Victor Tatarskiy
@greenrat.bsky.social
1.8K followers 3.2K following 3.7K posts
Cell biologist and a cat person. I mainly study CDK8/19, cell cycle regulation, and new anti-cancer drug candidates. https://orcid.org/0000-0002-9080-5683
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greenrat.bsky.social
Hey! I'm Victor. I'm a cell and cancer biologist. My lab mainly studies CDK8/19, cell cycle regulation, and new anti-cancer drug candidates. I also love history and DnD, so don't be surprised if I follow you. I'm Russian (sorry) with family in the US, so there is occasional politics.
greenrat.bsky.social
In Russia, engineers are also the most fertile ground for crackpot theories. If you encounter a crackpot theory, it's almost always from someone with a PhD in "technical sciences" (aka engineering)
greenrat.bsky.social
Yeah, a lot of people in US admin, do look and sound like aliens. Bald Lizard Man, Red Croacky Disease Thing, Puppy Eater....
greenrat.bsky.social
isn't it a major OpenAI backer? :)))
EdZitronFace.JPG
greenrat.bsky.social
Don't know about this particular drug, but if there would be drugs supporting patients with cahexia it would be so important. This is a terrible symptom which leads to very fast decline, preventing treatments because the patient is to frail for it.
natrevdrugdiscov.nature.com
Cancer cachexia contender enters first pivotal trial www.nature.com/articles/d41...

Can Pfizer’s appetite-boosting antibody ponsegromab address a cancer-induced wasting syndrome — and help patients live longer in the process? Find out more in this news article #CancerGrandChallenges
Screenshot of story
greenrat.bsky.social
you mean Florida delusional? :))
Reposted by Victor Tatarskiy
dereklowe.bsky.social
Oh, the “vomiting ferret” model is absolutely a real thing - I’ve encountered it in my own drug discovery career.

They’re one of the smallest animals that show this response- weirdly, rodents can’t do it at all.
greenrat.bsky.social
ferrets are surprisingly good model for a lot of things, especially for lung diseases. GM ferrets models are used for cystic fibrosis and my colleagues were trying to make such a model. It's much harder then mice of course - they breed seasonally and not the friendliest of animals etc.
Reposted by Victor Tatarskiy
niko-kukushkin.bsky.social
My book, One Hand Clapping, landed in the NYU bookstore! Preorder yours today! Out everywhere Oct 21

www.barnesandnoble.com/w/one-hand-c...
greenrat.bsky.social
o you have 13+ years of a backlog of this to watch!
greenrat.bsky.social
Tregs are the asshole teachers of T cells not letting anyone have fun
greenrat.bsky.social
I think they are yellow. Brownish is also common, yes :)
Reposted by Victor Tatarskiy
poli.sisti.ca
Thread of things I'm learning as I read The Discovery of Insulin by Michael Bliss
Book cover, in the Special Centenary Edition with a forward by Alison Li.
greenrat.bsky.social
Yeah, I figured that non-mammalian people would know of these techniques the best :))
greenrat.bsky.social
Ha! That's logical, but never would have thought about it!
greenrat.bsky.social
I saw this protocol, too! The one I tried is more convinjent to get a lot of the concentrated antibody, I think
greenrat.bsky.social
This is actually my intention - getting a good antibody for IF. We have a good Cell Signaling ab for FACS and WB but it doesn't work well in IHC. I would probably give it one more clean, concentrate and we will be golden. Also of course for CO-IP and CHIP where it would be much cheaper