The cities of Petra and Udhruh were administrative and cultural centers in southern Jordan from Nabataean through Roman and Byzantine times into the early Islamic periods (first century BCE to eighth....

The authors investigate the heterogeneity of Toxoplasma bradyzoites prior to recrudescence. Tissue cysts from infected mice harbor multiple bradyzoite subtypes with distinct developmental fates as evi...

The architectural and ritual biography of dolmen ST_30 in the Rjile necropolis (Kufr Yuba, Jordan) provides new chronological and cultural insights in…

Archaeology often adheres to established periodisations, sometimes overlooking long-term societal transformations. One such shift in Northern Britain during the first millennium AD was the emergenc...

Zolnik et al. propose that the long-overlooked neocortical layer 6b (L6b) supports a key circuit for attention and related cognitive functions. L6b integrates neuromodulatory and cortical feedback to trigger, sustain, and precisely control higher-order thalamocortical loops needed for attentive processing.

One of the most severe and least understood forms of cutaneous leishmaniasis (CL) is leishmaniasis recidivans (LR), a chronic variant in which lesions…

This study presents a textile-based optical force myography (oFMG) sensor for human-machine interface applications. The textile oFMG sensor is designed for a thin, compact, and comfortable profile ba...

In this article, I introduce a cultural approach to musical care by situating health, well-being, and music engagement within specific cultural meaning systems....

npj Biofilms and Microbiomes - Gut microbiome–driven colorectal cancer via immune, metabolic, neural, and endocrine axes reprogramming

Management of low-density lipoprotein cholesterol (LDL-C) in patients who are statin-intolerant requires treatment options beyond statins. Pemafibrate…

Although creatine supplementation holds promising translational value for supporting brain health and cognitive function, the current body of literatu…

AbstractBackground and Aims. The 12-lead electrocardiogram (ECG) remains a cornerstone of cardiac diagnostics, yet existing artificial intelligence (AI) so

The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores....

Objective This study reviews the existing literature on patients diagnosed with sarcoidosis isolated to the larynx to improve our understanding of the diagnosis and management of this rare condition...

Although most patients with chronic constipation respond to medical therapy, a subset experiences refractory constipation (RC), which poses unique dia…

The current guideline-recommended clinic blood pressure (BP) measurement procedure takes nearly 10 minutes to complete and may not be feasible to implement in busy clinical practice settings. Addition...

Viral transport within host cells is critical for viral replication. The dense cytoskeletal network and specialized organelles in the cytoplasm create a complex microenvironment that severely restricts free diffusion of molecules exceeding 500 kDa (1, 2). Given their substantial size, often spanning tens to hundreds of nanometers in diameter, viruses cannot diffuse freely through the cytoplasm. Consequently, they must hijack host transport systems to reach their replication sites efficiently. The viral infection process typically involves several key steps: (i) attachment to host cell surface receptors, (ii) entry through the clathrin-mediated endocytosis (CME) pathway or membrane fusion, (iii) genome release, (iv) intracellular transport of viral genetic material to replication sites, (v) coordinated trafficking of viral components for assembly, and (vi) progeny virus release. Adaptor protein complexes (APs), essential regulators of transmembrane trafficking, are hijacked by viruses to mediate intracellular transport at multiple stages of infection.

Our study investigates the distinctive pathogenic properties of the SARS-CoV-2 spike (S) protein from highly virulent variants, with a particular focus on its delayed pathological effects in mice. Using a vesicular stomatitis virus (VSV) vector to transiently express the Ancestral and Delta variant S proteins in K18-hACE2 mice, we observed minimal acute symptoms initially; however, approximately 40% of the mice developed mild pulmonary inflammation, neutrophil activation, and microthrombosis, leading to death between 8 and 16 days post-infection. This delayed pathology was accompanied by elevated circulating levels of CXCL13 and IGFBP-1. Consistent with these findings, serum samples from long COVID patients also showed significantly increased IGFBP-1 levels, while CXCL13 levels were particularly elevated in individuals with more severe long COVID symptoms. These findings provide important observational evidence that may guide future mechanistic studies on long COVID and inform the development of potential therapeutic approaches.

Arterial walls of large- and intermediate-sized arteries consist of three layers, that is, the intima, the media, and the adventitia. Under physiological conditions, the intima mainly comprises endot...