This paper investigates the continuity and transformation of lithic production and subsistence strategies during the Late Pleistocene–Holocene transit…

At the end of the sixth and the beginning of the fifth millennium BC, inhabitants of the areas in and around the Aegean Sea started to use native or p…

The incidence of retinopathies is expected to increase globally as our population ages and diabetes becomes more prevalent. Neovascular age-related macular degeneration (nAMD) and proliferative diabetic retinopathy (PDR) are major causes of severe vision loss. These ophthalmological conditions are associated with neovascularization caused by excessive vascular endothelial growth factor (VEGF) secretion. This review focuses on the milestones achieved during the last few decades in treating retinopathies, presents a meta-analysis of key human clinical trials, and finally describes various novel therapies, some of which could potentially eliminate the need for intravitreal injections of anti-VEGF in the future. According to data from clinical trials and everyday medical practice, treatments targeting VEGF are efficient; however, they can cause various systemic (such as stroke) and ocular adverse events. The most frequently experienced adverse reactions (such as endophthalmitis or retinal detachment) are related to the injection process itself. These complications warrant the efforts invested in developing novel approaches, including gene therapy-based products and inhibitors of VEGF receptors. We discuss here the strengths and drawbacks of gene therapy and highlight the potential of small-molecule tyrosine kinase inhibitors (TKIs) as alternative anti-neovascularization agents. TKIs have recently been tested via numerous administration routes, including simple oral dosing of oral formulations in addition to intravitreal implants, which allow for a slow release, intravitreal depots, and suprachoroidal injections. All of which have shown different safety and efficacy profiles. We conclude that gene therapy products, especially TKIs, have the potential to become inhibitors of ocular neovascularization in the upcoming years. Graphical Abstract

The incidence of certain disease events such as myocardial infarction, stroke, aortic rupture, and sudden cardiac death is affected by the time of day…

Research on early hominin subsistence has been increasingly concerned with the exploitation of diverse food resources in prehistory, including coastal…

Abstract. We present a kinematic and dynamical analysis of six Galactic open clusters—NGC 2204, NGC 2660, NGC 2262, Czernik 32, Pismis 18, and NGC 2437, us

With the inception of most of the world's deltas about 8000 years ago, deltaic floodplains started offering, about a thousand years later, arable land…

Semaglutide or tirzepatide should be the first line treatment for people living with obesity and most of its complications, according to a new framework for the pharmacological treatment of obesity…

Triggering receptor expressed on myeloid cells 2 (TREM2), a transmembrane, lipid-sensing protein expressed by Kupffer cells, is thought to play a role…

Diplodocoidea is a diverse clade of sauropod dinosaurs that comprises three major lineages: Diplodocidae, Dicraeosauridae and Rebbachisauridae, with the former two united as Flagellicaudata. There ...

The human multisensory neural network supports advanced cognitive functions through cross-modal integration, recognition, and imagination by synergist…

Real-time, high-fidelity physiological signal acquisition, coupled with targeted in situ interventional regulation, is a prerequisite for intelligent …

AbstractObjective. We examined glomerular filtration rate (eGFR) in relation to cardiometabolic and glucoregulatory factors and prediabetes risk in healthy

The site of Loreto (Venosa Basin, Italy) was first discovered in 1929 and subsequently excavated during the latter half of the 20th century. The excavation revealed three archaeo-palaeontological lev...

In Peru, archaeological studies of Andean agriculture have generally focused on archaeobotanical remains, agrarian technologies, or the social and eco…

This study investigates long-term impacts of empires on local socio-ecosystems in western Anatolia (modern western Türkiye) over the past four millennia. We focus on Buldan Yayla Lake, located in a s....

Tissue-like bioelectronics have emerged as practical, user-friendly and unobtrusive systems for seamless bidirectional integration with the human body. Two-dimensional materials, being led by the prot...

Michigan State University scientists have pinpointed the molecular "switch" that supercharges sperm for their final sprint to an egg—a breakthrough that could reshape infertility treatments and pave t...

Current evidence indicates that Post COVID-19 Condition (PCC) is multifaceted with distinct phenotypes. While previous studies have identified symptom…

Purified eicosapentaenoic acid (EPA) and mixed eicosapentaenoic/docosahexaenoic acids (EPA/DHA) are omega-3 polyunsaturated fatty acids (n-3 PUFAs) of…

People with ataxia often experience stress-induced motor incoordination. Researchers have now discovered which receptor is responsible for this.

Scientific Reports - Assessment of physiological stress on plants grown in soil contaminated with microplastics

npj Biomedical Innovations - Central and peripheral neural circuits regulating glucose homeostasis