In vivo chimeric antigen receptor (CAR)-T cell engineering uses targeted delivery systems to generate CAR-T cells directly in patients, bypassing ex vivo manufacturing. This Review examines emerging viral and lipid nanoparticle platforms, early clinical proof of concept and potential applications beyond cancer.

The family of voltage-gated sodium channels (NaVs) are key mediators of electrical signals in excitable cells. In their broad Review, Waxman and colleagues discuss the potential to target NaVs in neurons, cardiac and skeletal muscle cells for the treatment of various neurological and muscular disorders.

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DNA damage to the somatic genome has been identified as a major cause of ageing. This Perspective provides an overview of current understanding of the role of genome instability in the ageing process and assesses therapeutic strategies targeting the cellular response to DNA damage to delay ageing and prevent associated diseases.

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RNA can be chemically modified by enzymes such as methyltransferases to regulate RNA metabolism, gene expression and other biological processes. This Review mainly focuses on the disease-relevant N6-m...

Lynda Stuart, president and CEO of the newly launched Fund for Science and Technology, discusses the philanthropic organization’s plans for bioscience and AI.

The potential of microsystem technologies to accelerate the development and clinical translation of immunotherapies is now being realized. This Review discusses recent advances in microsystem technolo...

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CD8 T cells and natural killer (NK) cells play a key role in cancer immunosurveillance. However, their anticancer activity is rapidly diminished in the tumour microenvironment, associated with a decli...