Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that naked mole-rat cyclic guanosine monophosphate–adenosine ...

A woman's fertility declines with age, which is often attributed to a fall in egg number and quality, but the environment of the ovaries themselves may also be responsible

Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09521-xSex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

The ticking of the biological clock is especially loud in the ovaries—the organs that store and release a woman's eggs.

A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...

We estimated 11 organ-specific proteomic aging using the elastic net regularization model. Our findings revealed that organ-specific proteomic aging is influenced by lifestyle factors and baseline he...

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

Publication date: November 2025 Source: Animal Behaviour, Volume 229 Author(s): Remi Sakamoto, Tadatoshi Ogura

Sexual size differences are widespread in biology, yet the "how" behind them often remains vague. We asked a concrete question in a classic model organism: when female flies are larger than males, do individual organs achieve this by adding more cells, enlarging the cells they already have, or mixing both strategies—and is this consistent across the body?

Harmful genetic changes in sperm become substantially more common as men age because some are actively favored during sperm production, new research has revealed.

Behavioural plasticity can play a key role in evolution by either facilitating or impeding genetic adaptation. The latter occurs when behaviours mitigate selection pressures that otherwise would targe...

Çağan Şekercioğlu was an ambitious, but perhaps naive graduate student when, 26 years ago, he embarked on a simple data-compilation project that would soon evolve into a massive career-defining achiev...

How to measure female ejaculate ejection, is it related to pre-mating sexual selection, or influenced by post-mating sexual environment? We explore these questions in fruit flies.

Over 20 species of geographically and phylogenetically diverse bird species produce convergent whining vocalizations towards their respective brood parasites. Model presentation and playback experiments across multiple continents suggest that these learned calls provoke an innate response even among allopatric species.

Isabelle P. Neylan, Ana L. Salgado, Rujuta V. Vaidya, Cullen Guillory & Morgan W. Kelly This is a plain language summary of a Functional Ecology research article which can be found here. Unders…

The testis, with the highest number of transcriptionally active genes among human tissues, offers a unique window into how aging affects complex gene regulation. Recent advancements in single-cell RNA sequencing have enabled multi-species studies of aging-related transcriptome changes in testes. However, a comprehensive aging-related cross-species platform for analyzing testicular single-cell transcriptomes remains absent. To address this gap, we developed Aging-TCA (Aging-related Testicular Cell Atlas, available at http://tca.xielab.tech/)— a comprehensive online platform containing aging-related testicular single cell and spatial transcriptome profiles from human, cynomolgus monkey, mouse, and zebrafish across 89 samples and over 460, 000 testicular cells, nuclei or spots. Aging-TCA provides versatile tools for temporal and spatial analyzing testicular aging, including aging-related testicular gene expression visualization, cell-cell communication comparisons, cell-trajectory analysis, gene regulatory network analysis, testicular cell type auto-identification, time-series analysis, and spatial transcriptome comparisons. In summary, we provide a novel platform Aging-TCA for advancing cross-species research into testicular aging, facilitating future investigations in this field.

There is a widespread belief, in both the scholarly literature and the popular press, that polygyny prevents large numbers of men from marrying by ...