NL9jy
#neuroskyence
bit.ly/44NL9jy
The Transmitter’s favorite essays of 2025
Throughout a tumultuous year in science, researchers opined on policy changes and funding uncertainty, as well as scientific trends and the impact of artificial-intelligence tools on the field.
bit.ly
December 29, 2025 at 4:01 PM
Amid a tumultuous year, researchers opined on policy changes, funding uncertainty, scientific trends and AI’s impact. Read essays by @tuthill.bsky.social, @bingbrunton.bsky.social, @kordinglab.bsky.social, @eboyden3.bsky.social, @docbecca.bsky.social, and Tim Requarth.
#neuroskyence
bit.ly/44NL9jy
#neuroskyence
bit.ly/44NL9jy
While much of machine learning is retrospective (learn the past distribution) learning in biology is prospective (learn for the future) - here we discuss some implications for neuroscience (with @tdverstynen.bsky.social, Josh Vogelstein, Pratik Chaudhari): www.cell.com/neuron/abstr...
Toward a science of prospective learning
In a constantly changing world, effective intelligence means anticipating future changes.
Kording et al. argue that organisms adapt prospectively, modeling how environments
and capabilities of the org...
www.cell.com
December 22, 2025 at 8:47 PM
While much of machine learning is retrospective (learn the past distribution) learning in biology is prospective (learn for the future) - here we discuss some implications for neuroscience (with @tdverstynen.bsky.social, Josh Vogelstein, Pratik Chaudhari): www.cell.com/neuron/abstr...
Reposted by Konrad Kording
So great! To paraphrase @lucinauddin.bsky.social: If we (researchers) aren't clear, it has downstream effects on translation (eg to) psychiatry. We must strive not just to publish papers, but to be clear!
𝗕𝗿𝗮𝗶𝗻 𝗻𝗲𝘁𝘄𝗼𝗿𝗸𝘀, 𝘄𝗵𝗮𝘁 𝗮𝗿𝗲 𝘁𝗵𝗲𝘆?
@lucinauddin.bsky.social explains many of the challenges and controversies! Great discussion too.
Check out the latest Neuroscience & Philosophy Salon.
youtu.be/pP5swFPR0Ns
@lucinauddin.bsky.social explains many of the challenges and controversies! Great discussion too.
Check out the latest Neuroscience & Philosophy Salon.
youtu.be/pP5swFPR0Ns
Prof. Lucina Uddin from UCLA discusses her views on brain networks as studied with functional MRI
YouTube video by Neuroscience & Philosophy Salon
youtu.be
December 16, 2025 at 10:31 PM
So great! To paraphrase @lucinauddin.bsky.social: If we (researchers) aren't clear, it has downstream effects on translation (eg to) psychiatry. We must strive not just to publish papers, but to be clear!
Reposted by Konrad Kording
How might AI shape the future of work? @kordinglab.bsky.social (Neuroscience) & @imarinescu.bsky.social (@pennsp2.bsky.social) have developed an interactive model that incorporates assumptions from both their fields to predict how AI will affect wages, jobs & the overall economy tinyurl.com/49b7vzmm
December 15, 2025 at 6:59 PM
How might AI shape the future of work? @kordinglab.bsky.social (Neuroscience) & @imarinescu.bsky.social (@pennsp2.bsky.social) have developed an interactive model that incorporates assumptions from both their fields to predict how AI will affect wages, jobs & the overall economy tinyurl.com/49b7vzmm
Reposted by Konrad Kording
In which @kordinglab.bsky.social argues LLMs are more like an electric motor than a drill, and starts to build a drill for scientific research.
open.substack.com/pub/kording/...
open.substack.com/pub/kording/...
The Electric Motor and the Drill - we use AI in the wrong way
Power tools are better than general purpose tools for most applications, my science planning app planyourscience.com is a result of this philosophy
open.substack.com
December 5, 2025 at 3:54 PM
In which @kordinglab.bsky.social argues LLMs are more like an electric motor than a drill, and starts to build a drill for scientific research.
open.substack.com/pub/kording/...
open.substack.com/pub/kording/...
New post: The Electric Motor and the Drill
LLM chat bots are like electric motors: can do anything, bad at everything. The problem is UI/UX. AI should be more like power tools. I built a science planner around this philosophy. 10,000 scientists use it now. open.substack.com/pub/kording/...
LLM chat bots are like electric motors: can do anything, bad at everything. The problem is UI/UX. AI should be more like power tools. I built a science planner around this philosophy. 10,000 scientists use it now. open.substack.com/pub/kording/...
The Electric Motor and the Drill - we use AI in the wrong way
Power tools are better than general purpose tools for most applications, my science planning app planyourscience.com is a result of this philosophy
open.substack.com
December 5, 2025 at 2:35 PM
New post: The Electric Motor and the Drill
LLM chat bots are like electric motors: can do anything, bad at everything. The problem is UI/UX. AI should be more like power tools. I built a science planner around this philosophy. 10,000 scientists use it now. open.substack.com/pub/kording/...
LLM chat bots are like electric motors: can do anything, bad at everything. The problem is UI/UX. AI should be more like power tools. I built a science planner around this philosophy. 10,000 scientists use it now. open.substack.com/pub/kording/...
Reposted by Konrad Kording
I'm biased, but I think Neuromatch has done a lot of good in helping make computational science education accessible. Please consider donating to help us continue!
Today is #GivingTuesday! Join us in helping to make computational science education accessible to everyone, everywhere!
Since, 2021, Neuromatch Academy and Climatematch Academy have supported nearly 14,000 learners from 135 countries.
Your support makes this possible.
neuromatch.io/donate/
Since, 2021, Neuromatch Academy and Climatematch Academy have supported nearly 14,000 learners from 135 countries.
Your support makes this possible.
neuromatch.io/donate/
December 2, 2025 at 8:25 PM
I'm biased, but I think Neuromatch has done a lot of good in helping make computational science education accessible. Please consider donating to help us continue!
How I contributed to rejecting one of my favorite papers of all times, Yes, I teach it to students daily, and refer to it in lots of papers. Sorry. open.substack.com/pub/kording/...
How I contributed to rejecting one of my favorite papers of all time
I believe we should talk about the mistakes we make.
open.substack.com
December 2, 2025 at 1:27 AM
How I contributed to rejecting one of my favorite papers of all times, Yes, I teach it to students daily, and refer to it in lots of papers. Sorry. open.substack.com/pub/kording/...
Reposted by Konrad Kording
PlanYourScience.com is live! 🔥
Professors: Running a class with research projects? You and your TAs will never have enough time to carefully guide every student through gap, hypotheses, experiment, data analysis, etc. I think every larger course running research projects should use this.
I think almost all scientific projects should be planned carefully. And I think an app can dramatically improve that. So I wrote an app for that (free for now, if you can fund this let me know). I tested it quite a bit (>8000 users in beta so far). try it: planyourscience.com
December 1, 2025 at 8:12 PM
PlanYourScience.com is live! 🔥
Let's compare our world models. I find that different people seem to have rather distinct internal world models. E.g. I personally have neither visual imagination nor an inner voice, found it weird others do. Here is a quick google forms to check idea:
docs.google.com/forms/d/e/1F...
docs.google.com/forms/d/e/1F...
World-models in your head
Talking with a lot of people, they have rather shocking different kinds of world-models. I believe that people have somewhat specialized simulators. Let me list some and then give you the chance to ad...
docs.google.com
November 24, 2025 at 1:31 AM
Let's compare our world models. I find that different people seem to have rather distinct internal world models. E.g. I personally have neither visual imagination nor an inner voice, found it weird others do. Here is a quick google forms to check idea:
docs.google.com/forms/d/e/1F...
docs.google.com/forms/d/e/1F...