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Reposted by Oli Clarke

Derek Lowe @dereklowe.bsky.social · 4h

One week from now I plan to be out marching against the idiotic criminals running our government. I'm not "getting paid" and I'm not part of any "Pro-Hamas" group. I'm just mad as hell.

I will not be punching any police officers, nor setting fires, nor breaking any glass. Why will I turn out? (1/2)

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Alister Burt @alisterburt.bsky.social · 3h

Don Fawcett’s big red book The Cell is available for free online!!

There are a bajillion cryo-ET projects in there, recommend a physical copy if you can find one - it’s my favourite coffee table book

Oli Clarke @olibclarke.bsky.social · 3h

And it's available to borrow/view at archive.org, nice!

archive.org/details/cell...

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Oli Clarke @olibclarke.bsky.social · 3h

Already ordered! found one for 60 USD with free shipping which seemed like a fair price for a hardcover of this kind

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Oli Clarke @olibclarke.bsky.social · 3h

And it's available to borrow/view at archive.org, nice!

archive.org/details/cell...

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Oli Clarke @olibclarke.bsky.social · 3h

ooh that looks excellent! going on the shopping list

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Oli Clarke @olibclarke.bsky.social · 4h

Also this hexagonal thing, and these short bow-ties (kind of reminiscent of TPP2 but shorter?). Also 400Å circle here

Oli Clarke @olibclarke.bsky.social · 4h

here with a 400Å circle you can see a little more detail on the sides

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Oli Clarke @olibclarke.bsky.social · 4h

possibly stupid question - does anyone in #teamtomo or #cryoem recognize these little stacks (from EMPIAR-12549, U2OS cell lamellae)? The green circle is 300Å, and the spacing between the layers is ~50Å. The fourth, bell-shaped thing is something else, also not sure of that one..

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Yamuna Krishnan @krishnanyamuna.bsky.social · 7h

Nobel Laureate Joachim Frank: "I will not be bookended by two fascist regimes." An impactful must-read. www.usnews.com/opinion/arti...

www.usnews.com

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Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 18h

My first thought was “wow I hope this guy didn’t give out his name because he could absolutely be charged” and yup, he is correct to stay anonymous.

This man’s account is shocking. His neighbors’ situation is shocking. The entire Chicago raid is shocking.

On the other side was a mom and her 7-year-old daughter, pleading for his help.
"I wasn't planning on letting her stay, but I didn't know what the hell was going on," the man said of his Venezuelan migrant neighbors. But he quickly relented. The little girl was inconsolable and hid under his bed.
"I didn't want them to take her," said the man, who didn't want to be named because he fears he'll be targeted by federal authorities for his actions.
"I gave her my bedroom, and I just told her,
'Just stay there. Don't open, don't, shh, just stay quiet," he recalled telling the mom and daughter as he choked back tears.

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Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 18h

Can you think of a single movie in which there is a video from the government denouncing its political opponents playing on a loop in public spaces in which that government was the good guy?

Ron Filipkowski @ronfilipkowski.bsky.social · 18h

A new Noem video is being played at airports trashing Democrats.

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 1d

Pres. Kornbluth articulates such moral clarity in this rejection of the proposed “compact”:

“the premise of the document is inconsistent with our core belief that scientific funding should be based on scientific merit alone”

orgchart.mit.edu/letters/rega...

Regarding the Compact | MIT Organization Chart

orgchart.mit.edu

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Frances Separovic @francesbiophys.bsky.social · 1d

Congratulations to our esteemed colleague, Richard Robson, whose work highlights the strong nexus between teaching and research. #chemistry
www.linkedin.com/posts/univer...

#unimelb | University of Melbourne | 71 comments

Congratulations to #UniMelb's Professor Richard Robson, who has been awarded the 2025 Nobel Prize in Chemistry alongside Professor Susumu Kitagawa of Kyoto University and Professor Omar M. Yaghi of th...

www.linkedin.com

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Stephan Gruber @gruberlab.bsky.social · 2d

How do SMC complexes load onto DNA to get ready for loop extrusion?

@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️.

Check out the new paper: www.cell.com/molecular-ce...

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Oli Clarke @olibclarke.bsky.social · 2d

no wonder - the Fab-antigen interaction in that structure is only resolved at very low resolution, not at the level of sidechain detail. Probably the starting model is to blame...?

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Alejandro Llorente, Ph.D. @llorentealejandro.bsky.social · 2d

1/9 🚀 Big news! As a result of 5 years of my PhD, building on a 30-year dream of my PI Dr. Nancy Carrasco, we think we've found a new way to treat cancer! We’ve released our preprint & I'm so excited to share this story! 🧵
www.biorxiv.org/content/10.1...
#Science #proteinengineering #proteindesing

Engineering substrate selectivity in the human sodium/iodide symporter (NIS)

Iodide (I-) uptake mediated by the Na+/I- symporter (NIS) is the first step in the biosynthesis of the thyroid hormones, of which I- is an essential constituent. NIS couples the inward transport of I-...

www.biorxiv.org

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ttsukaza @ttsukaza.bsky.social · 2d

Our MurJ/LysM paper has been published in Science Advances.

Kohga et al., Sci. Adv. (2025).

This study elucidates, through cryo-electron microscopy, the mechanism by which the small bacteriophage-derived protein LysM inhibits the lipid II flippase MurJ.

t.co/u5ZibBF0kA

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Oli Clarke @olibclarke.bsky.social · 2d

Congrats!!! 🍾 🎉

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James A. Letts @lettsscience.bsky.social · 3d

Exciting new preprint from the Maldonado Lab @ucdavis.bsky.social
Structure of photosystem I from Giant Kelp!! First brown algae structure of a photosystem and the first structure of any protein from giant kelp a major primary producer, ecosystem defining species.
www.biorxiv.org/content/10.1...

Structure of Photosystem I-FCP from giant kelp uncovers drivers of antenna evolution across the red lineage

Brown algae and other red-algae-derived organisms such as diatoms are major contributors to global CO2 fixation via photosynthesis. To understand the photosynthetic function of brown algae, we obtaine...

www.biorxiv.org

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Derek Lowe @dereklowe.bsky.social · 3d

Absolutely true. And I’m glad he’s saying it.

AFP News Agency @en.afp.com · 3d

"It is going to be disastrous if this continues"

Nobel Prize physics laureate John Clarke says Trump cuts will 'cripple' US scientific research

u.afp.com/SmAy

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Oli Clarke @olibclarke.bsky.social · 3d

One of my very first placements as an undergrad was with Richard Robson! Growing MOFs with uranyl ions (which sadly failed to crystallize) and organoborate triangles (which worked). Was one of my first experiences with structure determination and I was hooked - so happy to see this!

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Milot Mirdita @milot.bsky.social · 4d

AFDB v6 is already available in Foldseek!

🚀 search.foldseek.com

foldseek databases Alphafold/UniProt50 afdb50 tmp
foldseek easy-search query.cif afdb50 res.m8 tmp --cluster-search 0/1 (Reps only / all 241M)

Thanks @ebi.embl.org and DeepMind for working with us to make it available to everyone.

EMBL-EBI @ebi.embl.org · 4d

We’re renewing our collaboration with Google DeepMind!

We'll keep developing the AlphaFold Database to support protein science worldwide 🎉

To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.

www.ebi.ac.uk/about/news/t...

🖥️🧬 #AlphaFold
@pdbeurope.bsky.social

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cryoEM papers @cryoempapers.bsky.social · 4d

ANTIDOTE: A Metadata-Driven Neural Network for Improving CryoEM 3-D Particle Sorting www.biorxiv.org/content/10.1101/2025.10.06.680814v1 #cryoem

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The Daum Lab @daumlab.bsky.social · 5d

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

www.science.org

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Sjors Scheres @sjorsscheres.bsky.social · 6d

If you are interesting in developing new algorithms for #cryoEM as a #PhD student or as a #postdoc, then do email or DM me. We have exciting opportunities coming up.

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