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Reposted by Juha Hulmi

Sakari Mäntyselkä @smantyselka.bsky.social · 1d

I am pleased to share our new research article (in press version) entitled Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth. Link in the comments. 1/3 #myoblue #SkeletalMuscle

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Juha Hulmi @juhahulmi.bsky.social · 2d

Infograph:

Juha Hulmi @juhahulmi.bsky.social · 2d

Great work from my PhD student:
@smantyselka.bsky.social

Juha Hulmi @juhahulmi.bsky.social · 2d

New study from our lab! Human muscle cells incorporate glucose into proteins, RNA, and lipids, and anabolic stimulation further increased these processes. Resistance training increased metabolites and enzymes of these processes, e.g., PHGDH, which was shown to be anabolic.
tinyurl.com/2744e22s

Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth | American Journal of Physiology-Cell Physiology | American Physiological Society

Skeletal muscle is the main consumer of glucose after a mixed meal, and resistance exercise further increases muscle glucose uptake. Emerging evidence suggests that glucose uptake in muscles is not on...

tinyurl.com

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Juha Hulmi @juhahulmi.bsky.social · 5d

Elite strength and physique athletes differ in sport-specific muscle size and power. In these athletes, the muscle size contributes to muscle strength. Finally, females have better strength endurance than males, independent of the training background. tinyurl.com/39dfz977

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Juha Hulmi @juhahulmi.bsky.social · 10d

Researchers investigated muscle memory of exercise in mice and the results suggest that skeletal muscle retains a metabolic memory of endurance exercise, which enhances adaptations following retraining:
journals.physiology.org/doi/full/10....

Muscle memory of exercise optimizes mitochondrial metabolism to support skeletal muscle growth | American Journal of Physiology-Cell Physiology | American Physiological Society

Exercise protects against age-related declines in skeletal muscle mass and function while improving overall health. Exercise can also prime long-term muscle health to enhance adaptations upon exercise...

journals.physiology.org

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Juha Hulmi @juhahulmi.bsky.social · 13d

Our findings provide new insight into the metabolomic signature of low energy availability (LEA) and support metabolomics as a tool for early detection of LEA.
physoc.onlinelibrary.wiley.com/doi/10.14814...

Metabolic signature of short‐term low energy availability

Exposure to low energy availability (LEA) can potentially detrimentally affect athletes' health and performance. Timely identification is crucial, yet its detection is often delayed until severe symp...

physoc.onlinelibrary.wiley.com

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Juha Hulmi @juhahulmi.bsky.social · 19d

2 min video of our recent study in J Physiol. physoc.onlinelibrary.wiley.com/doi/10.1113/...

The link below:

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Reposted by Juha Hulmi

Jyväskylän yliopisto | University of Jyväskylä, JYU @uniofjyvaskyla.bsky.social · Sep 11

Why do some progress faster in resistance training? 💪
How do genetics and physiology shape training responses? 🏋️‍♀️
Join us in Jyväskylä, Finland, Nov 19–21 for the Inter-Individual Variation in Resistance Training Responses Conference.
www.jyu.fi/en/news/indi...

Individual responses to exercise training as the main theme of an international conference in Jyväskylä, November 19–21, 2025

Why do some people progress faster in exercise training than others? How can training responses be predicted, and how does genetics influence the outcomes of training? These questions are addressed at the international coaching science conference.

www.jyu.fi

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Juha Hulmi @juhahulmi.bsky.social · Sep 10

Thanks for the comment @atanas-g-atanasov.bsky.social. That was our goal in our proof-of-concept research.

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Reposted by Juha Hulmi

Craig A. Goodman @craigagoodman1.bsky.social · Jul 8

Combined angiogenic and hypertrophic gene therapy enhances skeletal muscle growth
journals.physiology.org/doi/abs/10.1...

Combined angiogenic and hypertrophic gene therapy enhances skeletal muscle growth | American Journal of Physiology-Cell Physiology | American Physiological Society

Skeletal muscle atrophy in response to pathophysiological stimuli or disuse includes loss of muscle mass and strength. Targeting signaling pathways regulating muscle growth can counteract muscle loss,...

journals.physiology.org

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Reposted by Juha Hulmi

Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · Sep 6

Sarcopenia is accelerated loss of skeletal muscle mass and function commonly, but not exclusively, associated with advancing age. It is observed across many species including humans in whom it can lead to decline in physical function and mobility. https://www.nature.c...

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Juha Hulmi @juhahulmi.bsky.social · Sep 6

physoc.onlinelibrary.wiley.com/doi/10.1113/...

Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training

Abstract figure legend Human skeletal muscle proteome response was investigated after 10-week resistance training (RT1) followed by 10-week training cessation (i.e. detraining, DT), and finally, 10-w...

physoc.onlinelibrary.wiley.com

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Juha Hulmi @juhahulmi.bsky.social · Sep 6

The authors discuss our recent article (link in comments) and its implications. Many questions remain to be elucidated. Muscle memory research is still in its early stages.

physoc.onlinelibrary.wiley.com/doi/10.1113/...
@jphysiol.bsky.social

What is next for the ‘muscle memory’ conundrum? Unresolved questions and future research directions

Click on the article title to read more.

physoc.onlinelibrary.wiley.com

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Reposted by Juha Hulmi

Abigail Mackey @abigailmackey1.bsky.social · Sep 5

An interesting read:
physoc.onlinelibrary.wiley.com/doi/10.1113/...

The state of mechanistic research in the evidence‐based medicine era: A sandwalk between triangulation and hierarchies

Click on the article title to read more.

physoc.onlinelibrary.wiley.com

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Reposted by Juha Hulmi

Kevin Hall @kevinh-phd.bsky.social · Aug 31

I truly enjoyed this discussion with Dr. Mike covering a range of topics on food, nutrition, and metabolism. We also discuss my reasons for leaving NIH and what’s needed to really improve nutrition science.

youtu.be/WBllzAb_vAk?...

“Why I Quit The NIH” | Nutrition Researcher Kevin Hall

YouTube video by Doctor Mike

youtu.be

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Reposted by Juha Hulmi

Juha Hulmi @juhahulmi.bsky.social · Jul 2

Conference: Inter-individual variation in exercise. Please join! The speakers are e.g.
@mackinprof.bsky.social, @abigailmackey1.bsky.social, M Bamman, T Hornberger, M Roberts, B Schoenfeld, M Perola, G Nader, E Sillanpää, A Hecksteden, W Derave, P Atherton, J Ahtiainen and me.
tinyurl.com/34xzsdss

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Juha Hulmi @juhahulmi.bsky.social · Aug 20

We showed that varying proximity-to-failure may not enhance short-term RT adaptations, but it allows RT with lower RPE. RIR accuracy was already good at baseline in trained individuals, but further improved by RT, supporting its use to guide training practices. link.springer.com/article/10.1...

Influence of Varying Proximity-to-Failure on Muscular Adaptations and Repetitions-in-Reserve Estimation Accuracy in Resistance-Trained Individuals - Journal of Science in Sport and Exercise

Purpose The effects of varying proximity-to-failure during a resistance training (RT) program remain undetermined. Hence, we explored the influence of varying proximity-to-failure on muscular adaptati...

link.springer.com

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Reposted by Juha Hulmi

The Journal of Physiology @jphysiol.bsky.social · Aug 7

Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆

See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️

physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Reposted by Juha Hulmi

Kevin Murach @kevinmurachphd.bsky.social · Aug 6

“Muscle memory theory: A critical evaluation” in @JPhysiol led by postdoc Nate Serrano physoc.onlinelibrary.wiley.com/doi/10.1113/...

Muscle memory theory: A critical evaluation

Click on the article title to read more.

physoc.onlinelibrary.wiley.com

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Reposted by Juha Hulmi

Martino V. Franchi @mvfranchi.bsky.social · Aug 2

This was a very cool project to work on!
More to come on this topic from our lab, I hope soon!

The Journal of Physiology @jphysiol.bsky.social · Jul 18

Martino V. Franchi et al. observed that previous short-term disuse dictates muscle #geneexpression and #physiological adaptations to subsequent resistance exercise 🧬 🚴‍♂️

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...