Craig A. Goodman
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craigagoodman1.bsky.social
Craig A. Goodman
@craigagoodman1.bsky.social
500 followers 270 following 680 posts
Senior Scientist that investigates the molecular mechanisms that regulate skeletal muscle mass and function in health and in various disease states. Protein synthesis, ubiquitin biology.
https://scholar.google.com.au/citations?user=ICAcUqUAAAAJ&hl=en
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craigagoodman1.bsky.social
Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles
onlinelibrary.wiley.com/doi/10.1002/...
Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles
Introduction Myostatin (MSTN), a transforming growth factor-beta (TGF-β) superfamily member, is an evolutionarily conserved negative regulator of skeletal muscle mass. Loss of MSTN commonly promotes.....
onlinelibrary.wiley.com
November 25, 2025 at 10:11 PM
craigagoodman1.bsky.social
Effect of Neuromuscular Electrical Stimulation for Older Critically Ill Patients in the ICU: A Randomized Controlled Trial
journals.lww.com/ccejournal/f...
journals.lww.com
November 25, 2025 at 10:09 PM
craigagoodman1.bsky.social
Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 25, 2025 at 7:54 AM
craigagoodman1.bsky.social
Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 24, 2025 at 8:23 PM
craigagoodman1.bsky.social
The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 24, 2025 at 8:22 PM
craigagoodman1.bsky.social
Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues
www.sciencedirect.com/science/chap...
Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues
Communication between tissues or different cells within a tissue is often a result of secreted molecules such as metabolites, lipids, nucleic acids, o…
www.sciencedirect.com
November 24, 2025 at 8:21 PM
craigagoodman1.bsky.social
MicroCT enables simultaneous longitudinal tracking of murine pancreatic cancer progression and cachexia
aacrjournals.org/cancerrescom...
MicroCT enables simultaneous longitudinal tracking of murine pancreatic cancer progression and cachexia
Abstract. Preclinical models of pancreatic ductal adenocarcinoma (PDAC) can greatly benefit from noninvasive imaging for evaluating disease progression and therapeutic response. Imaging approaches tha...
aacrjournals.org
November 24, 2025 at 8:17 PM
craigagoodman1.bsky.social
Ubiquitin Specific Peptidase 51 Exacerbates Skeletal Muscle Injury by Enhancing APAF1-Mediated Apoptosis and Pyroptosis
faseb.onlinelibrary.wiley.com/doi/10.1096/...
Ubiquitin Specific Peptidase 51 Exacerbates Skeletal Muscle Injury by Enhancing APAF1‐Mediated Apoptosis and Pyroptosis
In the Skeletal Muscle Injury (SMI) microenvironment, Ubiquitin Specific Peptidase 51 (USP51) expression is significantly upregulated, functional studies uncovered that USP51 interacts with and deubi...
faseb.onlinelibrary.wiley.com
November 23, 2025 at 7:31 PM
craigagoodman1.bsky.social
Profiling muscle mass, function and molecular signalling in females aged 18-80 years and their associations with sex hormones
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Profiling muscle mass, function and molecular signalling in females aged 18–80 years and their associations with sex hormones
Abstract figure legend This study mapped the trajectory of muscle ageing at the whole-body, whole-muscle and cellular level in 96 healthy females aged between 18 and 80 years old, whilst controlling ...
physoc.onlinelibrary.wiley.com
November 23, 2025 at 7:29 PM
Reposted by Craig A. Goodman
aups-physiology.bsky.social
🎉 Today’s the day! AuPS 2025 has officially begun in Parramatta!
We’re ready for four days of physiology, networking, new collaborations — and lots of science in action.
📸 Don’t forget to join the social media challenge!
Post publicly using #AuPS2025 #Physiology
November 23, 2025 at 2:06 AM
craigagoodman1.bsky.social
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells
www.nature.com/articles/s41...
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells - Nature Communications
Aging impairs the regenerative capacity of skeletal muscle stem cells. Here, the authors identify a stem cell-specific fibronectin splice variant and show that its cell-autonomous secretion through th...
www.nature.com
November 22, 2025 at 4:13 PM
craigagoodman1.bsky.social
FLASH: innovative integrated enzymatic-fluorescent labeling for automated muscle fiber typing, metabolic and morphometric analysis
skeletalmusclejournal.biomedcentral.com/articles/10....
FLASH: innovative integrated enzymatic-fluorescent labeling for automated muscle fiber typing, metabolic and morphometric analysis - Skeletal Muscle
Background Skeletal muscle is a dynamic tissue capable of structural and metabolic remodeling in response to physiological and pathological stimuli. These adaptations are central to understanding the ...
skeletalmusclejournal.biomedcentral.com
November 22, 2025 at 4:12 PM
craigagoodman1.bsky.social
Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice
molmed.biomedcentral.com/articles/10....
Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice - Molecular Medicine
Background Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogen...
molmed.biomedcentral.com
November 21, 2025 at 7:30 PM
craigagoodman1.bsky.social
Daily Myofibrillar Protein Synthesis Rates Do Not Differ During Interval Compared to Continuous Exercise Training Matched for Duration and Work in Healthy Young Men
journals.humankinetics.com/view/journal...
journals.humankinetics.com
November 21, 2025 at 7:27 PM
craigagoodman1.bsky.social
Effects of repetition duration on skeletal muscle hypertrophy in a rat model of resistance exercise
journals.physiology.org/doi/abs/10.1...
Effects of repetition duration on skeletal muscle hypertrophy in a rat model of resistance exercise | Journal of Applied Physiology | American Physiological Society
This study aimed to elucidate the effects of repetition duration (contraction duration for each repetition) of resistance exercise on muscle hypertrophy and its underlying mechanisms using a rat exerc...
journals.physiology.org
November 21, 2025 at 7:26 PM
craigagoodman1.bsky.social
Utilizing accelerated and delayed murine models of aging to address the "healthspan issue" - A review of skeletal muscle health
www.sciencedirect.com/science/arti...
Utilizing accelerated and delayed murine models of aging to address the “healthspan issue” – A review of skeletal muscle health
The gap between lifespan and healthspan is increasing globally, resulting in millions of individuals spending additional years burdened by frailty or …
www.sciencedirect.com
November 20, 2025 at 4:38 PM
craigagoodman1.bsky.social
HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com
November 20, 2025 at 4:37 PM
craigagoodman1.bsky.social
A Single Day of Reduced Activity Alters the Next Day's Transcriptomic and Metabolic Exercise Response
journals.physiology.org/doi/abs/10.1...
A Single Day of Reduced Activity Alters the Next Day’s Transcriptomic and Metabolic Exercise Response | American Journal of Physiology-Endocrinology and Metabolism | American Physiological Society
Regular aerobic exercise decreases the risk of metabolic diseases; however, reduced physical activity may attenuate these beneficial adaptations. This study investigated the influence of a single day ...
journals.physiology.org
November 18, 2025 at 4:26 PM
craigagoodman1.bsky.social
The canonical ER stress IRE1α/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia
www.embopress.org/doi/full/10....
The canonical ER stress IRE1α/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia | EMBO Molecular Medicine
imageimageThe study identifies the IRE1α/XBP1 arm of the ER stress-induced unfolded protein response as a key driver of skeletal muscle wasting and demonstrates that its genetic or pharmacological inh...
www.embopress.org
November 18, 2025 at 4:25 PM
craigagoodman1.bsky.social
Small-Molecule Targeting MuRF1 Protects Against Denervation-Induced Diaphragmatic Dysfunction: Underlying Molecular Mechanisms
onlinelibrary.wiley.com/doi/10.1002/...
Small‐Molecule Targeting MuRF1 Protects Against Denervation‐Induced Diaphragmatic Dysfunction: Underlying Molecular Mechanisms
Background Mechanical inactivity rapidly induces diaphragm muscle fibres' contractile dysfunction and atrophy. Diaphragm weakness can impair respiratory function, quality of life and increase risks ...
onlinelibrary.wiley.com
November 17, 2025 at 4:33 PM
craigagoodman1.bsky.social
mTORC1 regulates autophagosomal components recycling through SNX16 phosphorylation
www.pnas.org/doi/10.1073/...
mTORC1 regulates autophagosomal components recycling through SNX16 phosphorylation | PNAS
During autophagy, the contents enclosed within autophagosomes are degraded, while the outer membrane components are recycled from autolysosomes by ...
www.pnas.org
November 16, 2025 at 10:16 PM
craigagoodman1.bsky.social
Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8+ T cell-secreted CCL5
www.thelancet.com/journals/ebi...
Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8+ T cell-secreted CCL5
Our research has uncovered a muscle-bone communication mechanism primarily mediated by IL-33, linking muscle dysfunction to bone loss. This interaction could be a promising therapeutic target for musc...
www.thelancet.com
November 15, 2025 at 9:14 PM
craigagoodman1.bsky.social
Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis
www.nature.com/articles/s41...
Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis - Nature Communications
In mdx mouse fetuses, the lack of dystrophin markedly impairs secondary myogenesis due to reduced muscle stem cell polarity. AAK1 deletion restores polarity and rescues secondary myogenesis, revealing...
www.nature.com
November 15, 2025 at 9:13 PM
craigagoodman1.bsky.social
Impaired cAMP-PKA-CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia
www.nature.com/articles/s42...
Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia - Nature Metabolism
Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in mice.
www.nature.com
November 13, 2025 at 4:29 PM
craigagoodman1.bsky.social
Fast Myosin Binding Protein-C Is a Vital Regulator in Young and Aged Fast Skeletal Muscle Homeostasis
onlinelibrary.wiley.com/doi/10.1002/...
Fast Myosin Binding Protein‐C Is a Vital Regulator in Young and Aged Fast Skeletal Muscle Homeostasis
Background Skeletal muscle plays a vital role in voluntary movement and locomotion. Fast-twitch muscle fibres are characterized by their rapid contraction kinetics, high-force generation and a disti...
onlinelibrary.wiley.com
November 13, 2025 at 4:28 PM